PT2563904E - Meio de cultura de células aperfeiçoado - Google Patents
Meio de cultura de células aperfeiçoado Download PDFInfo
- Publication number
- PT2563904E PT2563904E PT117172403T PT11717240T PT2563904E PT 2563904 E PT2563904 E PT 2563904E PT 117172403 T PT117172403 T PT 117172403T PT 11717240 T PT11717240 T PT 11717240T PT 2563904 E PT2563904 E PT 2563904E
- Authority
- PT
- Portugal
- Prior art keywords
- culture medium
- cell culture
- improved cell
- improved
- medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32783610P | 2010-04-26 | 2010-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2563904E true PT2563904E (pt) | 2015-05-12 |
Family
ID=44074260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117172403T PT2563904E (pt) | 2010-04-26 | 2011-04-25 | Meio de cultura de células aperfeiçoado |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | USRE48864E1 (enExample) |
| EP (1) | EP2563904B1 (enExample) |
| JP (3) | JP6347949B2 (enExample) |
| KR (1) | KR101828623B1 (enExample) |
| CN (1) | CN102858952B (enExample) |
| AU (1) | AU2011246503B2 (enExample) |
| BR (1) | BR112012027282B1 (enExample) |
| CA (1) | CA2797356C (enExample) |
| DK (1) | DK2563904T3 (enExample) |
| ES (1) | ES2533074T3 (enExample) |
| IL (1) | IL222452B (enExample) |
| MX (1) | MX2012012526A (enExample) |
| PL (1) | PL2563904T3 (enExample) |
| PT (1) | PT2563904E (enExample) |
| RU (1) | RU2644651C2 (enExample) |
| SG (1) | SG185038A1 (enExample) |
| WO (1) | WO2011134920A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2500413A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| US8895709B2 (en) | 2008-10-20 | 2014-11-25 | Abbvie Inc. | Isolation and purification of antibodies using protein A affinity chromatography |
| NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| ES2755907T3 (es) | 2010-04-26 | 2020-04-24 | Novartis Ag | Medio de cultivo celular mejorado |
| BR112012027282B1 (pt) | 2010-04-26 | 2020-09-29 | Novartis Ag | Meio de cultura de células aperfeiçoado e processo para a produção de um polipeptídeo recombinante |
| JP5824527B2 (ja) * | 2010-12-07 | 2015-11-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 供給物混合装置およびその使用 |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
| KR20140091706A (ko) | 2011-10-18 | 2014-07-22 | 코히러스 바이오사이언시즈, 인코포레이티드 | 염화나트륨으로 안정화된 에타너셉트 제형 |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| EP2869817A4 (en) | 2012-07-09 | 2016-04-06 | Coherus Biosciences Inc | STABLE AQUEOUS FORMULATIONS OF ETANERCEPT |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201504249XA (en) | 2012-09-02 | 2015-07-30 | Abbvie Inc | Methods to control protein heterogeneity |
| HUE036524T2 (hu) | 2012-09-11 | 2018-07-30 | Coherus Biosciences Inc | Nagy tisztaságú és kiváló kitermelésû helyesen hajtogatott etanercept |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| CA2899308C (en) | 2013-03-14 | 2017-04-18 | Abbvie Inc. | Low acidic species adalimumab compositions and uses thereof |
| AU2014310555B2 (en) | 2013-08-20 | 2018-01-18 | Lek Pharmaceuticals D.D. | Cell culture medium and process for controlling alpha-amidation and/or C-terminal amino acid cleavage of polypeptides |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| SG10201800772TA (en) * | 2013-10-11 | 2018-03-28 | Regeneron Pharma | Metabolically optimized cell culture |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| EP3683316A1 (en) | 2014-01-30 | 2020-07-22 | Coherus Biosciences, Inc. | Perfusion media |
| MX368664B (es) | 2014-04-29 | 2019-10-10 | Novartis Ag | Células novedosas de vertebrados y métodos para la expresión recombinante de un polipéptido de interés. |
| EP2975050B1 (en) | 2014-07-18 | 2019-05-29 | Sandoz Ag | Quantification of misfolded TNFR2:Fc |
| RU2759945C2 (ru) * | 2015-12-17 | 2021-11-19 | Лайф Текнолоджиз Корпорейшн | Гранулы, используемые в клеточной культуре, и способы их получения |
| CA3019753C (en) * | 2016-04-05 | 2021-10-26 | Pfizer Inc. | Cell culture process |
| JP6943972B2 (ja) * | 2017-03-31 | 2021-10-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 灌流培地 |
| SG11201908891YA (en) * | 2017-03-31 | 2019-10-30 | Boehringer Ingelheim Int | Perfusion medium |
| AU2020261411B2 (en) | 2019-04-26 | 2025-10-02 | Allogene Therapeutics, Inc. | Methods of manufacturing allogeneic car T cells |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| EP4056678A4 (en) * | 2019-11-05 | 2023-12-06 | Ajinomoto Co., Inc. | Method for producing protein |
