IL71324A - N-phenyl-n'-cycloalkylalkanoyl-piperazines,their production and pharmaceutical compositions containing them - Google Patents
N-phenyl-n'-cycloalkylalkanoyl-piperazines,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL71324A IL71324A IL71324A IL7132484A IL71324A IL 71324 A IL71324 A IL 71324A IL 71324 A IL71324 A IL 71324A IL 7132484 A IL7132484 A IL 7132484A IL 71324 A IL71324 A IL 71324A
- Authority
- IL
- Israel
- Prior art keywords
- groups
- radical
- phenyl
- group
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3310871 | 1983-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL71324A0 IL71324A0 (en) | 1984-06-29 |
| IL71324A true IL71324A (en) | 1987-08-31 |
Family
ID=6194617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL71324A IL71324A (en) | 1983-03-25 | 1984-03-23 | N-phenyl-n'-cycloalkylalkanoyl-piperazines,their production and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4547505A (es) |
| EP (1) | EP0120465B1 (es) |
| JP (1) | JPS59205362A (es) |
| AT (1) | ATE20887T1 (es) |
| AU (1) | AU560579B2 (es) |
| CA (1) | CA1211435A (es) |
| DD (1) | DD213215A5 (es) |
| DE (1) | DE3460325D1 (es) |
| DK (1) | DK142084A (es) |
| ES (2) | ES8501384A1 (es) |
| FI (1) | FI841181A (es) |
| HU (1) | HU191643B (es) |
| IL (1) | IL71324A (es) |
| NO (1) | NO841163L (es) |
| PT (1) | PT78304B (es) |
| SU (1) | SU1297727A3 (es) |
| ZA (1) | ZA842185B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536071B1 (fr) * | 1982-11-12 | 1986-07-11 | Sanofi Sa | Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant |
| EP0582065A1 (en) * | 1986-08-15 | 1994-02-09 | WHITBY RESEARCH, Inc. | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst |
| US4797405A (en) * | 1987-10-26 | 1989-01-10 | Eli Lilly And Company | Stabilized pergolide compositions |
| ES2061953T3 (es) * | 1988-11-24 | 1994-12-16 | Akzo Nv | Un procedimiento para preparar una composicion farmaceutica. |
| EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
| US5648352A (en) * | 1991-09-13 | 1997-07-15 | Merck & Co., Inc. | Piperazinylcamphorsulfonyl oxytocin antagonists |
| EP0533242A3 (en) * | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
| EP0533240A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
| EP0533241A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
| JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| HU209678B (en) * | 1992-06-09 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them |
| JPH09500133A (ja) * | 1993-07-16 | 1997-01-07 | メルク エンド カンパニー インコーポレーテッド | オキシトシンのアンタゴニストである置換ピペラジニル樟脳誘導体 |
| ES2125206B1 (es) * | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
| ES2167276B1 (es) * | 2000-10-20 | 2003-04-01 | Esteve Labor Dr | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
| JP4723242B2 (ja) | 2002-06-12 | 2011-07-13 | ケモセントリックス インコーポレーティッド | 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体 |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US8013156B2 (en) * | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| CA2558211C (en) * | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| WO2008079838A1 (en) * | 2006-12-20 | 2008-07-03 | Astrazeneca Ab | Compounds and uses thereof |
| US8389510B2 (en) * | 2005-11-18 | 2013-03-05 | Astrazeneca Ab | Crystalline forms |
| TW201446748A (zh) * | 2007-08-22 | 2014-12-16 | Astrazeneca Ab | 環丙基醯胺衍生物 |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| EP2536701A4 (en) * | 2010-02-18 | 2014-05-07 | Astrazeneca Ab | SOLID FORMS WITH A CYCLOPROPYLAMID DERIVATIVE |
| EP2536702A4 (en) * | 2010-02-18 | 2013-07-10 | Astrazeneca Ab | NEW CRYSTALLINE FORM OF A CYCLOPROPYLBENZAMIDE DERIVATIVE |
| FR3000065A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
| CN115368318B (zh) * | 2022-06-22 | 2023-11-03 | 山东辰龙药业有限公司 | 一种伏硫西汀的合成方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG12387A (en) * | 1975-04-21 | 1978-12-31 | Merck & Co Inc | Process for preparing of piperazinyl pyrazines |
| JPS52286A (en) * | 1975-05-27 | 1977-01-05 | Kyorin Pharmaceut Co Ltd | Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives |
| GB1534593A (en) * | 1976-09-03 | 1978-12-06 | Soc D Etudes Prod Chimique | N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it |
| AU546260B2 (en) * | 1980-06-16 | 1985-08-22 | Ferrosan A.B. | Diphenylbutyl-1-acylpiperazines |
