|
CA2628241C
(en)
|
2005-11-07 |
2016-02-02 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
EP2124974B1
(en)
|
2007-01-05 |
2017-03-15 |
Indiana University Research and Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
EP2487184A1
(en)
|
2007-02-15 |
2012-08-15 |
Indiana University Research and Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
WO2009058662A2
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
AU2009260302B2
(en)
|
2008-06-17 |
2014-10-23 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
BRPI0915282A2
(pt)
|
2008-06-17 |
2017-02-07 |
Univ Indiana Res & Tech Corp |
agonistas mistos baseados no gip para o tratamento de distúrbios metabólicos e obesidade
|
|
KR20110039230A
(ko)
|
2008-06-17 |
2011-04-15 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
생리학적 pH 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체
|
|
SG172291A1
(en)
|
2008-12-19 |
2011-07-28 |
Univ Indiana Res & Tech Corp |
Amide based glucagon superfamily peptide prodrugs
|
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
|
BRPI1014508A2
(pt)
|
2009-06-16 |
2016-04-05 |
Univ Indiana Res & Tech Corp |
análogos de peptídeo de glucagon, dimer de dois peptídeos de glucagon, composição farmacêutica deles derivada e métodos para seu uso"
|
|
HUE026255T2
(en)
|
2009-07-13 |
2016-06-28 |
Zealand Pharma As |
Acylated glucagon analogues
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
JO2976B1
(en)
|
2009-12-22 |
2016-03-15 |
ايلي ليلي اند كومباني |
Axentomodulin polypeptide
|
|
CN102834108A
(zh)
|
2010-01-27 |
2012-12-19 |
印第安纳大学研究及科技有限公司 |
用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物
|
|
CA2797133C
(en)
|
2010-04-27 |
2019-08-06 |
Zealand Pharma A/S |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
|
CN103079587B
(zh)
|
2010-05-13 |
2016-05-11 |
印第安纳大学研究及科技有限公司 |
呈现核激素受体活性的胰高血糖素超家族肽
|
|
CN103179976A
(zh)
|
2010-05-13 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
呈现g蛋白偶联受体活性的胰高血糖素超家族肽
|
|
CN103179979A
(zh)
|
2010-06-24 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰高血糖素超家族肽前药
|
|
EA201390941A1
(ru)
|
2010-12-22 |
2013-12-30 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Аналоги глюкагона, проявляющие активность на рецепторе gip
|
|
WO2012150503A2
(en)
*
|
2011-05-03 |
2012-11-08 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
WO2012153196A2
(en)
*
|
2011-05-10 |
2012-11-15 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
CA2838503C
(en)
*
|
2011-06-10 |
2020-02-18 |
Hanmi Science Co., Ltd. |
Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
|
|
TR201901402T4
(tr)
|
2011-06-17 |
2019-02-21 |
Hanmi Science Co Ltd |
Oksintomodulin ve bir immünoglobulin fragmanı içeren bir konjugat ve onun kullanımı.
|
|
CN103857408B
(zh)
|
2011-06-22 |
2017-04-12 |
印第安那大学科技研究公司 |
胰高血糖素/glp‑1受体协同激动剂
|
|
BR112013032717A2
(pt)
|
2011-06-22 |
2017-01-24 |
Univ Indiana Res & Tech Corp |
coagonistas do receptor de glucagon/glp-1
|
|
US9944687B2
(en)
|
2011-07-04 |
2018-04-17 |
Imperial Innovations Limited |
Compounds and their effects on feeding behaviour
|
|
US9259477B2
(en)
|
2011-11-03 |
2016-02-16 |
Zealand Pharma A/S |
GLP-1 receptor agonist peptide gastrin conjugates
|
|
ES2672880T3
(es)
*
|
2011-11-17 |
2018-06-18 |
Indiana University Research And Technology Corporation |
Péptidos de la superfamilia de glucagón que muestran actividad de receptor de glucocorticoides
|
|
AU2013276610A1
(en)
|
2012-06-14 |
2015-01-15 |
Sanofi |
Exendin-4 peptide analogues
|
|
WO2013192129A1
(en)
|
2012-06-21 |
2013-12-27 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting gip receptor activity
|
|
MY170671A
(en)
|
2012-07-23 |
2019-08-26 |
Zealand Pharma As |
Glucagon analogues
|
|
KR101968344B1
(ko)
*
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
AR092873A1
(es)
|
2012-09-26 |
2015-05-06 |
Cadila Healthcare Ltd |
Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
|
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
|
EP3610856B1
(en)
|
2012-11-06 |
2021-08-18 |
Hanmi Pharm. Co., Ltd. |
Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
|
|
KR101993393B1
(ko)
*
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
EP2935318A1
(en)
*
|
2012-12-19 |
2015-10-28 |
Novo Nordisk A/S |
Novel glp-1 receptor agonists with cholesterol efflux activity
|
|
MX2015008077A
(es)
|
2012-12-21 |
2015-10-30 |
Sanofi Sa |
Derivados de exendina-4 como agonistas dobles de glp1/gip o trigonal de glp1-gip/glucagon.
