ES8501383A1 - Procedimiento para preparar derivados de piperazina - Google Patents
Procedimiento para preparar derivados de piperazinaInfo
- Publication number
- ES8501383A1 ES8501383A1 ES530901A ES530901A ES8501383A1 ES 8501383 A1 ES8501383 A1 ES 8501383A1 ES 530901 A ES530901 A ES 530901A ES 530901 A ES530901 A ES 530901A ES 8501383 A1 ES8501383 A1 ES 8501383A1
- Authority
- ES
- Spain
- Prior art keywords
- groups
- radical
- phenyl
- group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIPERAZINA.CONSISTE EN PREPARAR COMPUESTOS DE FORMULA GENERAL (I) EN DONDE R1 ES UN RADICAL FENILO, PIRIDILO U OTROS, R2 REPRESENTA UN RADICAL ADAMANTILO U OTROS Y ALK ES UNA CADENA ALQUILENO C1-C6 LINEAL O RAMIFICADA. SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) EN DONDE Z ES EL GRUPO R1 O -CO-ALK-R2, CON UN COMPUESTO DE FORMULA GENERAL ZKX EN DONDE X SIGNIFICA UN ATOMO DE HALOGENO CASO DE QUE ZK SEA EL GRUPO R1 Y Z SEA EL GRUPO -CO-ALK-R2 U OTROS, Y EN LOS COMPUESTOS OBTENIDOS SE REDUCE EVENTUALMENTE UN GRUPO NITRO PARA DAR EL GRUPO AMINO Y TRANSFORMADOS EN LAS SALES POR ADICION DE ACIDOS.SE USA COMO SEDANTE COMO EFECTO AMORTIGUADOR SOBRE EL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3310871 | 1983-03-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES530901A0 ES530901A0 (es) | 1984-11-16 |
ES8501383A1 true ES8501383A1 (es) | 1984-11-16 |
Family
ID=6194617
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530902A Granted ES530902A0 (es) | 1983-03-25 | 1984-03-23 | Procedimiento para preparar derivados de piperazina |
ES530901A Expired ES8501383A1 (es) | 1983-03-25 | 1984-03-23 | Procedimiento para preparar derivados de piperazina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530902A Granted ES530902A0 (es) | 1983-03-25 | 1984-03-23 | Procedimiento para preparar derivados de piperazina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4547505A (es) |
EP (1) | EP0120465B1 (es) |
JP (1) | JPS59205362A (es) |
AT (1) | ATE20887T1 (es) |
AU (1) | AU560579B2 (es) |
CA (1) | CA1211435A (es) |
DD (1) | DD213215A5 (es) |
DE (1) | DE3460325D1 (es) |
DK (1) | DK142084A (es) |
ES (2) | ES530902A0 (es) |
FI (1) | FI841181A (es) |
HU (1) | HU191643B (es) |
IL (1) | IL71324A (es) |
NO (1) | NO841163L (es) |
PT (1) | PT78304B (es) |
SU (1) | SU1297727A3 (es) |
ZA (1) | ZA842185B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2536071B1 (fr) * | 1982-11-12 | 1986-07-11 | Sanofi Sa | Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant |
EP0582065A1 (en) * | 1986-08-15 | 1994-02-09 | WHITBY RESEARCH, Inc. | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst |
US4797405A (en) * | 1987-10-26 | 1989-01-10 | Eli Lilly And Company | Stabilized pergolide compositions |
ES2061953T3 (es) * | 1988-11-24 | 1994-12-16 | Akzo Nv | Un procedimiento para preparar una composicion farmaceutica. |
EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
US5648352A (en) * | 1991-09-13 | 1997-07-15 | Merck & Co., Inc. | Piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533242A3 (en) * | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533240A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533241A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
HU209678B (en) * | 1992-06-09 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them |
US5686454A (en) * | 1993-07-16 | 1997-11-11 | Merck & Co., Inc. | Camphorcarbonyl |
ES2125206B1 (es) | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
ES2167276B1 (es) * | 2000-10-20 | 2003-04-01 | Esteve Labor Dr | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
DE60328690D1 (de) | 2002-06-12 | 2009-09-17 | Chemocentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
JP4960085B2 (ja) * | 2003-03-19 | 2012-06-27 | エクセリクシス, インク. | Tie−2モジュレータと使用方法 |
CA2558211C (en) * | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US8389510B2 (en) * | 2005-11-18 | 2013-03-05 | Astrazeneca Ab | Crystalline forms |
WO2008079838A1 (en) * | 2006-12-20 | 2008-07-03 | Astrazeneca Ab | Compounds and uses thereof |
KR101588466B1 (ko) | 2007-08-22 | 2016-01-25 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체 |
TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
NZ602108A (en) * | 2010-02-18 | 2014-09-26 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
