PT3064498T - Derivados de pirazolopirimidona ou de pirrolotriazona, método de preparação dos mesmos, e aplicações farmacêuticas dos mesmos - Google Patents
Derivados de pirazolopirimidona ou de pirrolotriazona, método de preparação dos mesmos, e aplicações farmacêuticas dos mesmosInfo
- Publication number
- PT3064498T PT3064498T PT148580905T PT14858090T PT3064498T PT 3064498 T PT3064498 T PT 3064498T PT 148580905 T PT148580905 T PT 148580905T PT 14858090 T PT14858090 T PT 14858090T PT 3064498 T PT3064498 T PT 3064498T
- Authority
- PT
- Portugal
- Prior art keywords
- pyrazolopyrimidone
- pharmaceutical applications
- preparing same
- pyrrolotriazone
- derivatives
- Prior art date
Links
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical compound N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310525956 | 2013-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3064498T true PT3064498T (pt) | 2019-10-14 |
Family
ID=53003302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT148580905T PT3064498T (pt) | 2013-10-30 | 2014-09-30 | Derivados de pirazolopirimidona ou de pirrolotriazona, método de preparação dos mesmos, e aplicações farmacêuticas dos mesmos |
Country Status (21)
Country | Link |
---|---|
US (3) | US10005781B2 (pt) |
EP (1) | EP3064498B1 (pt) |
JP (1) | JP6412563B2 (pt) |
CN (1) | CN104884457B (pt) |
AU (1) | AU2014344504C1 (pt) |
BR (1) | BR112016008799B1 (pt) |
CA (1) | CA2927641C (pt) |
CY (1) | CY1122196T1 (pt) |
DK (1) | DK3064498T3 (pt) |
ES (1) | ES2747839T3 (pt) |
HR (1) | HRP20191679T1 (pt) |
HU (1) | HUE046314T2 (pt) |
LT (1) | LT3064498T (pt) |
MX (1) | MX2016005142A (pt) |
PL (1) | PL3064498T3 (pt) |
PT (1) | PT3064498T (pt) |
RS (1) | RS59457B1 (pt) |
RU (1) | RU2674977C2 (pt) |
SI (1) | SI3064498T1 (pt) |
TW (1) | TWI675838B (pt) |
WO (1) | WO2015062391A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3064498T1 (sl) * | 2013-10-30 | 2019-11-29 | Shanghai hengrui pharmaceutical co ltd | Derivati pirazolopirimidona ali pirolotriazona, postopki priprave le-teh in farmacevtske uporabe le-teh |
TWI751220B (zh) * | 2016-11-07 | 2022-01-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種GnRH受體拮抗劑的多晶型及其製備方法 |
WO2018086608A1 (zh) * | 2016-11-14 | 2018-05-17 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
EP3660017A4 (en) * | 2017-07-28 | 2020-12-30 | Jiangsu Hengrui Medicine Co., Ltd. | PROCESS FOR PREPARATION OF A HETERARYL PYRIMIDONE DERIVATIVE AND INTERMEDIATE OF A HETERARYL PYRIMIDONE DERIVATIVE |
CN109970662B (zh) * | 2017-12-27 | 2023-06-30 | 上海科胜药物研发有限公司 | 一种制备噁拉戈利中间体的方法 |
CN117203209A (zh) * | 2021-04-02 | 2023-12-08 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
CN115260211B (zh) * | 2021-04-29 | 2024-02-06 | 长春金赛药业有限责任公司 | 含噻吩稠环类衍生物、药物组合物及其制备方法和应用 |
CN117769424A (zh) * | 2021-08-30 | 2024-03-26 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶工艺 |
CN115141809B (zh) * | 2022-08-30 | 2023-05-02 | 南京诺唯赞生物科技股份有限公司 | 一种检测gnrh结合蛋白生物学活性的方法及试剂盒 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5171835A (en) | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
US20020065309A1 (en) | 1999-08-04 | 2002-05-30 | Ge Peng | Novel Bicyclic and tricyclic pyrrolidine derivatives as GnRH antagonists |
JP5072166B2 (ja) * | 2002-01-30 | 2012-11-14 | 武田薬品工業株式会社 | チエノピリミジン化合物、その製造法および用途 |
EP1479684A4 (en) * | 2002-01-30 | 2006-01-04 | Takeda Pharmaceutical | THIENOPYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE |
AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
JP4039574B2 (ja) * | 2003-01-29 | 2008-01-30 | 武田薬品工業株式会社 | チエノピリミジン化合物およびその用途 |
US7714017B2 (en) * | 2004-10-12 | 2010-05-11 | Decode Genetics, Ehf | Carboxylic acid peri-substituted bicyclics for occlusive artery disease |
EP1841448A2 (en) * | 2004-12-30 | 2007-10-10 | Diakine Therapeutics, Inc. | Pharmaceutical compositions and methods for restoring beta-cell mass and function |
JPWO2006083005A1 (ja) * | 2005-02-03 | 2008-06-26 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体およびその用途 |
JP2008533025A (ja) | 2005-03-07 | 2008-08-21 | ワイス | キノキサリンジヒドロハライド二水和物およびそのための合成方法 |
CN101468988A (zh) * | 2007-12-26 | 2009-07-01 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
JPWO2010026993A1 (ja) | 2008-09-03 | 2012-02-02 | 武田薬品工業株式会社 | 製剤における吸収性改善方法および吸収性が改善された製剤 |
KR20110132575A (ko) * | 2009-03-23 | 2011-12-08 | 그렌마크 파머수티칼스 에스. 아. | Trpa1 조절자로서 융합된 피리미딘디온 유도체 |
TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
