PT2041282T - Ácidos nucleicos que se ligam a fde-1 - Google Patents

Info

Publication number

PT2041282T

PT2041282T PT77861607T PT07786160T PT2041282T PT 2041282 T PT2041282 T PT 2041282T PT 77861607 T PT77861607 T PT 77861607T PT 07786160 T PT07786160 T PT 07786160T PT 2041282 T PT2041282 T PT 2041282T

Authority

PT

Portugal

Prior art keywords

nucleic acid

type

nucleotide

rna

seq

Prior art date

2006-07-18

Links

• Espacenet
• Global Dossier
• Discuss

• 150000007523 nucleic acids Chemical class 0.000 title claims description 559
• 102000039446 nucleic acids Human genes 0.000 title claims description 537
• 108020004707 nucleic acids Proteins 0.000 title claims description 537
• 238000009739 binding Methods 0.000 title description 258
• 230000027455 binding Effects 0.000 title description 257
• 125000003729 nucleotide group Chemical group 0.000 claims description 418
• 239000002773 nucleotide Substances 0.000 claims description 405
• 101100243082 Caenorhabditis elegans pde-1 gene Proteins 0.000 claims description 214
• 241000282414 Homo sapiens Species 0.000 claims description 137
• 239000003814 drug Substances 0.000 claims description 76
• 238000001514 detection method Methods 0.000 claims description 69
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 59
• 201000010099 disease Diseases 0.000 claims description 49
• 238000000034 method Methods 0.000 claims description 38
• 230000004048 modification Effects 0.000 claims description 33
• 238000012986 modification Methods 0.000 claims description 33
• 101710182961 Endothelial differentiation-related factor 1 Proteins 0.000 claims description 30
• 102100032450 Endothelial differentiation-related factor 1 Human genes 0.000 claims description 30
• 101710159618 Endothelial differentiation-related factor 1 homolog Proteins 0.000 claims description 30
• 238000009396 hybridization Methods 0.000 claims description 30
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 25
• 239000005557 antagonist Substances 0.000 claims description 25
• 206010027476 Metastases Diseases 0.000 claims description 15
• 102000005962 receptors Human genes 0.000 claims description 15
• 108020003175 receptors Proteins 0.000 claims description 15
• 206010061218 Inflammation Diseases 0.000 claims description 13
• 230000004054 inflammatory process Effects 0.000 claims description 13
• 206010012689 Diabetic retinopathy Diseases 0.000 claims description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims description 12
• 230000009401 metastasis Effects 0.000 claims description 11
• 208000035475 disorder Diseases 0.000 claims description 10
• 210000004072 lung Anatomy 0.000 claims description 9
• 208000002780 macular degeneration Diseases 0.000 claims description 9
• 108010061299 CXCR4 Receptors Proteins 0.000 claims description 8
• 102000012000 CXCR4 Receptors Human genes 0.000 claims description 8
• 230000033115 angiogenesis Effects 0.000 claims description 8
• 230000002401 inhibitory effect Effects 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 210000001672 ovary Anatomy 0.000 claims description 8
• 206010029113 Neovascularisation Diseases 0.000 claims description 7
• 208000034038 Pathologic Neovascularization Diseases 0.000 claims description 7
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 7
• 201000008968 osteosarcoma Diseases 0.000 claims description 7
• 210000000496 pancreas Anatomy 0.000 claims description 7
• 210000002307 prostate Anatomy 0.000 claims description 7
• 208000032612 Glial tumor Diseases 0.000 claims description 6
• 206010018338 Glioma Diseases 0.000 claims description 6
• 206010029260 Neuroblastoma Diseases 0.000 claims description 6
• 239000002253 acid Substances 0.000 claims description 6
• 210000000481 breast Anatomy 0.000 claims description 6
• 210000001072 colon Anatomy 0.000 claims description 6
• 238000003745 diagnosis Methods 0.000 claims description 6
• 230000001404 mediated effect Effects 0.000 claims description 6
• 201000001441 melanoma Diseases 0.000 claims description 6
• 201000006417 multiple sclerosis Diseases 0.000 claims description 6
• 210000001989 nasopharynx Anatomy 0.000 claims description 6
• 201000008383 nephritis Diseases 0.000 claims description 6
• 201000008482 osteoarthritis Diseases 0.000 claims description 6
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
• 210000002784 stomach Anatomy 0.000 claims description 6
• 208000011580 syndromic disease Diseases 0.000 claims description 6
• 210000001685 thyroid gland Anatomy 0.000 claims description 6
• 230000007812 deficiency Effects 0.000 claims description 5
• 208000032839 leukemia Diseases 0.000 claims description 5
• 208000010115 WHIM syndrome Diseases 0.000 claims description 4
• 239000000470 constituent Substances 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
• 239000004480 active ingredient Substances 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 256
• 229920001223 polyethylene glycol Polymers 0.000 description 95
• 108091027076 Spiegelmer Proteins 0.000 description 93
• 210000004027 cell Anatomy 0.000 description 66
• 239000000523 sample Substances 0.000 description 50
• 238000003556 assay Methods 0.000 description 47
• 108091023037 Aptamer Proteins 0.000 description 43
• 239000002202 Polyethylene glycol Substances 0.000 description 41
• 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 30
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 30
• 230000035605 chemotaxis Effects 0.000 description 28
• 239000000243 solution Substances 0.000 description 27
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 26
• 239000003550 marker Substances 0.000 description 24
• 230000000052 comparative effect Effects 0.000 description 23
• 230000008569 process Effects 0.000 description 23
• 150000001875 compounds Chemical class 0.000 description 22
• 239000003446 ligand Substances 0.000 description 22
• 239000000872 buffer Substances 0.000 description 21
• 229940124597 therapeutic agent Drugs 0.000 description 21
• 150000003254 radicals Chemical class 0.000 description 20
• 102000019034 Chemokines Human genes 0.000 description 19
• 108010012236 Chemokines Proteins 0.000 description 19
• 230000003993 interaction Effects 0.000 description 19
• 238000000159 protein binding assay Methods 0.000 description 19
