PT2681219E - Compostos derivados da 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina úteis como inibidores da beta-secretase (bace) - Google Patents

Compostos derivados da 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina úteis como inibidores da beta-secretase (bace) Download PDF

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Publication number
PT2681219E
PT2681219E PT127072767T PT12707276T PT2681219E PT 2681219 E PT2681219 E PT 2681219E PT 127072767 T PT127072767 T PT 127072767T PT 12707276 T PT12707276 T PT 12707276T PT 2681219 E PT2681219 E PT 2681219E
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PT
Portugal
Prior art keywords
bace
secretase
pyrazin
pyrazolo
dihydro
Prior art date
Application number
PT127072767T
Other languages
English (en)
Portuguese (pt)
Inventor
Henricus Jacobus Maria Gijsen
Andrés Avelino Trabanco-Suárez
Juan Antonio Vega Ramiro
Michiel Luc Maria Van Gool
Francisca Delgado-Jiménez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT2681219E publication Critical patent/PT2681219E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT127072767T 2011-03-01 2012-02-29 Compostos derivados da 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina úteis como inibidores da beta-secretase (bace) PT2681219E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11156463 2011-03-01

Publications (1)

Publication Number Publication Date
PT2681219E true PT2681219E (pt) 2016-02-10

Family

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PT127072767T PT2681219E (pt) 2011-03-01 2012-02-29 Compostos derivados da 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina úteis como inibidores da beta-secretase (bace)

Country Status (27)

Country Link
US (1) US9346811B2 (OSRAM)
EP (1) EP2681219B1 (OSRAM)
JP (1) JP5853033B2 (OSRAM)
KR (1) KR102012671B1 (OSRAM)
CN (1) CN103415519B (OSRAM)
AU (1) AU2012222394B2 (OSRAM)
BR (1) BR112013022039A2 (OSRAM)
CA (1) CA2824360C (OSRAM)
CL (1) CL2013002486A1 (OSRAM)
CO (1) CO6751282A2 (OSRAM)
CY (1) CY1117663T1 (OSRAM)
DK (1) DK2681219T3 (OSRAM)
EA (1) EA022649B1 (OSRAM)
ES (1) ES2558779T3 (OSRAM)
HR (1) HRP20160030T1 (OSRAM)
HU (1) HUE026338T2 (OSRAM)
IL (1) IL228158A (OSRAM)
MX (1) MX338333B (OSRAM)
MY (1) MY161407A (OSRAM)
PH (1) PH12013501807A1 (OSRAM)
PL (1) PL2681219T3 (OSRAM)
PT (1) PT2681219E (OSRAM)
SG (1) SG192963A1 (OSRAM)
SI (1) SI2681219T1 (OSRAM)
UA (1) UA109800C2 (OSRAM)
WO (1) WO2012117027A1 (OSRAM)
ZA (1) ZA201306545B (OSRAM)

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CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
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JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
EA032662B1 (ru) * 2013-06-12 2019-06-28 Янссен Фармацевтика Нв ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE)
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EA031041B1 (ru) 2014-12-18 2018-11-30 Янссен Фармацевтика Нв Соединения 2,3,4,5-тетрагидропиридин-6-амин и 3,4-дигидро-2h-пиррол-5-амин - ингибиторы бета-секретазы
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Also Published As

Publication number Publication date
NZ614551A (en) 2014-06-27
CY1117663T1 (el) 2017-05-17
CO6751282A2 (es) 2013-09-16
EA022649B1 (ru) 2016-02-29
EA201391251A1 (ru) 2014-01-30
KR102012671B1 (ko) 2019-08-21
CN103415519A (zh) 2013-11-27
CA2824360C (en) 2020-01-14
MX2013010040A (es) 2013-11-04
MY161407A (en) 2017-04-14
JP5853033B2 (ja) 2016-02-09
IL228158A (en) 2016-07-31
US20140005200A1 (en) 2014-01-02
DK2681219T3 (en) 2016-01-18
PL2681219T3 (pl) 2016-03-31
EP2681219A1 (en) 2014-01-08
SG192963A1 (en) 2013-09-30
CN103415519B (zh) 2016-03-02
BR112013022039A2 (pt) 2016-11-29
KR20140010052A (ko) 2014-01-23
HK1188784A1 (zh) 2014-05-16
AU2012222394A1 (en) 2013-07-25
EP2681219B1 (en) 2015-10-28
PH12013501807A1 (en) 2015-09-30
CA2824360A1 (en) 2012-09-07
HUE026338T2 (en) 2016-05-30
WO2012117027A1 (en) 2012-09-07
MX338333B (es) 2016-04-11
JP2014506907A (ja) 2014-03-20
HRP20160030T1 (hr) 2016-02-12
IL228158A0 (en) 2013-11-25
ZA201306545B (en) 2015-03-25
CL2013002486A1 (es) 2014-02-21
US9346811B2 (en) 2016-05-24
SI2681219T1 (sl) 2016-02-29
AU2012222394B2 (en) 2016-06-16
UA109800C2 (xx) 2015-10-12
ES2558779T3 (es) 2016-02-08

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