BRPI0821450A2 - Derivado (aza) indol substituído na posição 5, proceso para a preparação do mesmo, composto intermediário, e, composição farmacêutica. - Google Patents
Derivado (aza) indol substituído na posição 5, proceso para a preparação do mesmo, composto intermediário, e, composição farmacêutica.Info
- Publication number
- BRPI0821450A2 BRPI0821450A2 BRPI0821450-6A BRPI0821450A BRPI0821450A2 BR PI0821450 A2 BRPI0821450 A2 BR PI0821450A2 BR PI0821450 A BRPI0821450 A BR PI0821450A BR PI0821450 A2 BRPI0821450 A2 BR PI0821450A2
- Authority
- BR
- Brazil
- Prior art keywords
- aza
- substituted
- preparation
- pharmaceutical composition
- intermediate compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07425830A EP2078711A1 (en) | 2007-12-28 | 2007-12-28 | (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor |
PCT/EP2008/067622 WO2009083436A1 (en) | 2007-12-28 | 2008-12-16 | (aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0821450A2 true BRPI0821450A2 (pt) | 2015-06-16 |
Family
ID=39167787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0821450-6A BRPI0821450A2 (pt) | 2007-12-28 | 2008-12-16 | Derivado (aza) indol substituído na posição 5, proceso para a preparação do mesmo, composto intermediário, e, composição farmacêutica. |
Country Status (21)
Country | Link |
---|---|
US (2) | US8399477B2 (pt) |
EP (3) | EP2078711A1 (pt) |
JP (1) | JP5698985B2 (pt) |
KR (2) | KR101671874B1 (pt) |
CN (1) | CN101910127B (pt) |
AR (1) | AR069961A1 (pt) |
AU (1) | AU2008342705B2 (pt) |
BR (1) | BRPI0821450A2 (pt) |
CA (1) | CA2707339C (pt) |
DK (2) | DK2234968T3 (pt) |
EA (1) | EA020373B1 (pt) |
ES (2) | ES2523167T3 (pt) |
GE (1) | GEP20125547B (pt) |
HK (2) | HK1165410A1 (pt) |
IL (1) | IL206062A (pt) |
PL (2) | PL2444392T3 (pt) |
PT (2) | PT2444392E (pt) |
SG (1) | SG187400A1 (pt) |
SI (2) | SI2234968T1 (pt) |
UA (1) | UA100867C2 (pt) |
WO (1) | WO2009083436A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101365824B1 (ko) | 2010-10-22 | 2014-02-20 | 엘지디스플레이 주식회사 | 유기전계발광소자 |
SG11201606080SA (en) | 2014-02-03 | 2016-08-30 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
RU2681537C2 (ru) * | 2014-04-14 | 2019-03-07 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Амидные производные и их фармацевтически приемлемые соли, способ их получения и медицинское применение |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
EP3377482B1 (en) | 2015-11-20 | 2021-05-12 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
CN107033026A (zh) * | 2017-06-07 | 2017-08-11 | 李博强 | 一种对硝基苯肼盐酸盐的制备方法 |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
MX2020000887A (es) | 2017-07-24 | 2020-07-22 | Vitae Pharmaceuticals Llc | Inhibidores de ror?. |
KR20210024983A (ko) * | 2019-08-26 | 2021-03-08 | 국제약품 주식회사 | 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물 |
CN114605303A (zh) * | 2022-03-14 | 2022-06-10 | 武汉工程大学 | 一种地拉韦啶及其中间体的合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2354766A1 (fr) * | 1976-06-17 | 1978-01-13 | Labaz | Derives n-aminoalkyles d'indole et procedes pour les preparer |
US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
AU2720199A (en) * | 1998-02-03 | 1999-08-23 | Boehringer Ingelheim Pharma Kg | Five-membered, benzo-condensed heterocycles used as antithrombotic agents |
DE19834751A1 (de) * | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
EP1265897A1 (en) * | 2000-03-20 | 2002-12-18 | Axys Pharmaceuticals, Inc. | Non-amidine containing protease inhibitors |
