PT2807183T - Miméticos sintéticos de apelina para tratamento de insuficiência cardíaca - Google Patents

Miméticos sintéticos de apelina para tratamento de insuficiência cardíaca

Info

Publication number
PT2807183T
PT2807183T PT137119533T PT13711953T PT2807183T PT 2807183 T PT2807183 T PT 2807183T PT 137119533 T PT137119533 T PT 137119533T PT 13711953 T PT13711953 T PT 13711953T PT 2807183 T PT2807183 T PT 2807183T
Authority
PT
Portugal
Prior art keywords
treatment
heart failure
synthetic apelin
mimetics
apelin mimetics
Prior art date
Application number
PT137119533T
Other languages
English (en)
Inventor
Yasoshima Kayo
Hu Qi-Ying
Zecri Frédéric
Golosov Andrei
Grosche Philipp
Imase Hidetomo
Thomas Parker David
Zhao Hongjuan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2807183(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2807183T publication Critical patent/PT2807183T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
PT137119533T 2012-01-27 2013-01-25 Miméticos sintéticos de apelina para tratamento de insuficiência cardíaca PT2807183T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591557P 2012-01-27 2012-01-27
US201261717760P 2012-10-24 2012-10-24
US201261731697P 2012-11-30 2012-11-30

Publications (1)

Publication Number Publication Date
PT2807183T true PT2807183T (pt) 2018-05-29

Family

ID=47997598

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137119533T PT2807183T (pt) 2012-01-27 2013-01-25 Miméticos sintéticos de apelina para tratamento de insuficiência cardíaca

Country Status (43)

