PT78304A - Neue n-phenyl-n'-cycloalkylalkanoyl-piperazine und verfahren zu deren herstellung - Google Patents

Neue n-phenyl-n'-cycloalkylalkanoyl-piperazine und verfahren zu deren herstellung

Info

Publication number
PT78304A
PT78304A PT78304A PT7830484A PT78304A PT 78304 A PT78304 A PT 78304A PT 78304 A PT78304 A PT 78304A PT 7830484 A PT7830484 A PT 7830484A PT 78304 A PT78304 A PT 78304A
Authority
PT
Portugal
Prior art keywords
groups
radical
phenyl
group
formula
Prior art date
Application number
PT78304A
Other languages
German (de)
English (en)
Other versions
PT78304B (de
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of PT78304A publication Critical patent/PT78304A/pt
Publication of PT78304B publication Critical patent/PT78304B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT78304A 1983-03-25 1984-03-23 Neue n-phenyl-n'-cycloalkylalkanoyl-piperazine und verfahren zu deren herstellung PT78304B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3310871 1983-03-25

Publications (2)

Publication Number Publication Date
PT78304A true PT78304A (de) 1984-04-01
PT78304B PT78304B (de) 1986-04-22

Family

ID=6194617

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78304A PT78304B (de) 1983-03-25 1984-03-23 Neue n-phenyl-n'-cycloalkylalkanoyl-piperazine und verfahren zu deren herstellung

Country Status (17)

Country Link
US (1) US4547505A (pt)
EP (1) EP0120465B1 (pt)
JP (1) JPS59205362A (pt)
AT (1) ATE20887T1 (pt)
AU (1) AU560579B2 (pt)
CA (1) CA1211435A (pt)
DD (1) DD213215A5 (pt)
DE (1) DE3460325D1 (pt)
DK (1) DK142084A (pt)
ES (2) ES8501383A1 (pt)
FI (1) FI841181A (pt)
HU (1) HU191643B (pt)
IL (1) IL71324A (pt)
NO (1) NO841163L (pt)
PT (1) PT78304B (pt)
SU (1) SU1297727A3 (pt)
ZA (1) ZA842185B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536071B1 (fr) * 1982-11-12 1986-07-11 Sanofi Sa Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0582065A1 (en) * 1986-08-15 1994-02-09 WHITBY RESEARCH, Inc. 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst
US4797405A (en) * 1987-10-26 1989-01-10 Eli Lilly And Company Stabilized pergolide compositions
ES2061953T3 (es) * 1988-11-24 1994-12-16 Akzo Nv Un procedimiento para preparar una composicion farmaceutica.
EP0385043A1 (en) * 1989-02-28 1990-09-05 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New derivatives of 4-substituted piperazines
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533241A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
HU209678B (en) * 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
EP0708765A4 (en) * 1993-07-16 1996-06-26 Merck & Co Inc PIPERAZINYLCAMPHER DERIVATIVES SUBSTITUTED AS OXYTOCIN ANTAGONISTS
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
AU2004221812B2 (en) * 2003-03-19 2010-02-18 Exelixis Inc. Tie-2 modulators and methods of use
CN1950082B (zh) * 2004-03-03 2013-02-06 凯莫森特里克斯股份有限公司 双环和桥连的含氮杂环化物
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
EP2120563A4 (en) * 2006-12-20 2011-04-27 Astrazeneca Ab CONNECTIONS AND ITS USES
KR20150076264A (ko) * 2007-08-22 2015-07-06 아스트라제네카 아베 시클로프로필 아미드 유도체
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
TW201136898A (en) * 2010-02-18 2011-11-01 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
MX336333B (es) * 2010-02-18 2016-01-15 Astrazeneca Ab Nueva forma cristalina de un derivado de ciclopropilbenzamida.
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421695B (sv) * 1975-04-21 1982-01-25 Merck & Co Inc Sett att framstella piperazinylpyraziner
JPS52286A (en) * 1975-05-27 1977-01-05 Kyorin Pharmaceut Co Ltd Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
WO1981003658A1 (en) * 1980-06-16 1981-12-24 Ferrosan Ab Diphenylbutyl-1-acylpiperazines
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
JPS591474A (ja) * 1982-06-07 1984-01-06 Nippon Iyakuhin Kogyo Kk ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類

Also Published As

Publication number Publication date
HU191643B (en) 1987-03-30
DD213215A5 (de) 1984-09-05
AU560579B2 (en) 1987-04-09
EP0120465A1 (de) 1984-10-03
JPS59205362A (ja) 1984-11-20
FI841181A (fi) 1984-09-26
DK142084D0 (da) 1984-02-29
CA1211435A (en) 1986-09-16
FI841181A0 (fi) 1984-03-23
SU1297727A3 (ru) 1987-03-15
PT78304B (de) 1986-04-22
IL71324A0 (en) 1984-06-29
US4547505A (en) 1985-10-15
ES530901A0 (es) 1984-11-16
ES8501384A1 (es) 1984-11-16
DK142084A (da) 1984-09-26
AU2605784A (en) 1984-09-27
NO841163L (no) 1984-09-26
EP0120465B1 (de) 1986-07-23
DE3460325D1 (en) 1986-08-28
ES530902A0 (es) 1984-11-16
IL71324A (en) 1987-08-31
ZA842185B (en) 1984-10-31
ATE20887T1 (de) 1986-08-15
ES8501383A1 (es) 1984-11-16

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