PT3037089T - Ester etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia - Google Patents

Ester etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia

Info

Publication number
PT3037089T
PT3037089T PT161524475T PT16152447T PT3037089T PT 3037089 T PT3037089 T PT 3037089T PT 161524475 T PT161524475 T PT 161524475T PT 16152447 T PT16152447 T PT 16152447T PT 3037089 T PT3037089 T PT 3037089T
Authority
PT
Portugal
Prior art keywords
ethyl ester
acid ethyl
eicosapentaenoic acid
treating hypertriglyceridemia
hypertriglyceridemia
Prior art date
Application number
PT161524475T
Other languages
English (en)
Original Assignee
Amarin Pharmaceuticals Ie Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42102041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3037089(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amarin Pharmaceuticals Ie Ltd filed Critical Amarin Pharmaceuticals Ie Ltd
Publication of PT3037089T publication Critical patent/PT3037089T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass
PT161524475T 2009-02-10 2010-02-09 Ester etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia PT3037089T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15129109P 2009-02-10 2009-02-10
US17375509P 2009-04-29 2009-04-29

Publications (1)

Publication Number Publication Date
PT3037089T true PT3037089T (pt) 2020-03-04

Family

ID=42102041

Family Applications (3)

Application Number Title Priority Date Filing Date
PT131561227T PT2596786T (pt) 2009-02-10 2010-02-09 Utilização de éster etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia
PT107044646T PT2395991E (pt) 2009-02-10 2010-02-09 Utilização de éster etílico de ácido eicosapentaenóico para tratamento de hipertrigliceridemia
PT161524475T PT3037089T (pt) 2009-02-10 2010-02-09 Ester etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT131561227T PT2596786T (pt) 2009-02-10 2010-02-09 Utilização de éster etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia
PT107044646T PT2395991E (pt) 2009-02-10 2010-02-09 Utilização de éster etílico de ácido eicosapentaenóico para tratamento de hipertrigliceridemia

Country Status (24)

