DK142084D0 - N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf - Google Patents

N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf

Info

Publication number
DK142084D0
DK142084D0 DK1420/84A DK142084A DK142084D0 DK 142084 D0 DK142084 D0 DK 142084D0 DK 1420/84 A DK1420/84 A DK 1420/84A DK 142084 A DK142084 A DK 142084A DK 142084 D0 DK142084 D0 DK 142084D0
Authority
DK
Denmark
Prior art keywords
groups
radical
phenyl
group
formula
Prior art date
Application number
DK1420/84A
Other languages
English (en)
Other versions
DK142084A (da
Inventor
Gerhard Oepen
Juergen Engel
Vladimir Jakovlev
Klaus Thiemer
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of DK142084D0 publication Critical patent/DK142084D0/da
Publication of DK142084A publication Critical patent/DK142084A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK142084A 1983-03-25 1984-02-29 N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf DK142084A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3310871 1983-03-25

Publications (2)

Publication Number Publication Date
DK142084D0 true DK142084D0 (da) 1984-02-29
DK142084A DK142084A (da) 1984-09-26

Family

ID=6194617

Family Applications (1)

Application Number Title Priority Date Filing Date
DK142084A DK142084A (da) 1983-03-25 1984-02-29 N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf

Country Status (17)

Country Link
US (1) US4547505A (da)
EP (1) EP0120465B1 (da)
JP (1) JPS59205362A (da)
AT (1) ATE20887T1 (da)
AU (1) AU560579B2 (da)
CA (1) CA1211435A (da)
DD (1) DD213215A5 (da)
DE (1) DE3460325D1 (da)
DK (1) DK142084A (da)
ES (2) ES8501384A1 (da)
FI (1) FI841181A (da)
HU (1) HU191643B (da)
IL (1) IL71324A (da)
NO (1) NO841163L (da)
PT (1) PT78304B (da)
SU (1) SU1297727A3 (da)
ZA (1) ZA842185B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536071B1 (fr) * 1982-11-12 1986-07-11 Sanofi Sa Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0582065A1 (en) * 1986-08-15 1994-02-09 WHITBY RESEARCH, Inc. 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst
US4797405A (en) * 1987-10-26 1989-01-10 Eli Lilly And Company Stabilized pergolide compositions
ES2061953T3 (es) * 1988-11-24 1994-12-16 Akzo Nv Un procedimiento para preparar una composicion farmaceutica.
EP0385043A1 (en) * 1989-02-28 1990-09-05 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New derivatives of 4-substituted piperazines
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533241A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
HU209678B (en) * 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
JPH09500133A (ja) * 1993-07-16 1997-01-07 メルク エンド カンパニー インコーポレーテッド オキシトシンのアンタゴニストである置換ピペラジニル樟脳誘導体
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
CN1867336B (zh) 2002-06-12 2010-05-12 凯莫森特里克斯股份有限公司 1-芳基-4-取代的哌嗪衍生物及其制药用途
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US8013156B2 (en) * 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
EP1720545B1 (en) * 2004-03-03 2014-10-29 ChemoCentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
US20100093699A1 (en) * 2006-12-20 2010-04-15 Astrazeneca Ab Compounds and uses thereof - 177
PT2195293E (pt) * 2007-08-22 2014-01-21 Astrazeneca Ab Derivados da ciclopropilamida
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
AU2011218490B9 (en) * 2010-02-18 2014-12-18 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
RU2012136148A (ru) 2010-02-18 2014-03-27 Астразенека Аб Новая кристаллическая форма производного циклопропилбензамида
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421695B (sv) * 1975-04-21 1982-01-25 Merck & Co Inc Sett att framstella piperazinylpyraziner
JPS52286A (en) * 1975-05-27 1977-01-05 Kyorin Pharmaceut Co Ltd Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
EP0042366B1 (en) * 1980-06-16 1984-11-07 AB Ferrosan Diphenylbutyl-1-acylpiperazines
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
JPS591474A (ja) * 1982-06-07 1984-01-06 Nippon Iyakuhin Kogyo Kk ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類

Also Published As

Publication number Publication date
CA1211435A (en) 1986-09-16
FI841181A (fi) 1984-09-26
SU1297727A3 (ru) 1987-03-15
ES530902A0 (es) 1984-11-16
ES8501383A1 (es) 1984-11-16
IL71324A (en) 1987-08-31
DK142084A (da) 1984-09-26
NO841163L (no) 1984-09-26
EP0120465B1 (de) 1986-07-23
EP0120465A1 (de) 1984-10-03
AU2605784A (en) 1984-09-27
JPS59205362A (ja) 1984-11-20
ATE20887T1 (de) 1986-08-15
PT78304B (de) 1986-04-22
DE3460325D1 (en) 1986-08-28
DD213215A5 (de) 1984-09-05
FI841181A0 (fi) 1984-03-23
PT78304A (de) 1984-04-01
ES530901A0 (es) 1984-11-16
ZA842185B (en) 1984-10-31
HU191643B (en) 1987-03-30
AU560579B2 (en) 1987-04-09
ES8501384A1 (es) 1984-11-16
US4547505A (en) 1985-10-15
IL71324A0 (en) 1984-06-29

Similar Documents

Publication Publication Date Title
DK142084D0 (da) N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf
ATE168685T1 (de) Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel
NO20025821L (no) 2-aminokarbonyl-9H-purinderivater
FI954746A0 (fi) Urea- ja amidijohdannaisia ja niiden käyttö solukalvojen kaliumkanavien säätelyyn
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
DK0874812T3 (da) Hidtil ukendte 2,3,5-trimethyl-4-hydroxyanilidderivater, fremstilling deraf og terapeutisk anvendelse deraf
FR2742749B1 (fr) Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DK0766696T3 (da) Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser
KR920701178A (ko) 3-아릴옥사졸리디논 유도체, 그의 제조방법 및 그의 치료 용도
ES455741A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,3-bencenodimetanol.
NO982927L (no) Biologisk aktive benzotiazolon etanaminer
DE69837334D1 (de) Heterozyclische verbindungen, ihr herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen
SE8904127D0 (sv) New biocyclic amino-substituted compounds
SE9603285D0 (sv) New compounds
ATE20066T1 (de) Neue basisch substituierte 4-phenyl-4,5,6,7tetrahydrothieno-(2,3-c)pyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FI971177A0 (fi) Bisyklisiä karboksiamideja 5-HT1A-antagonisteina
DE69521895D1 (de) Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten
ATE205189T1 (de) Benzolsulfonylamin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DK0462468T3 (da) 9-amino-2-phenylbicyclo(3.3.1)nonaner og 9-amino-2-phenylbicyclo(3.3.1)non-2-ener og terapeutiske midler indeholdende disse
YU49004B (sh) LANOSTA-7,9-DIEN-3Гџ, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE
ECSP951538A (es) Derivados de quinoxalina utiles en terapia

Legal Events

Date Code Title Description
PBP Patent lapsed
AHB Application shelved due to non-payment