PT2734521T - Compostos tetra-hidropirrido-piridina e tetra-dropirridopirimidina e sua utilização como moduladores do recetor c5a - Google Patents
Compostos tetra-hidropirrido-piridina e tetra-dropirridopirimidina e sua utilização como moduladores do recetor c5aInfo
- Publication number
- PT2734521T PT2734521T PT127430239T PT12743023T PT2734521T PT 2734521 T PT2734521 T PT 2734521T PT 127430239 T PT127430239 T PT 127430239T PT 12743023 T PT12743023 T PT 12743023T PT 2734521 T PT2734521 T PT 2734521T
- Authority
- PT
- Portugal
- Prior art keywords
- tetrahydropyrido
- pyridine
- receptor modulators
- pyrimidine compounds
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161510643P | 2011-07-22 | 2011-07-22 | |
US201161539732P | 2011-09-27 | 2011-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2734521T true PT2734521T (pt) | 2017-08-11 |
Family
ID=46604083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT127430239T PT2734521T (pt) | 2011-07-22 | 2012-07-20 | Compostos tetra-hidropirrido-piridina e tetra-dropirridopirimidina e sua utilização como moduladores do recetor c5a |
Country Status (25)
Country | Link |
---|---|
US (2) | US8846656B2 (pt) |
EP (1) | EP2734521B1 (pt) |
JP (1) | JP6040237B2 (pt) |
KR (1) | KR20140096020A (pt) |
CN (1) | CN103814027B (pt) |
AP (1) | AP2014007398A0 (pt) |
AR (1) | AR087288A1 (pt) |
AU (1) | AU2012287183B2 (pt) |
BR (1) | BR112014001468A2 (pt) |
CA (1) | CA2842528A1 (pt) |
CL (1) | CL2014000171A1 (pt) |
CO (1) | CO6862157A2 (pt) |
CR (1) | CR20140032A (pt) |
EA (1) | EA201490320A1 (pt) |
ES (1) | ES2637167T3 (pt) |
IL (1) | IL230501A0 (pt) |
MA (1) | MA35275B1 (pt) |
MX (1) | MX336497B (pt) |
PE (1) | PE20141281A1 (pt) |
PL (1) | PL2734521T3 (pt) |
PT (1) | PT2734521T (pt) |
TN (1) | TN2014000030A1 (pt) |
TW (1) | TW201311688A (pt) |
UY (1) | UY34209A (pt) |
WO (1) | WO2013016197A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103108871B (zh) * | 2010-09-16 | 2014-09-10 | 诺华股份有限公司 | 17α-羟化酶/C17,20-裂合酶抑制剂 |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
US8846656B2 (en) | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
MX2014013428A (es) * | 2012-05-04 | 2015-02-04 | Novartis Ag | Moduladores de la ruta del complemento y usos de los mismos. |
US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
CN105229003B (zh) * | 2013-03-14 | 2017-03-15 | 诺华股份有限公司 | 作为补体因子b抑制剂用于治疗眼科疾病的2‑(1h‑吲哚‑4‑基甲基)‑3h‑咪唑并[4,5‑b]吡啶‑6‑甲腈衍生物 |
PT2986610T (pt) | 2013-04-19 | 2018-03-09 | Incyte Holdings Corp | Heterociclos bicíclicos como inibidores de fgfr |
ES2946751T3 (es) | 2013-10-24 | 2023-07-25 | Univ Boston | Sistema de infusión para prevenir la canalización incorrecta de múltiples medicamentos |
US9676728B2 (en) | 2013-10-30 | 2017-06-13 | Novartis Ag | 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof |
TWI700283B (zh) * | 2014-08-04 | 2020-08-01 | 德商拜耳製藥公司 | 2-(嗎啉-4-基)-1,7-萘啶 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CN107108610B (zh) | 2014-12-30 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 用于治疗和预防肝炎b病毒感染的新的四氢吡啶并嘧啶和四氢吡啶并吡啶化合物 |
AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
EP3878850A1 (en) | 2016-12-22 | 2021-09-15 | Boehringer Ingelheim International GmbH | Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
MX2019014292A (es) * | 2017-05-31 | 2022-04-07 | Chemocentryx Inc | Anillos 5-5 fusionados como inhibidores c5a. |
EP3630775B1 (en) * | 2017-05-31 | 2022-12-14 | ChemoCentryx, Inc. | 6-5 FUSED RINGS AS C5a INHIBITORS |
CA3085835A1 (en) | 2017-12-21 | 2019-06-27 | Boehringer Ingelheim International Gmbh | Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors |
EP3728202A4 (en) | 2017-12-22 | 2021-05-26 | ChemoCentryx, Inc. | DIARYL-SUBSTITUTED 5,5-CONDENSED RING COMPOUNDS AS C5AR INHIBITORS |
US10828285B2 (en) | 2017-12-22 | 2020-11-10 | Chemocentryx, Inc. | Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors |
ES2933820T3 (es) * | 2018-01-10 | 2023-02-14 | Idorsia Pharmaceuticals Ltd | Derivados de 2,4,6,7-tetrahidro-pirazolo[4,3-d]pirimidina-5-ona y compuestos relacionados como moduladores del receptor c5a para el tratamiento de la vasculitis y las enfermedades inflamatorias |
