|
CA2628241C
(en)
|
2005-11-07 |
2016-02-02 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
SG177953A1
(en)
|
2007-01-05 |
2012-02-28 |
Univ Indiana Res & Tech Corp |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
JP6017754B2
(ja)
|
2007-02-15 |
2016-11-02 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
グルカゴン/glp−1受容体コアゴニスト
|
|
US8981047B2
(en)
|
2007-10-30 |
2015-03-17 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
CA2702289A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
BRPI0915282A2
(pt)
|
2008-06-17 |
2017-02-07 |
Univ Indiana Res & Tech Corp |
agonistas mistos baseados no gip para o tratamento de distúrbios metabólicos e obesidade
|
|
CA2728284C
(en)
|
2008-06-17 |
2019-09-10 |
Richard D. Dimarchi |
Glucagon/glp-1 receptor co-agonists
|
|
EP2307037A4
(en)
|
2008-06-17 |
2011-08-03 |
Univ Indiana Res & Tech Corp |
GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
|
|
AR074811A1
(es)
|
2008-12-19 |
2011-02-16 |
Univ Indiana Res & Tech Corp |
Profarmaco de peptido de la superfamilia de glucagon basados en amida
|
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
|
US9150632B2
(en)
|
2009-06-16 |
2015-10-06 |
Indiana University Research And Technology Corporation |
GIP receptor-active glucagon compounds
|
|
US9156901B2
(en)
|
2009-07-13 |
2015-10-13 |
Ditte Riber |
Acylated glucagon analogues
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
AR079345A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina
|
|
CN102834108A
(zh)
|
2010-01-27 |
2012-12-19 |
印第安纳大学研究及科技有限公司 |
用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物
|
|
WO2011134471A1
(en)
|
2010-04-27 |
2011-11-03 |
Zealand Pharma A/S |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
|
KR20130111923A
(ko)
|
2010-05-13 |
2013-10-11 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
G-단백결합 수용체 활성을 나타내는 글루카곤 슈퍼패밀리 펩티드
|
|
EP2569000B1
(en)
|
2010-05-13 |
2017-09-27 |
Indiana University Research and Technology Corporation |
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
|
|
CA2796894A1
(en)
|
2010-06-24 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Amide based glucagon superfamily peptide prodrugs
|
|
WO2012088116A2
(en)
|
2010-12-22 |
2012-06-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting gip receptor activity
|
|
WO2012150503A2
(en)
*
|
2011-05-03 |
2012-11-08 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
EP2707713A2
(en)
*
|
2011-05-10 |
2014-03-19 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
AR086866A1
(es)
*
|
2011-06-10 |
2014-01-29 |
Hanmi Science Co Ltd |
Derivados de oxintomodulina y composicion farmaceutica que los comprende para el tratamiento de la obesidad
|
|
PT2721062T
(pt)
*
|
2011-06-17 |
2019-02-12 |
Hanmi Science Co Ltd |
Conjugado que compreende oxintomodulina e um fragmento de imunoglobulina e utilização do mesmo
|
|
PH12013502671A1
(en)
|
2011-06-22 |
2022-04-08 |
Univ Indiana Res & Tech Corp |
Glucagon/glp-1 receptor co-agonists
|
|
EP2723766A4
(en)
|
2011-06-22 |
2015-05-20 |
Univ Indiana Res & Tech Corp |
COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR
|
|
EP2729493B1
(en)
|
2011-07-04 |
2020-06-10 |
IP2IPO Innovations Limited |
Novel compounds and their effects on feeding behaviour
|
|
CN104144704B
(zh)
|
2011-11-03 |
2018-03-23 |
西兰制药公司 |
Glp‑1受体激动剂肽胃泌素缀合物
|
|
