PT825197E - Novos derivados de 6-hidroxi e 6-oxo-androstano com actividade sobre o sistema cardiovascular e composicoes farmaceuticas que os contem - Google Patents
Novos derivados de 6-hidroxi e 6-oxo-androstano com actividade sobre o sistema cardiovascular e composicoes farmaceuticas que os contem Download PDFInfo
- Publication number
- PT825197E PT825197E PT97111651T PT97111651T PT825197E PT 825197 E PT825197 E PT 825197E PT 97111651 T PT97111651 T PT 97111651T PT 97111651 T PT97111651 T PT 97111651T PT 825197 E PT825197 E PT 825197E
- Authority
- PT
- Portugal
- Prior art keywords
- androstane
- dione
- androstan
- dimethylaminoethoxyimino
- dimethylaminopropoxy
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
- XWCQCIXHSIXOAW-IJPPCXMXSA-N (5s,8s,9s,10r,13s,14s)-10,13-dimethyl-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one Chemical class C([C@@H]1C(=O)C2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 XWCQCIXHSIXOAW-IJPPCXMXSA-N 0.000 title abstract description 5
- 230000000694 effects Effects 0.000 title description 5
- 210000000748 cardiovascular system Anatomy 0.000 title description 2
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 206010020772 Hypertension Diseases 0.000 claims abstract description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 5
- 206010019280 Heart failures Diseases 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract 2
- -1 R 5 Chemical group 0.000 claims description 103
- 229910052757 nitrogen Inorganic materials 0.000 claims description 86
- 150000001875 compounds Chemical class 0.000 claims description 40
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
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- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
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- PUCJZHMJFADQGY-LHYCFKSISA-N (3s,5s,8r,9s,10r,13s,14s)-3-[(z)-2-aminoethoxyiminomethyl]-10,13-dimethyl-2,3,4,5,7,8,9,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthrene-6,17-dione Chemical compound C1[C@@H](\C=N/OCCN)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=O)[C@H]21 PUCJZHMJFADQGY-LHYCFKSISA-N 0.000 claims description 2
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 claims description 2
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- 125000005842 heteroatom Chemical group 0.000 claims description 2
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633349A DE19633349A1 (de) | 1996-08-19 | 1996-08-19 | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT825197E true PT825197E (pt) | 2001-01-31 |
Family
ID=7802998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97111651T PT825197E (pt) | 1996-08-19 | 1997-07-09 | Novos derivados de 6-hidroxi e 6-oxo-androstano com actividade sobre o sistema cardiovascular e composicoes farmaceuticas que os contem |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5914324A (enExample) |
| EP (1) | EP0825197B1 (enExample) |
| JP (1) | JP4297994B2 (enExample) |
| AT (1) | ATE196768T1 (enExample) |
| DE (2) | DE19633349A1 (enExample) |
| DK (1) | DK0825197T3 (enExample) |
| ES (1) | ES2151698T3 (enExample) |
| GR (1) | GR3034821T3 (enExample) |
| PT (1) | PT825197E (enExample) |
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| IT1317031B1 (it) * | 2000-05-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. |
| US8168621B2 (en) | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
| US10174070B2 (en) | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| US20080119447A1 (en) * | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
| TWI392682B (zh) | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 |