Country Link
US (4) US8673848B2 (pt)
EP (1) EP2807183B1 (pt)
JP (2) JP6313222B2 (pt)
KR (2) KR20200003229A (pt)
CN (1) CN104220452B (pt)
AP (1) AP2014007846A0 (pt)
AR (1) AR089808A1 (pt)
AU (1) AU2013213265C1 (pt)
BR (1) BR112014018306A8 (pt)
CA (1) CA2862240A1 (pt)
CL (1) CL2014001994A1 (pt)
CO (1) CO7020879A2 (pt)
CR (1) CR20140364A (pt)
CU (1) CU24266B1 (pt)
CY (1) CY1120239T1 (pt)
DK (1) DK2807183T3 (pt)
EA (1) EA027853B1 (pt)
EC (1) ECSP14016014A (pt)
ES (1) ES2670832T3 (pt)
GT (1) GT201400166A (pt)
HK (1) HK1200470A1 (pt)
HR (1) HRP20180806T1 (pt)
HU (1) HUE039137T2 (pt)
IL (1) IL233792B (pt)
JO (1) JO3380B1 (pt)
LT (1) LT2807183T (pt)
MX (1) MX351569B (pt)
MY (1) MY172268A (pt)
NZ (1) NZ627772A (pt)
PE (1) PE20142194A1 (pt)
PH (1) PH12014501701A1 (pt)
PL (1) PL2807183T3 (pt)
PT (1) PT2807183T (pt)
RS (1) RS57200B1 (pt)
SG (1) SG11201404369PA (pt)
SI (1) SI2807183T1 (pt)
TN (1) TN2014000318A1 (pt)
TR (1) TR201807309T4 (pt)
TW (1) TWI576356B (pt)
UA (1) UA116196C2 (pt)
UY (1) UY34593A (pt)
WO (1) WO2013111110A2 (pt)
ZA (1) ZA201405400B (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673848B2 (en) * 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
WO2013009193A1 (en) 2011-07-13 2013-01-17 Fisher & Paykel Healthcare Limited Impeller and motor assembly
US8921307B2 (en) * 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
UY35144A (es) * 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CN104853781B (zh) * 2012-11-30 2017-10-24 诺华股份有限公司 从含二硫化物的蛋白质制备缀合物的方法
AU2013101734A4 (en) 2012-12-18 2015-09-24 Fisher & Paykel Healthcare Limited Impeller and motor assembly
ES2875957T3 (es) * 2012-12-20 2021-11-11 Amgen Inc Agonistas del receptor APJ y usos de los mismos
KR20150127596A (ko) * 2013-03-14 2015-11-17 리제너론 파아마슈티컬스, 인크. 아펠린 융합 단백질 및 이들의 용도
PE20160991A1 (es) 2013-07-25 2016-10-15 Novartis Ag Bioconjugados de polipeptidos de apelina sintetica
CN105612172A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状多肽
CN105612174A (zh) * 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的二硫化物环状多肽
WO2015013165A1 (en) * 2013-07-25 2015-01-29 Novartis Ag Cyclic apelin derivatives for the treatment of heart failure
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
CA2931299C (en) * 2013-11-20 2024-03-05 Regeneron Pharmaceuticals, Inc. Aplnr modulators and uses thereof
MX2016006674A (es) 2013-11-26 2016-12-09 Novartis Ag Metodos para la conjugacion de oxima con polipeptidos modificados con cetona.
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
JP6740133B2 (ja) * 2014-03-25 2020-08-12 ランティオペプ ベスローテン ヴェンノーツハップＬａｎｔｈｉｏＰｅｐ Ｂ．Ｖ． 環状アペリン類似体
GB201407532D0 (en) * 2014-04-29 2014-06-11 Univ Ulster Apelin analogues
EP3145552B1 (en) 2014-05-23 2020-03-04 Novartis AG Methods for making conjugates from disulfide-containing proteins
EP3157942B1 (en) 2014-06-23 2020-06-17 Novartis AG Site specific protein modifications
US10588980B2 (en) * 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
BR112017014194A2 (pt) * 2015-01-23 2018-01-09 Novartis Ag conjugados de ácido graxo de apelina sintéticos com meia-vida melhorada
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
USD790683S1 (en) * 2015-03-11 2017-06-27 Resmed Limited Pressurized air delivery console
US10426818B2 (en) * 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
CA2985542C (en) 2015-05-20 2023-10-10 Amgen Inc. Triazole agonists of the apj receptor
EP3416688B1 (en) 2016-02-15 2022-08-17 INSERM - Institut National de la Santé et de la Recherche Médicale Apelin for use in the treatment of post-operative cognitive dysfunction
EP3452466B1 (en) 2016-05-03 2020-08-12 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
EP3528820B1 (en) 2016-10-19 2023-10-04 Avive, Inc. Novel pegylated liposomal formulations of apelin for treatment of cardiovascular-related diseases
WO2018093579A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
WO2018097944A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
US11400247B2 (en) 2016-12-22 2022-08-02 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
EP3615820A4 (en) 2017-04-23 2021-01-06 Fisher & Paykel Healthcare Limited BREATHING ASSISTANCE DEVICE
WO2019051494A1 (en) 2017-09-11 2019-03-14 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND USES THEREOF
GB2584206B (en) 2017-10-06 2022-06-15 Fisher & Paykel Healthcare Ltd Closed loop oxygen control
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
MA52487A (fr) 2018-05-01 2021-03-10 Amgen Inc Pyrimidinones substituées en tant qu'agonistes du récepteur apj
WO2020099929A1 (en) 2018-11-14 2020-05-22 Roivant Sciences Gmbh A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin
ES2957324T3 (es) * 2019-02-27 2024-01-17 Air Liquide Dispositivo de suministro de gas con bolsa deformable y sensores de presión diferencial
CN112007027B (zh) * 2020-09-14 2022-07-15 长春金赛药业有限责任公司 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128208C (en) 1992-11-17 2004-01-06 Ronald Godiska Novel seven transmembrane receptors
GB2281513B (en) * 1993-08-31 1997-12-03 Ulco Eng Pty Ltd Ventilator disconnect alarm