US8859491B2
(en)
*
|
2011-11-17 |
2014-10-14 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
|
|
CA2875743A1
(en)
*
|
2012-06-14 |
2013-12-19 |
Sanofi |
Exendin-4 peptide analogues
|
|
US9340600B2
(en)
|
2012-06-21 |
2016-05-17 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting GIP receptor activity
|
|
CN109456400A
(zh)
|
2012-07-23 |
2019-03-12 |
西兰制药公司 |
胰高血糖素类似物
|
|
KR101968344B1
(ko)
*
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
AR092873A1
(es)
|
2012-09-26 |
2015-05-06 |
Cadila Healthcare Ltd |
Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
|
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
|
KR102311517B1
(ko)
|
2012-11-06 |
2021-10-14 |
한미약품 주식회사 |
옥신토모듈린과 면역글로불린 단편을 포함하는 단백질 결합체의 액상 제제
|
|
KR101993393B1
(ko)
*
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
US20150344540A1
(en)
*
|
2012-12-19 |
2015-12-03 |
Novo Nordisk A/S |
Novel glp-1 receptor agonists with cholesterol efflux activity
|
|
SG10201705097PA
(en)
|
2012-12-21 |
2017-07-28 |
Sanofi Sa |
Functionalized exendin-4 derivatives
|
|
EP2976331B1
(en)
|
2013-03-21 |
2017-03-01 |
Sanofi-Aventis Deutschland GmbH |
Synthesis of hydantoin containing peptide products
|
|
HUE033371T2
(en)
|
2013-03-21 |
2017-11-28 |
Sanofi Aventis Deutschland |
Process for the preparation of peptide products containing a ring imide
|
|
WO2014161835A1
(en)
|
2013-04-03 |
2014-10-09 |
Sanofi |
Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof
|
|
JP6822839B2
(ja)
*
|
2013-09-13 |
2021-01-27 |
ザ・スクリップス・リサーチ・インスティテュート |
修飾された治療剤、及びその組成物
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
RS57632B1
(sr)
|
2013-10-17 |
2018-11-30 |
Zealand Pharma As |
Acilovani analozi glukagona
|
|
CN105849122B
(zh)
|
2013-11-06 |
2021-04-30 |
西兰制药公司 |
Gip-glp-1双重激动剂化合物及方法
|
|
JP2017503474A
(ja)
|
2013-11-06 |
2017-02-02 |
ジーランド ファーマ アクティーゼルスカブ |
グルカゴン−glp−1−gipトリプルアゴニスト化合物
|
|
WO2015086728A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
|
TW201609796A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
非醯化之艾塞那肽-4(exendin-4)胜肽類似物
|
|
TW201609797A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
雙重glp-1/升糖素受體促效劑
|
|
TW201609800A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
做為雙重glp-1/升糖素受體促效劑之艾塞那肽-4胜肽類似物
|
|
EP3080154B1
(en)
|
2013-12-13 |
2018-02-07 |
Sanofi |
Dual glp-1/gip receptor agonists
|
|
US10039809B2
(en)
|
2013-12-18 |
2018-08-07 |
The California Institute For Biomedical Research |
Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
|
|
MX2016010599A
(es)
|
2014-02-18 |
2016-11-18 |
Novo Nordisk As |
Analogos de glucagon estables y uso para el tratamiento de hipoglucemia.
|
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
|
TWI772252B
(zh)
|
2014-09-16 |
2022-08-01 |
南韓商韓美藥品股份有限公司 |
長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
|
|
CN106519015B
(zh)
*
|
2014-09-23 |
2020-04-17 |
深圳市图微安创科技开发有限公司 |
胃泌酸调节素类似物
|
|
CA3093383A1
(en)
|
2014-10-24 |
2016-04-28 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
TWI705973B
(zh)
|
2014-10-29 |
2020-10-01 |
丹麥商西蘭製藥公司 |
Gip促效劑化合物及方法
|
|
US11135271B2
(en)
*
|
2014-12-30 |
2021-10-05 |
Hanmi Pharm. Co., Ltd. |
Glucagon derivatives with improved stability
|
|
KR102418477B1
(ko)
|
2014-12-30 |
2022-07-08 |
한미약품 주식회사 |
글루카곤 유도체
|
|
PL3283507T3
(pl)
|
2015-04-16 |
2020-05-18 |
Zealand Pharma A/S |
