PT1851239E - Vírus de rna com replicação deficiente como vacinas - Google Patents
Vírus de rna com replicação deficiente como vacinas Download PDFInfo
- Publication number
- PT1851239E PT1851239E PT06706871T PT06706871T PT1851239E PT 1851239 E PT1851239 E PT 1851239E PT 06706871 T PT06706871 T PT 06706871T PT 06706871 T PT06706871 T PT 06706871T PT 1851239 E PT1851239 E PT 1851239E
- Authority
- PT
- Portugal
- Prior art keywords
- cell
- iii
- dna molecule
- genome
- replication
- Prior art date
Links
- 230000010076 replication Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 230000002950 deficient Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 3
- 102000053602 DNA Human genes 0.000 abstract 3
- 238000012258 culturing Methods 0.000 abstract 2
- 241001493065 dsRNA viruses Species 0.000 abstract 2
- 230000009368 gene silencing by RNA Effects 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 102000053642 Catalytic RNA Human genes 0.000 abstract 1
- 108090000994 Catalytic RNA Proteins 0.000 abstract 1
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 abstract 1
- 101150062031 L gene Proteins 0.000 abstract 1
- 101710141454 Nucleoprotein Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 101150084044 P gene Proteins 0.000 abstract 1
- 102100034574 P protein Human genes 0.000 abstract 1
- 101710181008 P protein Proteins 0.000 abstract 1
- 101710177166 Phosphoprotein Proteins 0.000 abstract 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 1
- 108091030071 RNAI Proteins 0.000 abstract 1
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 1
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 108091092562 ribozyme Proteins 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- 239000012873 virucide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005006388A DE102005006388A1 (de) | 2005-02-11 | 2005-02-11 | Replikationsdefiziente RNA-Viren als Impfstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1851239E true PT1851239E (pt) | 2009-04-28 |
Family
ID=36353666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06706871T PT1851239E (pt) | 2005-02-11 | 2006-02-10 | Vírus de rna com replicação deficiente como vacinas |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20090041725A1 (pt) |
| EP (2) | EP1851239B1 (pt) |
| JP (2) | JP5679620B2 (pt) |
| KR (1) | KR101279636B1 (pt) |
| CN (1) | CN101155826B (pt) |
| AT (1) | ATE421529T1 (pt) |
| AU (1) | AU2006212385B2 (pt) |
| BR (1) | BRPI0607487A2 (pt) |
| CA (1) | CA2599036C (pt) |
| DE (2) | DE102005006388A1 (pt) |
| DK (1) | DK1851239T3 (pt) |
| EA (1) | EA015013B1 (pt) |
| ES (1) | ES2321651T3 (pt) |
| HK (1) | HK1118297A1 (pt) |
| HR (1) | HRP20090230T1 (pt) |
| IL (1) | IL185147A (pt) |
| MX (1) | MX2007009628A (pt) |
| PL (1) | PL1851239T3 (pt) |
| PT (1) | PT1851239E (pt) |
| RS (1) | RS50977B (pt) |
| SI (1) | SI1851239T1 (pt) |
| WO (1) | WO2006084746A1 (pt) |
| ZA (1) | ZA200707216B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005006388A1 (de) | 2005-02-11 | 2006-08-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Replikationsdefiziente RNA-Viren als Impfstoffe |
| HRP20221475T3 (hr) | 2007-12-27 | 2023-01-06 | Universität Zürich | Replikacijski defektni vektori arenavirusa |
| EP2085479A1 (en) * | 2008-01-31 | 2009-08-05 | Institut Pasteur | Reverse genetics of negative-strand rna viruses in yeast |
| JP5633075B2 (ja) * | 2009-05-18 | 2014-12-03 | 独立行政法人産業技術総合研究所 | 多能性幹細胞作成用ベクター材料及びこれを用いた多能性幹細胞作成方法 |
| US9365866B2 (en) | 2009-06-03 | 2016-06-14 | National Institute Of Advanced Industrial Science And Technology | Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same |
| DE102010018961B4 (de) * | 2010-04-23 | 2012-09-20 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Genetisch modifiziertes Paramyxovirus zur Behandlung von Tumorerkrankungen |
| ES2640113T3 (es) | 2011-02-08 | 2017-10-31 | Mie University | Método para producir un vector viral para la transferencia génica |
| JP6757121B2 (ja) * | 2011-10-05 | 2020-09-16 | ジェンヴェック エルエルシー | シミアン（ゴリラ）アデノウイルス又はアデノウイルスベクター、及び使用方法 |
| EP2669381A1 (en) * | 2012-05-30 | 2013-12-04 | AmVac AG | Method for expression of heterologous proteins using a recombinant negative-strand RNA virus vector comprising a mutated P protein |
| EP2968506B1 (en) | 2013-03-15 | 2019-07-31 | Université de Genève | Anti-mycobacterial vaccines |
| EP2813574B1 (en) * | 2013-06-10 | 2019-02-20 | RSV Genius GmbH | Semi-live respiratory syncytial virus vaccine |
| WO2014198407A1 (en) * | 2013-06-10 | 2014-12-18 | Amvac Ag | Semi-live respiratory syncytial virus vaccine |
| WO2023227758A1 (en) | 2022-05-25 | 2023-11-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccine with reduced anti-vector antigenicity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