Country Link
US (29) US8293727B2 (pt)
EP (5) EP2395991B1 (pt)
KR (2) KR20140007973A (pt)
AU (1) AU2010213899B2 (pt)
BR (1) BRPI1007518A2 (pt)
CA (3) CA3008079C (pt)
CY (2) CY1122628T1 (pt)
DK (3) DK2395991T3 (pt)
ES (3) ES2769926T3 (pt)
HK (2) HK1165698A1 (pt)
HR (3) HRP20130811T1 (pt)
HU (1) HUE048299T2 (pt)
LT (2) LT3037089T (pt)
MX (1) MX2011008448A (pt)
NZ (1) NZ594395A (pt)
PH (1) PH12015500407B1 (pt)
PL (3) PL2395991T3 (pt)
PT (3) PT2596786T (pt)
RU (2) RU2505292C2 (pt)
SG (3) SG10201400685SA (pt)
SI (3) SI2395991T1 (pt)
SM (1) SMT201300095B (pt)
WO (1) WO2010093634A1 (pt)
ZA (1) ZA201105612B (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9901809D0 (en) * 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
US20110236476A1 (en) 2008-09-02 2011-09-29 Amarin Corporation Plc. Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
PL2376077T3 (pl) 2009-01-12 2017-10-31 Biokier Inc Kompozycja i sposób leczenia cukrzycy
KR20140007973A (ko) 2009-02-10 2014-01-20 아마린 파마, 인크. 고중성지방혈증 치료 방법
NZ627238A (en) 2009-04-29 2016-02-26 Amarin Pharmaceuticals Ie Ltd Stable pharmaceutical composition comprising ethyl eicosapentaenoate
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
MY172372A (en) 2009-06-15 2019-11-21 Amarin Pharmaceuticals Ie Ltd Compositions and methods for lowering triglycerides
MX2012003459A (es) 2009-09-23 2012-05-22 Biokier Inc Composicion y metodo para el tratamiento de la diabetes.
WO2011038122A1 (en) 2009-09-23 2011-03-31 Amarin Corporation Plc Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
US20110178105A1 (en) 2010-01-15 2011-07-21 E.I. Du Pont De Nemours And Company Clinical benefits of eicosapentaenoic acid in humans
KR20130026428A (ko) * 2010-03-04 2013-03-13 아마린 파마, 인크. 심혈관 질환을 치료 및/또는 예방하기 위한 조성물 및 방법
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en) * 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US8952000B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
US8715648B2 (en) 2011-02-16 2014-05-06 Pivotal Therapeutics Inc. Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2800469B1 (en) 2012-01-06 2021-08-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
EP2800563B1 (en) 2012-01-06 2018-07-11 Omthera Pharmaceuticals Inc. Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form
EP2846790A4 (en) * 2012-02-14 2016-03-23 Photonz Corp Ltd METHOD OF SUPERVISING THE CONSUMPTION OF AN ALICAMENT COMPRISING EICOSAPENTAENOIC ACID FOR THE PREVENTION AND / OR MANAGEMENT OF A DISEASE OR A CONDITION OF THE DISEASE
AR095182A1 (es) 2012-05-07 2015-09-30 Omthera Pharmaceuticals Inc Composiciones de estatinas y ácidos grasos omega-3
JP6254939B2 (ja) 2012-05-15 2017-12-27 持田製薬株式会社 高血中高感度ｃ反応性蛋白質患者の心血管疾患一次予防剤
WO2013192109A1 (en) 2012-06-17 2013-12-27 Matinas Biopharma, Inc. Omega-3 pentaenoic acid compositions and methods of use
US20140004183A1 (en) * 2012-06-29 2014-01-02 Amarin Pharmaceuticals Ireland Limited Methods for treating cardiovascular disease in statin-tolerant subjects
EP2866801A4 (en) * 2012-06-29 2016-02-10 Amarin Pharmaceuticals Ie Ltd METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT SUBJECTED TO STATIN TREATMENT
US20140005265A1 (en) * 2012-06-29 2014-01-02 Amarin Pharmaceuticals Ireland Limited Methods for treating hypertriglyceridemia
US20150157593A1 (en) * 2012-06-29 2015-06-11 Amarin Pharmaceuticals Ireland Limited Methods of reducing ldl-p
CA2886178C (en) * 2012-09-28 2020-12-01 Mochida Pharmaceutical Co., Ltd. Composition for reducing new-onset diabetes
WO2014074552A2 (en) * 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US10123986B2 (en) 2012-12-24 2018-11-13 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US9629820B2 (en) 2012-12-24 2017-04-25 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US20140213648A1 (en) * 2012-12-31 2014-07-31 Amarin Pharmaceuticals Ireland Limited Methods of increasing epa blood levels
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US20140221452A1 (en) * 2013-02-06 2014-08-07 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and 5-htp and methods of use thereof
US20140221358A1 (en) * 2013-02-06 2014-08-07 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and diazoxide and methods of use thereof
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
CA2905671A1 (en) * 2013-03-13 2014-09-18 Matinas Biopharma Inc. Omega-3 pentaenoic acid compositions and methods of use
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
KR102039522B1 (ko) * 2013-06-03 2019-11-26 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 근거리 무선 통신(ｎｆｃ)을 이용한 ｎｆｃ 태그의 기록방법 및 장치
US20140357717A1 (en) * 2013-06-04 2014-12-04 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
JP6804823B2 (ja) * 2013-10-14 2020-12-23 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティーＡｒｉｚｏｎａ Ｂｏａｒｄ ｏｆ Ｒｅｇｅｎｔｓ ｏｎ ｂｅｈａｌｆ ｏｆ Ａｒｉｚｏｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ 白金錯体およびデバイス
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US10547995B2 (en) * 2015-04-30 2020-01-28 Lg Electronics Inc. Method and device for transmitting/receiving data using Bluetooth mesh network
US10183044B2 (en) 2015-05-15 2019-01-22 P Tech, Llc Systems and methods for thrombosis prevention
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (en) 2017-05-19 2018-11-22 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
AU2018360730A1 (en) 2017-10-30 2020-05-21 Montreal Heart Institute Methods of treating elevated plasma cholesterol
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
KR102296068B1 (ko) 2018-09-24 2021-09-02 애머린 파마슈티칼스 아일랜드 리미티드 대상체에서 심혈관 사건의 위험도를 감소시키는 방법