Acylowany analog glukagonu
|
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
|
WO2016198624A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
|
|
WO2016198628A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
|
|
US10696725B2
(en)
*
|
2015-06-30 |
2020-06-30 |
Hanmi Pharm. Co., Ltd. |
Glucagon derivative and a composition comprising a long acting conjugate of the same
|
|
AR105284A1
(es)
|
2015-07-10 |
2017-09-20 |
Sanofi Sa |
Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
|
|
EP3359191A4
(en)
|
2015-10-05 |
2019-05-29 |
Merck Sharp & Dohme Corp. |
ANTIBODY PEPTIDE CONJUGATES WITH AGONISTEACTIVITY ON GLUCAGON RECEPTORS AND GLUCAGON-LIKE PEPTIDE-1
|
|
WO2017062271A2
(en)
|
2015-10-06 |
2017-04-13 |
Merck Sharp & Dohme Corp. |
Antibody drug conjugate for anti-inflammatory applications
|
|
EP3377521A4
(en)
|
2015-10-27 |
2019-05-01 |
Merck Sharp & Dohme Corp. |
LONG-ACTING CO AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
|
|
EP3394091A4
(en)
*
|
2015-12-09 |
2019-12-18 |
Merck Sharp & Dohme Corp. |
CO-AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
|
|
CN116063453A
(zh)
|
2015-12-31 |
2023-05-05 |
韩美药品株式会社 |
胰高血糖素/glp-1/gip受体三重激动剂
|
|
WO2017132103A2
(en)
|
2016-01-29 |
2017-08-03 |
Merck Sharp & Dohme Corp. |
Phosphonate linkers and their use to facilitate cellular retention of compounds
|
|
TN2018000452A1
(en)
*
|
2016-06-29 |
2020-06-15 |
Hanmi Pharm Ind Co Ltd |
Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
|
|
AR110299A1
(es)
|
2016-12-02 |
2019-03-13 |
Sanofi Sa |
Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
|
|
EP3551651B1
(en)
|
2016-12-09 |
2024-03-06 |
Zealand Pharma A/S |
Acylated glp-1/glp-2 dual agonists
|
|
CN108299553B
(zh)
*
|
2017-01-13 |
2021-07-16 |
博瑞生物医药(苏州)股份有限公司 |
胃泌酸调节素修饰物
|
|
CN106986924A
(zh)
*
|
2017-03-23 |
2017-07-28 |
中国药科大学 |
胃泌酸调节素(oxm)类似物及其应用
|
|
CN116854804A
(zh)
*
|
2017-08-16 |
2023-10-10 |
东亚St株式会社 |
酰化胃泌酸调节素肽类似物
|
|
MX2020003217A
(es)
|
2017-09-25 |
2020-07-29 |
Merck Sharp & Dohme |
Coagonistas de accion prolongada de los receptores de glucagon y glp-1.
|
|
CN120887972A
(zh)
*
|
2017-11-24 |
2025-11-04 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的胰高血糖素类似物
|
|
CN109836504B
(zh)
*
|
2017-11-24 |
2022-08-02 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的多结构域活性蛋白
|
|
WO2020098657A1
(zh)
*
|
2018-11-12 |
2020-05-22 |
天津药物研究院有限公司 |
具有双重受体激动作用的胰高血糖素衍生肽及其用途
|
|
MX2021007444A
(es)
|
2018-12-21 |
2021-08-05 |
Jiangsu Hengrui Medicine Co |
Proteina biespecifica.
|
|
US11471512B2
(en)
|
2019-03-01 |
2022-10-18 |
Merck Sharp & Dohme Llc |
Pharmaceutical compositions of a peptide
|
|
CN110684082B
(zh)
*
|
2019-10-08 |
2021-12-10 |
江苏诺泰澳赛诺生物制药股份有限公司 |
Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途
|
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
|
KR102154959B1
(ko)
*
|
2020-04-29 |
2020-09-10 |
동아에스티 주식회사 |
지속형 glp-1 및 글루카곤 수용체 이중작용제
|
|
WO2021227989A1
(zh)
*
|
2020-05-09 |
2021-11-18 |
天津药物研究院有限公司 |
具有双受体激动作用的多肽衍生物及其用途
|
|
CN112898405B
(zh)
*
|
2021-01-22 |
2023-02-28 |
深圳市图微安创科技开发有限公司 |
多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
|
|
KR20240032010A
(ko)
|
2021-06-09 |
2024-03-08 |
더 스크립스 리서치 인스티튜트 |
장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법
|
|
CN119930789A
(zh)
*
|
2023-11-06 |
2025-05-06 |
成都奥达生物科技有限公司 |
一种gcg激动剂化合物
|