PT625197E - Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacao - Google Patents
Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacaoInfo
- Publication number
- PT625197E PT625197E PT93902110T PT93902110T PT625197E PT 625197 E PT625197 E PT 625197E PT 93902110 T PT93902110 T PT 93902110T PT 93902110 T PT93902110 T PT 93902110T PT 625197 E PT625197 E PT 625197E
- Authority
- PT
- Portugal
- Prior art keywords
- mammal
- human
- expression system
- dna sequence
- casein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108020005029 5' Flanking Region Proteins 0.000 abstract 2
- 108010076119 Caseins Proteins 0.000 abstract 2
- 101710087237 Whey acidic protein Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000004602 germ cell Anatomy 0.000 abstract 2
- 210000001161 mammalian embryo Anatomy 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000282836 Camelus dromedarius Species 0.000 abstract 1
- 241000283707 Capra Species 0.000 abstract 1
- 102000011632 Caseins Human genes 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 235000017274 Diospyros sandwicensis Nutrition 0.000 abstract 1
- 101000793859 Homo sapiens Kappa-casein Proteins 0.000 abstract 1
- 241000282838 Lama Species 0.000 abstract 1
- 108010011756 Milk Proteins Proteins 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 235000013350 formula milk Nutrition 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 235000021247 β-casein Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dairy Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9288A DK8892D0 (da) | 1992-01-23 | 1992-01-23 | Humant proteingen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT625197E true PT625197E (pt) | 2003-04-30 |
Family
ID=8089602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93902110T PT625197E (pt) | 1992-01-23 | 1993-01-25 | Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacao |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6222094B1 (de) |
| EP (1) | EP0625197B1 (de) |
| JP (1) | JP3467272B2 (de) |
| AT (1) | ATE229071T1 (de) |
| AU (1) | AU3346493A (de) |
| CA (1) | CA2128110A1 (de) |
| DE (1) | DE69332537T2 (de) |
| DK (2) | DK8892D0 (de) |
| ES (1) | ES2188592T3 (de) |
| PT (1) | PT625197E (de) |
| WO (1) | WO1993015196A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| JP3670003B2 (ja) * | 1992-06-15 | 2005-07-13 | ファーミング ビー．ブイ． | ウシ種による組み換えポリペプチドの製造及びトランスジェニック法 |
| NZ279676A (en) * | 1994-03-09 | 1998-04-27 | Abbott Lab | Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates |
| MX198456B (es) * | 1994-03-09 | 2000-09-05 | Abbott Lab | Animales trangenicos que producen oligosacaridos y glucoconjugados. |
| US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
| US5750176A (en) * | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
| US5576300A (en) * | 1994-09-16 | 1996-11-19 | Abbott Laboratories | Method for inhibition of human rotavirus infection |
| US5712250A (en) * | 1994-09-16 | 1998-01-27 | Abbott Laboratories | Product for inhibition of human rotavirus infection |
| AU711437B2 (en) * | 1994-09-16 | 1999-10-14 | Abbott Laboratories | Inhibition of human rotavirus infection |
| US6455280B1 (en) | 1998-12-22 | 2002-09-24 | Genset S.A. | Methods and compositions for inhibiting neoplastic cell growth |
| US6514825B1 (en) * | 2000-06-28 | 2003-02-04 | Conexant Systems, Inc. | Technique for reducing 1/f noise in MOSFETs |
| CN101724075B (zh) | 2001-10-10 | 2014-04-30 | 诺和诺德公司 | 肽的重构和糖缀合 |
| WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| EP2292273A3 (de) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodellierung und Glycokonjugation von Peptiden |
| CN1925741B (zh) * | 2002-05-24 | 2010-11-10 | A2有限公司 | 动物基因分型方法 |
| US7011949B2 (en) * | 2002-09-30 | 2006-03-14 | Agilent Technologies, Inc. | Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications |
| CN1980948B (zh) | 2002-11-27 | 2011-08-10 | Dmi生物科学公司 | 治疗由增强磷酸化介导的疾病和病况 |
| US7871793B2 (en) | 2004-02-20 | 2011-01-18 | Burnham Institute For Medical Research | Antimicrobial carbohydrates and methods of using same |
| US7968762B2 (en) * | 2004-07-13 | 2011-06-28 | Van Andel Research Institute | Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF) |
| WO2006089921A1 (en) * | 2005-02-24 | 2006-08-31 | Dsm Ip Assets B.V. | Blood pressure lowering peptides from glycomacropeptide |
| WO2007035870A2 (en) * | 2005-09-20 | 2007-03-29 | Prolacta Bioscience, Inc. | A method for testing milk |
| WO2010119088A2 (en) * | 2009-04-15 | 2010-10-21 | Bodo Melnik | Milk and milk-based products modified to exhibit a reduced insulinemic index and/or reduced mitogenic activity |
| EP2693883B1 (de) * | 2011-04-07 | 2018-12-26 | Cornell University | Silylmonomere zur multimerisierung in einer wässrigen lösung und verwendungsverfahren dafür |
| WO2013052456A1 (en) | 2011-10-05 | 2013-04-11 | Nanosys, Inc. | Silicon nanostructure active materials for lithium ion batteries and processes, compositions, components, and devices related thereto |