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377526A (en) 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
CA1239587A (en) 1983-10-24 1988-07-26 David Rubin Combined fatty acid composition for lowering blood cholestrol and triglyceride levels
US4526902A (en) 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
JPS6135356A (ja) * 1984-07-27 1986-02-19 Nippon Oil & Fats Co Ltd 血液脂質脂肪酸の分析方法
US4920098A (en) 1986-09-17 1990-04-24 Baxter International Inc. Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases
US5252333A (en) 1987-04-27 1993-10-12 Scotia Holdings Plc Lithium salt-containing pharmaceutical compositions
US5198468A (en) 1987-06-24 1993-03-30 Efamol Holdings Plc Essential fatty acid composition
US4843095A (en) 1987-08-07 1989-06-27 Century Laboratories, Inc. Free fatty acids for treatment or propyhlaxis of rheumatoid arthritis arthritis
GB8819110D0 (en) 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
US5116871A (en) 1988-09-13 1992-05-26 Efamol Holdings Plc Fatty acid therapy and compositions for the treatment of myalgic encephalomyelitis
GB2223943A (en) 1988-10-21 1990-04-25 Tillotts Pharma Ag Oral disage forms of omega-3 polyunsaturated acids
US4935243A (en) 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
JP2839276B2 (ja) 1989-01-23 1998-12-16 日本分光工業株式会社 超臨界流体抽出・分離方法及び装置
GB8906369D0 (en) 1989-03-20 1989-05-04 Tisdale Michael J Eicosapentaenoic acid
US5457130A (en) 1989-03-20 1995-10-10 Cancer Research Campaign Technology Limited Eicosapentaenoic acid used to treat cachexia
CA2043615C (en) 1990-06-04 2001-08-14 Kazuhiko Hata Method of producing eicosapentaenoic acid or the ester derivative thereof
GB9012651D0 (en) 1990-06-06 1990-07-25 Efamol Holdings Essential fatty acid treatment
JP3103588B2 (ja) 1990-11-16 2000-10-30 持田製薬株式会社 リポプロテイン（ａ）低下剤
SE9101642D0 (sv) 1991-05-30 1991-05-30 Kabi Pharmacia Ab Phospholipids
US5215630A (en) 1991-06-04 1993-06-01 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation
AU2384292A (en) * 1991-07-30 1993-03-02 North Carolina State University Method and apparatus for measuring blood lipoprotein levels by nmr spectroscopy
DE4133694C2 (de) 1991-10-11 1993-10-07 Fresenius Ag Verwendung einer Emulsion mit mehrfach ungesättigten Fettsären zur i.v.-Verabreichung zur Behandlung von Hauterkrankungen
JP3400466B2 (ja) 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
JPH0649479A (ja) 1992-07-28 1994-02-22 Maruha Corp ω−３不飽和脂肪酸系化合物の安定化法
US5888541A (en) 1992-08-21 1999-03-30 Scotia Holdings Plc Fatty acid treatment
GB9217780D0 (en) 1992-08-21 1992-10-07 Efamol Holdings Fatty acid treatment
GB9300125D0 (en) 1993-01-06 1993-03-03 Scotia Holdings Plc Compositions containing esters of unsaturated fatty acids
WO1994028891A1 (en) 1993-06-04 1994-12-22 Martek Biosciences Corporation Method of treating coronary vascular disease using docosahexaenoic acid
GB9403857D0 (en) 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US5760081A (en) 1994-05-10 1998-06-02 The General Hospital Corporation Omega 3 fatty acids in the prevention of ventricular fibrillation
AU711482B2 (en) 1994-06-28 1999-10-14 Scotia Holdings Plc Compositions for treatment of diabetic complications