• 238000011282 treatment Methods 0.000 description 19
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
• 206010028980 Neoplasm Diseases 0.000 description 18
• 101100123718 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pda-1 gene Proteins 0.000 description 18
• 239000002609 medium Substances 0.000 description 18
• 229940079593 drug Drugs 0.000 description 17
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
• 238000005259 measurement Methods 0.000 description 16
• 239000000203 mixture Substances 0.000 description 16
• 101001016384 Homo sapiens Endothelial differentiation-related factor 1 Proteins 0.000 description 15
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
• 102000057934 human EDF1 Human genes 0.000 description 15
• 238000011161 development Methods 0.000 description 14
• 230000018109 developmental process Effects 0.000 description 14
• -1 nucleotide nucleic acids Chemical class 0.000 description 14
• 238000004458 analytical method Methods 0.000 description 13
• 229960002685 biotin Drugs 0.000 description 13
• 235000020958 biotin Nutrition 0.000 description 13
• 239000011616 biotin Substances 0.000 description 13
• 210000004379 membrane Anatomy 0.000 description 13
• 239000000556 agonist Substances 0.000 description 12
• 238000002474 experimental method Methods 0.000 description 12
• 239000012528 membrane Substances 0.000 description 12
• 230000000638 stimulation Effects 0.000 description 12
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 12
• 241000700159 Rattus Species 0.000 description 11
• 230000015572 biosynthetic process Effects 0.000 description 11
• 230000000295 complement effect Effects 0.000 description 11
• 238000012606 in vitro cell culture Methods 0.000 description 11
• 230000009467 reduction Effects 0.000 description 11
• 235000002639 sodium chloride Nutrition 0.000 description 11
• 201000011510 cancer Diseases 0.000 description 10
• 230000012010 growth Effects 0.000 description 10
• 108090000623 proteins and genes Proteins 0.000 description 10
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 10
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
• 108010090804 Streptavidin Proteins 0.000 description 9
• 210000003719 b-lymphocyte Anatomy 0.000 description 9
• 239000011230 binding agent Substances 0.000 description 9
• 231100000673 dose–response relationship Toxicity 0.000 description 9
• 238000002347 injection Methods 0.000 description 9
• 239000007924 injection Substances 0.000 description 9
• 235000018102 proteins Nutrition 0.000 description 9
• 102000004169 proteins and genes Human genes 0.000 description 9
• 230000004044 response Effects 0.000 description 9
• 239000011780 sodium chloride Substances 0.000 description 9
• 230000008878 coupling Effects 0.000 description 8
• 238000010168 coupling process Methods 0.000 description 8
• 238000005859 coupling reaction Methods 0.000 description 8
• 238000010494 dissociation reaction Methods 0.000 description 8
• 230000005593 dissociations Effects 0.000 description 8
• 230000000694 effects Effects 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• RRWFUWRLNIZICP-UHFFFAOYSA-N 1-bromo-2-phenoxybenzene Chemical compound BrC1=CC=CC=C1OC1=CC=CC=C1 RRWFUWRLNIZICP-UHFFFAOYSA-N 0.000 description 7
• 102000008186 Collagen Human genes 0.000 description 7
• 108010035532 Collagen Proteins 0.000 description 7
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 7
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 7
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
• 238000004422 calculation algorithm Methods 0.000 description 7
• 229920001436 collagen Polymers 0.000 description 7
• 230000006870 function Effects 0.000 description 7
• 230000005764 inhibitory process Effects 0.000 description 7
• 239000007788 liquid Substances 0.000 description 7
• 239000011159 matrix material Substances 0.000 description 7
• 230000005012 migration Effects 0.000 description 7
• 238000013508 migration Methods 0.000 description 7
• 230000002265 prevention Effects 0.000 description 7
• 108090000765 processed proteins & peptides Proteins 0.000 description 7
• 239000000126 substance Substances 0.000 description 7
• 238000012360 testing method Methods 0.000 description 7
• 210000001519 tissue Anatomy 0.000 description 7
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
• 102000043136 MAP kinase family Human genes 0.000 description 6
• 108091054455 MAP kinase family Proteins 0.000 description 6
• 241001529936 Murinae Species 0.000 description 6
• 229920002472 Starch Polymers 0.000 description 6
• 239000013543 active substance Substances 0.000 description 6
• 150000001412 amines Chemical class 0.000 description 6
• 150000001413 amino acids Chemical group 0.000 description 6
• 239000002775 capsule Substances 0.000 description 6
• 239000003795 chemical substances by application Substances 0.000 description 6
• 230000007423 decrease Effects 0.000 description 6
• 230000003247 decreasing effect Effects 0.000 description 6
• BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 6
• 238000011534 incubation Methods 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 230000002829 reductive effect Effects 0.000 description 6
• 210000001525 retina Anatomy 0.000 description 6
• 238000012216 screening Methods 0.000 description 6
• 235000019698 starch Nutrition 0.000 description 6
• 210000000130 stem cell Anatomy 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• 238000003786 synthesis reaction Methods 0.000 description 6
• QAPSNMNOIOSXSQ-YNEHKIRRSA-N 1-[(2r,4s,5r)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)C1 QAPSNMNOIOSXSQ-YNEHKIRRSA-N 0.000 description 5
• 108090001008 Avidin Proteins 0.000 description 5
• 201000004569 Blindness Diseases 0.000 description 5
• 206010006187 Breast cancer Diseases 0.000 description 5
• 208000026310 Breast neoplasm Diseases 0.000 description 5
• 102000009410 Chemokine receptor Human genes 0.000 description 5
• 108050000299 Chemokine receptor Proteins 0.000 description 5
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
• 241001465754 Metazoa Species 0.000 description 5
• 241000699666 Mus <mouse, genus> Species 0.000 description 5
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
