PT1579859E - Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal - Google Patents
Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal Download PDFInfo
- Publication number
- PT1579859E PT1579859E PT04007177T PT04007177T PT1579859E PT 1579859 E PT1579859 E PT 1579859E PT 04007177 T PT04007177 T PT 04007177T PT 04007177 T PT04007177 T PT 04007177T PT 1579859 E PT1579859 E PT 1579859E
- Authority
- PT
- Portugal
- Prior art keywords
- sci
- formula
- phenyl
- alkyl
- treatment
- Prior art date
Links
- 208000020431 spinal cord injury Diseases 0.000 title claims abstract description 47
- 238000011282 treatment Methods 0.000 title claims abstract description 14
- 229940124530 sulfonamide Drugs 0.000 title claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims description 28
- -1 2-pyridyl-ethyl Chemical group 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 claims description 2
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 2
- 125000005544 phthalimido group Chemical group 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 1
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003431 oxalo group Chemical group 0.000 claims 1
- 101150035983 str1 gene Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 13
- 210000000265 leukocyte Anatomy 0.000 description 11
- 238000011084 recovery Methods 0.000 description 10
- 230000033001 locomotion Effects 0.000 description 9
- 230000003902 lesion Effects 0.000 description 8
- 230000006378 damage Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000008595 infiltration Effects 0.000 description 5
- 238000001764 infiltration Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 210000003141 lower extremity Anatomy 0.000 description 5
- 230000000750 progressive effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000007115 recruitment Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 150000003456 sulfonamides Chemical class 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 230000028266 oligodendrocyte apoptotic process Effects 0.000 description 3
- 210000004248 oligodendroglia Anatomy 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000003859 lipid peroxidation Effects 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 210000003622 mature neutrocyte Anatomy 0.000 description 2
- URZONQSEPBBTSB-HNCPQSOCSA-N methanesulfonamide;(2r)-2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical compound CS(N)(=O)=O.CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 URZONQSEPBBTSB-HNCPQSOCSA-N 0.000 description 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 102000003390 tumor necrosis factor Human genes 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
- 102100033215 DNA nucleotidylexotransferase Human genes 0.000 description 1
- 101150040913 DUT gene Proteins 0.000 description 1
- 208000016192 Demyelinating disease Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 1
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 1
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- 102000004889 Interleukin-6 Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 102100026236 Interleukin-8 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102100025136 Macrosialin Human genes 0.000 description 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
- 208000019430 Motor disease Diseases 0.000 description 1
- 102000008763 Neurofilament Proteins Human genes 0.000 description 1
- 108010088373 Neurofilament Proteins Proteins 0.000 description 1
- 206010033892 Paraplegia Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000005057 finger movement Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 125000005280 halo alkyl sulfonyloxy group Chemical group 0.000 description 1
- 125000004438 haloalkoxy group Chemical group 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000030505 negative regulation of chemotaxis Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000005044 neurofilament Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000016273 neuron death Effects 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04007177A EP1579859B1 (en) | 2004-03-25 | 2004-03-25 | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1579859E true PT1579859E (pt) | 2007-03-30 |
Family
ID=34854609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04007177T PT1579859E (pt) | 2004-03-25 | 2004-03-25 | Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090030083A1 (enExample) |
| EP (1) | EP1579859B1 (enExample) |
| JP (1) | JP4988550B2 (enExample) |
| KR (2) | KR101327150B1 (enExample) |
| CN (2) | CN103054842A (enExample) |
| AT (1) | ATE347883T1 (enExample) |
| AU (1) | AU2005226901B2 (enExample) |
| BR (1) | BRPI0509167A (enExample) |
| CA (1) | CA2555162C (enExample) |
| CY (1) | CY1107562T1 (enExample) |
| DE (1) | DE602004003673T2 (enExample) |
| DK (1) | DK1579859T3 (enExample) |
| ES (1) | ES2279248T3 (enExample) |
| IL (1) | IL177169A (enExample) |
| MX (1) | MXPA06009085A (enExample) |
| NO (1) | NO20064793L (enExample) |