IT1274734B (it) 1994-08-25 1997-07-24 Prospa Bv Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti
MY118354A (en) 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
GB9519661D0 (en) 1995-09-27 1995-11-29 Scotia Holdings Plc Fatty acid treatment
AU2738497A (en) 1996-04-24 1997-11-12 Brigham And Women's Hospital Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder
TW425285B (en) 1996-06-10 2001-03-11 Viva America Marketing Inc Fish oil and garlic nutritive supplement
US5861399A (en) 1996-07-17 1999-01-19 Heart Care Partners Methods and compositions for the rapid and enduring relief of inadequate myocardial function
US20020055539A1 (en) 1996-10-02 2002-05-09 Bockow Barry I. Compositions and methods for treating cardiovascular conditions
KR100657642B1 (ko) 1996-10-11 2006-12-19 스카리스타 리미티드 에이코사펜타엔산 및/또는 스테아리돈산을 포함하여 이루어지는 오일
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
EP1025842B1 (en) 1997-10-30 2004-07-21 Morishita Jintan Co., Ltd. Double-leyered capsule of unsaturated fatty acid or derivative thereof and process for producing the same
EP1039893B1 (en) 1997-12-10 2011-02-02 Cyclosporine Therapeutics Limited Pharmaceutical compositions containing an omega-3 fatty acid oil
US20020055529A1 (en) 1998-12-02 2002-05-09 Bisgaier Charles Larry Method for treating alzheimer's disease
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
US20030104048A1 (en) 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US6193999B1 (en) 1999-03-01 2001-02-27 Banner Pharmacaps, Inc. Gum acacia substituted soft gelatin capsules
EP1072198B1 (de) 1999-07-28 2008-05-14 SWISS CAPS Rechte und Lizenzen AG Präparat zur Verwendung als Medikament und/oder Nahrungsmittelergänzung
WO2001015552A1 (en) 1999-08-30 2001-03-08 Ocean Nutrition Canada Ltd. A nutritional supplement for lowering serum triglyceride and cholesterol levels
DK1157692T3 (da) 2000-05-22 2006-02-06 Pro Aparts Investimentos E Con Sammensætning af fedtsyrer indeholdende mindst 80 vægt-% EPA og DHA, derivater deraf og farmaceutisk anvendelse deraf
GB0016045D0 (en) 2000-06-29 2000-08-23 Laxdale Limited Therapeutic combinations of fatty acids
BR0113200A (pt) 2000-08-15 2003-09-16 Pfizer Prod Inc Combinação terapêutica
ITMI20010129A1 (it) 2001-01-25 2002-07-25 Pharmacia & Upjohn Spa Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco
GB0111282D0 (en) 2001-05-09 2001-06-27 Laxdale Ltd Potentiation of therapeutic effects of fatty acids
SK14502003A3 (en) 2001-05-30 2004-10-05 Laxdale Ltd Coenzyme Q and eicosapentaenoic acid
ITMI20012384A1 (it) 2001-11-12 2003-05-12 Quatex Nv Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori
ITMI20020269A1 (it) 2002-02-12 2003-08-12 Victorix Assets Ltd Uso di steri etilici di acidi poliinsaturi omega-3 in pazienti con insufficienza cardiaca
HUP0200686A2 (hu) 2002-02-22 2003-09-29 EURO- "H" Beruházásszervezż és Ingatlanhasznosító Kft. Elektronikus berendezés és eljárás számsorozat eltalálására irányuló játékokban való részvételre kommunikációs berendezésen keresztül
US20030166614A1 (en) 2002-03-01 2003-09-04 Harrison Stanley F. Method for reducing cholesterol and triglycerides
US7157235B2 (en) * 2002-06-17 2007-01-02 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
