PT90372B - Processo para a preparacao de um derivado do acido n- acetil-6-amino-hexanoico - Google Patents
Processo para a preparacao de um derivado do acido n- acetil-6-amino-hexanoico Download PDFInfo
- Publication number
- PT90372B PT90372B PT90372A PT9037289A PT90372B PT 90372 B PT90372 B PT 90372B PT 90372 A PT90372 A PT 90372A PT 9037289 A PT9037289 A PT 9037289A PT 90372 B PT90372 B PT 90372B
- Authority
- PT
- Portugal
- Prior art keywords
- acetyl
- preparation
- aminohexanoic acid
- solvent
- nerethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims abstract 3
- BHRARTUEBYQRLW-UHFFFAOYSA-N 2-acetyl-6-aminohexanoic acid Chemical class CC(=O)C(C(O)=O)CCCCN BHRARTUEBYQRLW-UHFFFAOYSA-N 0.000 title 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 150000003751 zinc Chemical class 0.000 claims abstract description 5
- 239000011787 zinc oxide Substances 0.000 claims abstract description 4
- 239000002798 polar solvent Substances 0.000 claims abstract 3
- 239000002253 acid Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000011701 zinc Substances 0.000 abstract description 4
- 150000003839 salts Chemical class 0.000 abstract description 3
- WDSCBUNMANHPFH-UHFFFAOYSA-N acexamic acid Chemical compound CC(=O)NCCCCCC(O)=O WDSCBUNMANHPFH-UHFFFAOYSA-N 0.000 abstract 2
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Description
Descrição presente inv-encao refere—se a un.
paraçao de te? derivado do acido N-ac2til-3-ar?ino-he?:ai'.oivo, na. sal de zinco do referido ãcido de fórmula geral :adarrnnte / CM-CCT-H- (CL,) -CCO 7 Zn j z. e — z
Dote sal possui propriedades arti-ulcerosas.
processo da presente invenção caracterisa-se por fazer reagir o oxido de zinco, econaricarrente nais acessível que outros derivados, con. V-acetil-S-arúno-hexanõico, ntn solvente ou r.ústura de solventes de preferencia ãgua.
Λ teríperatura pode ser igual ou inferior ã da etulΊ' ção do solvente; de preferência utiliza-se una teaperatura d.e uns 30°C.
O sal pole-se ohter por cristalização no nesno solvente ou adicionar outro solvente no que seja nenos solúvel para aunentar o rendimento; filtra e seca-se
Para facilidade de explicação, ilustra-se a invenção, nas não se linita, con os exsaplos seguintes:
- 1 BAD ORIGINAL
V -
dXCrgrlO 1Dissolvor-se 2,0 ç de ãcido “ê.cetil-j-sr.iiro-her-rHnõico am G „1 fa ã-gua destilada; eleva-so a. ter.çroratura d2 dissolução a 30°C e vai-se adicionando pcuco a pouco 0,47 g de õ:ido do zinco. £uando tnr.ina a adição, mantem-se a reacção a essa temperatura o cer;. agitação durante 15 minutes, doismdc—se arrefecer er;. seguida.
R’,3 t-3· acro se atinge ,o, geratura cccpreendida. entre 40 e 50 C, adiciona-se C ml de acetona -a arrefece-se até -5°C. Deiezar-se durante 12 horas a essa ter.çeratura, filtrao «·
-ss, lava-se car. acetona e soca-se a COO. Obtco-se assim. um go branco e cristalino gue é o sal de zinco do ãcido ZT-acetil-3-aminc-i’enanoico
Ponto de fusão: 133-135°C dnãlise elonentar:
Calculado (1) gara C. /g^/L/VSn:
±O as.j 7. O
C- 04. . c p4 . 7-J/-'- f íi. JfG: t
Cncontrado (ê):
,34 ; 0: 23,41 e Zn: 15,35
C: 45,00 ; C: 5,57 ; d: 5,70 e Zn: 15/ .rn.glo .Verte-se num. reactor do capacidade apropriada 2,0 g dc ãcido V-acetil-5-ai’;ino-he;srióico e 0,47 g de crido da zin.co e adiciona-se 5 ml cie ãgua destilada. “leva-se a temperatura atê 30cC ca;. agitação e i-.iants2.t-se durante 30 minutos. Deira-se esfriar a. temperatura ambiente o posteriormente leva-se a O°C. Oeira-se 12 horas a OoC e filtra—se, lava-se ccu acetona e seca-se a 60°C
Cbtzm-se assim ijr.i coapxsto .branco e cristal i no cem as resmas caracteristicas gue o do enemplo 1.
