CN102036679A - 用松弛素治疗与急性心力衰竭相关的呼吸困难 - Google Patents

用松弛素治疗与急性心力衰竭相关的呼吸困难 Download PDF

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Publication number
CN102036679A
CN102036679A CN2009801177504A CN200980117750A CN102036679A CN 102036679 A CN102036679 A CN 102036679A CN 2009801177504 A CN2009801177504 A CN 2009801177504A CN 200980117750 A CN200980117750 A CN 200980117750A CN 102036679 A CN102036679 A CN 102036679A
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CN
China
Prior art keywords
relaxin
pharmaceutically active
heart failure
individual
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801177504A
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English (en)
Chinese (zh)
Inventor
E·乌奈莫里
S·L·特伊奇曼
G·库特尔
D·R·斯图尔特
M·J·维特豪斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corthera Inc
Original Assignee
Corthera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corthera Inc filed Critical Corthera Inc
Priority to CN201310127326.6A priority Critical patent/CN103212063B/zh
Priority to CN201610565105.0A priority patent/CN106177914A/zh
Publication of CN102036679A publication Critical patent/CN102036679A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801177504A 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难 Pending CN102036679A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201310127326.6A CN103212063B (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难
CN201610565105.0A CN106177914A (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US61/127,889 2008-05-16
US19054508P 2008-08-28 2008-08-28
US61/190,545 2008-08-28
US20124008P 2008-12-08 2008-12-08
US61/201,240 2008-12-08
US16433309P 2009-03-27 2009-03-27
US61/164,333 2009-03-27
PCT/US2009/044249 WO2009140659A2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201310127326.6A Division CN103212063B (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难
CN201610565105.0A Division CN106177914A (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难

Publications (1)

Publication Number Publication Date
CN102036679A true CN102036679A (zh) 2011-04-27

Family

ID=40834101

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2009801177504A Pending CN102036679A (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难
CN201310127326.6A Expired - Fee Related CN103212063B (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难
CN201610565105.0A Pending CN106177914A (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201310127326.6A Expired - Fee Related CN103212063B (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难
CN201610565105.0A Pending CN106177914A (zh) 2008-05-16 2009-05-15 用松弛素治疗与急性心力衰竭相关的呼吸困难

Country Status (30)

Country Link
US (7) US8053411B2 (https=)
EP (2) EP2288373B1 (https=)
JP (4) JP5651586B2 (https=)
CN (3) CN102036679A (https=)
AR (1) AR071810A1 (https=)
AU (1) AU2009246114B2 (https=)
BR (1) BRPI0913011A2 (https=)
CA (1) CA2724540C (https=)
CR (1) CR11749A (https=)
CY (1) CY1116925T1 (https=)
DK (1) DK2288373T3 (https=)
EA (2) EA201500552A1 (https=)
ES (1) ES2546287T3 (https=)
GB (2) GB2459983B (https=)
HK (1) HK1202054A1 (https=)
HR (1) HRP20150845T1 (https=)
HU (1) HUE025483T2 (https=)
IL (3) IL208992A (https=)
MA (1) MA32389B1 (https=)
MX (1) MX2010012450A (https=)
MY (2) MY159803A (https=)
NZ (3) NZ589009A (https=)
PL (1) PL2288373T3 (https=)
PT (1) PT2288373E (https=)
SG (2) SG10201609580YA (https=)
SI (1) SI2288373T1 (https=)
TW (1) TWI386202B (https=)
UA (1) UA99953C2 (https=)
WO (1) WO2009140659A2 (https=)
ZA (1) ZA201007449B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930440A (zh) * 2011-07-01 2014-07-16 拜耳知识产权有限责任公司 松弛素融合多肽及其用途
CN104220098A (zh) * 2012-02-14 2014-12-17 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0912559A2 (pt) * 2008-05-16 2015-10-13 Corthera Inc método de tratar insuficiência cardíaca crônica
CA2724540C (en) 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
EP2544706B1 (en) 2010-03-10 2015-06-17 The University Of Melbourne Modulating aquaporins with relaxin
US9465039B2 (en) 2010-08-06 2016-10-11 Mycartis Nv Perlecan as a biomarker for renal dysfunction
EA030886B1 (ru) * 2010-08-17 2018-10-31 Амбркс, Инк. Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
AU2013202269A1 (en) * 2011-10-26 2013-05-16 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
US9452973B2 (en) 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1
KR102299073B1 (ko) * 2012-10-26 2021-09-09 치에시 파마슈티시 에스.피.아. 심부전에서 혈압을 조절하고 호흡곤란을 감소시키는 방법
PT2981258T (pt) * 2013-04-05 2020-10-19 Scpharmaceuticals Inc Formulações farmacêuticas para administração subcutânea de furosemida
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
MX2016010087A (es) * 2014-02-03 2016-10-07 Novartis Ag Filtros para equipos de infusion.
EP2946788A1 (en) * 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
US20170100460A1 (en) * 2014-06-13 2017-04-13 Novartis Ag Use of serelaxin to reduce gdf-15
PT3387019T (pt) 2015-12-09 2022-01-14 Scripps Research Inst Proteínas de fusão de imunoglobulina de relaxina e métodos de uso
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
PE20191716A1 (es) 2017-02-08 2019-12-05 Bristol Myers Squibb Co Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
ES3041602T3 (en) 2018-12-10 2025-11-13 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
US12397005B2 (en) 2019-01-04 2025-08-26 Sq Innovation Ag Pharmaceutical compositions of torsemide and uses thereof
US11246851B2 (en) 2019-01-04 2022-02-15 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
PH12021551811A1 (en) 2019-01-31 2022-03-21 Scpharmaceuticals Inc Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
JP2025528469A (ja) 2022-08-31 2025-08-28 リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー． カーゲー 免疫抑制薬及び処置方法
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