EP1547588B1 (en) 2002-08-20 2013-12-11 Kowa Company, Ltd. Soft capsule preparation
AU2003284617A1 (en) 2002-11-22 2004-06-18 Nippon Suisan Kaisha, Ltd. Composition containing organic substance having double bond with improved oxidation stability
GB0228079D0 (en) 2002-12-02 2003-01-08 Laxdale Ltd Huntington's Disease
JP2006519244A (ja) 2003-03-05 2006-08-24 ゾルファイ　ファーマスーティカルズ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング 糖尿病患者の治療におけるω−３−脂肪酸の使用
EP1605781A1 (en) 2003-03-18 2005-12-21 Novartis AG Compositions comprising fatty acids and amino acids
ITMI20032247A1 (it) 2003-11-19 2005-05-20 Tiberio Bruzzese Interazione di derivati polari di composti insaturi con substrati inorganici
GB2409644B (en) 2003-12-31 2005-12-21 Igennus Ltd Formulation comprising eicosapentaenoic acid or an ester thereof and a triterpene or an ester thereof
US7022713B2 (en) * 2004-02-19 2006-04-04 Kowa Co., Ltd. Hyperlipemia therapeutic agent
WO2005114190A2 (en) * 2004-05-19 2005-12-01 Ppd Biomarker Discovery Sciences, Llc Methods of identifying biomarkers
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
ITRM20040395A1 (it) 2004-08-03 2004-11-03 Sigma Tau Ind Farmaceuti Composizione comprendente statine e acidi grassi omega 3.
JP2008509154A (ja) 2004-08-06 2008-03-27 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 新規なスタチン薬剤組成物および関連治療方法
EP1790338A4 (en) 2004-09-13 2007-12-12 Santen Pharmaceutical Co Ltd THERAPEUTIC AGENT FOR KERATOCONJUNTIVA DISEASES
CN1759834B (zh) * 2004-09-17 2010-06-23 中国医学科学院医药生物技术研究所 黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途
CA2581775A1 (en) 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
WO2006085144A2 (en) 2004-10-15 2006-08-17 Photonz Corporation Limited Compositions containing high omega-3 and low saturated fatty acid levels
FR2878747B1 (fr) 2004-12-03 2007-03-30 Pierre Fabre Medicament Sa Utilisation d'acide(s) gras omega-3 pour le traitement de l'hypercholesterolemie causee par un traitement anti-retroviral chez les patients infectes par le vih
MX2007006707A (es) 2004-12-06 2008-01-16 Reliant Pharmaceuticals Inc Acidos grasos omega-3 y agente dislipidemico para terapia lipidica.
US20070191467A1 (en) 2004-12-06 2007-08-16 Reliant Pharmaceutical, Inc. Statin and omega-3 fatty acids for lipid therapy
US20060135610A1 (en) 2004-12-22 2006-06-22 Bortz Jonathan D Cardiovascular compositions
GB2421909A (en) 2004-12-23 2006-07-12 Laxdale Ltd Pharmaceutical compositions comprising EPA and methods of use
US20060189682A1 (en) * 2005-02-02 2006-08-24 Payne Joseph E Water soluble prodrugs of COX-2 inhibitors
CN101208083A (zh) 2005-03-08 2008-06-25 瑞莱恩特医药品有限公司 利用他汀和Omega-3脂肪酸治疗及其组合产品
EP1790339B1 (en) 2005-07-08 2014-06-04 Mochida Pharmaceutical Co., Ltd. Composition for prevention of occurrence of cardiovascular event
RU2290185C1 (ru) * 2005-07-26 2006-12-27 Дмитрий Николаевич Мясников Композиция для нормализации липидного обмена и снижения массы тела и способ её получения
EA200800451A1 (ru) 2005-07-28 2008-08-29 Релайэнт Фармасьютикалз, Инк. Лечение дигидропиридиновыми блокаторами кальциевых каналов и жирными кислотами омега-3 и их комбинированным продуктом
ITMI20051560A1 (it) 2005-08-10 2007-02-11 Tiberio Bruzzese Composizione di acidi grassi n-3 con elevata concentrazione di epa e-o dha e contenente acidi grassi n-6