US11608336B2 (en) * | 2018-04-02 | 2023-03-21 | Chemocentryx, Inc. | Prodrugs of fused-bicyclic C5aR antagonists |
PE20210920A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Formas solidas de un inhibidor de fgfr y procesos para prepararlas |
BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
EP4107146A1 (en) * | 2020-02-17 | 2022-12-28 | Alesta Therapeutics BV | Gcn2 modulator compounds |
CN116323623A (zh) | 2020-09-18 | 2023-06-23 | 拜耳公司 | 作为SOS1抑制剂的吡啶并[2,3-d]嘧啶-4-胺 |
US20230382856A1 (en) * | 2020-10-30 | 2023-11-30 | Daiichi Sankyo Company, Limited | Method of producing 3-methyl-4-halo-indole derivative |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
US4727149A (en) | 1982-03-11 | 1988-02-23 | John Wyeth & Brother Limited | Preparation of nitriles of fused ring pyridine derivatives |
US5853740A (en) | 1996-08-07 | 1998-12-29 | Abbott Laboratories | Delivery system for pharmaceutical agents encapsulated with oils |
AU2001290914A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
AU2003253130A1 (en) | 2002-08-19 | 2004-03-03 | Glenmark Pharmaceuticals Limited | Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders |
JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
CA2520465A1 (en) | 2003-03-28 | 2004-10-14 | Scios Inc. | Bi-cyclic pyrimidine inhibitors of tgf.beta. |
ES2388547T3 (es) | 2003-04-18 | 2012-10-16 | Eli Lilly And Company | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas de 5-HT 1F |
AR045445A1 (es) * | 2003-08-05 | 2005-10-26 | Vertex Pharma | Compuestos ihinibidores de canales ionicos regulados por voltaje |
GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
US7482350B2 (en) | 2004-05-08 | 2009-01-27 | Neurogen Corporation | 4,5-disubstituted-2-aryl pyrimidines |
US7429666B2 (en) | 2004-06-10 | 2008-09-30 | Merck Frosst Canada Ltd. | Pyridine analogs as C5a antagonists |
AP2007003923A0 (en) | 2004-09-30 | 2007-02-28 | Tibotec Pharm Ltd | Hcv inhibiting bi-cyclic pyrimidines |
CN101273039A (zh) | 2005-08-12 | 2008-09-24 | 默克公司 | 可用作p38激酶抑制剂的杂二环化合物 |
ES2348122T3 (es) | 2006-04-20 | 2010-11-30 | F. Hoffmann-La Roche Ag | Derivados de diazepano moduladores de receptores de quimioquina. |
WO2007125320A1 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
WO2009023669A1 (en) | 2007-08-13 | 2009-02-19 | Janssen Pharmaceutica N.V. | Substituted 5,6,7,8-tetrahydroquinoline derivatives, compositions, and methods of use thereof |
UA101676C2 (uk) | 2008-07-31 | 2013-04-25 | Дженентек, Инк. | Піримідинові сполуки, композиції і способи застосування |
US7989463B2 (en) | 2008-09-03 | 2011-08-02 | Dr. Reddy's Laboratories Limited | Biccyclic compounds as GATA modulators |
AR073304A1 (es) | 2008-09-22 | 2010-10-28 | Jerini Ag | Moduladores del receptor de bradiquinina b2 de molecula pequena |
WO2010120994A2 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis |
US20120244192A1 (en) | 2009-04-27 | 2012-09-27 | Cook Gary P | Sustained release formulations of peptidomimetic drugs and uses thereof |
US8492392B2 (en) | 2009-05-27 | 2013-07-23 | Merck Sharp & Dohme Corp. | Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors |
EP2467382B1 (en) | 2009-08-17 | 2014-06-25 | Merck Sharp & Dohme Corp. | Amino tetrahydro-pyridopyrimidine pde10 inhibitors |
JP2013032290A (ja) | 2009-11-20 | 2013-02-14 | Dainippon Sumitomo Pharma Co Ltd | 新規縮合ピリミジン誘導体 |
US8846656B2 (en) | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
AU2012315988A1 (en) | 2011-09-30 | 2014-04-10 | Kineta, Inc. | Anti-viral compounds |
WO2013082535A2 (en) | 2011-12-02 | 2013-06-06 | Board Of Regents Of The University Of Nebraska | Controlled-release peptide compositions and uses thereof |
-
2012
- 2012-07-19 US US13/553,120 patent/US8846656B2/en not_active Expired - Fee Related
- 2012-07-20 MX MX2014000898A patent/MX336497B/es unknown
- 2012-07-20 CA CA2842528A patent/CA2842528A1/en not_active Abandoned
- 2012-07-20 UY UY0001034209A patent/UY34209A/es not_active Application Discontinuation