| US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| JPS591474A (ja) * | 1982-06-07 | 1984-01-06 | Nippon Iyakuhin Kogyo Kk | ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類 |
-
1984
- 1984-02-24 US US06/583,324 patent/US4547505A/en not_active Expired - Fee Related
- 1984-02-29 DK DK142084A patent/DK142084A/da not_active Application Discontinuation
- 1984-03-21 JP JP59052465A patent/JPS59205362A/ja active Pending
- 1984-03-22 AT AT84103136T patent/ATE20887T1/de not_active IP Right Cessation
- 1984-03-22 DE DE8484103136T patent/DE3460325D1/de not_active Expired
- 1984-03-22 EP EP84103136A patent/EP0120465B1/de not_active Expired
- 1984-03-22 DD DD84261152A patent/DD213215A5/de unknown
- 1984-03-23 HU HU841168A patent/HU191643B/hu unknown
- 1984-03-23 SU SU843713674A patent/SU1297727A3/ru active
- 1984-03-23 FI FI841181A patent/FI841181A/fi not_active Application Discontinuation
- 1984-03-23 CA CA000450313A patent/CA1211435A/en not_active Expired
- 1984-03-23 IL IL71324A patent/IL71324A/xx not_active IP Right Cessation
- 1984-03-23 PT PT78304A patent/PT78304B/pt unknown
- 1984-03-23 ZA ZA842185A patent/ZA842185B/xx unknown
- 1984-03-23 AU AU26057/84A patent/AU560579B2/en not_active Ceased
- 1984-03-23 ES ES530902A patent/ES8501384A1/es not_active Expired
- 1984-03-23 NO NO841163A patent/NO841163L/no unknown
- 1984-03-23 ES ES530901A patent/ES530901A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| HU191643B (en) | 1987-03-30 |
| ATE20887T1 (de) | 1986-08-15 |
| AU560579B2 (en) | 1987-04-09 |
| CA1211435A (en) | 1986-09-16 |
| IL71324A0 (en) | 1984-06-29 |
| ES530902A0 (es) | 1984-11-16 |
| ES8501383A1 (es) | 1984-11-16 |
| FI841181A0 (fi) | 1984-03-23 |
| EP0120465B1 (de) | 1986-07-23 |
| PT78304A (de) | 1984-04-01 |
| PT78304B (de) | 1986-04-22 |
| AU2605784A (en) | 1984-09-27 |
| ES8501384A1 (es) | 1984-11-16 |
| US4547505A (en) | 1985-10-15 |
| NO841163L (no) | 1984-09-26 |
| DD213215A5 (de) | 1984-09-05 |
| SU1297727A3 (ru) | 1987-03-15 |
| ES530901A0 (es) | 1984-11-16 |
| DK142084D0 (da) | 1984-02-29 |
| ZA842185B (en) | 1984-10-31 |
| EP0120465A1 (de) | 1984-10-03 |
| JPS59205362A (ja) | 1984-11-20 |
| DE3460325D1 (en) | 1986-08-28 |
| DK142084A (da) | 1984-09-26 |
| FI841181A (fi) | 1984-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL71324A0 (en) | N-phenyl-n'-cycloalkylalkanoyl-piperazines,their production and pharmaceutical compositions containing them | |
| TW330202B (en) | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | |
| ATE168685T1 (de) | Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel | |
| TR200003478T2 (tr) | Antikanser maddeleri olarak faydalı izotiyazol türevleri | |
| ZA9610418B (en) | Phenylimidazolidines containing in particular a nitrooxy or carbonyloxy radical, preparation process and intermediates, use as medicaments, new uses and pharmaceutical compositions. | |
| SE9702564D0 (sv) | New compounds | |
| GR3033786T3 (en) | Novel 2,3,5-trimethyl-4-hydroxy anilide derivatives, preparation thereof and therapeutical use thereof | |
| EP0313458A3 (en) | Imidazo(2,1-b)benzothiazoles and their acid addition salts, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | |
| DE69102477D1 (de) | 3-Aminochroman-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen. | |
| DE69837334D1 (de) | Heterozyclische verbindungen, ihr herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen | |
| GB8829593D0 (en) | Novel compounds | |
| SE8904127D0 (sv) | New biocyclic amino-substituted compounds | |
| ATE20066T1 (de) | Neue basisch substituierte 4-phenyl-4,5,6,7tetrahydrothieno-(2,3-c)pyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| IL115085A0 (en) | Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them | |
| ZA934110B (en) | Diacylglycerol nicotinates, process fot their preparation and the pharmaceutical compositions which contain them | |
| DE69521895D1 (de) | Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten | |
| MY111111A (en) | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl -1-heterocyclyl) methylamine drrivatives | |
| MX9707911A (es) | Derivados de amina 1-[w-(3,4-dihidro-2-naftalenil)alquil]- ciclica, proceso para su preparacion y composiciones farmaceuticas que contienen los mismos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9K | Patent not in force due to non-payment of renewal fees |