PT89250A - Processo para a preparacao de derivados de tieno{3,2-f} {1,2,4}triazolo{4,3-a} {1,4}diazepina e {1,2,4}triazolo{4,3-a} {1,4}benzodiazepina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de tieno{3,2-f} {1,2,4}triazolo{4,3-a} {1,4}diazepina e {1,2,4}triazolo{4,3-a} {1,4}benzodiazepina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT89250A PT89250A PT89250A PT8925088A PT89250A PT 89250 A PT89250 A PT 89250A PT 89250 A PT89250 A PT 89250A PT 8925088 A PT8925088 A PT 8925088A PT 89250 A PT89250 A PT 89250A
- Authority
- PT
- Portugal
- Prior art keywords
- triazolo
- lower alkoxy
- integer
- carbon
- lower alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 3
- 108010003541 Platelet Activating Factor Proteins 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 206010040560 shock Diseases 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13472687A | 1987-12-18 | 1987-12-18 | |
| US22794888A | 1988-08-03 | 1988-08-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89250A true PT89250A (pt) | 1989-12-29 |
| PT89250B PT89250B (pt) | 1993-07-30 |
Family
ID=26832617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89250A PT89250B (pt) | 1987-12-18 | 1988-12-16 | Processo para a preparacao de derivados de tieno{3,2-f} {1,2,4}triazolo{4,3-a} {1,4}diazepina e {1,2,4}triazolo{4,3-a} {1,4}benzodiazepina e de composicoes farmaceuticas que os contem |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0320992B1 (pt) |
| JP (1) | JPH0725762B2 (pt) |
| KR (1) | KR890009932A (pt) |
| CN (1) | CN1031057C (pt) |
| AT (1) | ATE109148T1 (pt) |
| AU (1) | AU612441B2 (pt) |
| CA (1) | CA1327570C (pt) |
| CS (1) | CS833288A2 (pt) |
| DE (1) | DE3850866T2 (pt) |
| DK (1) | DK704088A (pt) |
| ES (1) | ES2056889T3 (pt) |
| FI (1) | FI88799C (pt) |
| HU (1) | HU204273B (pt) |
| IE (1) | IE63762B1 (pt) |
| IL (1) | IL88688A0 (pt) |
| MC (1) | MC1999A1 (pt) |
| NO (1) | NO167920C (pt) |
| NZ (1) | NZ227341A (pt) |
| PT (1) | PT89250B (pt) |
| RU (1) | RU2094436C1 (pt) |
| YU (1) | YU46991B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| JP2959598B2 (ja) * | 1990-10-12 | 1999-10-06 | 吉富製薬株式会社 | 光学活性なチエノトリアゾロジアゼピン化合物 |
| US5130315A (en) * | 1991-01-10 | 1992-07-14 | Raymond R. Wittekind | 1-piperazinyl-2-butenes and -2-butynes |
| WO1994006802A1 (en) * | 1992-09-18 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compound and medicinal use thereof |
| US5302590A (en) * | 1992-12-18 | 1994-04-12 | Hoffmann-La Roche Inc. | Compounds useful as dual antagonists of platelet activating factor and leukotriene D4 |
| EP1925614A1 (en) * | 2002-03-28 | 2008-05-28 | Wisys Technology Foundation, Inc. | Anxiolytic agents with reduced sedative and ataxic effects |
| AU2003230754B2 (en) | 2002-03-28 | 2007-10-25 | Wisys Technology Foundation, Inc. | Anxiolytic agents with reduced sedative and ataxic effects |
| US7618958B2 (en) | 2004-06-30 | 2009-11-17 | Wisys Technology Foundation, Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| KR101238430B1 (ko) * | 2004-07-27 | 2013-02-28 | 길리애드 사이언시즈, 인코포레이티드 | 이미다조［4,5-ｄ］피리미딘, 그들의 용도 및 제조방법 |
| WO2006031491A2 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirolactam cgrp receptor antagonists |
| AU2005285083B2 (en) * | 2004-09-13 | 2011-03-10 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantoin CGRP receptor antagonists |
| ES2526671T3 (es) * | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| UA110640C2 (uk) * | 2011-05-05 | 2016-01-25 | Янссен Фармацевтика Нв | ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9662324B2 (en) * | 2013-05-01 | 2017-05-30 | Academia Sinica | Methods and compositions for treating β-thalassemia and sickle cell disease |
| CN103694253A (zh) * | 2013-11-04 | 2014-04-02 | 湖南华腾制药有限公司 | 一种噻吩并三唑并[4,3-a][1,4]二氮杂卓类化合物的制备方法 |
| DK3157928T3 (da) | 2014-06-20 | 2019-05-20 | Constellation Pharmaceuticals Inc | Krystallinske former af 2-((4s)-6-(4-chlorphenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamid |
| EP3535253A1 (en) * | 2016-11-01 | 2019-09-11 | H. Hoffnabb-La Roche Ag | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| DE3778559D1 (de) * | 1986-01-21 | 1992-06-04 | Boehringer Ingelheim Kg | Thieno-1,4-diazepine. |
| DE3610848A1 (de) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | Neue 1,4-diazepine |
| DE3878833T2 (de) * | 1987-05-28 | 1993-06-09 | Yoshitomi Pharmaceutical | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
-
1988
- 1988-12-06 MC MC882021A patent/MC1999A1/xx unknown
- 1988-12-15 IL IL88688A patent/IL88688A0/xx unknown
- 1988-12-15 NZ NZ227341A patent/NZ227341A/en unknown
- 1988-12-15 CS CS888332A patent/CS833288A2/cs unknown
- 1988-12-15 CA CA000585981A patent/CA1327570C/en not_active Expired - Fee Related
- 1988-12-16 DK DK704088A patent/DK704088A/da not_active Application Discontinuation
- 1988-12-16 AU AU26989/88A patent/AU612441B2/en not_active Ceased
- 1988-12-16 AT AT88121165T patent/ATE109148T1/de not_active IP Right Cessation
- 1988-12-16 NO NO885597A patent/NO167920C/no unknown
- 1988-12-16 IE IE375888A patent/IE63762B1/en not_active IP Right Cessation
- 1988-12-16 ES ES88121165T patent/ES2056889T3/es not_active Expired - Lifetime
- 1988-12-16 HU HU886449A patent/HU204273B/hu not_active IP Right Cessation
- 1988-12-16 DE DE3850866T patent/DE3850866T2/de not_active Expired - Fee Related
- 1988-12-16 EP EP88121165A patent/EP0320992B1/en not_active Expired - Lifetime
- 1988-12-16 JP JP63316555A patent/JPH0725762B2/ja not_active Expired - Lifetime
- 1988-12-16 FI FI885820A patent/FI88799C/fi not_active IP Right Cessation
- 1988-12-16 PT PT89250A patent/PT89250B/pt not_active IP Right Cessation
- 1988-12-16 YU YU228088A patent/YU46991B/sh unknown
- 1988-12-17 KR KR1019880016887A patent/KR890009932A/ko not_active Application Discontinuation
- 1988-12-17 CN CN88108697A patent/CN1031057C/zh not_active Expired - Fee Related
-
1992
- 1992-01-31 RU SU925010684A patent/RU2094436C1/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19930119 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20020731 Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20020731 |