MX2012009473A (es) | 2010-02-18 | 2012-09-12 | Astrazeneca Ab | Procesos para preparar derivados de ciclopropilamidas e intermedios asociados con estas. |
FR3000065A1 (fr) * | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
CN115368318B (zh) * | 2022-06-22 | 2023-11-03 | 山东辰龙药业有限公司 | 一种伏硫西汀的合成方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EG12387A (en) * | 1975-04-21 | 1978-12-31 | Merck & Co Inc | Process for preparing of piperazinyl pyrazines |
JPS52286A (en) * | 1975-05-27 | 1977-01-05 | Kyorin Pharmaceut Co Ltd | Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives |
GB1534593A (en) * | 1976-09-03 | 1978-12-06 | Soc D Etudes Prod Chimique | N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it |
WO1981003658A1 (en) * | 1980-06-16 | 1981-12-24 | Ferrosan Ab | Diphenylbutyl-1-acylpiperazines |
US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
JPS591474A (ja) * | 1982-06-07 | 1984-01-06 | Nippon Iyakuhin Kogyo Kk | ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類 |
-
1984
- 1984-02-24 US US06/583,324 patent/US4547505A/en not_active Expired - Fee Related
- 1984-02-29 DK DK142084A patent/DK142084A/da not_active Application Discontinuation
- 1984-03-21 JP JP59052465A patent/JPS59205362A/ja active Pending
- 1984-03-22 AT AT84103136T patent/ATE20887T1/de not_active IP Right Cessation
- 1984-03-22 EP EP84103136A patent/EP0120465B1/de not_active Expired
- 1984-03-22 DD DD84261152A patent/DD213215A5/de unknown
- 1984-03-22 DE DE8484103136T patent/DE3460325D1/de not_active Expired
- 1984-03-23 AU AU26057/84A patent/AU560579B2/en not_active Ceased
- 1984-03-23 NO NO841163A patent/NO841163L/no unknown
- 1984-03-23 ES ES530902A patent/ES530902A0/es active Granted
- 1984-03-23 SU SU843713674A patent/SU1297727A3/ru active
- 1984-03-23 PT PT78304A patent/PT78304B/pt unknown
- 1984-03-23 IL IL71324A patent/IL71324A/xx not_active IP Right Cessation
- 1984-03-23 ES ES530901A patent/ES8501383A1/es not_active Expired
- 1984-03-23 FI FI841181A patent/FI841181A/fi not_active Application Discontinuation
- 1984-03-23 CA CA000450313A patent/CA1211435A/en not_active Expired
- 1984-03-23 ZA ZA842185A patent/ZA842185B/xx unknown
- 1984-03-23 HU HU841168A patent/HU191643B/hu unknown
Also Published As
Publication number | Publication date |
---|---|
EP0120465A1 (de) | 1984-10-03 |
PT78304B (de) | 1986-04-22 |
SU1297727A3 (ru) | 1987-03-15 |
FI841181A0 (fi) | 1984-03-23 |
NO841163L (no) | 1984-09-26 |
DE3460325D1 (en) | 1986-08-28 |
AU560579B2 (en) | 1987-04-09 |
IL71324A0 (en) | 1984-06-29 |
EP0120465B1 (de) | 1986-07-23 |
ZA842185B (en) | 1984-10-31 |
ES530901A0 (es) | 1984-11-16 |
CA1211435A (en) | 1986-09-16 |
US4547505A (en) | 1985-10-15 |
DD213215A5 (de) | 1984-09-05 |
DK142084A (da) | 1984-09-26 |
ES8501384A1 (es) | 1984-11-16 |
PT78304A (de) | 1984-04-01 |
ATE20887T1 (de) | 1986-08-15 |
FI841181A (fi) | 1984-09-26 |
HU191643B (en) | 1987-03-30 |
IL71324A (en) | 1987-08-31 |
DK142084D0 (da) | 1984-02-29 |
JPS59205362A (ja) | 1984-11-20 |
ES530902A0 (es) | 1984-11-16 |
AU2605784A (en) | 1984-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8501383A1 (es) | Procedimiento para preparar derivados de piperazina | |
AU3530795A (en) | Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents | |
FR2742749B1 (fr) | Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques | |
GR3033786T3 (en) | Novel 2,3,5-trimethyl-4-hydroxy anilide derivatives, preparation thereof and therapeutical use thereof | |
SE8904127D0 (sv) | New biocyclic amino-substituted compounds | |
ATE20066T1 (de) | Neue basisch substituierte 4-phenyl-4,5,6,7tetrahydrothieno-(2,3-c)pyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
IL115085A0 (en) | Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them | |
TR199900984T2 (xx) | Benzens�lfonamid t�revleri ve ad� ge�en t�revleri i�eren ila�lar. | |
DE69521895D1 (de) | Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten | |
TW336224B (en) | Compound useful as adhesion receptor antagonists, their preparation processes, and pharmaceutical compositions containing same | |
ES8300675A1 (es) | Procedimiento de preparacion de derivados de etanolamina. | |
MX9707911A (es) | Derivados de amina 1-[w-(3,4-dihidro-2-naftalenil)alquil]- ciclica, proceso para su preparacion y composiciones farmaceuticas que contienen los mismos. | |
YU49004B (sh) | LANOSTA-7,9-DIEN-3Гџ, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE |