PT1828167E - Derivados de acrilamida como agentes antibióticos - Google Patents
Derivados de acrilamida como agentes antibióticos Download PDFInfo
- Publication number
- PT1828167E PT1828167E PT58585035T PT05858503T PT1828167E PT 1828167 E PT1828167 E PT 1828167E PT 58585035 T PT58585035 T PT 58585035T PT 05858503 T PT05858503 T PT 05858503T PT 1828167 E PT1828167 E PT 1828167E
- Authority
- PT
- Portugal
- Prior art keywords
- antibiotic agents
- acrylamide derivatives
- acrylamide
- derivatives
- antibiotic
- Prior art date
Links
- 150000003926 acrylamides Chemical class 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57694504P | 2004-06-04 | 2004-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1828167E true PT1828167E (pt) | 2014-10-08 |
Family
ID=37889654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT58585035T PT1828167E (pt) | 2004-06-04 | 2005-06-06 | Derivados de acrilamida como agentes antibióticos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8450307B2 (enExample) |
| EP (2) | EP2848614A3 (enExample) |
| JP (1) | JP5087406B2 (enExample) |
| KR (1) | KR101299399B1 (enExample) |
| CA (1) | CA2568914C (enExample) |
| CY (1) | CY1115713T1 (enExample) |
| DK (1) | DK1828167T3 (enExample) |
| ES (1) | ES2515101T3 (enExample) |
| PL (1) | PL1828167T3 (enExample) |
| PT (1) | PT1828167E (enExample) |
| SI (1) | SI1828167T1 (enExample) |
| WO (1) | WO2007053131A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ECSP003699A (es) | 1999-10-08 | 2002-04-23 | Smithkline Beecham Corp | Inhibidores de fab i |
| JP4387804B2 (ja) * | 2001-04-06 | 2009-12-24 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | ＦａｂＩ阻害剤 |
| EP2054422B1 (en) * | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamide derivatives as fab i inhibitors |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| BRPI0819883A2 (pt) | 2007-11-28 | 2017-05-23 | Sequoia Pharmaceuticals Inc | composições e métodos para inibir citocromo p450 2d6 |
| WO2010089993A1 (ja) | 2009-02-03 | 2010-08-12 | クミアイ化学工業株式会社 | 縮合環化した２－ピリドン誘導体及び除草剤 |
| MX2012005759A (es) | 2009-11-18 | 2012-10-03 | Fab Pharma S A S | Acrilamidas heterociclicas novedosas y su uso como farmacos. |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| HUP1000598A2 (en) | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
| JP5990526B2 (ja) | 2010-11-05 | 2016-09-14 | セノミックス インコーポレイテッド | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| EP2742047B1 (en) * | 2011-08-10 | 2021-05-12 | Janssen Sciences Ireland Unlimited Company | Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones |
| CN108003155A (zh) * | 2011-08-10 | 2018-05-08 | 爱尔兰詹森科学公司 | 抗菌的高哌啶基取代的3,4二氢-1h[1,8]萘啶酮类 |
| JO3611B1 (ar) * | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
| EP3330269B1 (en) * | 2011-09-19 | 2023-06-07 | Kumar, Ajay | Heterocyclic compounds as inhibitors of fatty acid biosynthesis for bacterial infections |
| TR201909016T4 (tr) | 2012-06-19 | 2019-07-22 | Debiopharm Int Sa | (E)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamidin ön ilaç türevleri. |
| CA2879623C (en) * | 2012-08-10 | 2021-11-02 | Janssen Sciences Ireland Uc | Fused bicyclic azole heterocycle as inhibitors of the enzyme fabi |
| CA2880262C (en) | 2012-08-10 | 2021-11-16 | Janssen Sciences Ireland Uc | Nitrogen-based heterocycloalkyl derivatives as inhibitors of the enzyme fabi |
