PT1828172E - Derivados de pirrol com a actividade antagonista de receptor crth2 - Google Patents

Derivados de pirrol com a actividade antagonista de receptor crth2 Download PDF

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Publication number
PT1828172E
PT1828172E PT05815747T PT05815747T PT1828172E PT 1828172 E PT1828172 E PT 1828172E PT 05815747 T PT05815747 T PT 05815747T PT 05815747 T PT05815747 T PT 05815747T PT 1828172 E PT1828172 E PT 1828172E
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PT
Portugal
Prior art keywords
cyano
phenyl
pyrrol
acetic acid
trifluoromethyl
Prior art date
Application number
PT05815747T
Other languages
English (en)
Portuguese (pt)
Inventor
Simon James Watson
Catherine Leblanc
David Andrew Sandham
Claire Adcock
Kamlesh Jagdis Bala
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34090028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1828172(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Novartis Pharma Gmbh filed Critical Novartis Ag
Publication of PT1828172E publication Critical patent/PT1828172E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
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PT05815747T 2004-12-14 2005-12-12 Derivados de pirrol com a actividade antagonista de receptor crth2 PT1828172E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0427381.9A GB0427381D0 (en) 2004-12-14 2004-12-14 Organic compounds

Publications (1)

Publication Number Publication Date
PT1828172E true PT1828172E (pt) 2010-02-17

Family

ID=34090028

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05815747T PT1828172E (pt) 2004-12-14 2005-12-12 Derivados de pirrol com a actividade antagonista de receptor crth2

Country Status (21)

Country Link
US (1) US20100087432A1 (enExample)
EP (1) EP1828172B1 (enExample)
JP (1) JP2008523130A (enExample)
KR (1) KR20070087605A (enExample)
CN (1) CN101072773B (enExample)
AR (1) AR052266A1 (enExample)
AT (1) ATE449772T1 (enExample)
AU (1) AU2005315881C1 (enExample)
BR (1) BRPI0518607A2 (enExample)
CA (1) CA2587934A1 (enExample)
DE (1) DE602005017935D1 (enExample)
ES (1) ES2335519T3 (enExample)
GB (1) GB0427381D0 (enExample)
GT (1) GT200500360A (enExample)
MX (1) MX2007007098A (enExample)
PE (1) PE20060736A1 (enExample)
PL (1) PL1828172T3 (enExample)
PT (1) PT1828172E (enExample)
RU (1) RU2007126761A (enExample)
TW (1) TW200635921A (enExample)
WO (1) WO2006063763A1 (enExample)

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GB0611695D0 (en) * 2006-06-13 2006-07-26 Novartis Ag Organic compounds
TW200848019A (en) * 2007-03-06 2008-12-16 Wyeth Corp Aryl sulfonamides useful for modulation of the progesterone receptor
EP2327693B9 (en) 2007-12-14 2012-10-24 Pulmagen Therapeutics (Asthma) Limited Indoles and their therapeutic use
KR101276530B1 (ko) * 2009-02-24 2013-06-18 머크 캐나다 인크. Ｃｒｔｈ２ 수용체 길항제로서의 인돌 유도체
WO2011079007A1 (en) 2009-12-23 2011-06-30 Ironwood Pharmaceuticals, Inc. Crth2 modulators
BR112012024114B1 (pt) 2010-03-22 2021-02-09 Idorsia Pharmaceuticals Ltd Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
WO2011117184A1 (de) 2010-03-24 2011-09-29 Bayer Cropscience Ag Fludioxonil-derivate
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
WO2012078210A1 (en) * 2010-12-08 2012-06-14 Ironwood Pharmaceuticals, Inc. Crth2 modulators and preparation thereof
JP5964945B2 (ja) 2011-04-14 2016-08-03 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ７−（ヘテロアリ−ル−アミノ）−６，７，８，９−テトラヒドロピリド［１，２−ａ］インド−ル酢酸誘導体及びプロスタグランジンＤ２受容体調節剤としてのそれらの使用
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
ES2624379T3 (es) 2011-12-21 2017-07-14 Idorsia Pharmaceuticals Ltd Derivados de heterociclilo y su uso como moduladores del receptor de prostaglandina D2
WO2013155422A1 (en) * 2012-04-12 2013-10-17 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
ES2461415B1 (es) * 2012-10-16 2015-03-16 Consejo Superior De Investigaciones Científicas (Csic) Derivados funcionalizados e inmunorreactivos para el fungicida fludioxonil
CN103553990B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 用卤素卤化合成2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
CN103588686B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 一种用卤素卤化制备2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
CN103553991B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 一种制备2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
TWI649321B (zh) 2014-03-17 2019-02-01 瑞士商愛杜西亞製藥有限公司 氮雜吲哚乙酸衍生物及彼等作為前列腺素ｄ２受體調節劑之用途
WO2015140701A1 (en) 2014-03-18 2015-09-24 Actelion Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
AU2016323262B2 (en) 2015-09-15 2020-11-19 Idorsia Pharmaceuticals Ltd Crystalline forms
CN108164502B (zh) * 2018-03-06 2021-04-13 苏州华一新能源科技有限公司 1,3-丙烷磺酸内酯的制备方法
CN112602714B (zh) * 2020-12-23 2021-11-16 华南农业大学 一类咯菌腈羧酸衍生物在用于植物维管组织靶向药剂中的应用

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EP0386681A1 (de) * 1989-03-08 1990-09-12 Ciba-Geigy Ag 3-Aryl-4-cyano-pyrrol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende mikrobiozide Mittel
US20050101657A1 (en) * 2001-12-28 2005-05-12 Takeda Chemical Industries Ltd. Androgen receptor antagonists
JP4316232B2 (ja) * 2001-12-28 2009-08-19 武田薬品工業株式会社 アンドロゲン受容体拮抗剤
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CA2568742A1 (en) * 2004-05-29 2005-12-08 7Tm Pharma A/S Substituted thiazoleacetic as crth2 ligands

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RU2007126761A (ru) 2009-01-27
KR20070087605A (ko) 2007-08-28
AU2005315881A1 (en) 2006-06-22
AU2005315881B2 (en) 2009-09-24
ATE449772T1 (de) 2009-12-15
CN101072773B (zh) 2011-01-19
CA2587934A1 (en) 2006-06-22
TW200635921A (en) 2006-10-16
JP2008523130A (ja) 2008-07-03
PL1828172T3 (pl) 2010-05-31
MX2007007098A (es) 2007-06-22
DE602005017935D1 (de) 2010-01-07
US20100087432A1 (en) 2010-04-08
WO2006063763A1 (en) 2006-06-22
CN101072773A (zh) 2007-11-14
EP1828172A1 (en) 2007-09-05
EP1828172B1 (en) 2009-11-25
PE20060736A1 (es) 2006-09-08
BRPI0518607A2 (pt) 2008-11-25
AR052266A1 (es) 2007-03-07
GB0427381D0 (en) 2005-01-19
ES2335519T3 (es) 2010-03-29
GT200500360A (es) 2006-08-07
AU2005315881C1 (en) 2010-03-11

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