EP0645119A3 (en) * 1993-09-27 1998-04-15 Ohmeda Inc. Disabling apnoea volume software
US5598838A (en) * 1995-04-07 1997-02-04 Healthdyne Technologies, Inc. Pressure support ventilatory assist system
CA2222830C (en) * 1996-12-02 2004-03-30 Fisher & Paykel Limited Humidifier sleep apnea treatment apparatus
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
CA2313246A1 (en) 1997-12-24 1999-07-08 Takeda Chemical Industries, Ltd. Polypeptide, their production and use
AU5759399A (en) 1998-09-25 2000-04-17 Takeda Chemical Industries Ltd. Peptide derivative
CN1322211A (zh) 1998-10-05 2001-11-14 武田药品工业株式会社 除去n－末端蛋氨酸的方法
US7045532B2 (en) 1999-04-30 2006-05-16 Millennium Pharmaceuticals, Inc. ACE-2 modulating compounds and methods of use thereof
DE60119714T2 (de) 2000-03-23 2006-09-07 Takeda Chemical Industries, Ltd. Peptidderivat
AU2001264937A1 (en) 2000-05-23 2001-12-03 Genaissance Pharmaceuticals, Inc. Haplotypes of the agtrl1 gene
US6349724B1 (en) * 2000-07-05 2002-02-26 Compumedics Sleep Pty. Ltd. Dual-pressure blower for positive air pressure device
US7574368B2 (en) * 2000-12-15 2009-08-11 Ric Investments, Llc System and method for upgrading a pressure generating system
CA2453434C (en) 2001-07-16 2009-04-14 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7157035B2 (en) * 2001-12-14 2007-01-02 Fisher & Paykel Healthcare Limited Method of forming a respiratory conduit
TW545624U (en) * 2002-01-18 2003-08-01 Enermax Technology Corp Computer environment temperature/rotation speed display and self-adjusted fan speed device
WO2003063892A1 (fr) 2002-01-29 2003-08-07 Takeda Chemical Industries, Ltd. Utilisation d'apeline
US7086399B2 (en) * 2002-05-29 2006-08-08 Fisher & Paykel Healthcare Limited Apparatus for delivery of humidified gases therapy, associated methods and analysis tools
ATE471722T1 (de) 2003-03-12 2010-07-15 Univ Arizona State Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
US7947280B2 (en) 2003-05-22 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Apelin and uses thereof
WO2005029066A2 (en) 2003-05-22 2005-03-31 Agilent Technologies, Inc. Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof
EP1520861A1 (en) 2003-09-11 2005-04-06 Aventis Pharma Deutschland GmbH Test system for the identification of APJ receptor ligands
WO2005106493A1 (en) 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled apelin receptor (apj)
JP2008515768A (ja) 2004-06-17 2008-05-15 エム ユー エス シー ファンデーション フォー リサーチ ディベロップメント 非天然アミノ酸
US20060045880A1 (en) 2004-08-23 2006-03-02 Krieg Paul A Methods for modulating angiogenesis and apoptosis with apelin compositions
JP2008013436A (ja) 2004-10-14 2008-01-24 Kanazawa Univ 血管形成促進剤
WO2006047558A2 (en) 2004-10-26 2006-05-04 The General Hospital Corporation Methods for detecting a trial fibrillation and related conditions
WO2006076736A2 (en) 2005-01-14 2006-07-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for modulating angiogenesis, lymphangiogenesis, and apoptosis with apelin compositions
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
US8673848B2 (en) * 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
EP1876448A1 (en) 2005-09-30 2008-01-09 DIGILAB BioVisioN GmbH Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones.
US7736346B2 (en) 2005-10-18 2010-06-15 Biocardia, Inc. Bio-interventional therapeutic treatments for cardiovascular diseases
US20080031871A1 (en) 2006-02-21 2008-02-07 Allen Margaret L Memory and learning impairments associated with disruption of Ephrin receptor A6 (EphA6) gene
WO2007123233A1 (ja) 2006-04-25 2007-11-01 Kyushu University, National University Corporation 動脈硬化性疾患関連遺伝子、およびその利用
WO2009033819A2 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
KR20100056515A (ko) 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
US20110123534A1 (en) 2007-12-12 2011-05-26 Erasmus University Medical Center Rotterdam Novel compounds for modulating neovascularisation and methods of treatment using these compounds
WO2009075566A1 (en) 2007-12-12 2009-06-18 Erasmus University Medical Center Rotterdam Biomarkers for cardiovascular disease
KR20110091702A (ko) 2008-11-04 2011-08-12 앵커 테라퓨틱스, 인코포레이티드 Ａｐｊ 수용체 화합물
WO2010115874A1 (en) 2009-04-07 2010-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment and the diagnosis ofpulmonary arterial hypertension
JP2013509874A (ja) 2009-11-04 2013-03-21 エラスムス ユニバーシティ メディカル センター ロッテルダム 新脈管形成を調節する為の新規化合物及びこれらの化合物を使用する処置方法
CA2797033C (en) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
RU2457216C1 (ru) 2010-12-21 2012-07-27 Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) Додекапептиды, обладающие кардиопротекторными свойствами
AU2013208109A1 (en) 2012-01-09 2014-08-14 Anchor Therapeutics, Inc. APJ receptor compounds
WO2015013165A1 (en) 2013-07-25 2015-01-29 Novartis Ag Cyclic apelin derivatives for the treatment of heart failure
PE20160991A1 (es) 2013-07-25 2016-10-15 Novartis Ag Bioconjugados de polipeptidos de apelina sintetica
CN105612172A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状多肽
CN105612174A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的二硫化物环状多肽