• 229930182555 Penicillin Natural products 0.000 description 5
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 5
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 5
• 208000000389 T-cell leukemia Diseases 0.000 description 5
• 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 5
• 239000007983 Tris buffer Substances 0.000 description 5
• 230000004913 activation Effects 0.000 description 5
• 210000000709 aorta Anatomy 0.000 description 5
• 230000009286 beneficial effect Effects 0.000 description 5
• 210000004204 blood vessel Anatomy 0.000 description 5
• 238000006243 chemical reaction Methods 0.000 description 5
• 238000002648 combination therapy Methods 0.000 description 5
• 230000008030 elimination Effects 0.000 description 5
• 238000003379 elimination reaction Methods 0.000 description 5
• 150000002148 esters Chemical class 0.000 description 5
• 230000006320 pegylation Effects 0.000 description 5
• 229940049954 penicillin Drugs 0.000 description 5
• 150000008300 phosphoramidites Chemical class 0.000 description 5
• 230000036470 plasma concentration Effects 0.000 description 5
• 230000035755 proliferation Effects 0.000 description 5
• 239000008107 starch Substances 0.000 description 5
• 229960005322 streptomycin Drugs 0.000 description 5
• 210000002536 stromal cell Anatomy 0.000 description 5
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
• YWENWUYXQUWRHQ-LPEHRKFASA-N Arg-Cys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)N)C(=O)O YWENWUYXQUWRHQ-LPEHRKFASA-N 0.000 description 4
• 102100021943 C-C motif chemokine 2 Human genes 0.000 description 4
• 108050006947 CXC Chemokine Proteins 0.000 description 4
• 102000019388 CXC chemokine Human genes 0.000 description 4
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• UQHGAYSULGRWRG-WHFBIAKZSA-N Glu-Ser Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(O)=O UQHGAYSULGRWRG-WHFBIAKZSA-N 0.000 description 4
• MMFKFJORZBJVNF-UWVGGRQHSA-N His-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 MMFKFJORZBJVNF-UWVGGRQHSA-N 0.000 description 4
• MLTRLIITQPXHBJ-BQBZGAKWSA-N Leu-Asn Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC(N)=O MLTRLIITQPXHBJ-BQBZGAKWSA-N 0.000 description 4
• NFNVDJGXRFEYTK-YUMQZZPRSA-N Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O NFNVDJGXRFEYTK-YUMQZZPRSA-N 0.000 description 4
• 101710163270 Nuclease Proteins 0.000 description 4
• 229920001213 Polysorbate 20 Polymers 0.000 description 4
• 229930006000 Sucrose Natural products 0.000 description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
• 210000001744 T-lymphocyte Anatomy 0.000 description 4
• PITVQFJBUFDJDD-XEGUGMAKSA-N Trp-Ile Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)=CNC2=C1 PITVQFJBUFDJDD-XEGUGMAKSA-N 0.000 description 4
• 238000009825 accumulation Methods 0.000 description 4
• 238000007792 addition Methods 0.000 description 4
• 108010093581 aspartyl-proline Proteins 0.000 description 4
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
• 210000001185 bone marrow Anatomy 0.000 description 4
• 239000003153 chemical reaction reagent Substances 0.000 description 4
• 238000004590 computer program Methods 0.000 description 4
• 230000009089 cytolysis Effects 0.000 description 4
• 206010012601 diabetes mellitus Diseases 0.000 description 4
• 238000009510 drug design Methods 0.000 description 4
• 230000002255 enzymatic effect Effects 0.000 description 4
• 210000002919 epithelial cell Anatomy 0.000 description 4
• 238000011156 evaluation Methods 0.000 description 4
• 230000004438 eyesight Effects 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 108010025306 histidylleucine Proteins 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 4
• 238000001990 intravenous administration Methods 0.000 description 4
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
• 230000003211 malignant effect Effects 0.000 description 4
• 108010087904 neutravidin Proteins 0.000 description 4
• 229920000642 polymer Polymers 0.000 description 4
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 239000000600 sorbitol Substances 0.000 description 4
• 238000006467 substitution reaction Methods 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• 238000013268 sustained release Methods 0.000 description 4
• 239000012730 sustained-release form Substances 0.000 description 4
• 230000001225 therapeutic effect Effects 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• 210000004881 tumor cell Anatomy 0.000 description 4
• 238000005406 washing Methods 0.000 description 4
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
• WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 3
• DFCIPNHFKOQAME-FXQIFTODSA-N Arg-Ala-Asn Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O DFCIPNHFKOQAME-FXQIFTODSA-N 0.000 description 3
• WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 3
• 102100032367 C-C motif chemokine 5 Human genes 0.000 description 3
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 description 3
• 108010040471 CC Chemokines Proteins 0.000 description 3
• 102000001902 CC Chemokines Human genes 0.000 description 3
• 108020004414 DNA Proteins 0.000 description 3
• 239000007995 HEPES buffer Substances 0.000 description 3
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 3
• 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 description 3
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 3
• 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 3
• 102000004890 Interleukin-8 Human genes 0.000 description 3
• 108090001007 Interleukin-8 Proteins 0.000 description 3
• YSPZCHGIWAQVKQ-AVGNSLFASA-N Lys-Pro-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN YSPZCHGIWAQVKQ-AVGNSLFASA-N 0.000 description 3
• 241000699670 Mus sp. Species 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• YUJLIIRMIAGMCQ-CIUDSAMLSA-N Ser-Leu-Ser Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O YUJLIIRMIAGMCQ-CIUDSAMLSA-N 0.000 description 3
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
• 239000006180 TBST buffer Substances 0.000 description 3
• FBVUOEYVGNMRMD-NAKRPEOUSA-N Val-Cys-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C(C)C)N FBVUOEYVGNMRMD-NAKRPEOUSA-N 0.000 description 3
