PT902783E - Derivados hidrofobicos do taxano que promovem hidrolise - Google Patents

Derivados hidrofobicos do taxano que promovem hidrolise

Info

Publication number
PT902783E
PT902783E PT96930847T PT96930847T PT902783E PT 902783 E PT902783 E PT 902783E PT 96930847 T PT96930847 T PT 96930847T PT 96930847 T PT96930847 T PT 96930847T PT 902783 E PT902783 E PT 902783E
Authority
PT
Portugal
Prior art keywords
taxane
hydrocarbon
taxano
hydrolysis
hpg
Prior art date
Application number
PT96930847T
Other languages
English (en)
Inventor
Eric Mayhew
Shaukat Ali
Andrew S Janoff
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of PT902783E publication Critical patent/PT902783E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
PT96930847T 1995-09-12 1996-09-12 Derivados hidrofobicos do taxano que promovem hidrolise PT902783E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US357595P 1995-09-12 1995-09-12

Publications (1)

Publication Number Publication Date
PT902783E true PT902783E (pt) 2002-09-30

Family

ID=21706522

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96930847T PT902783E (pt) 1995-09-12 1996-09-12 Derivados hidrofobicos do taxano que promovem hidrolise

Country Status (22)

Country Link
US (1) US5703117A (pt)
EP (1) EP0902783B1 (pt)
JP (1) JP4192208B2 (pt)
KR (1) KR100401220B1 (pt)
CN (1) CN1100770C (pt)
AT (2) ATE309235T1 (pt)
CA (1) CA2231750C (pt)
CZ (1) CZ288562B6 (pt)
DE (2) DE69620802T2 (pt)
DK (2) DK0902783T3 (pt)
ES (2) ES2179208T3 (pt)
HK (1) HK1016169A1 (pt)
HU (1) HU226325B1 (pt)
IL (1) IL123595A (pt)
MX (1) MX9801871A (pt)
NO (1) NO319521B1 (pt)
NZ (1) NZ318300A (pt)
PL (1) PL187738B1 (pt)
PT (1) PT902783E (pt)
SK (1) SK283199B6 (pt)
TR (1) TR199800443T1 (pt)
WO (1) WO1997010234A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107332A (en) * 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) * 1996-02-16 2003-12-23 Elan Pharmaceuticals, Inc. D and L etherlipid stereoisomers and liposomes
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
PT1964557E (pt) 1997-11-10 2013-02-20 Sloan Kettering Inst Cancer Processo para a produção de formulações de trióxido de arsénio
BR9911031A (pt) * 1998-05-20 2002-01-29 Liposome Co Inc Novas formulações em partìculas
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
DE60004630T2 (de) * 1999-01-12 2004-06-17 Quanam Medical Corp., Santa Clara Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
US6607689B1 (en) * 2000-08-29 2003-08-19 Micron Technology, Inc. Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (en) * 2001-10-22 2008-12-31 Viroblock SA New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications
EP1461056A4 (en) * 2001-11-26 2006-01-25 Supergen Inc PROCESS FOR THE PREPARATION AND USE OF POLYOXYETHYLATED CICRIC OIL IN PHARMACEUTICAL COMPOSITIONS
AU2003249882B2 (en) * 2002-06-26 2008-09-18 Medigene Ag Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
WO2004069224A2 (en) 2003-02-03 2004-08-19 Neopharm, Inc. Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs
JP5139814B2 (ja) * 2005-02-18 2013-02-06 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー 医療装置に結合した改善された疎水性を有した薬剤
WO2006110862A2 (en) * 2005-04-12 2006-10-19 Wisconsin Alumni Research Foundation Micelle composition of polymer and passenger drug
JP2011517683A (ja) * 2008-04-10 2011-06-16 アブラクシス バイオサイエンス, エルエルシー 疎水性タキサン誘導体の組成物およびその使用
AU2009234127B2 (en) * 2008-04-10 2015-04-30 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
WO2011038278A2 (en) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
CN105503844A (zh) * 2015-12-11 2016-04-20 上海大学 C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) * 2019-12-03 2022-01-28 沈阳药科大学 卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
EP0626953A4 (en) * 1992-12-23 1995-05-03 Bristol Myers Squibb Co NEW SIDE CHAINS WEARING TAXANS AND THEIR INTERMEDIATE PRODUCTS.
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives

