PT2288373E - Método de tratamento da dispneia associado com insuficiência cardíaca aguda - Google Patents

Método de tratamento da dispneia associado com insuficiência cardíaca aguda Download PDF

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Publication number
PT2288373E
PT2288373E PT97477400T PT09747740T PT2288373E PT 2288373 E PT2288373 E PT 2288373E PT 97477400 T PT97477400 T PT 97477400T PT 09747740 T PT09747740 T PT 09747740T PT 2288373 E PT2288373 E PT 2288373E
Authority
PT
Portugal
Prior art keywords
relaxin
treating
heart failure
acute heart
dyspnea associated
Prior art date
Application number
PT97477400T
Other languages
English (en)
Portuguese (pt)
Inventor
Elaine Unemori
Sam L Teichman
Cotter Gad
Dennis R Stewart
Martha Jo Whitehouse
Original Assignee
Corthera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corthera Inc filed Critical Corthera Inc
Publication of PT2288373E publication Critical patent/PT2288373E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT97477400T 2008-05-16 2009-05-15 Método de tratamento da dispneia associado com insuficiência cardíaca aguda PT2288373E (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US19054508P 2008-08-28 2008-08-28
US20124008P 2008-12-08 2008-12-08
US16433309P 2009-03-27 2009-03-27

Publications (1)

Publication Number Publication Date
PT2288373E true PT2288373E (pt) 2015-10-19

Family

ID=40834101

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97477400T PT2288373E (pt) 2008-05-16 2009-05-15 Método de tratamento da dispneia associado com insuficiência cardíaca aguda

Country Status (30)

Country Link
US (7) US8053411B2 (https=)
EP (2) EP2288373B1 (https=)
JP (4) JP5651586B2 (https=)
CN (3) CN102036679A (https=)
AR (1) AR071810A1 (https=)
AU (1) AU2009246114B2 (https=)
BR (1) BRPI0913011A2 (https=)
CA (1) CA2724540C (https=)
CR (1) CR11749A (https=)
CY (1) CY1116925T1 (https=)
DK (1) DK2288373T3 (https=)
EA (2) EA201500552A1 (https=)
ES (1) ES2546287T3 (https=)
GB (2) GB2459983B (https=)
HK (1) HK1202054A1 (https=)
HR (1) HRP20150845T1 (https=)
HU (1) HUE025483T2 (https=)
IL (3) IL208992A (https=)
MA (1) MA32389B1 (https=)
MX (1) MX2010012450A (https=)
MY (2) MY159803A (https=)
NZ (3) NZ701038A (https=)
PL (1) PL2288373T3 (https=)
PT (1) PT2288373E (https=)
SG (2) SG191587A1 (https=)
SI (1) SI2288373T1 (https=)
TW (1) TWI386202B (https=)
UA (1) UA99953C2 (https=)
WO (1) WO2009140659A2 (https=)
ZA (1) ZA201007449B (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011520917A (ja) * 2008-05-16 2011-07-21 コーセラ，インコーポレーテッド 慢性心不全の治療方法
CN102036679A (zh) 2008-05-16 2011-04-27 科尔泰拉公司 用松弛素治疗与急性心力衰竭相关的呼吸困难
BR112012022654A2 (pt) * 2010-03-10 2016-11-01 Univ Florida modulação de aquaporinas com relaxina
EP2601532B1 (en) * 2010-08-06 2016-01-27 Mycartis N.V. Perlecan as a biomarker for renal dysfunction
MA34521B1 (fr) 2010-08-17 2013-09-02 Ambrx Inc Polypeptides de relaxine modifiés et leurs utilisations
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
EP2726502A1 (en) * 2011-07-01 2014-05-07 Bayer Intellectual Property GmbH Relaxin fusion polypeptides and uses thereof
WO2013059879A1 (en) * 2011-10-26 2013-05-02 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
CN108310396B (zh) * 2012-02-14 2022-07-15 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
WO2013165606A1 (en) 2012-05-04 2013-11-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of the relaxin receptor 1
UA117571C2 (uk) * 2012-10-26 2018-08-27 Чіесі Фармацеутічі С.П.А. Способи контролювання кров'яного тиску та зниження диспное при серцевій недостатності
MX367165B (es) 2013-04-05 2019-08-07 Scpharmaceuticals Inc Formulaciones farmacéuticas para administración subcutánea de furosemida.
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CA2935628A1 (en) * 2014-02-03 2015-08-06 Novartis Ag Filters for infusion sets
EP2946788A1 (en) * 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
CN106413740A (zh) * 2014-06-13 2017-02-15 诺华股份有限公司 用于降低gdf‑15的serelaxin应用
WO2017100540A2 (en) 2015-12-09 2017-06-15 The California Institute For Biomedical Research Relaxin immunoglobulin fusion proteins and methods of use
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
WO2020120482A1 (en) 2018-12-10 2020-06-18 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
EP3906019B1 (en) 2019-01-04 2025-11-26 SQ Innovation AG Pharmaceutical compositions of furosemide
US12397005B2 (en) 2019-01-04 2025-08-26 Sq Innovation Ag Pharmaceutical compositions of torsemide and uses thereof
EA202192129A1 (ru) 2019-01-31 2021-10-19 ЭсСиФАРМАСЬЮТИКАЛЗ ИНК. Концентрированные жидкие фармацевтические составы фуросемида и способы их введения
AU2023332056A1 (en) 2022-08-31 2025-03-13 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Immunosuppressive medicament and method of treatment
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023321A (en) 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
US5478807A (en) 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
EP0707650B1 (en) 1993-06-21 2003-05-21 Genentech, Inc. Process for producing human relaxin
CA2145515A1 (en) * 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US5811395A (en) 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
EP0845992B1 (en) * 1995-08-15 2002-11-20 Connetics Corporation Use of relaxin for promoting angiogenesis
WO2001058468A1 (en) * 2000-02-09 2001-08-16 Connetics Corporation Use of relaxin to treat diseases related to vasoconstriction
DE10155843A1 (de) * 2000-11-16 2003-01-30 Immundiagnostik Ag Verfahren zur Prognose und Diagnose von Herzinsuffizienz
US20050113286A1 (en) * 2002-03-18 2005-05-26 Schreiner George F. Methods for treating congestive heart failure
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
CN1968717B (zh) * 2004-03-30 2013-08-21 延世大学教产学协力团 含有松弛素基因的基因送递系统和使用松弛素的药物组合物
US20060264367A1 (en) 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
US20080077025A1 (en) 2005-07-11 2008-03-27 Leticia Delgado-Herrera Methods for determining how to treat congestive heart failure
US8492329B2 (en) 2007-07-12 2013-07-23 Compugen Ltd. Bioactive peptides and methods of using same
JP2011520917A (ja) 2008-05-16 2011-07-21 コーセラ，インコーポレーテッド 慢性心不全の治療方法
CN102036679A (zh) * 2008-05-16 2011-04-27 科尔泰拉公司 用松弛素治疗与急性心力衰竭相关的呼吸困难