• 230000006907 apoptotic process Effects 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 230000006399 behavior Effects 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 229950004398 broxuridine Drugs 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 210000003161 choroid Anatomy 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 230000000875 corresponding effect Effects 0.000 description 3
• 238000009295 crossflow filtration Methods 0.000 description 3
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
• 238000007405 data analysis Methods 0.000 description 3
• 230000003111 delayed effect Effects 0.000 description 3
• 239000003937 drug carrier Substances 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 210000002889 endothelial cell Anatomy 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 230000029142 excretion Effects 0.000 description 3
• 210000002950 fibroblast Anatomy 0.000 description 3
• 239000008103 glucose Substances 0.000 description 3
• 230000011132 hemopoiesis Effects 0.000 description 3
• 238000004128 high performance liquid chromatography Methods 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 230000009545 invasion Effects 0.000 description 3
• 210000000265 leukocyte Anatomy 0.000 description 3
• 150000002632 lipids Chemical class 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 210000003563 lymphoid tissue Anatomy 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 3
• 230000009871 nonspecific binding Effects 0.000 description 3
• 238000007911 parenteral administration Methods 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 239000002953 phosphate buffered saline Substances 0.000 description 3
• 229920001184 polypeptide Polymers 0.000 description 3
• 239000011148 porous material Substances 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 210000001948 pro-b lymphocyte Anatomy 0.000 description 3
• 102000004196 processed proteins & peptides Human genes 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 238000011002 quantification Methods 0.000 description 3
• 230000002285 radioactive effect Effects 0.000 description 3
• 239000011541 reaction mixture Substances 0.000 description 3
• 230000002207 retinal effect Effects 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 239000000829 suppository Substances 0.000 description 3
• 230000000699 topical effect Effects 0.000 description 3
• 230000004614 tumor growth Effects 0.000 description 3
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• 239000011534 wash buffer Substances 0.000 description 3
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
• VKIGAWAEXPTIOL-UHFFFAOYSA-N 2-hydroxyhexanenitrile Chemical compound CCCCC(O)C#N VKIGAWAEXPTIOL-UHFFFAOYSA-N 0.000 description 2
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
• 208000030507 AIDS Diseases 0.000 description 2
• 108010005094 Advanced Glycation End Products Proteins 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• HHRAXZAYZFFRAM-CIUDSAMLSA-N Ala-Leu-Asn Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O HHRAXZAYZFFRAM-CIUDSAMLSA-N 0.000 description 2
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
• YUWPMEXLKGOSBF-GACAOOTBSA-N Anecortave acetate Chemical compound O=C1CC[C@]2(C)C3=CC[C@]4(C)[C@](C(=O)COC(=O)C)(O)CC[C@H]4[C@@H]3CCC2=C1 YUWPMEXLKGOSBF-GACAOOTBSA-N 0.000 description 2
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
• 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
• 102100032366 C-C motif chemokine 7 Human genes 0.000 description 2
• 102100034871 C-C motif chemokine 8 Human genes 0.000 description 2
• 102100036153 C-X-C motif chemokine 6 Human genes 0.000 description 2
• 108010055166 Chemokine CCL5 Proteins 0.000 description 2
• 108010014419 Chemokine CXCL1 Proteins 0.000 description 2
• 102000016950 Chemokine CXCL1 Human genes 0.000 description 2
• 208000005590 Choroidal Neovascularization Diseases 0.000 description 2
• 206010060823 Choroidal neovascularisation Diseases 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 2
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 208000032843 Hemorrhage Diseases 0.000 description 2
• KFQDSSNYWKZFOO-LSJOCFKGSA-N His-Val-Ala Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(O)=O KFQDSSNYWKZFOO-LSJOCFKGSA-N 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 description 2
• 108010002352 Interleukin-1 Proteins 0.000 description 2
• SITWEMZOJNKJCH-UHFFFAOYSA-N L-alanine-L-arginine Natural products CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N SITWEMZOJNKJCH-UHFFFAOYSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
• 206010025323 Lymphomas Diseases 0.000 description 2
• 102100035304 Lymphotactin Human genes 0.000 description 2
• 206010025421 Macule Diseases 0.000 description 2
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• 208000000172 Medulloblastoma Diseases 0.000 description 2
• 208000034578 Multiple myelomas Diseases 0.000 description 2
• 241000699660 Mus musculus Species 0.000 description 2
• 238000005481 NMR spectroscopy Methods 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 108010079855 Peptide Aptamers Proteins 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 108091000080 Phosphotransferase Proteins 0.000 description 2
• 206010035226 Plasma cell myeloma Diseases 0.000 description 2
• 102100036154 Platelet basic protein Human genes 0.000 description 2
• PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 2
• 208000017442 Retinal disease Diseases 0.000 description 2
• 206010038923 Retinopathy Diseases 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
• 230000001594 aberrant effect Effects 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 235000010419 agar Nutrition 0.000 description 2
• 235000001014 amino acid Nutrition 0.000 description 2
• 229940024606 amino acid Drugs 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 229960001232 anecortave Drugs 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 206010003246 arthritis Diseases 0.000 description 2
• 230000017531 blood circulation Effects 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 238000004364 calculation method Methods 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 238000001516 cell proliferation assay Methods 0.000 description 2
• 239000006285 cell suspension Substances 0.000 description 2
• 239000002975 chemoattractant Substances 0.000 description 2