WO2011090935A1 (en) | 2010-01-19 | 2011-07-28 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
CN102807568B (zh) * | 2011-05-31 | 2015-11-25 | 正大天晴药业集团股份有限公司 | 噻二唑衍生物类dpp-iv抑制剂 |
WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
UA123760C2 (uk) * | 2011-11-11 | 2021-06-02 | Гіліад Аполло, Ллс | Сполука (варіанти) та композиція, що містить сполуку |
JP6209171B2 (ja) | 2012-02-28 | 2017-10-04 | ティウムバイオ カンパニー、リミテッドTiumBio Co., Ltd. | ゴナドトロピン放出ホルモン受容体アンタゴニスト、その製造方法および該アンタゴニストを含む医薬組成物 |
CN102807569B (zh) * | 2012-08-21 | 2015-02-25 | 四川大学 | 一种镇静催眠的化合物及其制备方法和用途 |
SI3064498T1 (sl) * | 2013-10-30 | 2019-11-29 | Shanghai hengrui pharmaceutical co ltd | Derivati pirazolopirimidona ali pirolotriazona, postopki priprave le-teh in farmacevtske uporabe le-teh |
-
2014
- 2014-09-30 SI SI201431353T patent/SI3064498T1/sl unknown
- 2014-09-30 JP JP2016522010A patent/JP6412563B2/ja active Active
- 2014-09-30 PT PT148580905T patent/PT3064498T/pt unknown
- 2014-09-30 ES ES14858090T patent/ES2747839T3/es active Active
- 2014-09-30 RU RU2016119135A patent/RU2674977C2/ru active
- 2014-09-30 US US15/031,410 patent/US10005781B2/en active Active
- 2014-09-30 BR BR112016008799-2A patent/BR112016008799B1/pt active IP Right Grant
- 2014-09-30 MX MX2016005142A patent/MX2016005142A/es unknown
- 2014-09-30 LT LTEP14858090.5T patent/LT3064498T/lt unknown
- 2014-09-30 WO PCT/CN2014/087906 patent/WO2015062391A1/zh active Application Filing
- 2014-09-30 RS RSP20191238 patent/RS59457B1/sr unknown
- 2014-09-30 HU HUE14858090A patent/HUE046314T2/hu unknown
- 2014-09-30 CN CN201480003662.2A patent/CN104884457B/zh active Active
- 2014-09-30 DK DK14858090.5T patent/DK3064498T3/da active
- 2014-09-30 AU AU2014344504A patent/AU2014344504C1/en active Active
- 2014-09-30 CA CA2927641A patent/CA2927641C/en active Active
- 2014-09-30 PL PL14858090T patent/PL3064498T3/pl unknown
- 2014-09-30 EP EP14858090.5A patent/EP3064498B1/en active Active
- 2014-10-20 TW TW103136105A patent/TWI675838B/zh active
-
2018
- 2018-05-02 US US15/969,098 patent/US10344034B2/en active Active
-
2019
- 2019-05-20 US US16/416,418 patent/US10633388B2/en active Active
- 2019-09-17 HR HRP20191679 patent/HRP20191679T1/hr unknown
- 2019-09-18 CY CY20191100975T patent/CY1122196T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1232224A1 (zh) | 取代脲衍生物及其在藥物中的應用 | |
PT3061747T (pt) | Derivados pirídicos de cetona, método para preparar os mesmos e aplicação farmacêutica dos mesmos | |
HRP20161202T8 (hr) | Novi derivati fosfata, postupak njihove priprave i farmaceutski pripravci koji ih sadrže | |
HK1215567A1 (zh) | 五元併六元雜環化合物、其製備方法、藥物組合物和應用 | |
SI2829539T1 (sl) | Novi derivati pirola, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo | |
HUE046314T2 (hu) | Pirazolopirimidon vagy pirrolotriazon származékok, eljárás ezek elõállítására és gyógyászati alkalmazásaik | |
HK1205118A1 (zh) | 環烷基甲酸類衍生物、其製備方法及其在醫藥上的應用 | |
IL243734A0 (en) | History of oxoquinazolinyl-butanamide, their preparation containing them | |
EP3000133A4 (en) | SENSORS, METHOD OF MANUFACTURING AND DEVICES | |
EP3395366C0 (en) | METHOD FOR DESIGNING A DRUG, DRUG OBTAINED AND ASSOCIATED APPLICATION | |
EP3012256A4 (en) | HETEROCYCLIC BENZIMIDAZOLE-2-PIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, PROCESS FOR PREPARATION AND USE THEREOF | |
EP3072893A4 (en) | Ketone derivatives of imidazoles, pharmaceutical combinations and uses thereof | |
IL243227A0 (en) | History of diaminocyclopentane carboxamide, their preparation and pharmaceutical preparations containing them | |
EP2941418A4 (en) | N1-CYCLIC AMIN-N5 SUBSTITUTED BIGUANIDE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREWITH | |
HK1206329A1 (en) | Phenol derivative, method of preparing same, and pharmaceutical application of same | |
DK3091005T3 (da) | 1,2-naphthoquinonderivat og fremgangsmåde til fremstilling deraf | |
PL3055679T3 (pl) | Środek do wykrywania pęknięć, sposób jego wytwarzania i zastosowanie środka do wykrywania pęknięć | |
EP2952519A4 (en) | PROTOPANOXADIOL DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF | |
EP3078659A4 (en) | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | |
EP2987794A4 (en) | VINBLASTINE DERIVATIVES, PROCESS FOR THEIR SYNTHESIS AND THEIR APPLICATION | |
GB201307082D0 (en) | Pharmaceutical composition comprising 15-HETrE and methods of using the same | |
HK1244814A1 (zh) | 一種薯蕷皂苷元-3-位衍生物及其製備方法和用途 |