Also Published As

Publication number Publication date
WO2009140659A3 (en) 2010-07-22
IL208992A (en) 2013-09-30
AR071810A1 (es) 2010-07-14
SG10201609580YA (en) 2016-12-29
US20130116181A1 (en) 2013-05-09
HK1202054A1 (en) 2015-09-18
DK2288373T3 (en) 2015-09-28
US20120040902A1 (en) 2012-02-16
EP2829280A1 (en) 2015-01-28
EA201001771A1 (ru) 2011-06-30
MY159803A (en) 2017-02-15
JP2011520918A (ja) 2011-07-21
MX2010012450A (es) 2011-03-21
GB2459983A (en) 2009-11-18
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
SI2288373T1 (sl) 2015-12-31
CY1116925T1 (el) 2017-04-05
HK1151229A1 (en) 2012-01-27
CN106177914A (zh) 2016-12-07
US8415301B2 (en) 2013-04-09
EP2288373A2 (en) 2011-03-02
NZ701038A (en) 2016-01-29
US8053411B2 (en) 2011-11-08
GB2459983B (en) 2010-04-28
US20100048475A1 (en) 2010-02-25
BRPI0913011A2 (pt) 2019-09-03
IL247351A0 (en) 2016-09-29
HK1140693A1 (en) 2010-10-22
US20150320834A1 (en) 2015-11-12
EP2288373B1 (en) 2015-06-24
CN103212063A (zh) 2013-07-24
AU2009246114A1 (en) 2009-11-19
US9205132B2 (en) 2015-12-08
US9066916B2 (en) 2015-06-30
IL208992A0 (en) 2011-01-31
PL2288373T3 (pl) 2015-11-30
SG191587A1 (en) 2013-07-31
HK1139051A1 (en) 2010-09-10
JP5875646B2 (ja) 2016-03-02
GB2462221A (en) 2010-02-03
HK1187550A1 (zh) 2014-04-11
GB0918132D0 (en) 2009-12-02
JP2016053040A (ja) 2016-04-14
EA201500552A1 (ru) 2016-07-29
US9579363B2 (en) 2017-02-28
US20130210730A1 (en) 2013-08-15
ES2546287T3 (es) 2015-09-22
HRP20150845T1 (hr) 2015-11-06
JP5638044B2 (ja) 2014-12-10
CA2724540A1 (en) 2009-11-19
IL228244A (en) 2016-10-31
JP2015013870A (ja) 2015-01-22
GB0908432D0 (en) 2009-06-24
US20120040903A1 (en) 2012-02-16
HUE025483T2 (en) 2016-02-29
TWI386202B (zh) 2013-02-21
JP5651586B2 (ja) 2015-01-14
CN103212063B (zh) 2015-07-22
WO2009140659A2 (en) 2009-11-19
MY158327A (en) 2016-09-30
ZA201007449B (en) 2011-06-29
CA2724540C (en) 2014-07-08
GB2462221B (en) 2010-09-01
NZ598709A (en) 2013-09-27
AU2009246114B2 (en) 2013-01-31
EA022948B1 (ru) 2016-03-31
TW200948353A (en) 2009-12-01
UA99953C2 (uk) 2012-10-25
CN102036679A (zh) 2011-04-27
US8372809B2 (en) 2013-02-12
CR11749A (es) 2011-02-11
JP2013040174A (ja) 2013-02-28
US20170151311A1 (en) 2017-06-01

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