DK217289A - Substitueret guanin-nukleosid-derivat, praeparater fremstillet deraf, samt dets anvendelse som laegemiddel - Google Patents

Substitueret guanin-nukleosid-derivat, praeparater fremstillet deraf, samt dets anvendelse som laegemiddel Download PDF

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Publication number
DK217289A
DK217289A DK217289A DK217289A DK217289A DK 217289 A DK217289 A DK 217289A DK 217289 A DK217289 A DK 217289A DK 217289 A DK217289 A DK 217289A DK 217289 A DK217289 A DK 217289A
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DK
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Prior art keywords
preparations
medicine
substituted guanine
guanine nucleoside
substituents
Prior art date
Application number
DK217289A
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English (en)
Other versions
DK170780B1 (da
DK217289D0 (da
Inventor
Michael Goodman
Robert Chen
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of DK217289D0 publication Critical patent/DK217289D0/da
Publication of DK217289A publication Critical patent/DK217289A/da
Application granted granted Critical
Publication of DK170780B1 publication Critical patent/DK170780B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK217289A 1988-05-05 1989-05-03 Substituerede guaninnucleosidderivater, immunreaktionsforstærkende præparater deraf, og fremgangsmåde til at forøge en immunreaktion DK170780B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19069488 1988-05-05
US07/190,694 US5093318A (en) 1983-11-01 1988-05-05 Immunostimulating guanosine derivatives and their pharmaceutical compositions

Publications (3)

Publication Number Publication Date
DK217289D0 DK217289D0 (da) 1989-05-03
DK217289A true DK217289A (da) 1989-11-06
DK170780B1 DK170780B1 (da) 1996-01-15

Family

ID=22702383

Family Applications (1)

Application Number Title Priority Date Filing Date
DK217289A DK170780B1 (da) 1988-05-05 1989-05-03 Substituerede guaninnucleosidderivater, immunreaktionsforstærkende præparater deraf, og fremgangsmåde til at forøge en immunreaktion

Country Status (12)

Country Link
US (1) US5093318A (da)
EP (1) EP0341066B1 (da)
JP (1) JP2790846B2 (da)
AT (1) ATE113957T1 (da)
AU (1) AU619539B2 (da)
CA (1) CA1320196C (da)
DE (1) DE68919266T2 (da)
DK (1) DK170780B1 (da)
ES (1) ES2063125T3 (da)
GR (1) GR3015018T3 (da)
IE (1) IE66321B1 (da)
PT (1) PT90464B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
US7307166B1 (en) 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
WO1994007904A1 (en) * 1992-10-01 1994-04-14 Mcneilab, Inc. Derivatives of 7,8-disubstituted guanosines
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US5441942A (en) * 1994-05-27 1995-08-15 The Scripps Research Institute 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US5382580A (en) * 1994-05-27 1995-01-17 The Scripps Research Institute N9 morpholino derivatives of 7,8-disubstituted guanines
US5786359A (en) * 1994-05-27 1998-07-28 The Scripps Research Institute N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US5773424A (en) * 1994-12-16 1998-06-30 Research Corporation Technologies, Inc. Treatment of toxoplasmosis
US20030100520A1 (en) * 1997-01-21 2003-05-29 Philip Needleman Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
AU3786299A (en) 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
US6562801B1 (en) 1999-04-15 2003-05-13 Board Of Regents, The University Of Texas System PpGpp and pppGpp as immunomodulatory agents
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
WO2001095935A1 (en) * 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
EP1790344B1 (en) 2000-07-07 2011-02-23 Spectrum Pharmaceuticals, Inc. Methods for treatment of disease-induced peripheral neuropathy and related conditions
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
AU2001297693A1 (en) * 2000-12-08 2002-09-12 Coley Pharmaceutical Gmbh Cpg-like nucleic acids and methods of use thereof
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
US7351413B2 (en) * 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
EP1608403A2 (en) * 2003-04-02 2005-12-28 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations for topical application
DE602006003913D1 (de) * 2005-09-22 2009-01-08 Hoffmann La Roche Selektive o-acylierung von nukleosiden
MX2010001284A (es) * 2007-08-02 2010-08-31 Biondvax Pharmaceuticals Ltd Vacunas contra la influenza con multiepitope multimerico.
EP2722056A1 (en) 2007-12-03 2014-04-23 President and Fellows of Harvard College CT062, a Chlamydia antigen
CN102239253A (zh) 2008-12-03 2011-11-09 普罗蒂亚维仕尼科技有限公司 谷氨酰tRNA合成酶（GtS）片段
WO2011067758A2 (en) 2009-12-02 2011-06-09 Protea Vaccine Technologies Ltd. Immunogenic fragments and multimers from streptococcus pneumoniae proteins
AU2011360572B2 (en) 2011-02-22 2017-03-02 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
EP2833900B1 (en) 2012-04-01 2018-09-19 Technion Research & Development Foundation Limited Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
CN106163553B (zh) 2014-04-03 2021-07-23 彼昂德瓦克斯医药有限公司 多聚体-多表位流感多肽的组合物及其产生
US11059824B2 (en) 2018-05-25 2021-07-13 Primmune Therapeutics, Inc. Substituted purines as TLR7 agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643992A (en) * 1982-11-09 1987-02-17 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US4539205A (en) * 1982-11-09 1985-09-03 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US4948730A (en) * 1982-11-09 1990-08-14 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods

Also Published As

Publication number Publication date
DK170780B1 (da) 1996-01-15
ATE113957T1 (de) 1994-11-15
DK217289D0 (da) 1989-05-03
GR3015018T3 (en) 1995-05-31
AU619539B2 (en) 1992-01-30
US5093318A (en) 1992-03-03
EP0341066A3 (en) 1990-05-30
JPH0256496A (ja) 1990-02-26
DE68919266D1 (de) 1994-12-15
ES2063125T3 (es) 1995-01-01
EP0341066B1 (en) 1994-11-09
EP0341066A2 (en) 1989-11-08
CA1320196C (en) 1993-07-13
JP2790846B2 (ja) 1998-08-27
PT90464B (pt) 1994-12-30
IE891463L (en) 1989-11-05
PT90464A (pt) 1989-11-30
IE66321B1 (en) 1995-12-27
DE68919266T2 (de) 1995-06-01
AU3399989A (en) 1989-11-09

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