PT75878B - Process for preparing them 2-(fluoroalkylthio)substituted penems and pharmaceutical compositions containing them - Google Patents

Process for preparing them 2-(fluoroalkylthio)substituted penems and pharmaceutical compositions containing them

Info

Publication number
PT75878B
PT75878B PT75878A PT7587882A PT75878B PT 75878 B PT75878 B PT 75878B PT 75878 A PT75878 A PT 75878A PT 7587882 A PT7587882 A PT 7587882A PT 75878 B PT75878 B PT 75878B
Authority
PT
Portugal
Prior art keywords
fluoroalkylthio
preparing
pharmaceutical compositions
compositions containing
penems
Prior art date
Application number
PT75878A
Other languages
English (en)
Other versions
PT75878A (en
Inventor
Viyyoor M Girijavallabhan
Combie Stuart W Mc
Ashit K Ganguly
Patrick Anthony Pinto
Richard William Versace
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PT75878A publication Critical patent/PT75878A/pt
Publication of PT75878B publication Critical patent/PT75878B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT75878A 1981-11-25 1982-11-22 Process for preparing them 2-(fluoroalkylthio)substituted penems and pharmaceutical compositions containing them PT75878B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (2)

Publication Number Publication Date
PT75878A PT75878A (en) 1982-12-01
PT75878B true PT75878B (en) 1986-01-15

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
PT75878A PT75878B (en) 1981-11-25 1982-11-22 Process for preparing them 2-(fluoroalkylthio)substituted penems and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US4411906A (pt)
EP (1) EP0080162B1 (pt)
JP (1) JPS5892683A (pt)
KR (1) KR890005148B1 (pt)
AT (1) ATE20666T1 (pt)
AU (1) AU560838B2 (pt)
CA (1) CA1207753A (pt)
DE (1) DE3271955D1 (pt)
DK (1) DK153553C (pt)
FI (1) FI76091C (pt)
HK (1) HK56889A (pt)
HU (1) HU190044B (pt)
IE (1) IE54219B1 (pt)
IL (1) IL67327A0 (pt)
MY (1) MY8700708A (pt)
NO (1) NO159796C (pt)
NZ (1) NZ202574A (pt)
OA (1) OA07255A (pt)
PH (1) PH19647A (pt)
PT (1) PT75878B (pt)
SG (1) SG88388G (pt)
ZA (1) ZA828602B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (en) * 1982-03-26 1987-07-29 Hoechst Uk Limited 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
ATE112778T1 (de) * 1982-11-29 1994-10-15 Schering Corp Verfahren zur herstellung von penem-verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
ATE283707T1 (de) * 1998-01-13 2004-12-15 Daiichi Suntory Pharma Co Ltd Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
ATE20666T1 (de) 1986-07-15
FI76091B (fi) 1988-05-31
NO823903L (no) 1983-05-26
KR840002403A (ko) 1984-07-02
AU9078782A (en) 1983-06-02
AU560838B2 (en) 1987-04-16
NZ202574A (en) 1986-06-11
US4411906A (en) 1983-10-25
HU190044B (en) 1986-08-28
DK153553B (da) 1988-07-25
DK153553C (da) 1988-12-19
OA07255A (fr) 1984-04-30
DE3271955D1 (en) 1986-08-14
NO159796B (no) 1988-10-31
MY8700708A (en) 1987-12-31
NO159796C (no) 1989-02-08
JPS5892683A (ja) 1983-06-02
ZA828602B (en) 1983-09-28
IE822765L (en) 1983-05-25
FI823997A0 (fi) 1982-11-22
EP0080162A1 (en) 1983-06-01
HK56889A (en) 1989-07-21
IL67327A0 (en) 1983-03-31
FI76091C (fi) 1988-09-09
US4814442A (en) 1989-03-21
PH19647A (en) 1986-06-04
EP0080162B1 (en) 1986-07-09
PT75878A (en) 1982-12-01
FI823997L (fi) 1983-05-26
SG88388G (en) 1989-06-16
DK519382A (da) 1983-05-26
IE54219B1 (en) 1989-07-19
CA1207753A (en) 1986-07-15
KR890005148B1 (ko) 1989-12-14

Similar Documents

Publication Publication Date Title
GB2273655B (en) Veterinary compositions for the treatment of mastitis
DE3271955D1 (en) 2-(fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them
GR3001347T3 (en) (1r,5s,6s)-2-(substituted thio)-6-((r)-1-hydroxy-ethyl)-1-methyl-carbapenem-3-carboxylic-acid derivatives
HUT45538A (en) Process for producing quinoline derivatives and pharmaceutical compositions containing them
EP0487986A3 (en) Process for the preparation of esters of (6s)-6,8-dihydroxyoctanoic acid
AU5729180A (en) 2-((2-aminoethyl)thio)6-(1-hydroxyethyl)penem-3-caroxylic acid
DE3363607D1 (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(oxoalkyl)-1-piperazinyl)-3-quinoline-carboxylic acids and their derivatives, process for their preparation and antibacterial agents containing them
IL68307A (en) Process for the preparation of 2-substituted penem derivatives
FR2518098B1 (fr) Procede pour la preparation de derives penem optiquement actifs
AU1746188A (en) (5R, 6S, 1R)-6-(1-hydroxyethyl)-2-(methoxymethyl)penem-3- carboxylic acid derivatives
EP0472826A3 (en) Novel quinolinecarboxylic acid derivatives, use thereof, antibacterial agent containing the same, process for preparing said compounds and intermediate compound
MY101822A (en) (5r,6s,8r)-6-(1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl-)thiopenem-3-carboxylic acid.
PH18096A (en) Antibacterial 6-(2-amino-2-(4-acyloxyphznyl)-acetamido penicillanoyloxymethyl penicillanate,1,1-dioxide compounds
DZ1818A1 (fr) Procédé de préparation de compositions orales cotenant des quinolones.
DE3067794D1 (en) Cephem derivatives, process for producing thereof, and antibacterial agents comprising said compounds
IL87226A0 (en) (1r,5s,6s)-2-(substituted thio)-6-((r)-1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid derivatives,their production and pharmaceutical compositions containing them
PT83560A (en) Process for preparing 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
PL245813A1 (en) Process for preparing 6-alpha-methoxy-6-beta(2-/methylphenoxycarbonyl/-2-/thienyl-3/-acetamido)-penicillanic acid
PT72291B (en) Process for the preparation of 6-aminopenicillanic acid-1,1-dioxide
IL63892A (en) 7-(2-(aminothiazol-4yl)acetamido)cephalosporin derivatives,processes for producing the same and pharmaceutical compositions comprising them
FI921108A0 (fi) Menetelmä alkalimetallihydroksidin valmistamiseksi

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960731