- 2012-07-20 AP AP2014007398A patent/AP2014007398A0/xx unknown
- 2012-07-20 PE PE2014000114A patent/PE20141281A1/es not_active Application Discontinuation
- 2012-07-20 PL PL12743023T patent/PL2734521T3/pl unknown
- 2012-07-20 EP EP12743023.9A patent/EP2734521B1/en active Active
- 2012-07-20 PT PT127430239T patent/PT2734521T/pt unknown
- 2012-07-20 JP JP2014521829A patent/JP6040237B2/ja not_active Expired - Fee Related
- 2012-07-20 CN CN201280045758.6A patent/CN103814027B/zh not_active Expired - Fee Related
- 2012-07-20 KR KR1020147004232A patent/KR20140096020A/ko not_active Application Discontinuation
- 2012-07-20 BR BR112014001468A patent/BR112014001468A2/pt not_active Application Discontinuation
- 2012-07-20 ES ES12743023T patent/ES2637167T3/es active Active
- 2012-07-20 TW TW101126407A patent/TW201311688A/zh unknown
- 2012-07-20 AU AU2012287183A patent/AU2012287183B2/en not_active Ceased
- 2012-07-20 WO PCT/US2012/047617 patent/WO2013016197A1/en active Application Filing
- 2012-07-20 EA EA201490320A patent/EA201490320A1/ru unknown
- 2012-07-23 AR ARP120102669A patent/AR087288A1/es unknown
-
2014
- 2014-01-16 IL IL230501A patent/IL230501A0/en unknown
- 2014-01-20 TN TNP2014000030A patent/TN2014000030A1/en unknown
- 2014-01-20 MA MA36696A patent/MA35275B1/fr unknown
- 2014-01-22 CL CL2014000171A patent/CL2014000171A1/es unknown
- 2014-01-22 CR CR20140032A patent/CR20140032A/es unknown
- 2014-01-24 CO CO14014580A patent/CO6862157A2/es active IP Right Grant
- 2014-08-08 US US14/455,848 patent/US9505755B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CR20140032A (es) | 2014-05-16 |
EP2734521B1 (en) | 2017-05-10 |
PL2734521T3 (pl) | 2017-10-31 |
AP2014007398A0 (en) | 2014-01-31 |
US20130184253A1 (en) | 2013-07-18 |
PE20141281A1 (es) | 2014-09-24 |
EP2734521A1 (en) | 2014-05-28 |
CL2014000171A1 (es) | 2014-10-03 |
US9505755B2 (en) | 2016-11-29 |
MX336497B (es) | 2016-01-21 |
AR087288A1 (es) | 2014-03-12 |
AU2012287183B2 (en) | 2014-11-20 |
IL230501A0 (en) | 2014-03-31 |
MX2014000898A (es) | 2014-02-19 |
CA2842528A1 (en) | 2013-01-31 |
TN2014000030A1 (en) | 2015-07-01 |
CN103814027A (zh) | 2014-05-21 |
US8846656B2 (en) | 2014-09-30 |
AU2012287183A1 (en) | 2014-01-30 |
JP6040237B2 (ja) | 2016-12-07 |
UY34209A (es) | 2013-02-28 |
EA201490320A1 (ru) | 2014-06-30 |
MA35275B1 (fr) | 2014-07-03 |
CN103814027B (zh) | 2016-07-06 |
ES2637167T3 (es) | 2017-10-11 |
BR112014001468A2 (pt) | 2017-01-10 |
US20140349995A1 (en) | 2014-11-27 |
CO6862157A2 (es) | 2014-02-10 |
KR20140096020A (ko) | 2014-08-04 |
TW201311688A (zh) | 2013-03-16 |
WO2013016197A1 (en) | 2013-01-31 |
JP2014521607A (ja) | 2014-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL230501A0 (en) | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and their use as a5c receptor modulators | |
GB2508204B (en) | Orthosis | |
GB201213700D0 (en) | Receptor antagnists II | |
EP2740774A4 (en) | Dispersion | |
TWI560388B (en) | Dampferzeugerheizrohrreparaturmittel und reparaturverfahren | |
IL251897A0 (en) | X-receptor modulators of the liver | |
GB201111705D0 (en) | Compounds and their use | |
PL3701800T3 (pl) | Zastosowanie | |
EP2860236A4 (en) | LIQUID CRYSTAL COMPOSITION | |
GB201004739D0 (en) | Receptor modulators | |
HK1206333A1 (en) | Liver receptor modulators | |
IL231082A0 (en) | Pyrimido-pyridazinone compounds and their use | |
GB201111630D0 (en) | Novel compounds and their use | |
LT2858606T (lt) | Įtvaras | |
HK1201270A1 (en) | Tetrazol-5-yl- and triazol-5-yl-aryl compounds and use thereof as herbicides -5---5-- | |
GB201214220D0 (en) | Radiosynthesis | |
GB201111775D0 (en) | Compounds and uses thereof | |
GB201114448D0 (en) | Compounds and their use | |
GB201223053D0 (en) | Receptor | |
HK1198587A1 (en) | Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals -2- | |
AP3693A (en) | Composition for anti-mosquito use | |
EP2805717A4 (en) | CUTTING HUNGER | |
GB201109653D0 (en) | Dispersion | |
GB201219451D0 (en) | Tiling | |
GB201104444D0 (en) | Compounds and their use |