EP1948168A4 (en) 2005-10-28 2010-10-06 Numerate Inc COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND / OR HMG-COA REDUCTASE
US20070104779A1 (en) * 2005-11-07 2007-05-10 Rongen Roelof M Treatment with omega-3 fatty acids and products thereof
BRPI0618455A2 (pt) 2005-11-11 2011-08-30 Mochida Pharm Co Ltd composição de geléia
JP2009520824A (ja) 2005-12-20 2009-05-28 セネストラ エルエルシー オメガ３脂肪酸製剤
ATE509624T1 (de) 2005-12-23 2011-06-15 Nutricia Nv Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
WO2007091338A1 (ja) * 2006-02-07 2007-08-16 Mochida Pharmaceutical Co., Ltd. 脳卒中再発予防用組成物
WO2007128801A1 (en) 2006-05-08 2007-11-15 Novartis Ag Combination of organic compounds
EP2777701A1 (en) 2006-05-31 2014-09-17 Mochida Pharmaceutical Co., Ltd. Composition for preventing the occurrence of a cardiovascular event in multiple risk patient comprising the ethyl ester of all-cis-5,8,11,14,17-icosapentaenoic acid
CA2656311C (en) 2006-07-05 2016-06-21 Photonz Corporation Limited Ultra pure epa and polar lipids produced in largely heterotrophic culture
US20090304784A1 (en) 2006-07-28 2009-12-10 V. Mane Fils Seamless capsules containing high amounts of polyunsaturated fatty acids and a flavouring component
CN101553221A (zh) 2006-10-10 2009-10-07 瑞莱恩特医药品有限公司 用于降低APO-B水平的抑制素和ω-3脂肪酸
US20080306154A1 (en) 2006-11-03 2008-12-11 My Svensson Treatment and prevention of major adverse cardiovascular events or major coronary evens by administering Omega-3 fatty acids
US20080125490A1 (en) 2006-11-03 2008-05-29 My Svensson Treatment and prevention of cardiovascular disease in patients with chronic kidney disease by administering Omega-3 Fatty Acids
WO2008088030A1 (ja) 2007-01-17 2008-07-24 Mochida Pharmaceutical Co., Ltd. 血栓もしくは塞栓に関連する疾患の予防又は治療用組成物
WO2008106787A1 (en) 2007-03-06 2008-09-12 Bioriginal Food & Science Corporation Soft gelatin capsule shells containing oil soluble flavoring and methods of making the same
AU2008272135B2 (en) 2007-06-29 2013-10-31 Takeda Pharmaceutical Company Limited Seamless capsule
US20090182049A1 (en) 2008-01-16 2009-07-16 Joar Arild Opheim Pharmaceutical Composition and Method for Treating Hypertriglyceridemia and Hypercholesterolemia in Humans
CA2724983A1 (en) 2008-05-20 2009-11-26 Mochida Pharmaceutical Co., Ltd. Composition for preventing cardiovascular event in high-risk patient
US20110236476A1 (en) 2008-09-02 2011-09-29 Amarin Corporation Plc. Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
KR20140007973A (ko) 2009-02-10 2014-01-20 아마린 파마, 인크. 고중성지방혈증 치료 방법
NZ627238A (en) 2009-04-29 2016-02-26 Amarin Pharmaceuticals Ie Ltd Stable pharmaceutical composition comprising ethyl eicosapentaenoate
MY172372A (en) 2009-06-15 2019-11-21 Amarin Pharmaceuticals Ie Ltd Compositions and methods for lowering triglycerides
WO2012059447A1 (en) 2010-11-04 2012-05-10 F. Hoffmann-La Roche Ag A composition comprising s-[2-([[1-(2-ethylbutyl)-cyclohexyl]-carbonyl]amino)phenyl]2-methylpropanethioate and croscarmellose sodium
US20140004183A1 (en) * 2012-06-29 2014-01-02 Amarin Pharmaceuticals Ireland Limited Methods for treating cardiovascular disease in statin-tolerant subjects