• 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 238000000576 coating method Methods 0.000 description 2
• 238000010835 comparative analysis Methods 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 230000021615 conjugation Effects 0.000 description 2
• 229920001577 copolymer Polymers 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 238000004925 denaturation Methods 0.000 description 2
• 230000036425 denaturation Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 239000008121 dextrose Substances 0.000 description 2
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 2
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 2
• 238000010790 dilution Methods 0.000 description 2
• 239000012895 dilution Substances 0.000 description 2
• 208000037765 diseases and disorders Diseases 0.000 description 2
• 238000004090 dissolution Methods 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 230000013020 embryo development Effects 0.000 description 2
• 239000003995 emulsifying agent Substances 0.000 description 2
• 210000000981 epithelium Anatomy 0.000 description 2
• 239000012091 fetal bovine serum Substances 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• 208000005017 glioblastoma Diseases 0.000 description 2
• 238000013537 high throughput screening Methods 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 239000006210 lotion Substances 0.000 description 2
• 239000000314 lubricant Substances 0.000 description 2
• 238000004020 luminiscence type Methods 0.000 description 2
• 210000001165 lymph node Anatomy 0.000 description 2
• 210000002540 macrophage Anatomy 0.000 description 2
• 235000019359 magnesium stearate Nutrition 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 229920000609 methyl cellulose Polymers 0.000 description 2
• 239000001923 methylcellulose Substances 0.000 description 2
• 235000010981 methylcellulose Nutrition 0.000 description 2
• 235000013336 milk Nutrition 0.000 description 2
• 239000008267 milk Substances 0.000 description 2
• 210000004080 milk Anatomy 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 230000030505 negative regulation of chemotaxis Effects 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 239000002674 ointment Substances 0.000 description 2
• 230000036542 oxidative stress Effects 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 102000020233 phosphotransferase Human genes 0.000 description 2
• 229960002169 plerixafor Drugs 0.000 description 2
• YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 description 2
• 229920000656 polylysine Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 239000013641 positive control Substances 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 201000007914 proliferative diabetic retinopathy Diseases 0.000 description 2
• 238000010379 pull-down assay Methods 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• 239000004627 regenerated cellulose Substances 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
• 239000001488 sodium phosphate Substances 0.000 description 2
• 229910000162 sodium phosphate Inorganic materials 0.000 description 2
• 239000007790 solid phase Substances 0.000 description 2
• 238000010532 solid phase synthesis reaction Methods 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 239000006228 supernatant Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 238000007910 systemic administration Methods 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 239000000454 talc Substances 0.000 description 2
• 229910052623 talc Inorganic materials 0.000 description 2
• 230000008685 targeting Effects 0.000 description 2
• 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
• 230000032258 transport Effects 0.000 description 2
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
• 239000002691 unilamellar liposome Substances 0.000 description 2
• 239000000080 wetting agent Substances 0.000 description 2
• 239000012224 working solution Substances 0.000 description 2
• ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• GXGKKIPUFAHZIZ-UHFFFAOYSA-N 5-benzylsulfanyl-2h-tetrazole Chemical compound C=1C=CC=CC=1CSC=1N=NNN=1 GXGKKIPUFAHZIZ-UHFFFAOYSA-N 0.000 description 1
• WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 208000008190 Agammaglobulinemia Diseases 0.000 description 1
• 229920000936 Agarose Polymers 0.000 description 1
• 206010001488 Aggression Diseases 0.000 description 1
• ODWSTKXGQGYHSH-FXQIFTODSA-N Ala-Arg-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O ODWSTKXGQGYHSH-FXQIFTODSA-N 0.000 description 1
• HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
• 206010002329 Aneurysm Diseases 0.000 description 1
• UKGGPJNBONZZCM-WDSKDSINSA-N Asp-Pro Chemical compound OC(=O)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O UKGGPJNBONZZCM-WDSKDSINSA-N 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• PCLCDPVEEFVAAQ-UHFFFAOYSA-N BCA 1 Chemical compound CC(CO)CCCC(C)C1=CCC(C)(O)C1CC2=C(O)C(O)CCC2=O PCLCDPVEEFVAAQ-UHFFFAOYSA-N 0.000 description 1
• 108010001478 Bacitracin Proteins 0.000 description 1
• GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 108050005711 C Chemokine Proteins 0.000 description 1
• 102000017483 C chemokine Human genes 0.000 description 1
• 102100036841 C-C motif chemokine 1 Human genes 0.000 description 1
• 102100023702 C-C motif chemokine 13 Human genes 0.000 description 1
• 101710112613 C-C motif chemokine 13 Proteins 0.000 description 1
• 101710155834 C-C motif chemokine 7 Proteins 0.000 description 1
• 101710155833 C-C motif chemokine 8 Proteins 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 description 1
• 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 description 1
• 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 description 1
• 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 description 1
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 1
• 102100025279 C-X-C motif chemokine 11 Human genes 0.000 description 1
• 101710098272 C-X-C motif chemokine 11 Proteins 0.000 description 1
• 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 1
• 102100039398 C-X-C motif chemokine 2 Human genes 0.000 description 1
• 102100036189 C-X-C motif chemokine 3 Human genes 0.000 description 1
• 101710085504 C-X-C motif chemokine 6 Proteins 0.000 description 1
