PT2444392E - Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação - Google Patents

Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação Download PDF

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Publication number
PT2444392E
PT2444392E PT111944575T PT11194457T PT2444392E PT 2444392 E PT2444392 E PT 2444392E PT 111944575 T PT111944575 T PT 111944575T PT 11194457 T PT11194457 T PT 11194457T PT 2444392 E PT2444392 E PT 2444392E
Authority
PT
Portugal
Prior art keywords
aza
intermediary
indole derivative
derivative substituted
substituted
Prior art date
Application number
PT111944575T
Other languages
English (en)
Portuguese (pt)
Inventor
Nicola Cazzolla
Guido Furlotti
Maria Alessandra Alisi
Giorgina Mangano
Isabella Coletta
Patrizia Dragone
Caterina Maugeri
Barbara Garofalo
Beatrice Garrone
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PT2444392E publication Critical patent/PT2444392E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT111944575T 2007-12-28 2008-12-16 Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação PT2444392E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07425830A EP2078711A1 (en) 2007-12-28 2007-12-28 (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Publications (1)

Publication Number Publication Date
PT2444392E true PT2444392E (pt) 2014-11-19

Family

ID=39167787

Family Applications (2)

Application Number Title Priority Date Filing Date
PT111944575T PT2444392E (pt) 2007-12-28 2008-12-16 Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação
PT88687256T PT2234968E (pt) 2007-12-28 2008-12-16 Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT88687256T PT2234968E (pt) 2007-12-28 2008-12-16 Derivado (aza)indolo substituído na posição 5, composição farmacêutica que o compreende, compostos intermediários e seu processo de preparação

Country Status (20)

Country Link
US (2) US8399477B2 (enExample)
EP (3) EP2078711A1 (enExample)
JP (1) JP5698985B2 (enExample)
KR (2) KR101671874B1 (enExample)
CN (1) CN101910127B (enExample)
AR (1) AR069961A1 (enExample)
AU (1) AU2008342705B2 (enExample)
BR (1) BRPI0821450A2 (enExample)
CA (1) CA2707339C (enExample)
DK (2) DK2234968T3 (enExample)
EA (1) EA020373B1 (enExample)
ES (2) ES2523167T3 (enExample)
GE (1) GEP20125547B (enExample)
IL (1) IL206062A (enExample)
PL (2) PL2234968T3 (enExample)
PT (2) PT2444392E (enExample)
SG (1) SG187400A1 (enExample)
SI (2) SI2234968T1 (enExample)
UA (1) UA100867C2 (enExample)
WO (1) WO2009083436A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101365824B1 (ko) 2010-10-22 2014-02-20 엘지디스플레이 주식회사 유기전계발광소자
RS59007B1 (sr) 2014-02-03 2019-08-30 Vitae Pharmaceuticals Llc Dihidropirolopiridinski inhibitori ror-gama
RU2681537C2 (ru) * 2014-04-14 2019-03-07 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Амидные производные и их фармацевтически приемлемые соли, способ их получения и медицинское применение
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2017024018A1 (en) * 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
KR20180086221A (ko) 2015-11-20 2018-07-30 비타이 파마슈티컬즈, 인코포레이티드 Ror-감마의 조절물질
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN107033026A (zh) * 2017-06-07 2017-08-11 李博强 一种对硝基苯肼盐酸盐的制备方法
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
MA49685A (fr) 2017-07-24 2021-04-14 Vitae Pharmaceuticals Llc INHIBITEURS DE ROR gamma
CN114302874B (zh) * 2019-08-26 2025-02-25 国际药品株式会社 吲哚甲酰胺衍生物和包含吲哚甲酰胺衍生物的药物组合物
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法
CN119019389A (zh) * 2024-06-05 2024-11-26 四川大学 7-氮杂吲哚类化合物及其合成方法和用途
CN119101040B (zh) * 2024-11-08 2025-03-21 杭州澳赛诺医药技术有限公司 一种通过去对称化合成芳基取代的手性四氢吡喃环的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2354766A1 (fr) 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
CA2319494A1 (en) * 1998-02-03 1999-08-12 Boehringer Ingelheim Pharma Kg 5-membered heterocyclic condensed benzoderivatives, the preparation thereof and their use as pharmaceuticals
DE19834751A1 (de) * 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2402516A1 (en) * 2000-03-20 2001-09-27 Roopa Rai Non-amidine containing protease inhibitors
US20020052373A1 (en) * 2000-10-26 2002-05-02 Zorn Stevin H. Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease
IL140096A0 (en) * 2000-12-05 2002-02-10 Internat Specialty Products Is Process for preparation of zafirlukast
DE10147672A1 (de) * 2001-09-27 2003-04-10 Bayer Ag Substituierte 2,5-Diamidoindole und ihre Verwendung
AU2003303217A1 (en) * 2002-12-20 2004-07-14 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
SE0300908D0 (sv) * 2003-03-31 2003-03-31 Astrazeneca Ab Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
CA2589779A1 (en) * 2004-12-23 2006-06-29 F. Hoffmann-La Roche Ag Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors
WO2007042816A1 (en) * 2005-10-12 2007-04-19 Biolipox Ab Benzoxazoles useful in the treatment of inflammation
MX2008012945A (es) * 2006-04-07 2009-01-15 Vertex Pharma Moduladores de transportadores de cartucho de union a adenosina-trifosfato celular (atp).
JP2008006663A (ja) * 2006-06-28 2008-01-17 Pilot Ink Co Ltd 出没式筆記具
ITMI20061368A1 (it) * 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo

Also Published As

Publication number Publication date
HK1165410A1 (en) 2012-10-05
US8871948B2 (en) 2014-10-28
JP2011507929A (ja) 2011-03-10
KR20100103569A (ko) 2010-09-27
CN101910127B (zh) 2013-01-23
UA100867C2 (uk) 2013-02-11
EA201070804A1 (ru) 2010-12-30
HK1145172A1 (en) 2011-04-08
PT2234968E (pt) 2013-06-03
PL2444392T3 (pl) 2015-03-31
BRPI0821450A2 (pt) 2015-06-16
AU2008342705A1 (en) 2009-07-09
US20130158269A1 (en) 2013-06-20
DK2444392T3 (en) 2014-12-08
GEP20125547B (en) 2012-05-25
US20100286189A1 (en) 2010-11-11
EP2234968A1 (en) 2010-10-06
EA020373B1 (ru) 2014-10-30
WO2009083436A1 (en) 2009-07-09
ES2408955T3 (es) 2013-06-24
KR20160029861A (ko) 2016-03-15
PL2234968T3 (pl) 2013-08-30
SI2234968T1 (sl) 2013-06-28
SI2444392T1 (sl) 2014-12-31
IL206062A (en) 2015-08-31
DK2234968T3 (da) 2013-06-17
KR101671874B1 (ko) 2016-11-03
JP5698985B2 (ja) 2015-04-08
IL206062A0 (en) 2010-11-30
EP2078711A1 (en) 2009-07-15
US8399477B2 (en) 2013-03-19
EP2234968B1 (en) 2013-03-27
ES2523167T3 (es) 2014-11-21
CN101910127A (zh) 2010-12-08
EP2444392A1 (en) 2012-04-25
AU2008342705B2 (en) 2013-11-14
CA2707339C (en) 2018-05-01
EP2444392B1 (en) 2014-09-24
SG187400A1 (en) 2013-02-28
CA2707339A1 (en) 2009-07-09
AR069961A1 (es) 2010-03-03

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