DK519382A - Fremgangsmaade til fremstilling af 2-(fluoralkylthio)-substituerede penem-forbindelser - Google Patents

Fremgangsmaade til fremstilling af 2-(fluoralkylthio)-substituerede penem-forbindelser Download PDF

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Publication number
DK519382A
DK519382A DK519382A DK519382A DK519382A DK 519382 A DK519382 A DK 519382A DK 519382 A DK519382 A DK 519382A DK 519382 A DK519382 A DK 519382A DK 519382 A DK519382 A DK 519382A
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DK
Denmark
Prior art keywords
fluoralkylthio
procedure
preparation
penem compounds
substituted penem
Prior art date
Application number
DK519382A
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English (en)
Other versions
DK153553B (da
DK153553C (da
Inventor
Viyyoor Moopil Girijavallabhan
Stuart Walter Mccombie
Ashit Kumar Ganguly
Us Patrick Anthony Pinto
Us Richard William Versace
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK519382A publication Critical patent/DK519382A/da
Publication of DK153553B publication Critical patent/DK153553B/da
Application granted granted Critical
Publication of DK153553C publication Critical patent/DK153553C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK519382A 1981-11-25 1982-11-22 Analogifremgangsmaade til fremstilling af 2-(fluoralkylthio)-substituerede penem-forbindelser DK153553C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
US32493181 1981-11-25

Publications (3)

Publication Number Publication Date
DK519382A true DK519382A (da) 1983-05-26
DK153553B DK153553B (da) 1988-07-25
DK153553C DK153553C (da) 1988-12-19

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
DK519382A DK153553C (da) 1981-11-25 1982-11-22 Analogifremgangsmaade til fremstilling af 2-(fluoralkylthio)-substituerede penem-forbindelser

Country Status (22)

Country Link
US (2) US4411906A (da)
EP (1) EP0080162B1 (da)
JP (1) JPS5892683A (da)
KR (1) KR890005148B1 (da)
AT (1) ATE20666T1 (da)
AU (1) AU560838B2 (da)
CA (1) CA1207753A (da)
DE (1) DE3271955D1 (da)
DK (1) DK153553C (da)
FI (1) FI76091C (da)
HK (1) HK56889A (da)
HU (1) HU190044B (da)
IE (1) IE54219B1 (da)
IL (1) IL67327A0 (da)
MY (1) MY8700708A (da)
NO (1) NO159796C (da)
NZ (1) NZ202574A (da)
OA (1) OA07255A (da)
PH (1) PH19647A (da)
PT (1) PT75878B (da)
SG (1) SG88388G (da)
ZA (1) ZA828602B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (en) * 1982-03-26 1987-07-29 Hoechst Uk Limited 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
ATE112778T1 (de) * 1982-11-29 1994-10-15 Schering Corp Verfahren zur herstellung von penem-verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
ATE283707T1 (de) * 1998-01-13 2004-12-15 Daiichi Suntory Pharma Co Ltd Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
ATE20666T1 (de) 1986-07-15
FI76091B (fi) 1988-05-31
NO823903L (no) 1983-05-26
KR840002403A (ko) 1984-07-02
PT75878B (en) 1986-01-15
AU9078782A (en) 1983-06-02
AU560838B2 (en) 1987-04-16
NZ202574A (en) 1986-06-11
US4411906A (en) 1983-10-25
HU190044B (en) 1986-08-28
DK153553B (da) 1988-07-25
DK153553C (da) 1988-12-19
OA07255A (fr) 1984-04-30
DE3271955D1 (en) 1986-08-14
NO159796B (no) 1988-10-31
MY8700708A (en) 1987-12-31
NO159796C (no) 1989-02-08
JPS5892683A (ja) 1983-06-02
ZA828602B (en) 1983-09-28
IE822765L (en) 1983-05-25
FI823997A0 (fi) 1982-11-22
EP0080162A1 (en) 1983-06-01
HK56889A (en) 1989-07-21
IL67327A0 (en) 1983-03-31
FI76091C (fi) 1988-09-09
US4814442A (en) 1989-03-21
PH19647A (en) 1986-06-04
EP0080162B1 (en) 1986-07-09
PT75878A (en) 1982-12-01
FI823997L (fi) 1983-05-26
SG88388G (en) 1989-06-16
IE54219B1 (en) 1989-07-19
CA1207753A (en) 1986-07-15
KR890005148B1 (ko) 1989-12-14

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