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• 102000004325 CX3C Chemokines Human genes 0.000 description 1
• 108010081635 CX3C Chemokines Proteins 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 229940122444 Chemokine receptor antagonist Drugs 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 206010009944 Colon cancer Diseases 0.000 description 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 241000699800 Cricetinae Species 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• 230000004568 DNA-binding Effects 0.000 description 1
• SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
• 238000008157 ELISA kit Methods 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 102100023688 Eotaxin Human genes 0.000 description 1
• 101710139422 Eotaxin Proteins 0.000 description 1
• 108090000394 Erythropoietin Proteins 0.000 description 1
• 102000003951 Erythropoietin Human genes 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 206010015866 Extravasation Diseases 0.000 description 1
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 102100034221 Growth-regulated alpha protein Human genes 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• 102100025255 Haptoglobin Human genes 0.000 description 1
• 108050005077 Haptoglobin Proteins 0.000 description 1
• FSOXZQBMPBQKGJ-QSFUFRPTSA-N His-Ile-Ala Chemical compound [O-]C(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]([NH3+])CC1=CN=CN1 FSOXZQBMPBQKGJ-QSFUFRPTSA-N 0.000 description 1
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
• 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 description 1
• 101000946794 Homo sapiens C-C motif chemokine 8 Proteins 0.000 description 1
• 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 description 1
• 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 description 1
• 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 description 1
• 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 1
• 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 description 1
• 101000947193 Homo sapiens C-X-C motif chemokine 3 Proteins 0.000 description 1
• 101000947177 Homo sapiens C-X-C motif chemokine 6 Proteins 0.000 description 1
• 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 1
• 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 1
• 101000804764 Homo sapiens Lymphotactin Proteins 0.000 description 1
• 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
• 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 description 1
• 101000826116 Homo sapiens Single-stranded DNA-binding protein 3 Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
• 206010020983 Hypogammaglobulinaemia Diseases 0.000 description 1
• 206010021143 Hypoxia Diseases 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 108010065920 Insulin Lispro Proteins 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 102100026236 Interleukin-8 Human genes 0.000 description 1
• 108010018951 Interleukin-8B Receptors Proteins 0.000 description 1
• 229930194542 Keto Natural products 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• XGDCYUQSFDQISZ-BQBZGAKWSA-N Leu-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(O)=O XGDCYUQSFDQISZ-BQBZGAKWSA-N 0.000 description 1
• 239000012097 Lipofectamine 2000 Substances 0.000 description 1
• AIXUQKMMBQJZCU-IUCAKERBSA-N Lys-Pro Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O AIXUQKMMBQJZCU-IUCAKERBSA-N 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 206010027454 Metastases to breast Diseases 0.000 description 1
• 208000009857 Microaneurysm Diseases 0.000 description 1
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 1
• 101100442582 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) spe-1 gene Proteins 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
• REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 229930040373 Paraformaldehyde Natural products 0.000 description 1
• 208000012641 Pigmentation disease Diseases 0.000 description 1
• 102100030304 Platelet factor 4 Human genes 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
• 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 102000001253 Protein Kinase Human genes 0.000 description 1
• 102000003923 Protein Kinase C Human genes 0.000 description 1
• 108090000315 Protein Kinase C Proteins 0.000 description 1
• 108010076504 Protein Sorting Signals Proteins 0.000 description 1
• 108091008103 RNA aptamers Proteins 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 230000010799 Receptor Interactions Effects 0.000 description 1
• 208000007135 Retinal Neovascularization Diseases 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 239000012722 SDS sample buffer Substances 0.000 description 1
• WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 108010034546 Serratia marcescens nuclease Proteins 0.000 description 1
• 102100023008 Single-stranded DNA-binding protein 3 Human genes 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• 108020004459 Small interfering RNA Proteins 0.000 description 1
• BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 230000009809 T cell chemotaxis Effects 0.000 description 1
• 108010045306 T134 peptide Proteins 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 1
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 1
• 208000001910 Ventricular Heart Septal Defects Diseases 0.000 description 1
• 208000000260 Warts Diseases 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• PTKRUDMLGIIORX-ITGWJZMWSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3s,4r,5r)-5-(3-carbamoyl-4h-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate;cyclohexanamine Chemical compound NC1CCCCC1.NC1CCCCC1.NC1CCCCC1.NC1CCCCC1.C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 PTKRUDMLGIIORX-ITGWJZMWSA-N 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• 230000004308 accommodation Effects 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• YJVBLROMQZEFPA-UHFFFAOYSA-L acid red 26 Chemical compound [Na+].[Na+].CC1=CC(C)=CC=C1N=NC1=C(O)C(S([O-])(=O)=O)=CC2=CC(S([O-])(=O)=O)=CC=C12 YJVBLROMQZEFPA-UHFFFAOYSA-L 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 230000033289 adaptive immune response Effects 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 150000003835 adenosine derivatives Chemical class 0.000 description 1
