HK56889A - 2-(fluoroalkylthio)substituted penems,processes for preparing them,and pharmaceutical compositions containing them - Google Patents

2-(fluoroalkylthio)substituted penems,processes for preparing them,and pharmaceutical compositions containing them

Info

Publication number
HK56889A
HK56889A HK568/89A HK56889A HK56889A HK 56889 A HK56889 A HK 56889A HK 568/89 A HK568/89 A HK 568/89A HK 56889 A HK56889 A HK 56889A HK 56889 A HK56889 A HK 56889A
Authority
HK
Hong Kong
Prior art keywords
fluoroalkylthio
preparing
processes
pharmaceutical compositions
compositions containing
Prior art date
Application number
HK568/89A
Other languages
English (en)
Inventor
Vivyoor Moopil Girijavallabhan
Combie Stuart Walter Mc
Ashit Kumar Ganguly
Patrick Anthony Pinto
Richard William Versace
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK56889A publication Critical patent/HK56889A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK568/89A 1981-11-25 1989-07-13 2-(fluoroalkylthio)substituted penems,processes for preparing them,and pharmaceutical compositions containing them HK56889A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (1)

Publication Number Publication Date
HK56889A true HK56889A (en) 1989-07-21

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
HK568/89A HK56889A (en) 1981-11-25 1989-07-13 2-(fluoroalkylthio)substituted penems,processes for preparing them,and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US4411906A (pt)
EP (1) EP0080162B1 (pt)
JP (1) JPS5892683A (pt)
KR (1) KR890005148B1 (pt)
AT (1) ATE20666T1 (pt)
AU (1) AU560838B2 (pt)
CA (1) CA1207753A (pt)
DE (1) DE3271955D1 (pt)
DK (1) DK153553C (pt)
FI (1) FI76091C (pt)
HK (1) HK56889A (pt)
HU (1) HU190044B (pt)
IE (1) IE54219B1 (pt)
IL (1) IL67327A0 (pt)
MY (1) MY8700708A (pt)
NO (1) NO159796C (pt)
NZ (1) NZ202574A (pt)
OA (1) OA07255A (pt)
PH (1) PH19647A (pt)
PT (1) PT75878B (pt)
SG (1) SG88388G (pt)
ZA (1) ZA828602B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (en) * 1982-03-26 1987-07-29 Hoechst Uk Limited 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
DE3382761T2 (de) * 1982-11-29 1995-03-09 Schering Corp Verfahren zur Herstellung von Penem-Verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
WO1999036098A1 (fr) * 1998-01-13 1999-07-22 Suntory Limited Composition antibacterienne contenant des antibiotiques et destinee a l'administration topique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
FI76091B (fi) 1988-05-31
AU560838B2 (en) 1987-04-16
DK153553B (da) 1988-07-25
FI76091C (fi) 1988-09-09
DE3271955D1 (en) 1986-08-14
SG88388G (en) 1989-06-16
IE54219B1 (en) 1989-07-19
DK153553C (da) 1988-12-19
PT75878B (en) 1986-01-15
MY8700708A (en) 1987-12-31
IL67327A0 (en) 1983-03-31
US4411906A (en) 1983-10-25
KR890005148B1 (ko) 1989-12-14
FI823997L (fi) 1983-05-26
OA07255A (fr) 1984-04-30
NO159796B (no) 1988-10-31
HU190044B (en) 1986-08-28
EP0080162B1 (en) 1986-07-09
IE822765L (en) 1983-05-25
DK519382A (da) 1983-05-26
EP0080162A1 (en) 1983-06-01
FI823997A0 (fi) 1982-11-22
PT75878A (en) 1982-12-01
NO159796C (no) 1989-02-08
US4814442A (en) 1989-03-21
KR840002403A (ko) 1984-07-02
JPS5892683A (ja) 1983-06-02
PH19647A (en) 1986-06-04
AU9078782A (en) 1983-06-02
CA1207753A (en) 1986-07-15
ATE20666T1 (de) 1986-07-15
NZ202574A (en) 1986-06-11
ZA828602B (en) 1983-09-28
NO823903L (no) 1983-05-26

Similar Documents

Publication Publication Date Title
FR2691326B1 (fr) Procede pour la production de composes antimicrobiens.
GB2273655B (en) Veterinary compositions for the treatment of mastitis
DE3271955D1 (en) 2-(fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them
DE3860977D1 (en) (1r,5s,6s)-2-(substituiertes thio)-6-((r)-1-hydroxy-aethyl)-1-methyl-carbapenem-3-carbonsaeurederivate.
HUT45538A (en) Process for producing quinoline derivatives and pharmaceutical compositions containing them
AU5729180A (en) 2-((2-aminoethyl)thio)6-(1-hydroxyethyl)penem-3-caroxylic acid
DE3363607D1 (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(oxoalkyl)-1-piperazinyl)-3-quinoline-carboxylic acids and their derivatives, process for their preparation and antibacterial agents containing them
IL68307A (en) Process for the preparation of 2-substituted penem derivatives
IL65306A0 (en) Bis-esters of 1,1-alkanediols with 6 beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics and pharmaceutical compositions containing them
AU1746188A (en) (5R, 6S, 1R)-6-(1-hydroxyethyl)-2-(methoxymethyl)penem-3- carboxylic acid derivatives
EP0472826A3 (en) Novel quinolinecarboxylic acid derivatives, use thereof, antibacterial agent containing the same, process for preparing said compounds and intermediate compound
PH25530A (en) Novle quinoline derivatives, processes for preparation thereof, antibacterial agent containing them
AU598018B2 (en) (5r,6s,8r)-6-(1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl) thiopenem-3-carboxylic acid
PH18096A (en) Antibacterial 6-(2-amino-2-(4-acyloxyphznyl)-acetamido penicillanoyloxymethyl penicillanate,1,1-dioxide compounds
DZ1818A1 (fr) Procédé de préparation de compositions orales cotenant des quinolones.
NZ217944A (en) Intermediates for preparation of 2-(1-oxo-3 thiolanylthio)-2-penem antibiotics
DE3163506D1 (en) Carboxamide compounds as srs-a antagonists, pharmaceutical compositions containing them, processes for the preparation, and intermediates useful therein
PT72291A (en) Process for the preparation of 6-aminopenicillanic acid-1,1-dioxide
IL63892A (en) 7-(2-(aminothiazol-4yl)acetamido)cephalosporin derivatives,processes for producing the same and pharmaceutical compositions comprising them
ATE58139T1 (de) (1r,5s,6s)-2-(substituiertes thio)-6-((r)-1hydroxy-|thyl>-1-methyl-carbapenem-3carbons|urederivate.