PT3298134T - Edição génica de mutações intrónicas profundas - Google Patents

Edição génica de mutações intrónicas profundas

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Publication number
PT3298134T
PT3298134T PT167188408T PT16718840T PT3298134T PT 3298134 T PT3298134 T PT 3298134T PT 167188408 T PT167188408 T PT 167188408T PT 16718840 T PT16718840 T PT 16718840T PT 3298134 T PT3298134 T PT 3298134T
Authority
PT
Portugal
Prior art keywords
gene editing
deep intronic
intronic mutations
mutations
deep
Prior art date
Application number
PT167188408T
Other languages
English (en)
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of PT3298134T publication Critical patent/PT3298134T/pt

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    • A61K38/46—Hydrolases (3)
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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PT167188408T 2015-05-16 2016-04-15 Edição génica de mutações intrónicas profundas PT3298134T (pt)

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EP (1) EP3298134B8 (pt)
JP (3) JP6985250B2 (pt)
KR (2) KR102584873B1 (pt)
CN (2) CN107849547B (pt)
AU (2) AU2016265255B2 (pt)
BR (1) BR112017024514A2 (pt)
CA (1) CA2986021A1 (pt)
ES (1) ES2952598T3 (pt)
HK (1) HK1252469A1 (pt)
IL (2) IL296365A (pt)
MX (2) MX2017014665A (pt)
PL (1) PL3298134T3 (pt)
PT (1) PT3298134T (pt)
RU (2) RU2759335C2 (pt)
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WO (1) WO2016186772A2 (pt)

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CA2853829C (en) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
EP3114227B1 (en) 2014-03-05 2021-07-21 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
WO2015138510A1 (en) 2014-03-10 2015-09-17 Editas Medicine., Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
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