Also Published As

Publication number Publication date
US20130171249A1 (en) 2013-07-04
CY1122628T1 (el) 2021-03-12
HRP20200065T1 (hr) 2020-04-03
US20130096197A1 (en) 2013-04-18
DK3037089T3 (da) 2020-01-20
EP2596786A1 (en) 2013-05-29
US20130102674A1 (en) 2013-04-25
US20240024277A1 (en) 2024-01-25
RU2019111131A (ru) 2020-10-15
SI2596786T1 (sl) 2020-03-31
PL2596786T3 (pl) 2020-06-01
US8357677B1 (en) 2013-01-22
US20120108663A1 (en) 2012-05-03
US20130004568A1 (en) 2013-01-03
US20120093924A1 (en) 2012-04-19
ES2768091T3 (es) 2020-06-19
US20120039997A1 (en) 2012-02-16
ES2769926T3 (es) 2020-06-29
EP2395991B1 (en) 2013-05-29
CY1122629T1 (el) 2021-03-12
US20130004566A1 (en) 2013-01-03
RU2505292C2 (ru) 2014-01-27
AU2010213899B2 (en) 2014-02-06
CA3008079A1 (en) 2010-08-19
RU2011137415A (ru) 2013-03-20
SG173612A1 (en) 2011-09-29
EP3037089B1 (en) 2019-11-27
WO2010093634A1 (en) 2010-08-19
PT2596786T (pt) 2020-03-04
SG10201400685SA (en) 2015-01-29
DK2395991T3 (da) 2013-09-02
BRPI1007518A2 (pt) 2018-02-20
EP3616694A1 (en) 2020-03-04
CA3089847A1 (en) 2010-08-19
MX2011008448A (es) 2012-02-28
LT2596786T (lt) 2020-01-10
HRP20200068T1 (hr) 2020-04-03
US8399446B2 (en) 2013-03-19
DK2596786T3 (da) 2020-02-24
EP3037089A1 (en) 2016-06-29
PL3037089T3 (pl) 2020-06-01
US20130171250A1 (en) 2013-07-04
US20130017256A1 (en) 2013-01-17
SI2395991T1 (sl) 2013-12-31
US8546372B2 (en) 2013-10-01
US20190038590A1 (en) 2019-02-07
US20120108660A1 (en) 2012-05-03
LT3037089T (lt) 2020-01-10
SG10201610916SA (en) 2017-02-27
US20130005809A1 (en) 2013-01-03
EP2395991A1 (en) 2011-12-21
CA3089847C (en) 2024-04-09
CA2751576A1 (en) 2010-08-19
US20200246300A1 (en) 2020-08-06
US20130331447A1 (en) 2013-12-12
US8524698B2 (en) 2013-09-03
US20210046036A1 (en) 2021-02-18
US20130164375A1 (en) 2013-06-27
HRP20130811T1 (en) 2013-09-30
KR101383006B1 (ko) 2014-04-08
PT2395991E (pt) 2013-09-03
US8293728B2 (en) 2012-10-23
US8426399B2 (en) 2013-04-23
NZ594395A (en) 2014-01-31
KR20140007973A (ko) 2014-01-20
US20110288171A1 (en) 2011-11-24
SMT201300095B (it) 2013-11-08
US20180185320A1 (en) 2018-07-05
HK1226307A1 (zh) 2017-09-29
HUE048299T2 (hu) 2020-07-28
RU2013154780A (ru) 2015-06-20
ES2426132T3 (es) 2013-10-21
PH12015500407A1 (en) 2015-09-21
PH12015500407B1 (en) 2015-09-21
US20130004567A1 (en) 2013-01-03
US8377920B2 (en) 2013-02-19
US20120108659A1 (en) 2012-05-03
US8314086B2 (en) 2012-11-20
US8431560B1 (en) 2013-04-30
US20210251941A1 (en) 2021-08-19
ZA201105612B (en) 2012-10-31
CA2751576C (en) 2018-07-03
US8367652B2 (en) 2013-02-05
US20170119722A1 (en) 2017-05-04
US8440650B1 (en) 2013-05-14
RU2686315C2 (ru) 2019-04-25
EP2596786B1 (en) 2019-11-27
SI3037089T1 (sl) 2020-03-31
US20100311834A1 (en) 2010-12-09
US8293727B2 (en) 2012-10-23
US8518929B2 (en) 2013-08-27
US20120156285A1 (en) 2012-06-21
US8324195B2 (en) 2012-12-04
US20120237594A1 (en) 2012-09-20
US20120157530A1 (en) 2012-06-21
KR20110110321A (ko) 2011-10-06
HK1165698A1 (en) 2012-10-12
PL2395991T3 (pl) 2013-11-29
CA3008079C (en) 2020-09-22
US8415335B2 (en) 2013-04-09
EP3865128A1 (en) 2021-08-18
US8318715B2 (en) 2012-11-27
AU2010213899A1 (en) 2011-08-25
US20210069142A1 (en) 2021-03-11

