OA07255A - Penems 2-fluoroalkylthio substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant. - Google Patents

Penems 2-fluoroalkylthio substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant.

Info

Publication number
OA07255A
OA07255A OA57848A OA57848A OA07255A OA 07255 A OA07255 A OA 07255A OA 57848 A OA57848 A OA 57848A OA 57848 A OA57848 A OA 57848A OA 07255 A OA07255 A OA 07255A
Authority
OA
OAPI
Prior art keywords
fluoroalkylthio
penems
substituted
processes
preparation
Prior art date
Application number
OA57848A
Other languages
English (en)
French (fr)
Inventor
Viyyoor M Girijavallabhan
Stuart W Mccombie
Ashit K Ganguly
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of OA07255A publication Critical patent/OA07255A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
OA57848A 1981-11-25 1982-11-23 Penems 2-fluoroalkylthio substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant. OA07255A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (1)

Publication Number Publication Date
OA07255A true OA07255A (fr) 1984-04-30

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
OA57848A OA07255A (fr) 1981-11-25 1982-11-23 Penems 2-fluoroalkylthio substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant.

Country Status (22)

Country Link
US (2) US4411906A (pt)
EP (1) EP0080162B1 (pt)
JP (1) JPS5892683A (pt)
KR (1) KR890005148B1 (pt)
AT (1) ATE20666T1 (pt)
AU (1) AU560838B2 (pt)
CA (1) CA1207753A (pt)
DE (1) DE3271955D1 (pt)
DK (1) DK153553C (pt)
FI (1) FI76091C (pt)
HK (1) HK56889A (pt)
HU (1) HU190044B (pt)
IE (1) IE54219B1 (pt)
IL (1) IL67327A0 (pt)
MY (1) MY8700708A (pt)
NO (1) NO159796C (pt)
NZ (1) NZ202574A (pt)
OA (1) OA07255A (pt)
PH (1) PH19647A (pt)
PT (1) PT75878B (pt)
SG (1) SG88388G (pt)
ZA (1) ZA828602B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (en) * 1982-03-26 1987-07-29 Hoechst Uk Limited 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
DE3382761T2 (de) * 1982-11-29 1995-03-09 Schering Corp Verfahren zur Herstellung von Penem-Verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
WO1999036098A1 (fr) * 1998-01-13 1999-07-22 Suntory Limited Composition antibacterienne contenant des antibiotiques et destinee a l'administration topique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
FI76091B (fi) 1988-05-31
AU560838B2 (en) 1987-04-16
DK153553B (da) 1988-07-25
HK56889A (en) 1989-07-21
FI76091C (fi) 1988-09-09
DE3271955D1 (en) 1986-08-14
SG88388G (en) 1989-06-16
IE54219B1 (en) 1989-07-19
DK153553C (da) 1988-12-19
PT75878B (en) 1986-01-15
MY8700708A (en) 1987-12-31
IL67327A0 (en) 1983-03-31
US4411906A (en) 1983-10-25
KR890005148B1 (ko) 1989-12-14
FI823997L (fi) 1983-05-26
NO159796B (no) 1988-10-31
HU190044B (en) 1986-08-28
EP0080162B1 (en) 1986-07-09
IE822765L (en) 1983-05-25
DK519382A (da) 1983-05-26
EP0080162A1 (en) 1983-06-01
FI823997A0 (fi) 1982-11-22
PT75878A (en) 1982-12-01
NO159796C (no) 1989-02-08
US4814442A (en) 1989-03-21
KR840002403A (ko) 1984-07-02
JPS5892683A (ja) 1983-06-02
PH19647A (en) 1986-06-04
AU9078782A (en) 1983-06-02
CA1207753A (en) 1986-07-15
ATE20666T1 (de) 1986-07-15
NZ202574A (en) 1986-06-11
ZA828602B (en) 1983-09-28
NO823903L (no) 1983-05-26

Similar Documents

Publication Publication Date Title
OA06727A (fr) Imidazo (1,2-a) pyridines, procédés pour leur préparation et compositions pharmaceutiques les contenant.
NL930112I1 (nl) Benzazepine-2-onen werkwijzen ter bereiding daarvan farmaceutische preparaten die deze verbindingen bevatten alsmede verbindingen voor de therapeutische toepassing
IT8149676A0 (it) Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono
FR2493322B1 (fr) Hydrates cristallins de tosylate de (d-a-amino a-phenylacetamido)-6 penicillanate de dioxo-1,1 penicillanoyloxymethyle utiles comme medicaments antimicrobiens et procedes de leur preparation
DE3462255D1 (en) Quinolone carboxylic acids, process for their preparation and antibacterial compositions containing them
OA07255A (fr) Penems 2-fluoroalkylthio substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant.
OA07602A (fr) Procédé de préparation de composés de céphem, nouveaux produits ainsi obtenus et compositions pharmaceutiques les renfermant.
PT76573A (fr) Procede de preparation de derives d'imidazo <1,2-a> pyridine et de compositions pharmaceutiques les contenant
NL7908318A (nl) Nieuwe verbindingen met antibiotische eigenschappen, werkwijze voor de bereiding daarvan, alsmede farmaceutische preparaten die deze bevatten.
FR2480603B1 (fr) Composition pharmaceutique pour administration par voie orale contenant de la cytidine-diphosphocholine
IL65306A0 (en) Bis-esters of 1,1-alkanediols with 6 beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics and pharmaceutical compositions containing them
IL68307A (en) Process for the preparation of 2-substituted penem derivatives
ZA842225B (en) Penem compounds,method for their preparation and pharmaceutical compositions containing them
FR2518098B1 (fr) Procede pour la preparation de derives penem optiquement actifs
OA07698A (fr) Nouveaux composés pénems, compositions pharmaceutiques les contenant, procédés pour leur préparation.
IT1209276B (it) Composizione farmaceutica per la somministrazione orale del metilestere dell'acido 13a-etil-2,3,5,6,12,13,13a,13b-ottaidro-12-idrossi1h-indolo-[3,2,1-de] pirido [3,2,1-ij] [1,5] naftiridina -12-carbossilico
FR2711524B1 (fr) Procédé de préparation de compositions orales contenant des quinolones.
IL66192A0 (en) Antibiotic compounds,their production and pharmaceutical compositions containing them
MY101822A (en) (5r,6s,8r)-6-(1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl-)thiopenem-3-carboxylic acid.
DE2961633D1 (en) Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation
DE3464601D1 (en) 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles, process for their preparation and medicines with anti-thrombotic effects containing them