| TWI389917B (zh) * | 2006-04-13 | 2013-03-21 | Sigma Tau Ind Farmaceuti | 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物 |
| TWI372762B (en) * | 2006-06-23 | 2012-09-21 | Sigma Tau Ind Farmaceuti | Amino derivatives of b-homoandrostanes and b-heteroandrostanes |
| WO2008067450A2 (en) | 2006-11-30 | 2008-06-05 | Endece, Llc | 6-alkoxyalkyl estradiol derivatives and methods of use |
| US8664210B2 (en) * | 2007-10-12 | 2014-03-04 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders |
| WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
| WO2012013816A1 (en) * | 2010-07-30 | 2012-02-02 | Medexis S.A. | Compounds and methods for treating neoplasia |
| ES2605960T3 (es) | 2010-09-14 | 2017-03-17 | Endece, Llc | Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta |
| CN103315968B (zh) * | 2013-06-26 | 2015-04-01 | 中国生命药物治疗有限公司 | 一种注射用粉针剂及其制备方法 |
| CN103360457B (zh) * | 2013-07-31 | 2015-10-07 | 中国生命药物治疗有限公司 | 一种雄甾烷二酮衍生物晶型及其制备方法 |
| PL3599243T3 (pl) | 2018-07-26 | 2023-08-21 | Cvie Therapeutics Limited | Związki podobne do 17beta-heterocyklilu naparstnicy do leczenia niewydolności serca |
| BR112021017009A2 (pt) | 2019-03-05 | 2021-11-09 | Windtree Therapeutics Inc | Formulação intravenosa contendo istaroxima para o tratamento da insuficiência cardíaca aguda (ahf) |
| ES2970792T3 (es) | 2019-10-09 | 2024-05-30 | Windtree Therapeutics Inc | Derivados de androstano con actividad como estimuladores puros o predominantemente puros de SERCA2A para el tratamiento de la insuficiencia cardíaca |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863885A (en) * | 1958-02-10 | 1958-12-09 | Upjohn Co | 17-isonitrosoandrostanes |
| FR7725M (enExample) * | 1967-06-22 | 1970-03-02 | ||
| CH504427A (de) * | 1967-12-06 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene |
| US5144017A (en) * | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| GB9201224D0 (en) * | 1992-01-21 | 1992-03-11 | Erba Carlo Spa | Difluoromethylenandrostenone derivatives and process for their preparation |
| DE4227605C2 (de) * | 1992-08-20 | 1995-02-16 | Sigma Tau Ind Farmaceuti | 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten |
| DE4232656C2 (de) * | 1992-09-29 | 1995-01-12 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen |
| DE4344236A1 (de) * | 1993-12-23 | 1995-06-29 | Sigma Tau Ind Farmaceuti | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
-
1996
- 1996-08-19 DE DE19633349A patent/DE19633349A1/de not_active Withdrawn
-
1997
- 1997-07-09 EP EP97111651A patent/EP0825197B1/en not_active Expired - Lifetime
- 1997-07-09 PT PT97111651T patent/PT825197E/pt unknown
- 1997-07-09 AT AT97111651T patent/ATE196768T1/de active
- 1997-07-09 DE DE69703228T patent/DE69703228T2/de not_active Expired - Lifetime
- 1997-07-09 ES ES97111651T patent/ES2151698T3/es not_active Expired - Lifetime
- 1997-07-09 DK DK97111651T patent/DK0825197T3/da active
- 1997-07-10 US US08/891,030 patent/US5914324A/en not_active Expired - Lifetime
- 1997-08-19 JP JP22285497A patent/JP4297994B2/ja not_active Expired - Lifetime
-
2000
- 2000-11-10 GR GR20000402508T patent/GR3034821T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1009139A1 (en) | 1999-05-28 |
| JP4297994B2 (ja) | 2009-07-15 |
| DK0825197T3 (da) | 2000-10-30 |
| DE69703228T2 (de) | 2001-02-22 |
| DE19633349A1 (de) | 1998-02-26 |
| ATE196768T1 (de) | 2000-10-15 |
| EP0825197A2 (en) | 1998-02-25 |
| EP0825197A3 (en) | 1999-04-14 |
| JPH1077292A (ja) | 1998-03-24 |
| US5914324A (en) | 1999-06-22 |
| ES2151698T3 (es) | 2001-01-01 |
| EP0825197B1 (en) | 2000-10-04 |
| GR3034821T3 (en) | 2001-02-28 |
| DE69703228D1 (de) | 2000-11-09 |
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