PT86062B - Processo para a preparacao de uma composicao farmaceutica para o tratamento da hipertensao e do colapso cardiaco congestivo contendo uma mistura sinergica de um antagonista do calcio com acido 7-<n-{1-(s)-etoxicarbonil-3-fenilpropil}-(s)-alanil>-1,4-ditia-7-azaspiro-{4,4}-nonano-8(s)-caboxilico e os seus sais farmaceuticamente aceitaveis - Google Patents

Processo para a preparacao de uma composicao farmaceutica para o tratamento da hipertensao e do colapso cardiaco congestivo contendo uma mistura sinergica de um antagonista do calcio com acido 7-<n-{1-(s)-etoxicarbonil-3-fenilpropil}-(s)-alanil>-1,4-ditia-7-azaspiro-{4,4}-nonano-8(s)-caboxilico e os seus sais farmaceuticamente aceitaveis Download PDF

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Publication number
PT86062B
PT86062B PT86062A PT8606287A PT86062B PT 86062 B PT86062 B PT 86062B PT 86062 A PT86062 A PT 86062A PT 8606287 A PT8606287 A PT 8606287A PT 86062 B PT86062 B PT 86062B
Authority
PT
Portugal
Prior art keywords
alkyl
carbon atoms
acid
alkoxy
dimethyl
Prior art date
Application number
PT86062A
Other languages
English (en)
Portuguese (pt)
Other versions
PT86062A (en
Inventor
Helene Siegl
Robert Paul Hof
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868626217A external-priority patent/GB8626217D0/en
Priority claimed from GB878713349A external-priority patent/GB8713349D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT86062A publication Critical patent/PT86062A/pt
Publication of PT86062B publication Critical patent/PT86062B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT86062A 1986-11-03 1987-11-02 Processo para a preparacao de uma composicao farmaceutica para o tratamento da hipertensao e do colapso cardiaco congestivo contendo uma mistura sinergica de um antagonista do calcio com acido 7-<n-{1-(s)-etoxicarbonil-3-fenilpropil}-(s)-alanil>-1,4-ditia-7-azaspiro-{4,4}-nonano-8(s)-caboxilico e os seus sais farmaceuticamente aceitaveis PT86062B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868626217A GB8626217D0 (en) 1986-11-03 1986-11-03 Pharmaceutical compositions
GB878713349A GB8713349D0 (en) 1987-06-08 1987-06-08 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
PT86062A PT86062A (en) 1987-12-01
PT86062B true PT86062B (pt) 1990-11-07

Family

ID=26291485

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86062A PT86062B (pt) 1986-11-03 1987-11-02 Processo para a preparacao de uma composicao farmaceutica para o tratamento da hipertensao e do colapso cardiaco congestivo contendo uma mistura sinergica de um antagonista do calcio com acido 7-<n-{1-(s)-etoxicarbonil-3-fenilpropil}-(s)-alanil>-1,4-ditia-7-azaspiro-{4,4}-nonano-8(s)-caboxilico e os seus sais farmaceuticamente aceitaveis

Country Status (25)

Country Link
KR (1) KR960005145B1 (de)
AT (1) AT397343B (de)
AU (1) AU615883B2 (de)
BE (1) BE1002063A4 (de)
CA (1) CA1314222C (de)
CH (1) CH677189A5 (de)
DE (1) DE3736505A1 (de)
DK (1) DK574087A (de)
ES (1) ES2010524A6 (de)
FI (1) FI874823A (de)
FR (1) FR2605885B1 (de)
GR (1) GR871680B (de)
HK (1) HK138893A (de)
HU (1) HU199681B (de)
IE (1) IE60496B1 (de)
IL (1) IL84343A (de)
IT (1) IT1212037B (de)
LU (1) LU87034A1 (de)
MY (1) MY102124A (de)
NL (1) NL8702502A (de)
NO (1) NO874539L (de)
NZ (1) NZ222401A (de)
PH (1) PH23249A (de)
PT (1) PT86062B (de)
SE (1) SE8704272L (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
FR2733911B1 (fr) * 1995-05-09 1998-05-29 Takeda Chemical Industries Ltd Composition pharmaceutique pour maladies renales ou cardio-vasculaires

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4520021A (en) * 1982-07-02 1985-05-28 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
DE3437917A1 (de) * 1984-10-17 1986-04-17 Bayer Ag, 5090 Leverkusen Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
GB2198641B (en) * 1986-11-03 1990-09-19 Sandoz Ltd Pharmaceutical composition for use against hypertension and congestive heart failure
IL88502A (en) * 1987-12-14 1993-04-04 Squibb & Sons Inc Pharmaceutical compositions containing an angiotensin converting enzyme inhibitor

Also Published As

Publication number Publication date
HUT47847A (en) 1989-04-28
GR871680B (en) 1988-05-02
FR2605885A1 (fr) 1988-05-06
NO874539L (no) 1988-05-04
FI874823A (fi) 1988-05-04
HU199681B (en) 1990-03-28
AU8057687A (en) 1988-05-05
IL84343A0 (en) 1990-02-09
ES2010524A6 (es) 1989-11-16
IL84343A (en) 1993-07-08
KR960005145B1 (ko) 1996-04-22
CA1314222C (en) 1993-03-09
CH677189A5 (de) 1991-04-30
DK574087A (da) 1988-05-04
NZ222401A (en) 1991-04-26
ATA286987A (de) 1993-08-15
IE872951L (en) 1988-05-03
PH23249A (en) 1989-06-16
SE8704272D0 (sv) 1987-11-02
MY102124A (en) 1992-03-31
PT86062A (en) 1987-12-01
AU615883B2 (en) 1991-10-17
LU87034A1 (fr) 1988-05-03
IE60496B1 (en) 1994-07-27
IT1212037B (it) 1989-11-08
SE8704272L (sv) 1988-05-04
FR2605885B1 (fr) 1993-09-10
NO874539D0 (no) 1987-11-02
DK574087D0 (da) 1987-11-02
FI874823A0 (fi) 1987-11-02
BE1002063A4 (fr) 1990-06-12
IT8748553A0 (it) 1987-10-30
HK138893A (en) 1993-12-24
DE3736505A1 (de) 1988-05-05
NL8702502A (nl) 1988-06-01
AT397343B (de) 1994-03-25
KR880006197A (ko) 1988-07-22

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