• 150000003838 adenosines Chemical class 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 230000016571 aggressive behavior Effects 0.000 description 1
• 208000012761 aggressive behavior Diseases 0.000 description 1
• 230000032683 aging Effects 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 230000002491 angiogenic effect Effects 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000003527 anti-angiogenesis Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000001745 anti-biotin effect Effects 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 230000003140 astrocytic effect Effects 0.000 description 1
• 230000001363 autoimmune Effects 0.000 description 1
• 229940120638 avastin Drugs 0.000 description 1
• 229960003071 bacitracin Drugs 0.000 description 1
• 229930184125 bacitracin Natural products 0.000 description 1
• CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 239000000440 bentonite Substances 0.000 description 1
• 229910000278 bentonite Inorganic materials 0.000 description 1
• 235000012216 bentonite Nutrition 0.000 description 1
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
• 229960000397 bevacizumab Drugs 0.000 description 1
• 239000012148 binding buffer Substances 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 229920002988 biodegradable polymer Polymers 0.000 description 1
• 239000004621 biodegradable polymer Substances 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 239000012472 biological sample Substances 0.000 description 1
• PFYXSUNOLOJMDX-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) carbonate Chemical compound O=C1CCC(=O)N1OC(=O)ON1C(=O)CCC1=O PFYXSUNOLOJMDX-UHFFFAOYSA-N 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
• 239000012888 bovine serum Substances 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 210000004958 brain cell Anatomy 0.000 description 1
• UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
• 210000001775 bruch membrane Anatomy 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 235000011148 calcium chloride Nutrition 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 229910001424 calcium ion Inorganic materials 0.000 description 1
• 238000011088 calibration curve Methods 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000034196 cell chemotaxis Effects 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000011712 cell development Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 230000012292 cell migration Effects 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 125000003636 chemical group Chemical group 0.000 description 1
• 239000002559 chemokine receptor antagonist Substances 0.000 description 1
• 230000035572 chemosensitivity Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 230000004456 color vision Effects 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 230000009918 complex formation Effects 0.000 description 1
• 230000001010 compromised effect Effects 0.000 description 1
• 210000002808 connective tissue Anatomy 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 239000011258 core-shell material Substances 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 239000003246 corticosteroid Substances 0.000 description 1
• 229960001334 corticosteroids Drugs 0.000 description 1
• 150000001887 cortisones Chemical class 0.000 description 1
• 238000011262 co‐therapy Methods 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 239000002254 cytotoxic agent Substances 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000010511 deprotection reaction Methods 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 239000007933 dermal patch Substances 0.000 description 1
• 239000000032 diagnostic agent Substances 0.000 description 1
• 229940039227 diagnostic agent Drugs 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 230000008034 disappearance Effects 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• 239000002612 dispersion medium Substances 0.000 description 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 229940105423 erythropoietin Drugs 0.000 description 1
• 229940073579 ethanolamine hydrochloride Drugs 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 238000004880 explosion Methods 0.000 description 1
• 210000003722 extracellular fluid Anatomy 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 230000036251 extravasation Effects 0.000 description 1
• 208000030533 eye disease Diseases 0.000 description 1
• 239000003889 eye drop Substances 0.000 description 1
• 229940012356 eye drops Drugs 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 238000010230 functional analysis Methods 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 230000024924 glomerular filtration Effects 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 201000005787 hematologic cancer Diseases 0.000 description 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 238000011134 hematopoietic stem cell transplantation Methods 0.000 description 1
• 230000003284 homeostatic effect Effects 0.000 description 1
• 102000046949 human MSC Human genes 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 210000004408 hybridoma Anatomy 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 230000007954 hypoxia Effects 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 230000003100 immobilizing effect Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 230000037451 immune surveillance Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 229940102213 injectable suspension Drugs 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 208000010746 intraretinal hemorrhage Diseases 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
• 125000000468 ketone group Chemical group 0.000 description 1
• 230000003907 kidney function Effects 0.000 description 1
• 150000002605 large molecules Chemical class 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• 150000002617 leukotrienes Chemical class 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 230000003908 liver function Effects 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 208000018769 loss of vision Diseases 0.000 description 1
• 231100000864 loss of vision Toxicity 0.000 description 1
• 229940076783 lucentis Drugs 0.000 description 1