| EA023475B1 (ru) * | 2012-10-08 | 2016-06-30 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK4, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL4, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-BLUE/pFK4 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL4 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ |
| EA023387B1 (ru) * | 2012-10-08 | 2016-05-31 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK3, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL3, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-Blue/pFK3 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL3 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ |
| EP3182842A1 (de) | 2014-08-21 | 2017-06-28 | Perfect Day, Inc. | Zusammensetzungen mit einem casein und verfahren zur herstellung davon |
| MX2019002109A (es) | 2016-08-25 | 2019-12-05 | Perfect Day Inc | Productos alimenticios que contienen proteínas de la leche y proteínas no animales, y métodos para su producción. |
| JP2022531390A (ja) * | 2019-05-02 | 2022-07-06 | ニュー カルチャー インコーポレイテッド | チーズおよびヨーグルト様組成物ならびに関連する方法 |
| JP2023543743A (ja) | 2020-09-18 | 2023-10-18 | スタンディング、オバスィオン | チーズ代替品を生産するための方法 |
| EP3970501A1 (de) | 2020-09-18 | 2022-03-23 | Baio | Verfahren zur herstellung von käseersatzstoffen |
| CA3191387A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US10894812B1 (en) * | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US11771105B2 (en) | 2021-08-17 | 2023-10-03 | New Culture Inc. | Dairy-like compositions and related methods |
| WO2023197003A2 (en) * | 2022-04-08 | 2023-10-12 | Mozza Foods, Inc. | Making cheese with soy proteins |
| EP4328240A1 (de) * | 2022-08-25 | 2024-02-28 | Real Deal Milk S.L. | Herstellung rekombinanter proteine |
| WO2024102436A1 (en) * | 2022-11-10 | 2024-05-16 | The Johns Hopkins University | System for modulating receptor tyrosine kinase signaling and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982004443A1 (en) | 1981-06-12 | 1982-12-23 | Ohio Univ | Genetic transformation of zygotes |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| EP0181634A3 (de) * | 1984-11-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Synthetisches Gen für menschliches Lysozym |
| ATE141646T1 (de) | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
| DE3751863T2 (de) | 1986-05-20 | 1996-12-12 | Gen Hospital Corp | Bestimmung der Insulin Expression |
| GB8615942D0 (en) | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
| AU7879987A (en) | 1986-08-28 | 1988-03-24 | Immunex Corp. | Expression of heterologous proteins by transgenic lactating mammals |
| EP0832981A1 (de) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US6020015A (en) * | 1988-09-22 | 2000-02-01 | Gaull; Gerald E. | Infant formula compositions and nutrition containing genetically engineered human milk proteins |
| JPH04506751A (ja) | 1989-09-11 | 1992-11-26 | ティー エスアイ コーポレーション | 遺伝子導入動物の乳汁中での成長ホルモンの生産 |
| EP0737746A3 (de) | 1989-12-01 | 1996-10-23 | Pharming B.V. | Herstellung rekombinanter Polypeptide durch Rinderarte und Transgenmethoden |
| US5795611A (en) * | 1989-12-20 | 1998-08-18 | Slattery; Charles W. | Human infant formulas containing recombinant human alpha-lactalbumin and beta-casein |
| US5391497A (en) | 1992-10-13 | 1995-02-21 | University Of Colorado Foundation, Inc. | Human k-casein |
-
1992
- 1992-01-23 DK DK9288A patent/DK8892D0/da not_active Application Discontinuation
-
1993
- 1993-01-25 EP EP93902110A patent/EP0625197B1/de not_active Expired - Lifetime
- 1993-01-25 US US08/256,799 patent/US6222094B1/en not_active Expired - Fee Related
- 1993-01-25 AT AT93902110T patent/ATE229071T1/de not_active IP Right Cessation
- 1993-01-25 DK DK93902110T patent/DK0625197T3/da active
- 1993-01-25 DE DE69332537T patent/DE69332537T2/de not_active Expired - Fee Related
- 1993-01-25 CA CA002128110A patent/CA2128110A1/en not_active Abandoned
- 1993-01-25 PT PT93902110T patent/PT625197E/pt unknown
- 1993-01-25 ES ES93902110T patent/ES2188592T3/es not_active Expired - Lifetime
- 1993-01-25 JP JP51286793A patent/JP3467272B2/ja not_active Expired - Fee Related
- 1993-01-25 AU AU33464/93A patent/AU3346493A/en not_active Abandoned
- 1993-01-25 WO PCT/DK1993/000024 patent/WO1993015196A1/en active IP Right Grant
-
1995
- 1995-06-05 US US08/462,437 patent/US6232094B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2128110A1 (en) | 1993-08-05 |
| AU3346493A (en) | 1993-09-01 |
| JPH07503136A (ja) | 1995-04-06 |
| WO1993015196A1 (en) | 1993-08-05 |
| EP0625197B1 (de) | 2002-12-04 |
| DE69332537D1 (de) | 2003-01-16 |
| ES2188592T3 (es) | 2003-07-01 |
| DE69332537T2 (de) | 2003-09-04 |
| EP0625197A1 (de) | 1994-11-23 |
| DK0625197T3 (da) | 2003-03-24 |
| US6232094B1 (en) | 2001-05-15 |
| US6222094B1 (en) | 2001-04-24 |
| JP3467272B2 (ja) | 2003-11-17 |
| ATE229071T1 (de) | 2002-12-15 |
| DK8892D0 (da) | 1992-01-23 |
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