US20020052373A1 (en) * | 2000-10-26 | 2002-05-02 | Zorn Stevin H. | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease |
IL140096A0 (en) * | 2000-12-05 | 2002-02-10 | Internat Specialty Products Is | Process for preparation of zafirlukast |
DE10147672A1 (de) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
US20060183753A1 (en) * | 2002-12-20 | 2006-08-17 | Bayer Healthcare Ag | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
SE0300908D0 (sv) * | 2003-03-31 | 2003-03-31 | Astrazeneca Ab | Azaindole derivatives, preparations thereof, uses thereof and compositions containing them |
WO2006066913A2 (en) * | 2004-12-23 | 2006-06-29 | F. Hoffmann-La Roche Ag | Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors |
JP2009511559A (ja) * | 2005-10-12 | 2009-03-19 | バイオリポックス エービー | 炎症の治療に有用なベンゾオキサゾール類 |
DK3091011T3 (en) * | 2006-04-07 | 2018-02-26 | Vertex Pharma | MODULATORS OF ATP BINDING CASSETTE TRANSPORT |
JP2008006663A (ja) * | 2006-06-28 | 2008-01-17 | Pilot Ink Co Ltd | 出没式筆記具 |
ITMI20061368A1 (it) * | 2006-07-14 | 2008-01-15 | Acraf | Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo |
-
2007
- 2007-12-28 EP EP07425830A patent/EP2078711A1/en not_active Withdrawn
-
2008
- 2008-12-16 KR KR1020107015290A patent/KR101671874B1/ko active IP Right Grant
- 2008-12-16 SI SI200830950T patent/SI2234968T1/sl unknown
- 2008-12-16 KR KR1020167004925A patent/KR20160029861A/ko not_active Application Discontinuation
- 2008-12-16 BR BRPI0821450-6A patent/BRPI0821450A2/pt not_active IP Right Cessation
- 2008-12-16 PL PL11194457T patent/PL2444392T3/pl unknown
- 2008-12-16 PT PT111944575T patent/PT2444392E/pt unknown
- 2008-12-16 SG SG2012095667A patent/SG187400A1/en unknown
- 2008-12-16 ES ES11194457.5T patent/ES2523167T3/es active Active
- 2008-12-16 ES ES08868725T patent/ES2408955T3/es active Active
- 2008-12-16 WO PCT/EP2008/067622 patent/WO2009083436A1/en active Application Filing
- 2008-12-16 PL PL08868725T patent/PL2234968T3/pl unknown
- 2008-12-16 AU AU2008342705A patent/AU2008342705B2/en not_active Ceased
- 2008-12-16 EP EP08868725A patent/EP2234968B1/en active Active
- 2008-12-16 EP EP11194457.5A patent/EP2444392B1/en not_active Not-in-force
- 2008-12-16 DK DK08868725.6T patent/DK2234968T3/da active
- 2008-12-16 UA UAA201006371A patent/UA100867C2/uk unknown
- 2008-12-16 EA EA201070804A patent/EA020373B1/ru not_active IP Right Cessation
- 2008-12-16 GE GEAP200811899A patent/GEP20125547B/en unknown
- 2008-12-16 US US12/745,356 patent/US8399477B2/en active Active
- 2008-12-16 SI SI200831326T patent/SI2444392T1/sl unknown
- 2008-12-16 PT PT88687256T patent/PT2234968E/pt unknown
- 2008-12-16 JP JP2010540098A patent/JP5698985B2/ja not_active Expired - Fee Related
- 2008-12-16 CN CN2008801227655A patent/CN101910127B/zh not_active Expired - Fee Related
- 2008-12-16 CA CA2707339A patent/CA2707339C/en not_active Expired - Fee Related
- 2008-12-16 DK DK11194457.5T patent/DK2444392T3/en active
- 2008-12-23 AR ARP080105698A patent/AR069961A1/es not_active Application Discontinuation
-
2010
- 2010-05-30 IL IL206062A patent/IL206062A/en not_active IP Right Cessation
- 2010-12-07 HK HK12105916.6A patent/HK1165410A1/xx not_active IP Right Cessation
- 2010-12-07 HK HK10111381.2A patent/HK1145172A1/xx not_active IP Right Cessation
-
2013
- 2013-02-15 US US13/768,013 patent/US8871948B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |