PT2912165T - Populações de células renais e utilizações das mesmas - Google Patents

Populações de células renais e utilizações das mesmas

Info

Publication number
PT2912165T
PT2912165T PT13786132T PT13786132T PT2912165T PT 2912165 T PT2912165 T PT 2912165T PT 13786132 T PT13786132 T PT 13786132T PT 13786132 T PT13786132 T PT 13786132T PT 2912165 T PT2912165 T PT 2912165T
Authority
PT
Portugal
Prior art keywords
cell populations
renal cell
renal
populations
cell
Prior art date
Application number
PT13786132T
Other languages
English (en)
Inventor
Basu Joydeep
Guthrie Kelly
JUSTEWICZ Dominic
Burnette Teresa
Bruce Andrew
W Kelley Russell
W Ludlow John
Original Assignee
Inregen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inregen filed Critical Inregen
Publication of PT2912165T publication Critical patent/PT2912165T/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081Purging biological preparations of unwanted cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/58Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10Mechanical dissociation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4742Keratin; Cytokeratin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/91045Acyltransferases (2.3)
    • G01N2333/91074Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT13786132T 2012-10-24 2013-10-24 Populações de células renais e utilizações das mesmas PT2912165T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261718150P 2012-10-24 2012-10-24
US201361876616P 2013-09-11 2013-09-11

Publications (1)

Publication Number Publication Date
PT2912165T true PT2912165T (pt) 2019-09-26

Family

ID=49517782

Family Applications (1)

Application Number Title Priority Date Filing Date
PT13786132T PT2912165T (pt) 2012-10-24 2013-10-24 Populações de células renais e utilizações das mesmas

Country Status (18)

Country Link
US (4) US20150246073A1 (pt)
EP (3) EP3901251A1 (pt)
JP (2) JP6509119B2 (pt)
KR (5) KR102460536B1 (pt)
CN (3) CN104937095B (pt)
AU (3) AU2013334276B2 (pt)
BR (2) BR122020018576B1 (pt)
CA (2) CA2889270A1 (pt)
DK (2) DK2912165T3 (pt)
ES (2) ES2744979T3 (pt)
HK (1) HK1215448A1 (pt)
HU (2) HUE046176T2 (pt)
NZ (2) NZ741724A (pt)
PL (2) PL3567099T3 (pt)
PT (1) PT2912165T (pt)
RU (1) RU2702721C2 (pt)
SI (1) SI2912165T1 (pt)
WO (1) WO2014066699A1 (pt)

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* Cited by examiner, † Cited by third party
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BR122020018576B1 (pt) 2012-10-24 2022-07-05 Inregen Método de preparação de uma composição terapêutica adequada para gerar uma resposta regenerativa em um rim de um indivíduo, composição terapêutica e uso da mesma
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
BR122019015270B1 (pt) * 2016-07-29 2022-03-03 Timothy A. Bertram Uso de uma composição compreendendo uma população de células renais selecionadas para o tratamento de nefropatia diabética
AU2018243725A1 (en) * 2017-03-31 2019-10-17 Prokidney Injectable cell and scaffold compositions
JP2020525003A (ja) * 2017-06-21 2020-08-27 バートナム,ティモシー,エー. 腎臓病治療のための免疫特権を有する生物活性腎細胞
JP7061766B2 (ja) * 2017-09-20 2022-05-02 学校法人同志社 Dj-1タンパク質産生促進用組成物
CN109266616A (zh) * 2018-08-21 2019-01-25 山西省人民医院 一种稳定表达aqp2蛋白的人源化小鼠足细胞模型及其构建方法和应用
CA3108729A1 (en) * 2018-08-31 2020-03-05 Timothy Bertram Compositions comprising cell-derived vesicles and uses thereof
KR20220022125A (ko) * 2019-05-02 2022-02-24 티모시 에이. 버트람 신장 및/또는 요로 기형을 갖는 대상체에서의 신장 질환의 치료
IL295156A (en) * 2020-01-28 2022-09-01 Kidneycure Ltd Process for production of kidney cells and treatment
CN116240161B (zh) * 2023-02-27 2024-05-10 四川大学华西医院 具有肾脏损伤修复作用的细胞外囊泡制备方法及应用

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US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
JP2020525003A (ja) * 2017-06-21 2020-08-27 バートナム,ティモシー,エー. 腎臓病治療のための免疫特権を有する生物活性腎細胞
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Also Published As

Publication number Publication date
KR102460536B1 (ko) 2022-10-31
BR112015009042A8 (pt) 2017-10-10
AU2019204178B2 (en) 2021-11-18
KR20150085818A (ko) 2015-07-24
JP2019141067A (ja) 2019-08-29
KR20210018965A (ko) 2021-02-18
ES2744979T8 (es) 2020-04-28
ES2744979T3 (es) 2020-02-27
EP3567099B1 (en) 2021-04-21
CN104937095A (zh) 2015-09-23
EP2912165B1 (en) 2019-06-19
KR20240096798A (ko) 2024-06-26
JP6696023B2 (ja) 2020-05-20
NZ707873A (en) 2019-01-25
US20150246073A1 (en) 2015-09-03
RU2015119514A (ru) 2016-12-20
DK2912165T3 (da) 2019-09-16
ES2876177T3 (es) 2021-11-12
RU2019118791A (ru) 2019-07-11
KR102160725B1 (ko) 2020-09-29
HK1215448A1 (zh) 2016-08-26
HUE046176T2 (hu) 2020-02-28
EP2912165A1 (en) 2015-09-02
US20170281684A1 (en) 2017-10-05
CA2889270A1 (en) 2014-05-01
AU2019204178A1 (en) 2019-07-04
US20220347221A1 (en) 2022-11-03
CA3240629A1 (en) 2014-05-01
WO2014066699A1 (en) 2014-05-01
KR20200113287A (ko) 2020-10-06
HUE054882T2 (hu) 2021-10-28
CN110184232A (zh) 2019-08-30
CN117660296A (zh) 2024-03-08
JP6509119B2 (ja) 2019-05-08
CN104937095B (zh) 2019-06-07
US11369639B2 (en) 2022-06-28
AU2022201010A1 (en) 2022-03-03
KR20220150419A (ko) 2022-11-10
AU2013334276A1 (en) 2015-05-14
BR112015009042B1 (pt) 2021-10-19
EP3901251A1 (en) 2021-10-27
RU2702721C2 (ru) 2019-10-09
AU2013334276B2 (en) 2019-07-04
DK3567099T3 (da) 2021-06-07
KR102215476B1 (ko) 2021-02-17
CN110184232B (zh) 2023-10-20
JP2016504017A (ja) 2016-02-12
EP3567099A1 (en) 2019-11-13
BR122020018576B1 (pt) 2022-07-05
PL3567099T3 (pl) 2021-11-29
SI2912165T1 (sl) 2019-11-29
PL2912165T3 (pl) 2020-01-31
KR102674303B1 (ko) 2024-06-12
US20200101112A1 (en) 2020-04-02
US10363274B2 (en) 2019-07-30
BR112015009042A2 (pt) 2017-07-04
NZ741724A (en) 2020-02-28

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