Also Published As

Publication number Publication date
CA2862240A1 (en) 2013-08-01
KR20200003229A (ko) 2020-01-08
CL2014001994A1 (es) 2014-11-03
PL2807183T3 (pl) 2018-08-31
JP2015506370A (ja) 2015-03-02
JO3380B1 (ar) 2019-03-13
US9982017B2 (en) 2018-05-29
AU2013213265B2 (en) 2016-05-26
KR102068370B1 (ko) 2020-01-21
CO7020879A2 (es) 2014-08-11
GT201400166A (es) 2015-10-15
SG11201404369PA (en) 2014-08-28
TN2014000318A1 (en) 2015-12-21
HK1200470A1 (en) 2015-08-07
TR201807309T4 (tr) 2018-06-21
US20150252076A1 (en) 2015-09-10
AU2013213265A1 (en) 2014-09-18
HUE039137T2 (hu) 2018-12-28
EP2807183B1 (en) 2018-02-28
PE20142194A1 (es) 2014-12-21
US8673848B2 (en) 2014-03-18
DK2807183T3 (en) 2018-06-06
ES2670832T3 (es) 2018-06-01
AU2013213265C1 (en) 2016-09-29
CU20140097A7 (es) 2015-03-30
CN104220452A (zh) 2014-12-17
KR20140117603A (ko) 2014-10-07
BR112014018306A2 (pt) 2017-06-20
ECSP14016014A (es) 2015-11-30
CU24266B1 (es) 2017-07-04
US9067971B2 (en) 2015-06-30
JP2018048157A (ja) 2018-03-29
US20140142022A1 (en) 2014-05-22
AR089808A1 (es) 2014-09-17
MY172268A (en) 2019-11-20
MX2014009085A (es) 2014-08-27
US20170232221A1 (en) 2017-08-17
SI2807183T1 (en) 2018-05-31
JP6313222B2 (ja) 2018-04-18
BR112014018306A8 (pt) 2017-07-11
EP2807183A2 (en) 2014-12-03
IL233792B (en) 2018-04-30
HRP20180806T1 (hr) 2018-06-29
CY1120239T1 (el) 2019-07-10
AP2014007846A0 (en) 2014-08-31
TWI576356B (zh) 2017-04-01
WO2013111110A2 (en) 2013-08-01
UA116196C2 (uk) 2018-02-26
ZA201405400B (en) 2016-08-31
IL233792A0 (en) 2014-09-30
CN104220452B (zh) 2018-01-26
UY34593A (es) 2013-09-02
WO2013111110A3 (en) 2013-10-31
JP6595553B2 (ja) 2019-10-23
NZ627772A (en) 2015-11-27
EA027853B1 (ru) 2017-09-29
PH12014501701A1 (en) 2014-10-13
EA201491433A1 (ru) 2014-12-30
LT2807183T (lt) 2018-05-10
MX351569B (es) 2017-10-19
TW201335190A (zh) 2013-09-01
CR20140364A (es) 2014-11-17
RS57200B1 (sr) 2018-07-31
US20130196899A1 (en) 2013-08-01

Similar Documents

Publication Publication Date Title
HRP20180806T1 (hr) Sintetički apelin-mimetici za liječenje zatajenja srca
HK1209323A1 (en) Esketamine for the treatment of treatment-refractory or treatment- resistant depression
HK1211475A1 (en) Combination therapy
IL263661A (en) Combination therapy for the treatment of glioblastoma
GB201218307D0 (en) Patient monitor
HK1218298A1 (zh) 用於治療心力衰竭的環狀多肽
GB201219873D0 (en) Diverticulitis treatment
HK1212253A1 (en) Combinations of modalities for the treatment of diabetes
HK1213324A1 (zh) 心力衰竭療法的選擇中的生物標記物
EP2867239A4 (en) OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DIABETES
IL235058A0 (en) Pharmaceutical combinations for the treatment of metabolic disorders
GB201217439D0 (en) Combination therapy
EP2895504A4 (en) TRPV3 AGONISTS FOR THE TREATMENT OF SKIN DISEASES
HK1210426A1 (en) Combination therapy
PT2883057T (pt) Diagnóstico de insuficiência cardíaca
HK1223280A1 (zh) 用於心力衰竭的預防或治療的人
AP2015008270A0 (en) Preparation for the treatment of tuberculosis
GB201211543D0 (en) Combination therapy
GB201207359D0 (en) Compounds for the treatment of metabolic disorders
GB201207363D0 (en) Compounds for the treatment of metabolic disorders
GB201219207D0 (en) Non-invasive monitor
GB201215621D0 (en) Medical solution