| IL297191A (en) * | 2020-04-15 | 2022-12-01 | Genentech Inc | A method for treating the medium before inoculation |
| JP2023537760A (ja) * | 2020-08-14 | 2023-09-05 | ブリストル－マイヤーズ スクイブ カンパニー | タンパク質の製造工程 |
| UY39484A (es) | 2020-11-02 | 2022-06-30 | Novartis Ag | Inhibidores de interleucina-17 |
| CN114606200B (zh) * | 2022-02-10 | 2025-07-18 | 上海迈邦生物科技有限公司 | Sp2/0细胞培养基及生产重组犬细小病毒单克隆抗体的方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| EP0283942B1 (en) | 1987-03-24 | 1992-05-20 | W.R. Grace & Co.-Conn. | Basal nutrient medium for cell culture |
| US6048728A (en) * | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| US5135866A (en) | 1989-03-03 | 1992-08-04 | W. R. Grace & Co.-Conn. | Very low protein nutrient medium for cell culture |
| CA2001550A1 (en) | 1989-03-03 | 1990-09-03 | Aaron H. Heifetz | Very low protein nutrient medium for cell culture |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| JPH0789908B2 (ja) | 1991-02-28 | 1995-10-04 | 倉敷紡績株式会社 | 動物細胞培養用無血清培地 |
| GB9118664D0 (en) * | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5830761A (en) | 1995-06-07 | 1998-11-03 | Genetics Institute, Inc. | Medium and methods for culturing mammalian cho cells |
| AU4330597A (en) | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
| US7294481B1 (en) | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
| EP1757700A3 (en) | 1999-04-26 | 2009-03-11 | Genentech, Inc. | Cell culture process for glycoproteins |
| WO2000073431A2 (en) | 1999-05-27 | 2000-12-07 | Pharmacia & Upjohn Company | Methods and compositions for measuring ion channel conductance |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| DK1242578T3 (da) | 1999-12-28 | 2004-07-26 | Iso Tis N V | Celledyrkningsmedium indeholdende vækstfaktorer og L-glutamin |
| ATE420945T1 (de) | 2001-02-15 | 2009-01-15 | Centocor Inc | Chemisch definiertes medium für kultivierte säugerzellen |
| WO2002101019A2 (en) | 2001-06-13 | 2002-12-19 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| JP4510938B2 (ja) | 2002-07-15 | 2010-07-28 | イミュネックス・コーポレーション | 哺乳動物細胞により産生されるタンパク質のシアル酸付加を調節する方法および培地 |
| KR20050088136A (ko) | 2002-12-23 | 2005-09-01 | 브리스톨-마이어스 스큅 컴퍼니 | 단백질 생산을 위한 포유류 세포 배양 방법 |
| GB0304799D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxosmithkline Biolog Sa | Novel method |
| DE10338536A1 (de) | 2003-08-19 | 2005-04-07 | Bircher Reglomat Ag | Verfahren zum Betreiben eines Radarsensors |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| US7294484B2 (en) * | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| WO2006113629A1 (en) | 2005-04-15 | 2006-10-26 | The Trustees Of Columbia University In The City Of New York | Chemically defined culture media for expansion and differentiation of epidermal cells and uses thereof for in vitro growth of hair follicles |
| US20070231895A1 (en) | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| PL2078071T3 (pl) * | 2006-11-08 | 2015-07-31 | Wyeth Llc | Racjonalnie opracowane pożywki do hodowli komórek |
| BR112012027282B1 (pt) | 2010-04-26 | 2020-09-29 | Novartis Ag | Meio de cultura de células aperfeiçoado e processo para a produção de um polipeptídeo recombinante |
-
2011
- 2011-04-25 BR BR112012027282-9A patent/BR112012027282B1/pt active IP Right Grant
- 2011-04-25 AU AU2011246503A patent/AU2011246503B2/en active Active
- 2011-04-25 CA CA2797356A patent/CA2797356C/en active Active
- 2011-04-25 KR KR1020127030709A patent/KR101828623B1/ko active Active
- 2011-04-25 DK DK11717240T patent/DK2563904T3/en active
- 2011-04-25 MX MX2012012526A patent/MX2012012526A/es active IP Right Grant
- 2011-04-25 EP EP11717240.3A patent/EP2563904B1/en not_active Revoked
- 2011-04-25 US US16/114,731 patent/USRE48864E1/en active Active
- 2011-04-25 CN CN201180021024.XA patent/CN102858952B/zh active Active
- 2011-04-25 US US13/643,998 patent/US9428727B2/en not_active Ceased
- 2011-04-25 PT PT117172403T patent/PT2563904E/pt unknown
- 2011-04-25 RU RU2012150346A patent/RU2644651C2/ru active
- 2011-04-25 WO PCT/EP2011/056508 patent/WO2011134920A1/en not_active Ceased
- 2011-04-25 SG SG2012079174A patent/SG185038A1/en unknown
- 2011-04-25 PL PL11717240T patent/PL2563904T3/pl unknown
- 2011-04-25 ES ES11717240.3T patent/ES2533074T3/es active Active
- 2011-04-25 JP JP2013506612A patent/JP6347949B2/ja active Active
-
2012
- 2012-10-15 IL IL222452A patent/IL222452B/en active IP Right Grant
-
2016
- 2016-08-03 JP JP2016152747A patent/JP6603628B2/ja active Active
-
2019
- 2019-08-01 JP JP2019142124A patent/JP7034991B2/ja active Active
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