• 238000000504 luminescence detection Methods 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 108010019677 lymphotactin Proteins 0.000 description 1
• 229940092110 macugen Drugs 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• 159000000003 magnesium salts Chemical class 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 210000003519 mature b lymphocyte Anatomy 0.000 description 1
• AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 210000003593 megakaryocyte Anatomy 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 239000011859 microparticle Substances 0.000 description 1
• 238000010232 migration assay Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• HZAXFHJVJLSVMW-UHFFFAOYSA-N monoethanolamine hydrochloride Natural products NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 238000011294 monotherapeutic Methods 0.000 description 1
• VDUIPQNXOQMTBF-UHFFFAOYSA-N n-ethylhydroxylamine Chemical compound CCNO VDUIPQNXOQMTBF-UHFFFAOYSA-N 0.000 description 1
• 210000004897 n-terminal region Anatomy 0.000 description 1
• 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
• 230000010807 negative regulation of binding Effects 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 239000002858 neurotransmitter agent Substances 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 230000009935 nitrosation Effects 0.000 description 1
• 238000007034 nitrosation reaction Methods 0.000 description 1
• 231100000957 no side effect Toxicity 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 239000002853 nucleic acid probe Substances 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 230000005868 ontogenesis Effects 0.000 description 1
• 239000006186 oral dosage form Substances 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000006072 paste Substances 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• 230000003950 pathogenic mechanism Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• LUYQYZLEHLTPBH-UHFFFAOYSA-N perfluorobutanesulfonyl fluoride Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=O LUYQYZLEHLTPBH-UHFFFAOYSA-N 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• QGVLYPPODPLXMB-QXYKVGAMSA-N phorbol Natural products C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@H]3C=C(CO)C[C@@]4(O)[C@H](C=C(C)C4=O)[C@@]13O)C2(C)C QGVLYPPODPLXMB-QXYKVGAMSA-N 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 150000008105 phosphatidylcholines Chemical class 0.000 description 1
• 150000004713 phosphodiesters Chemical class 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 238000002428 photodynamic therapy Methods 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 230000004983 pleiotropic effect Effects 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 229920001515 polyalkylene glycol Polymers 0.000 description 1
• 239000004417 polycarbonate Substances 0.000 description 1
• 229920000515 polycarbonate Polymers 0.000 description 1
• 229920002721 polycyanoacrylate Polymers 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 229920006324 polyoxymethylene Polymers 0.000 description 1
• 230000030786 positive chemotaxis Effects 0.000 description 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 230000001023 pro-angiogenic effect Effects 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 150000003180 prostaglandins Chemical class 0.000 description 1
• 108060006633 protein kinase Proteins 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 125000000714 pyrimidinyl group Chemical group 0.000 description 1
• 239000003642 reactive oxygen metabolite Substances 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 238000001525 receptor binding assay Methods 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 230000001172 regenerating effect Effects 0.000 description 1
• 238000004153 renaturation Methods 0.000 description 1
• 230000000241 respiratory effect Effects 0.000 description 1
• 239000000790 retinal pigment Substances 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 239000012898 sample dilution Substances 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 229940071089 sarcosinate Drugs 0.000 description 1
• 210000004761 scalp Anatomy 0.000 description 1
• 230000037390 scarring Effects 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 238000004088 simulation Methods 0.000 description 1
• 235000020183 skimmed milk Nutrition 0.000 description 1
• 201000010153 skin papilloma Diseases 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 235000015424 sodium Nutrition 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
• RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
• 239000008247 solid mixture Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 238000011895 specific detection Methods 0.000 description 1
• 238000013222 sprague-dawley male rat Methods 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000007939 sustained release tablet Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 150000003595 thromboxanes Chemical class 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 230000037317 transdermal delivery Effects 0.000 description 1
• 238000011830 transgenic mouse model Methods 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
• 229940117013 triethanolamine oleate Drugs 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 210000005167 vascular cell Anatomy 0.000 description 1
• 239000002525 vasculotropin inhibitor Substances 0.000 description 1
• YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 1
• 230000000007 visual effect Effects 0.000 description 1
• 230000004393 visual impairment Effects 0.000 description 1
• 238000011179 visual inspection Methods 0.000 description 1
• 229940061392 visudyne Drugs 0.000 description 1
• 239000003643 water by type Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 235000019786 weight gain Nutrition 0.000 description 1
• 238000002424 x-ray crystallography Methods 0.000 description 1
• 239000000230 xanthan gum Substances 0.000 description 1
• 235000010493 xanthan gum Nutrition 0.000 description 1
• 229920001285 xanthan gum Polymers 0.000 description 1
• 229940082509 xanthan gum Drugs 0.000 description 1
• 229930195724 β-lactose Natural products 0.000 description 1
• DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1