|
|
EP2976331B1
(en)
|
2013-03-21 |
2017-03-01 |
Sanofi-Aventis Deutschland GmbH |
Synthesis of hydantoin containing peptide products
|
|
MX365465B
(es)
|
2013-03-21 |
2019-06-04 |
Sanofi Aventis Deutschland |
Sintesis de productos peptidicos que contienen imida ciclica.
|
|
WO2014161835A1
(en)
|
2013-04-03 |
2014-10-09 |
Sanofi |
Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof
|
|
EP3043824B1
(en)
|
2013-09-13 |
2022-07-06 |
The Scripps Research Institute |
Modified therapeutic agents and compositions thereof
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
CA2926314C
(en)
|
2013-10-17 |
2023-08-29 |
Zealand Pharma A/S |
Acylated glucagon analogues
|
|
BR112016009889B1
(pt)
|
2013-11-06 |
2023-11-28 |
Zealand Pharma A/S |
Análogo do gip, composição farmacêutica compreendendo um análogo do gip, ou um sal farmaceuticamente aceitável do mesmo, e seu uso
|
|
EA035688B1
(ru)
|
2013-11-06 |
2020-07-27 |
Зилэнд Фарма А/С |
Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip
|
|
WO2015086729A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/gip receptor agonists
|
|
WO2015086733A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/glucagon receptor agonists
|
|
EP3080150B1
(en)
|
2013-12-13 |
2018-08-01 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
|
WO2015086731A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
|
|
EP3080152A1
(en)
|
2013-12-13 |
2016-10-19 |
Sanofi |
Non-acylated exendin-4 peptide analogues
|
|
KR102455171B1
(ko)
|
2013-12-18 |
2022-10-14 |
더 스크립스 리서치 인스티튜트 |
변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물
|
|
JP2017509603A
(ja)
*
|
2014-02-18 |
2017-04-06 |
ノヴォ ノルディスク アー/エス |
安定なグルカゴン類似体及び低血糖症の処置のための使用
|
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
|
TWI772252B
(zh)
|
2014-09-16 |
2022-08-01 |
南韓商韓美藥品股份有限公司 |
長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
|
|
CN106519015B
(zh)
*
|
2014-09-23 |
2020-04-17 |
深圳市图微安创科技开发有限公司 |
胃泌酸调节素类似物
|
|
WO2016065090A1
(en)
|
2014-10-24 |
2016-04-28 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
DK3212218T3
(da)
|
2014-10-29 |
2021-08-30 |
Zealand Pharma As |
GIP-agonistforbindelser og fremgangsmåder
|
|
KR102418477B1
(ko)
|
2014-12-30 |
2022-07-08 |
한미약품 주식회사 |
글루카곤 유도체
|
|
PE20230304A1
(es)
*
|
2014-12-30 |
2023-02-13 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagon como agentes hipoglucemicos y antiobesidad
|
|
WO2016166289A1
(en)
|
2015-04-16 |
2016-10-20 |
Zealand Pharma A/S |
Acylated glucagon analogue
|
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
|
WO2016198624A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
|
|
WO2016198628A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
|
|
CN108025041A
(zh)
|
2015-06-30 |
2018-05-11 |
韩美药品株式会社 |
胰高血糖素衍生物和包含其长效缀合物的组合物
|
|
AR105284A1
(es)
|
2015-07-10 |
2017-09-20 |
Sanofi Sa |
Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