Claims (1)
- - i Processe para a preparação de um. derivado Ec ácido E-acstil-S-amino-bexanõico, norreadaoente o sal cie zinco, ccz:. a formula / Glg-CCXEI- (CE) g-CCO_/2On, caracterizado por sa fazer reagir o ácido E-acetil-S-amino-b.ecranõieo cor. o õxido de zinco nur· solvente polar.A»Processo de acordo caa a reivindicação 1, caracterizado por o referido solvente polar ser ãgua.— 3 —Processo de acordo ccr. a reivindicação 1, caracterizado por a tezperatura da reacção ser igual ou inferior â da ebuli ção do solvente.Processo de acordo cor.·. a reivindicação 1, caracterizado per o referido sal de zinco se obter por cristalização no mesmo solvente, filtrando e secando-se em. seguida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8801281A ES2009266A6 (es) | 1988-04-27 | 1988-04-27 | Procedimiento para la preparacion de un derivado del acido n-acetil-6-aminohexanoico. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT90372A PT90372A (pt) | 1989-11-10 |
| PT90372B true PT90372B (pt) | 1995-03-31 |
Family
ID=8256036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT90372A PT90372B (pt) | 1988-04-27 | 1989-04-26 | Processo para a preparacao de um derivado do acido n- acetil-6-amino-hexanoico |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JP2588018B2 (pt) |
| BE (1) | BE1002546A3 (pt) |
| DE (1) | DE3913627C2 (pt) |
| DK (1) | DK201589A (pt) |
| ES (1) | ES2009266A6 (pt) |
| FR (1) | FR2630737B1 (pt) |
| GB (1) | GB2218090B (pt) |
| IE (1) | IE61517B1 (pt) |
| IT (1) | IT1229653B (pt) |
| NL (1) | NL8900901A (pt) |
| PT (1) | PT90372B (pt) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1311466A (en) * | 1968-12-23 | 1973-03-28 | Herbert Ltd A | Vertical spindle lathe for use in a machining complex |
| FR2062873B1 (pt) * | 1969-09-25 | 1973-07-13 | Choay Sa | |
| FR2147822B1 (pt) * | 1971-07-30 | 1974-10-18 | Centre Etd Ind Pharma | |
| ES466455A1 (es) * | 1978-01-30 | 1978-10-16 | Vinas Lab | Procedimiento para la preparacion de un nuevo derivado de 6-caprolactama. |
-
1988
- 1988-04-27 ES ES8801281A patent/ES2009266A6/es not_active Expired
-
1989
- 1989-04-06 IE IE110089A patent/IE61517B1/en not_active IP Right Cessation
- 1989-04-11 NL NL8900901A patent/NL8900901A/nl active Search and Examination
- 1989-04-11 GB GB8908095A patent/GB2218090B/en not_active Expired - Fee Related
- 1989-04-17 JP JP1098613A patent/JP2588018B2/ja not_active Expired - Fee Related
- 1989-04-21 IT IT8920252A patent/IT1229653B/it active
- 1989-04-25 FR FR898905461A patent/FR2630737B1/fr not_active Expired - Fee Related
- 1989-04-25 DE DE3913627A patent/DE3913627C2/de not_active Expired - Fee Related
- 1989-04-26 DK DK201589A patent/DK201589A/da not_active Application Discontinuation
- 1989-04-26 PT PT90372A patent/PT90372B/pt active IP Right Grant
- 1989-04-26 BE BE8900464A patent/BE1002546A3/fr active
Also Published As
| Publication number | Publication date |
|---|---|
| GB2218090A (en) | 1989-11-08 |
| IT1229653B (it) | 1991-09-06 |
| DE3913627A1 (de) | 1989-11-16 |
| IE61517B1 (en) | 1994-11-16 |
| IT8920252A0 (it) | 1989-04-21 |
| DK201589A (da) | 1989-10-28 |
| FR2630737A1 (fr) | 1989-11-03 |
| FR2630737B1 (fr) | 1991-11-08 |
| BE1002546A3 (fr) | 1991-03-19 |
| JP2588018B2 (ja) | 1997-03-05 |
| JPH02180859A (ja) | 1990-07-13 |
| DK201589D0 (da) | 1989-04-26 |
| NL8900901A (nl) | 1989-11-16 |
| GB2218090B (en) | 1991-12-11 |
| DE3913627C2 (de) | 1997-12-11 |
| PT90372A (pt) | 1989-11-10 |
| IE891100L (en) | 1989-10-27 |
| GB8908095D0 (en) | 1989-05-24 |
| ES2009266A6 (es) | 1989-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940909 |