Similar Documents

Publication Publication Date Title
HK1226307A1 (zh) 用於治療高甘油三酯血症的二十碳五烯酸乙酯
PL2352497T3 (pl) Proces przygotowania estrów aminokwasowych delta-9-thc
EP2550364A4 (en) SYSTEMS AND METHOD FOR THE PRODUCTION OF EICOSAPENTAIC ACID AND DOCOSAHEXAIC ACID FROM ALGAE
EP2442645A4 (en) ESTERS OF CHOLINE
PT2391620E (pt) Dicianopiridinas substituídas por alquilamina e seus profármacos de ésteres de aminoácidos
EP2483233A4 (en) HETEROATOMA CONTAINING SUBSTITUTED FATTY ACIDS
EP2444389A4 (en) PROCESS FOR THE PREPARATION OF 2-FLUOROACRYLIC ESTERS
HK1194360A1 (zh) 生產丙烯酸和丙烯酸酯的方法
ZA201100528B (en) Method for the synthesis of bioresourced acrylic acid esters
IL214887A0 (en) Fatty acid monoglyceride compositions
EP2357164A4 (en) PROCESS FOR THE PRODUCTION OF A -SUBSTITUTED ESTER
RS55972B1 (sr) Postupci za proizvodnju akrilnih kiselina i akrilata
PL2734495T3 (pl) Sposób syntezy omega-funkcjonalizowanych kwasów z kwasów tłuszczowych lub estrów tłuszczowych
EP2580342A4 (en) COMPOSITIONS COMPRISING EICOSAPENTAENOIC ACID USED FOR STRONG PURIFICATIONS
RS55954B1 (sr) Postupci za proizvodnju akrilnih kiselina i akrilata
EP2502922A4 (en) METH (ACRYLIC) ACID ESTER COMPOUND CONTAINING AN OXETANE CORE
EP2542232A4 (en) FATTY ACID INHIBITORS
RS56041B1 (sr) Postupci za proizvodnju akrilnih kiselina i akrilata
GB0904300D0 (en) Essential fatty acid compounds
GB0908912D0 (en) Saturated fatty acid triglyceride mixtures for making biocompatible coatings
ZA201107378B (en) Process for the preparation of a biphenyl-2ylcarbamic acid ester
EP2488480A4 (en) PROCESS FOR PREPARING PURE ACRYLATE SITTER
PL2550345T3 (pl) Podpałka na bazie estru kwasu tłuszczowego
EP2332902A4 (en) PROCESS FOR PRODUCING A -TRIFLUOROMETHYL-ESTER, -INSATURATED
PL390748A1 (pl) Sposób otrzymywania kwasu akrylowego