| WO2014072930A2 (en) * | 2012-11-09 | 2014-05-15 | Aurigene Discovery Technologies Limited | Fused pyridine derivatives as antibacterial agents |
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| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| US20230035837A1 (en) * | 2018-11-12 | 2023-02-02 | Debiopharm International S.A. | Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| MA56184A (fr) | 2019-06-14 | 2022-04-20 | Debiopharm Int Sa | Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| US20230140808A1 (en) * | 2020-04-07 | 2023-05-04 | Sanofi | (1 H-Indol-5-YL)Acrylamide Derivatives as Inhibitors of Tead Proteins and the Hippo-YAP1/TAZ Signaling Cascade for the Treatment of Cancer |
| WO2021243273A1 (en) * | 2020-05-29 | 2021-12-02 | Taxis Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| CN111991385A (zh) * | 2020-08-17 | 2020-11-27 | 暨南大学 | 棕榈油酸在抑制水产病原菌中的应用 |
| WO2022187329A1 (en) * | 2021-03-03 | 2022-09-09 | The Board Of Trustees Of The University Of Illinois | Fabi inhibitors for gram-negative pathogens |
| US12060148B2 (en) | 2022-08-16 | 2024-08-13 | Honeywell International Inc. | Ground resonance detection and warning system and method |
| WO2025073269A1 (zh) * | 2023-10-07 | 2025-04-10 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种FabI酶抑制剂及其应用 |
| WO2025078209A1 (en) * | 2023-10-09 | 2025-04-17 | Debiopharm International S.A. | Antibiotic compounds for treating bacterial infections |
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-
2005
- 2005-06-06 PT PT58585035T patent/PT1828167E/pt unknown
- 2005-06-06 US US11/628,569 patent/US8450307B2/en not_active Expired - Fee Related
- 2005-06-06 PL PL05858503T patent/PL1828167T3/pl unknown
- 2005-06-06 EP EP14179596.3A patent/EP2848614A3/en not_active Withdrawn
- 2005-06-06 SI SI200531900T patent/SI1828167T1/sl unknown
- 2005-06-06 EP EP05858503.5A patent/EP1828167B1/en not_active Expired - Lifetime
- 2005-06-06 DK DK05858503.5T patent/DK1828167T3/da active
- 2005-06-06 WO PCT/US2005/019805 patent/WO2007053131A2/en not_active Ceased
- 2005-06-06 KR KR1020077000169A patent/KR101299399B1/ko not_active Expired - Fee Related
- 2005-06-06 CA CA2568914A patent/CA2568914C/en not_active Expired - Fee Related
- 2005-06-06 JP JP2007543017A patent/JP5087406B2/ja not_active Expired - Fee Related
- 2005-06-06 ES ES05858503.5T patent/ES2515101T3/es not_active Expired - Lifetime
-
2013
- 2013-04-25 US US13/870,193 patent/US20140107106A1/en not_active Abandoned
-
2014
- 2014-10-31 CY CY20141100905T patent/CY1115713T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1115713T1 (el) | 2017-01-25 |
| WO2007053131A3 (en) | 2007-08-02 |
| CA2568914A1 (en) | 2005-12-04 |
| KR101299399B1 (ko) | 2013-08-22 |
| EP1828167A2 (en) | 2007-09-05 |
| EP1828167B1 (en) | 2014-08-06 |
| JP2008505194A (ja) | 2008-02-21 |
| CA2568914C (en) | 2013-09-24 |
| KR20080016517A (ko) | 2008-02-21 |
| US20140107106A1 (en) | 2014-04-17 |
| DK1828167T3 (da) | 2014-10-20 |
| US20100093705A1 (en) | 2010-04-15 |
| EP2848614A3 (en) | 2015-07-29 |
| ES2515101T3 (es) | 2014-10-29 |
| JP5087406B2 (ja) | 2012-12-05 |
| PL1828167T3 (pl) | 2015-02-27 |
| SI1828167T1 (sl) | 2014-12-31 |
| US8450307B2 (en) | 2013-05-28 |
| EP2848614A2 (en) | 2015-03-18 |
| WO2007053131A2 (en) | 2007-05-10 |
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