PT1963278E - Derivados substituídos de imidazolina - Google Patents
Derivados substituídos de imidazolina Download PDFInfo
- Publication number
- PT1963278E PT1963278E PT06841028T PT06841028T PT1963278E PT 1963278 E PT1963278 E PT 1963278E PT 06841028 T PT06841028 T PT 06841028T PT 06841028 T PT06841028 T PT 06841028T PT 1963278 E PT1963278 E PT 1963278E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- aryl
- saturated
- optionally substituted
- imidazoline derivatives
- Prior art date
Links
- 150000002462 imidazolines Chemical class 0.000 title abstract 3
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 101001122476 Homo sapiens Mu-type opioid receptor Proteins 0.000 abstract 2
- 102100028647 Mu-type opioid receptor Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000002075 anti-alcohol Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000001139 anti-pruritic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000003908 antipruritic agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005061430A DE102005061430A1 (de) | 2005-12-22 | 2005-12-22 | Substituierte Imidazolin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1963278E true PT1963278E (pt) | 2009-12-16 |
Family
ID=37946192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06841028T PT1963278E (pt) | 2005-12-22 | 2006-12-19 | Derivados substituídos de imidazolina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7728028B2 (enExample) |
| EP (1) | EP1963278B1 (enExample) |
| JP (1) | JP2009523124A (enExample) |
| CN (1) | CN101384557A (enExample) |
| AT (1) | ATE449075T1 (enExample) |
| AU (1) | AU2006334743B2 (enExample) |
| CA (1) | CA2633918A1 (enExample) |
| CY (1) | CY1110465T1 (enExample) |
| DE (2) | DE102005061430A1 (enExample) |
| DK (1) | DK1963278T3 (enExample) |
| ES (1) | ES2336833T3 (enExample) |
| IL (1) | IL192268A0 (enExample) |
| PL (1) | PL1963278T3 (enExample) |
| PT (1) | PT1963278E (enExample) |
| RU (1) | RU2427571C2 (enExample) |
| SI (1) | SI1963278T1 (enExample) |
| WO (1) | WO2007079927A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2257526T3 (pl) | 2008-03-27 | 2012-05-31 | Gruenenthal Gmbh | Pochodne spiro (5.5) undekanu |
| US8357705B2 (en) | 2008-03-27 | 2013-01-22 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| ES2694103T3 (es) | 2008-03-27 | 2018-12-18 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
| CL2009000731A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Gmbh | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. |
| JP5599774B2 (ja) | 2008-03-27 | 2014-10-01 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヒドロキシメチルシクロヘキシルアミン類 |
| HUE026184T2 (en) | 2008-03-27 | 2016-05-30 | Gruenenthal Gmbh | (Hetero-) aryl-cyclohexane derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9034798A (en) * | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treating pain |
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
| US7183276B2 (en) * | 2002-02-28 | 2007-02-27 | Takeda Pharmaceutical Company Limited | Azole compounds |
| US6878735B2 (en) * | 2002-05-31 | 2005-04-12 | Board Of Trustees Of Michigan State University | Multi-substituted imidazolines and method of use thereof |
| US7345078B2 (en) * | 2002-05-31 | 2008-03-18 | The Board Of Trustees Of Michigan State University | NF-κB inhibitors and uses thereof |
| DE102005061429A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxazol-Derivate |
-
2005
- 2005-12-22 DE DE102005061430A patent/DE102005061430A1/de not_active Withdrawn
-
2006
- 2006-12-19 AT AT06841028T patent/ATE449075T1/de active
- 2006-12-19 PT PT06841028T patent/PT1963278E/pt unknown
- 2006-12-19 JP JP2008546224A patent/JP2009523124A/ja not_active Ceased
- 2006-12-19 RU RU2008129377/04A patent/RU2427571C2/ru not_active IP Right Cessation
- 2006-12-19 DE DE502006005426T patent/DE502006005426D1/de active Active
- 2006-12-19 CN CNA2006800532577A patent/CN101384557A/zh active Pending
- 2006-12-19 SI SI200630546T patent/SI1963278T1/sl unknown
- 2006-12-19 ES ES06841028T patent/ES2336833T3/es active Active
- 2006-12-19 WO PCT/EP2006/012221 patent/WO2007079927A1/de not_active Ceased
- 2006-12-19 EP EP06841028A patent/EP1963278B1/de not_active Not-in-force
- 2006-12-19 DK DK06841028.1T patent/DK1963278T3/da active
- 2006-12-19 AU AU2006334743A patent/AU2006334743B2/en not_active Ceased
- 2006-12-19 CA CA002633918A patent/CA2633918A1/en not_active Abandoned
- 2006-12-19 PL PL06841028T patent/PL1963278T3/pl unknown
-
2008
- 2008-06-18 IL IL192268A patent/IL192268A0/en unknown
- 2008-06-20 US US12/143,566 patent/US7728028B2/en not_active Expired - Fee Related
-
2010
- 2010-02-02 CY CY20101100093T patent/CY1110465T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1963278T1 (sl) | 2010-03-31 |
| DE502006005426D1 (de) | 2009-12-31 |
| EP1963278B1 (de) | 2009-11-18 |
| US20090048323A1 (en) | 2009-02-19 |
| ATE449075T1 (de) | 2009-12-15 |
| AU2006334743A1 (en) | 2007-07-19 |
| RU2427571C2 (ru) | 2011-08-27 |
| CN101384557A (zh) | 2009-03-11 |
| US7728028B2 (en) | 2010-06-01 |
| CA2633918A1 (en) | 2007-07-19 |
| WO2007079927A1 (de) | 2007-07-19 |
| CY1110465T1 (el) | 2015-04-29 |
| AU2006334743B2 (en) | 2011-07-07 |
| HK1122019A1 (zh) | 2009-05-08 |
| EP1963278A1 (de) | 2008-09-03 |
| IL192268A0 (en) | 2008-12-29 |
| DE102005061430A1 (de) | 2007-07-05 |
| DK1963278T3 (da) | 2010-03-29 |
| JP2009523124A (ja) | 2009-06-18 |
| PL1963278T3 (pl) | 2010-04-30 |
| RU2008129377A (ru) | 2010-03-27 |
| ES2336833T3 (es) | 2010-04-16 |
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