|
|
US10800826B2
(en)
|
2015-10-05 |
2020-10-13 |
Merck Sharp & Dohme Corp. |
Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
|
|
EP3359194A4
(en)
|
2015-10-06 |
2019-04-24 |
Merck Sharp & Dohme Corp. |
ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
|
|
US10793615B2
(en)
|
2015-10-27 |
2020-10-06 |
Merck Sharp & Dohme Corp. |
Long-acting co-agonists of the glucagon and GLP-1 receptors
|
|
EP3394091A4
(en)
|
2015-12-09 |
2019-12-18 |
Merck Sharp & Dohme Corp. |
CO-AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
|
|
HK1258177A1
(en)
|
2015-12-31 |
2019-11-08 |
Hanmi Pharm. Co., Ltd. |
Persistent conjugate of triple activator activating glucagon, glp-1 and gip receptor
|
|
US10869929B2
(en)
|
2016-01-29 |
2020-12-22 |
Merck Sharp & Dohme Corp. |
Phosphonate linkers and their use to facilitate cellular retention of compounds
|
|
SG11201811697SA
(en)
*
|
2016-06-29 |
2019-01-30 |
Hanmi Pharmaceutical Co Ltd |
Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
|
|
TW201832783A
(zh)
|
2016-12-02 |
2018-09-16 |
法商賽諾菲公司 |
包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物
|
|
KR102502040B1
(ko)
|
2016-12-09 |
2023-02-24 |
질랜드 파마 에이/에스 |
아실화 glp-1/glp-2 이중 효능제
|
|
CN108299553B
(zh)
*
|
2017-01-13 |
2021-07-16 |
博瑞生物医药(苏州)股份有限公司 |
胃泌酸调节素修饰物
|
|
CN106986924A
(zh)
*
|
2017-03-23 |
2017-07-28 |
中国药科大学 |
胃泌酸调节素(oxm)类似物及其应用
|
|
CN116854804A
(zh)
*
|
2017-08-16 |
2023-10-10 |
东亚St株式会社 |
酰化胃泌酸调节素肽类似物
|
|
CA3076496A1
(en)
|
2017-09-25 |
2019-03-28 |
Merck Sharp & Dohme Corp. |
Long-acting co-agonists of the glucagon and glp-1 receptors
|
|
CN115304666B
(zh)
*
|
2017-11-24 |
2025-09-19 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的胰高血糖素类似物
|
|
CN109836504B
(zh)
*
|
2017-11-24 |
2022-08-02 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的多结构域活性蛋白
|
|
CN111171135B
(zh)
*
|
2018-11-12 |
2023-04-07 |
天津药物研究院有限公司 |
具有双重受体激动作用的胰高血糖素衍生肽及其用途
|
|
US20220153853A1
(en)
|
2018-12-21 |
2022-05-19 |
Jiangsu Hengrui Medicine Co., Ltd. |
Bispecific protein
|
|
US11471512B2
(en)
|
2019-03-01 |
2022-10-18 |
Merck Sharp & Dohme Llc |
Pharmaceutical compositions of a peptide
|
|
CN110684082B
(zh)
*
|
2019-10-08 |
2021-12-10 |
江苏诺泰澳赛诺生物制药股份有限公司 |
Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途
|
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
|
KR102154959B1
(ko)
*
|
2020-04-29 |
2020-09-10 |
동아에스티 주식회사 |
지속형 glp-1 및 글루카곤 수용체 이중작용제
|
|
JP2023525260A
(ja)
*
|
2020-05-09 |
2023-06-15 |
天津薬物研究院有限公司 |
二重受容体アゴニスト作用を有するポリペプチド誘導体及びその用途
|
|
CN112898405B
(zh)
*
|
2021-01-22 |
2023-02-28 |
深圳市图微安创科技开发有限公司 |
多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
|
|
IL309067A
(en)
|
2021-06-09 |
2024-02-01 |
Scripps Research Inst |
Long-acting dual gip/glp-1 peptide conjugates and methods of use
|
|
CN119930789A
(zh)
*
|
2023-11-06 |
2025-05-06 |
成都奥达生物科技有限公司 |
一种gcg激动剂化合物
|