| WO1997016539A1 (fr) * | 1995-11-01 | 1997-05-09 | Dnavec Research Inc. | Virus sendai recombinant |
| AU785148B2 (en) | 1999-12-10 | 2006-10-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| JP4791651B2 (ja) * | 2000-05-18 | 2011-10-12 | 株式会社ディナベック研究所 | 外来遺伝子導入用パラミクソウイルスベクター |
| KR20040039366A (ko) * | 2001-09-18 | 2004-05-10 | 가부시키가이샤 디나벡크 겐큐쇼 | 입자 형성능이 저하된 （－）가닥 ｒｎａ 바이러스 벡터의 검사방법 및 제조방법 |
| JP2004344001A (ja) * | 2003-03-07 | 2004-12-09 | Dnavec Research Inc | 胚性幹細胞に遺伝子を導入する方法 |
| JP2004357689A (ja) * | 2003-06-03 | 2004-12-24 | Dnavec Research Inc | 遺伝子導入ベクターの非侵襲的インビボ評価方法 |
| KR101020532B1 (ko) * | 2003-06-09 | 2011-03-09 | 와이어쓰 엘엘씨 | ｃＤＮＡ로부터의 비분절 네가티브 쇄 ＲＮＡ 바이러스의 회수를 위한 개선된 방법 |
| DE102005006388A1 (de) | 2005-02-11 | 2006-08-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Replikationsdefiziente RNA-Viren als Impfstoffe |
-
2005
- 2005-02-11 DE DE102005006388A patent/DE102005006388A1/de not_active Withdrawn
-
2006
- 2006-02-10 EA EA200701695A patent/EA015013B1/ru not_active IP Right Cessation
- 2006-02-10 EP EP06706871A patent/EP1851239B1/de active Active
- 2006-02-10 AT AT06706871T patent/ATE421529T1/de active
- 2006-02-10 PT PT06706871T patent/PT1851239E/pt unknown
- 2006-02-10 CA CA2599036A patent/CA2599036C/en not_active Expired - Fee Related
- 2006-02-10 CN CN2006800090622A patent/CN101155826B/zh active Active
- 2006-02-10 AU AU2006212385A patent/AU2006212385B2/en not_active Ceased
- 2006-02-10 PL PL06706871T patent/PL1851239T3/pl unknown
- 2006-02-10 JP JP2007554510A patent/JP5679620B2/ja not_active Expired - Fee Related
- 2006-02-10 DE DE502006002711T patent/DE502006002711D1/de active Active
- 2006-02-10 WO PCT/EP2006/001251 patent/WO2006084746A1/de active Application Filing
- 2006-02-10 ES ES06706871T patent/ES2321651T3/es active Active
- 2006-02-10 BR BRPI0607487-1A patent/BRPI0607487A2/pt not_active Application Discontinuation
- 2006-02-10 MX MX2007009628A patent/MX2007009628A/es active IP Right Grant
- 2006-02-10 DK DK06706871T patent/DK1851239T3/da active
- 2006-02-10 KR KR1020077020606A patent/KR101279636B1/ko active IP Right Grant
- 2006-02-10 EP EP09000617A patent/EP2045260A1/de not_active Withdrawn
- 2006-02-10 SI SI200630270T patent/SI1851239T1/sl unknown
- 2006-02-10 RS RSP-2009/0185A patent/RS50977B/sr unknown
-
2007
- 2007-08-09 IL IL185147A patent/IL185147A/en not_active IP Right Cessation
- 2007-08-09 US US11/836,322 patent/US20090041725A1/en not_active Abandoned
- 2007-08-27 ZA ZA200707216A patent/ZA200707216B/en unknown
-
2008
- 2008-08-20 HK HK08109296.4A patent/HK1118297A1/xx not_active IP Right Cessation
-
2009
- 2009-04-20 HR HR20090230T patent/HRP20090230T1/xx unknown
-
2012
- 2012-07-23 JP JP2012162993A patent/JP2012213407A/ja active Pending
-
2017
- 2017-05-25 US US15/605,568 patent/US11028409B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1118297A1 (en) | Replication-deficient rna viruses as vaccines | |
| EP1747023B1 (en) | Methods and compositions for reducing hcv viral genome amounts in a target cell | |
| Varnavski et al. | Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors | |
| Kneidinger et al. | Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery | |
| GB201103167D0 (en) | Gene silencing | |
| Rothe et al. | Rapid construction of adeno-associated virus vectors expressing multiple short hairpin RNAs with high antiviral activity against echovirus 30 | |
| Kayhan et al. | Inhibition of hepatitis B virus replication by shRNAs in stably HBV expressed HEPG2 2.2. 15 cell lines | |
| Peng et al. | shRNA driven by Pol II/T7 dual-promoter system effectively induce cell-specific RNA interference in mammalian cells | |
| WO2007149946A3 (en) | Composition and methods for expressing reporter molecules in mammalian cells | |
| Hinzman et al. | Selection for gene junction sequences important for VSV transcription | |
| US8957199B2 (en) | Oligoribonucleotide or peptide nucleic acid capable of inhibiting activity of hepatitis C virus | |
| JP4228071B2 (ja) | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド | |
| JP2017000015A (ja) | 目的遺伝子の発現誘導可能なウイルスベクター | |
| EP2485745B1 (en) | A composition for creating conditional lethality of virus mutants and for eliminating the viability of an eukaryotic cell | |
| AU2015201136B2 (en) | Methods and compositions for reducing viral genome amounts in a target cell | |
| CN115667524A (zh) | 病毒载体生产 | |
| TW200714713A (en) | A virus vector for inducing gene inactivation of plants | |
| JPWO2007100091A1 (ja) | フコシルトランスフェラーゼの発現を抑制するための組成物 | |
| JP2007110995A (ja) | 遺伝子導入方法 | |
| Scott | Inhibition of Rift Valley Fever virus using RNA interference technology | |
| US20170226550A1 (en) | Inhibitory rna for enhanced protein production in recombinant mammalian cells |