PT2550258E - Agentes indutores de apoptose para o tratamento de cancro e de doenças imunitárias e autoimunes - Google Patents

Agentes indutores de apoptose para o tratamento de cancro e de doenças imunitárias e autoimunes Download PDF

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Publication number
PT2550258E
PT2550258E PT117095794T PT11709579T PT2550258E PT 2550258 E PT2550258 E PT 2550258E PT 117095794 T PT117095794 T PT 117095794T PT 11709579 T PT11709579 T PT 11709579T PT 2550258 E PT2550258 E PT 2550258E
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PT
Portugal
Prior art keywords
amino
phenyl
sulfonyl
ylmethyl
piperazin
Prior art date
Application number
PT117095794T
Other languages
English (en)
Portuguese (pt)
Inventor
Hong Ding
Steven Elmore
Laura Hexamer
Aaron R Kunzer
Andrew J Souers
Gerard Sullivan
Michael Wendt
Cheol-Min Park
Original Assignee
Abbvie Inc
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Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PT2550258E publication Critical patent/PT2550258E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT117095794T 2010-03-25 2011-03-10 Agentes indutores de apoptose para o tratamento de cancro e de doenças imunitárias e autoimunes PT2550258E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31757510P 2010-03-25 2010-03-25

Publications (1)

Publication Number Publication Date
PT2550258E true PT2550258E (pt) 2015-11-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT117095794T PT2550258E (pt) 2010-03-25 2011-03-10 Agentes indutores de apoptose para o tratamento de cancro e de doenças imunitárias e autoimunes

Country Status (26)

Country Link
US (2) US8188077B2 (enExample)
EP (3) EP2550258B1 (enExample)
JP (1) JP5959501B2 (enExample)
KR (1) KR20130040834A (enExample)
CN (2) CN105218483A (enExample)
AU (1) AU2011229862B2 (enExample)
BR (1) BR112012024382A2 (enExample)
CA (1) CA2792276A1 (enExample)
DK (1) DK2550258T3 (enExample)
ES (1) ES2553143T3 (enExample)
HK (2) HK1200444A1 (enExample)
HR (1) HRP20151218T1 (enExample)
HU (1) HUE026241T2 (enExample)
IL (2) IL221771A (enExample)
MX (1) MX2012011086A (enExample)
NZ (2) NZ628298A (enExample)
PL (1) PL2550258T3 (enExample)
PT (1) PT2550258E (enExample)
RS (1) RS54388B1 (enExample)
RU (2) RU2015141713A (enExample)
SG (2) SG184094A1 (enExample)
SI (1) SI2550258T1 (enExample)
SM (1) SMT201600016B (enExample)
TW (2) TW201623291A (enExample)
WO (1) WO2011119345A2 (enExample)
ZA (1) ZA201206837B (enExample)

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RS54388B1 (sr) 2016-04-28
HRP20151218T1 (hr) 2016-01-01
JP2013523636A (ja) 2013-06-17
EP2957558A2 (en) 2015-12-23
HK1219092A1 (en) 2017-03-24
WO2011119345A3 (en) 2011-12-22
SG10201406608YA (en) 2014-12-30
SI2550258T1 (sl) 2016-01-29
WO2011119345A2 (en) 2011-09-29
US8188077B2 (en) 2012-05-29
US8343967B2 (en) 2013-01-01
ES2553143T3 (es) 2015-12-04
TWI535713B (zh) 2016-06-01
SG184094A1 (en) 2012-10-30
HUE026241T2 (en) 2016-06-28
BR112012024382A2 (pt) 2017-08-08
JP5959501B2 (ja) 2016-08-02
CN102947283A (zh) 2013-02-27
RU2568611C2 (ru) 2015-11-20
CA2792276A1 (en) 2011-09-29
DK2550258T3 (en) 2015-12-07
US20110237553A1 (en) 2011-09-29
RU2015141713A (ru) 2018-12-28
EP2957558A3 (en) 2016-03-02
SMT201600016B (it) 2016-02-25
US20120214796A1 (en) 2012-08-23
NZ628298A (en) 2015-11-27
PL2550258T3 (pl) 2016-01-29
CN105218483A (zh) 2016-01-06
IL221771A0 (en) 2012-12-02
RU2012145298A (ru) 2014-04-27
EP2757105A1 (en) 2014-07-23
KR20130040834A (ko) 2013-04-24
MX2012011086A (es) 2013-03-21
TW201139418A (en) 2011-11-16
TW201623291A (zh) 2016-07-01
CN102947283B (zh) 2015-10-07
HK1179614A1 (en) 2013-10-04
RU2015141713A3 (enExample) 2018-12-28
ZA201206837B (en) 2013-05-29
EP2550258B1 (en) 2015-08-19
EP2550258A2 (en) 2013-01-30
AU2011229862A1 (en) 2012-09-20
NZ602055A (en) 2014-08-29
HK1200444A1 (en) 2015-08-07
IL221771A (en) 2015-11-30
AU2011229862B2 (en) 2014-07-24
IL231702A0 (en) 2014-04-30

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