ES2336833T3 - Derivados de imidazolina sustituidos. - Google Patents

Derivados de imidazolina sustituidos. Download PDF

Info

Publication number
ES2336833T3
ES2336833T3 ES06841028T ES06841028T ES2336833T3 ES 2336833 T3 ES2336833 T3 ES 2336833T3 ES 06841028 T ES06841028 T ES 06841028T ES 06841028 T ES06841028 T ES 06841028T ES 2336833 T3 ES2336833 T3 ES 2336833T3
Authority
ES
Spain
Prior art keywords
methyl
dimethylamino
dihydro
imidazol
cyclohexylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06841028T
Other languages
English (en)
Spanish (es)
Inventor
Beatrix Merla
Stefan Oberborsch
Bernd Sundermann
Werner Englberger
Hagen-Heinrich Hennies
Heinz Graubaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Chemie Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH, Chemie Gruenenthal GmbH filed Critical Gruenenthal GmbH
Application granted granted Critical
Publication of ES2336833T3 publication Critical patent/ES2336833T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES06841028T 2005-12-22 2006-12-19 Derivados de imidazolina sustituidos. Active ES2336833T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005061430 2005-12-22
DE102005061430A DE102005061430A1 (de) 2005-12-22 2005-12-22 Substituierte Imidazolin-Derivate

Publications (1)

Publication Number Publication Date
ES2336833T3 true ES2336833T3 (es) 2010-04-16

Family

ID=37946192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06841028T Active ES2336833T3 (es) 2005-12-22 2006-12-19 Derivados de imidazolina sustituidos.

Country Status (17)

Country Link
US (1) US7728028B2 (enExample)
EP (1) EP1963278B1 (enExample)
JP (1) JP2009523124A (enExample)
CN (1) CN101384557A (enExample)
AT (1) ATE449075T1 (enExample)
AU (1) AU2006334743B2 (enExample)
CA (1) CA2633918A1 (enExample)
CY (1) CY1110465T1 (enExample)
DE (2) DE102005061430A1 (enExample)
DK (1) DK1963278T3 (enExample)
ES (1) ES2336833T3 (enExample)
IL (1) IL192268A0 (enExample)
PL (1) PL1963278T3 (enExample)
PT (1) PT1963278E (enExample)
RU (1) RU2427571C2 (enExample)
SI (1) SI1963278T1 (enExample)
WO (1) WO2007079927A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2257526T3 (pl) 2008-03-27 2012-05-31 Gruenenthal Gmbh Pochodne spiro (5.5) undekanu
US8357705B2 (en) 2008-03-27 2013-01-22 Gruenenthal Gmbh Substituted cyclohexyldiamines
ES2694103T3 (es) 2008-03-27 2018-12-18 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
CL2009000731A1 (es) 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea.
JP5599774B2 (ja) 2008-03-27 2014-10-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヒドロキシメチルシクロヘキシルアミン類
HUE026184T2 (en) 2008-03-27 2016-05-30 Gruenenthal Gmbh (Hetero-) aryl-cyclohexane derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9034798A (en) * 1997-08-28 1999-03-16 Eli Lilly And Company Method for treating pain
US5952360A (en) * 1997-08-28 1999-09-14 Eli Lilly And Company Method for treating neuropathic pain
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
US6878735B2 (en) * 2002-05-31 2005-04-12 Board Of Trustees Of Michigan State University Multi-substituted imidazolines and method of use thereof
US7345078B2 (en) * 2002-05-31 2008-03-18 The Board Of Trustees Of Michigan State University NF-κB inhibitors and uses thereof
DE102005061429A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxazol-Derivate

Also Published As

Publication number Publication date
PT1963278E (pt) 2009-12-16
SI1963278T1 (sl) 2010-03-31
DE502006005426D1 (de) 2009-12-31
EP1963278B1 (de) 2009-11-18
US20090048323A1 (en) 2009-02-19
ATE449075T1 (de) 2009-12-15
AU2006334743A1 (en) 2007-07-19
RU2427571C2 (ru) 2011-08-27
CN101384557A (zh) 2009-03-11
US7728028B2 (en) 2010-06-01
CA2633918A1 (en) 2007-07-19
WO2007079927A1 (de) 2007-07-19
CY1110465T1 (el) 2015-04-29
AU2006334743B2 (en) 2011-07-07
HK1122019A1 (zh) 2009-05-08
EP1963278A1 (de) 2008-09-03
IL192268A0 (en) 2008-12-29
DE102005061430A1 (de) 2007-07-05
DK1963278T3 (da) 2010-03-29
JP2009523124A (ja) 2009-06-18
PL1963278T3 (pl) 2010-04-30
RU2008129377A (ru) 2010-03-27

Similar Documents

Publication Publication Date Title
JP4885733B2 (ja) Ｏｒｌ１レセプターに対する親和性を有するスピロ環状シクロヘキサン誘導体
RU2525236C2 (ru) Замещенные производные 4-аминоциклогексана
ES2368266T3 (es) Derivados de ciclohexano espirocíclicos de efecto analgésico.
ES2482108T3 (es) Hidroximetilciclohexilaminas
US20070213351A1 (en) Spirocyclic cyclohexane compounds
US7589113B2 (en) Substituted oxadiazole compounds and their use as opioid receptor ligands
ES2395430T3 (es) Derivados de ciclohexil-1,4-diamina sustituidos con heteroarilo
PT1751093E (pt) Derivados de ácido ciclo-hexilacético substituídos
ES2336833T3 (es) Derivados de imidazolina sustituidos.
JP5650637B2 (ja) （ヘテロ−）アリール−シクロヘキサン誘導体
JP4663239B2 (ja) 置換された４−アミノシクロヘキサノール
PL208676B1 (pl) Podstawione 4-aminocykloheksanole, sposób ich wytwarzania, ich zastosowanie i środek leczniczy
ES2279195T3 (es) Derivados de 4-alquil/4-alquenil/4-alquenilmetil/-1-arilciclohexilamina.
JP4126271B2 (ja) 置換された４−アミノシクロヘキサノール誘導体
ES2482109T3 (es) Derivados de ácido ciclohexanoico sustituidos
JP2009520718A (ja) 鎮痛作用を有する置換されたオキサゾール誘導体
MX2008008067A (en) Substituted imidazoline derivatives
US20090215725A1 (en) Substituted 4-aminocyclohexane derivatives