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US5023321A (en) 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
WO1995000645A2 (en) 1993-06-21 1995-01-05 Genentech, Inc. Process for producing relaxin
US5952296A (en) * 1993-07-27 1999-09-14 Bigazzi; Mario Method of using relaxin as therapeutic or preventing agent
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US5811395A (en) 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
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US20050113286A1 (en) * 2002-03-18 2005-05-26 Schreiner George F. Methods for treating congestive heart failure
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
EP1729817B1 (en) * 2004-03-30 2014-03-05 Industry-Academic Cooperation Foundation Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin
US20060264367A1 (en) 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
TW200800206A (en) 2005-07-11 2008-01-01 Abbott Lab Methods for determining how to treat congestive heart failure
WO2009007848A2 (en) 2007-07-12 2009-01-15 Compugen Ltd. Bioactive peptides and method of using same
CA2724540C (en) * 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
BRPI0912559A2 (pt) 2008-05-16 2015-10-13 Corthera Inc método de tratar insuficiência cardíaca crônica

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930440A (zh) * 2011-07-01 2014-07-16 拜耳知识产权有限责任公司 松弛素融合多肽及其用途
CN104220098A (zh) * 2012-02-14 2014-12-17 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达

Also Published As

Publication number Publication date
PL2288373T3 (pl) 2015-11-30
WO2009140659A2 (en) 2009-11-19
US9205132B2 (en) 2015-12-08
BRPI0913011A2 (pt) 2019-09-03
US20120040903A1 (en) 2012-02-16
US20150320834A1 (en) 2015-11-12
HK1187550A1 (zh) 2014-04-11
MX2010012450A (es) 2011-03-21
CN106177914A (zh) 2016-12-07
CN103212063A (zh) 2013-07-24
JP5875646B2 (ja) 2016-03-02
EP2288373B1 (en) 2015-06-24
JP2015013870A (ja) 2015-01-22
JP2016053040A (ja) 2016-04-14
IL208992A0 (en) 2011-01-31
JP2011520918A (ja) 2011-07-21
US20130116181A1 (en) 2013-05-09
HK1139051A1 (en) 2010-09-10
EP2288373A2 (en) 2011-03-02
EA201500552A1 (ru) 2016-07-29
EA201001771A1 (ru) 2011-06-30
GB0908432D0 (en) 2009-06-24
CA2724540A1 (en) 2009-11-19
WO2009140659A3 (en) 2010-07-22
MY158327A (en) 2016-09-30
US9579363B2 (en) 2017-02-28
AR071810A1 (es) 2010-07-14
SG191587A1 (en) 2013-07-31
HK1202054A1 (en) 2015-09-18
HK1140693A1 (en) 2010-10-22
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
US9066916B2 (en) 2015-06-30
US20130210730A1 (en) 2013-08-15
HK1151229A1 (en) 2012-01-27
AU2009246114A1 (en) 2009-11-19
DK2288373T3 (en) 2015-09-28
SI2288373T1 (sl) 2015-12-31
GB2459983B (en) 2010-04-28
JP5638044B2 (ja) 2014-12-10
UA99953C2 (uk) 2012-10-25
MY159803A (en) 2017-02-15
NZ598709A (en) 2013-09-27
EP2829280A1 (en) 2015-01-28
NZ701038A (en) 2016-01-29
US8053411B2 (en) 2011-11-08
EA022948B1 (ru) 2016-03-31
GB0918132D0 (en) 2009-12-02
GB2462221B (en) 2010-09-01
TW200948353A (en) 2009-12-01
US20170151311A1 (en) 2017-06-01
CY1116925T1 (el) 2017-04-05
US20100048475A1 (en) 2010-02-25
US8415301B2 (en) 2013-04-09
JP5651586B2 (ja) 2015-01-14
IL228244A (en) 2016-10-31
HUE025483T2 (en) 2016-02-29
AU2009246114B2 (en) 2013-01-31
ES2546287T3 (es) 2015-09-22
CR11749A (es) 2011-02-11
IL208992A (en) 2013-09-30
GB2459983A (en) 2009-11-18
PT2288373E (pt) 2015-10-19
CA2724540C (en) 2014-07-08
GB2462221A (en) 2010-02-03
TWI386202B (zh) 2013-02-21
HRP20150845T1 (hr) 2015-11-06
US20120040902A1 (en) 2012-02-16
JP2013040174A (ja) 2013-02-28
CN103212063B (zh) 2015-07-22
US8372809B2 (en) 2013-02-12
ZA201007449B (en) 2011-06-29
SG10201609580YA (en) 2016-12-29
IL247351A0 (en) 2016-09-29

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Application publication date: 20110427