Also Published As

Publication number Publication date
MX9801871A (es) 1998-05-31
ATE309235T1 (de) 2005-11-15
ES2252347T3 (es) 2006-05-16
AU706290B2 (en) 1999-06-10
WO1997010234A1 (en) 1997-03-20
ES2179208T3 (es) 2003-01-16
HK1016169A1 (en) 1999-10-29
DE69635428T2 (de) 2006-06-14
DE69620802T2 (de) 2002-10-10
PL325477A1 (en) 1998-07-20
TR199800443T1 (xx) 1998-06-22
PL187738B1 (pl) 2004-09-30
DK0902783T3 (da) 2002-07-22
HU226325B1 (en) 2008-08-28
NO981071D0 (no) 1998-03-11
CZ288562B6 (cs) 2001-07-11
CZ71198A3 (cs) 1998-07-15
EP0902783A4 (pt) 1999-03-24
NO319521B1 (no) 2005-08-22
CN1100770C (zh) 2003-02-05
SK33498A3 (en) 1998-08-05
CA2231750A1 (en) 1997-03-20
EP0902783B1 (en) 2002-04-17
DE69620802D1 (de) 2002-05-23
US5703117A (en) 1997-12-30
CA2231750C (en) 2006-07-11
IL123595A (en) 2000-10-31
HUP9901433A2 (hu) 2001-04-28
EP0902783A1 (en) 1999-03-24
JP4192208B2 (ja) 2008-12-10
SK283199B6 (sk) 2003-03-04
KR100401220B1 (ko) 2004-03-20
NZ318300A (en) 1999-08-30
HUP9901433A3 (en) 2001-05-28
KR19990044409A (ko) 1999-06-25
IL123595A0 (en) 1998-10-30
AU6975696A (en) 1997-04-01
ATE216377T1 (de) 2002-05-15
DK1229030T3 (da) 2006-02-13
JP2001519755A (ja) 2001-10-23
DE69635428D1 (de) 2005-12-15
NO981071L (no) 1998-05-12
CN1202166A (zh) 1998-12-16

Similar Documents

Publication Publication Date Title
PT902783E (pt) Derivados hidrofobicos do taxano que promovem hidrolise
DE69713526D1 (de) Lösliche prodrugs von paclitaxel
PT977564E (pt) Forscolina para promocao da massa corporal magra
DE69226197D1 (de) Hämoglobine als arzneimittelabgabesystem
ES2154622T1 (es) Derivados del taxano hidrofobos.
CA2301057A1 (en) A method of administering liposomal encapsulated taxane
ES2103947T5 (es) Mejoras introducidas en o relacionadas con agentes de contraste.
ATE324119T1 (de) Verwendung von saccharid-konjugaten
DE69432607D1 (de) Inhalierbares kontrastmittel
KR890000101A (ko) 반월조직의 치료 개선방법 및 치료약제
CY1109695T1 (el) Μικροοργανισμοι αποδομησης οξαλικου ή ενζυμα αποδομησης οξαλικου για την προληψη παθησης σχετιζομενης με οξαλικο
UY25263A1 (es) 6-derivados sustitutivos del ácido micofenólico.-
SE8404283L (sv) Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
ITRM910002A1 (it) Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
DK1275389T3 (da) Præparater indeholdende C7-taxaner
DE69812100D1 (de) Adenosin enthaltendes arzneimittel
ATE141796T1 (de) 2',5'-oligoadenylat-derivate zur verwendung als heilmittel
EP1229030A3 (en) Hydrolysis-promoting taxane hydrophobic derivates
PT1058544E (pt) Inibicao da actividade do tnf
ES8605989A1 (es) Un metodo de preparar un complejo de fibronectina, dextrano y farmaco
IT208536Z2 (it) Struttura di cannula vaginale monouso, per l'applicazione di pomate, medicamenti semidensi e simili.
MX9709684A (es) Uso de derivados de vitamina d4 para tratamiento de trastornos de la piel.