| NZ (1) | NZ548917A (enExample) |
| PL (1) | PL1579859T3 (enExample) |
| PT (1) | PT1579859E (enExample) |
| RU (1) | RU2396075C2 (enExample) |
| SI (1) | SI1579859T1 (enExample) |
| WO (1) | WO2005092315A1 (enExample) |
| ZA (1) | ZA200608517B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2664359A1 (en) * | 2006-09-26 | 2008-04-03 | Case Western Reserve University | Cytokine signaling |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| CN103172547B (zh) * | 2011-12-20 | 2016-10-12 | 天津市国际生物医药联合研究院 | 磺酰胺衍生物的制备及其应用 |
| CN103159674A (zh) * | 2013-04-03 | 2013-06-19 | 苏州安诺生物医药技术有限公司 | 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途 |
| KR20220064039A (ko) | 2020-11-11 | 2022-05-18 | 정성삼 | 척수 손상 예방 또는 치료용 조성물 |
| KR102320780B1 (ko) | 2021-01-29 | 2021-11-02 | 정성삼 | 척추 통증 완화 및 척추 유연성 개선을 위한 조성물 및 이의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| IT1318466B1 (it) * | 2000-04-14 | 2003-08-25 | Dompe Spa | Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria. |
| ITMI20010206A1 (it) * | 2001-02-02 | 2002-08-02 | Dompe Spa | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
-
2004
- 2004-03-25 EP EP04007177A patent/EP1579859B1/en not_active Expired - Lifetime
- 2004-03-25 ES ES04007177T patent/ES2279248T3/es not_active Expired - Lifetime
- 2004-03-25 PL PL04007177T patent/PL1579859T3/pl unknown
- 2004-03-25 SI SI200430194T patent/SI1579859T1/sl unknown
- 2004-03-25 AT AT04007177T patent/ATE347883T1/de active
- 2004-03-25 DK DK04007177T patent/DK1579859T3/da active
- 2004-03-25 PT PT04007177T patent/PT1579859E/pt unknown
- 2004-03-25 DE DE602004003673T patent/DE602004003673T2/de not_active Expired - Lifetime
-
2005
- 2005-03-17 KR KR1020127023407A patent/KR101327150B1/ko not_active Expired - Fee Related
- 2005-03-17 CA CA2555162A patent/CA2555162C/en not_active Expired - Fee Related
- 2005-03-17 NZ NZ548917A patent/NZ548917A/en not_active IP Right Cessation
- 2005-03-17 CN CN2012104176511A patent/CN103054842A/zh active Pending
- 2005-03-17 WO PCT/EP2005/002822 patent/WO2005092315A1/en not_active Ceased
- 2005-03-17 RU RU2006137575/15A patent/RU2396075C2/ru not_active IP Right Cessation
- 2005-03-17 CN CNA2005800095602A patent/CN1933825A/zh active Pending
- 2005-03-17 US US10/588,454 patent/US20090030083A1/en not_active Abandoned
- 2005-03-17 JP JP2007504310A patent/JP4988550B2/ja not_active Expired - Fee Related
- 2005-03-17 AU AU2005226901A patent/AU2005226901B2/en not_active Ceased
- 2005-03-17 MX MXPA06009085A patent/MXPA06009085A/es active IP Right Grant
- 2005-03-17 KR KR1020067018031A patent/KR101312235B1/ko not_active Expired - Fee Related
- 2005-03-17 BR BRPI0509167-5A patent/BRPI0509167A/pt active Search and Examination
-
2006
- 2006-07-31 IL IL177169A patent/IL177169A/en not_active IP Right Cessation
- 2006-10-12 ZA ZA2006/08517A patent/ZA200608517B/en unknown
- 2006-10-23 NO NO20064793A patent/NO20064793L/no not_active Application Discontinuation
-
2007
- 2007-02-22 CY CY20071100248T patent/CY1107562T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1579859T3 (da) | 2007-04-10 |
| ATE347883T1 (de) | 2007-01-15 |
| KR20070018015A (ko) | 2007-02-13 |
| KR101327150B1 (ko) | 2013-11-06 |
| DE602004003673T2 (de) | 2007-10-04 |
| RU2006137575A (ru) | 2008-04-27 |
| MXPA06009085A (es) | 2007-04-02 |
| ES2279248T3 (es) | 2007-08-16 |
| WO2005092315A1 (en) | 2005-10-06 |
| NO20064793L (no) | 2006-10-23 |
| NZ548917A (en) | 2010-06-25 |
| CY1107562T1 (el) | 2013-03-13 |
| KR20120104445A (ko) | 2012-09-20 |
| KR101312235B1 (ko) | 2013-09-26 |
| CA2555162C (en) | 2012-11-27 |
| US20090030083A1 (en) | 2009-01-29 |
| AU2005226901B2 (en) | 2011-06-02 |
| DE602004003673D1 (de) | 2007-01-25 |
| IL177169A (en) | 2010-12-30 |
| EP1579859A1 (en) | 2005-09-28 |
| CA2555162A1 (en) | 2005-10-06 |
| AU2005226901A1 (en) | 2005-10-06 |
| EP1579859B1 (en) | 2006-12-13 |
| RU2396075C2 (ru) | 2010-08-10 |
| JP2007530478A (ja) | 2007-11-01 |
| SI1579859T1 (sl) | 2007-04-30 |
| CN1933825A (zh) | 2007-03-21 |
| CN103054842A (zh) | 2013-04-24 |
| BRPI0509167A (pt) | 2007-09-11 |
| ZA200608517B (en) | 2008-04-30 |
| IL177169A0 (en) | 2006-12-10 |
| PL1579859T3 (pl) | 2007-06-29 |
| JP4988550B2 (ja) | 2012-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106102737B (zh) | 色甘酸衍生物以及成像和治疗的相关方法 | |
| RU2727474C2 (ru) | Виды комбинированной терапии для лечения рака | |
| PT1505973E (pt) | Combinações para o tratamento de mieloma múltiplo | |
| US11679122B2 (en) | Therapeutic agent for nervous system disease | |
| US11738040B2 (en) | Composition for treating joint disease and kit containing same | |
| PT1579859E (pt) | Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal | |
| US10918609B2 (en) | Pharmaceutical composition for preventing or treating arthritis or inflammatory disease containing 2-methoxy-4-(3-(4-methoxyphenyl)propyl-1-en-1-yl)phenol as active ingredient | |
| EP1806136B1 (en) | Medicinal composition for prevention of transition to operative treatment for prostatic hypertrophy | |
| WO2012159122A1 (en) | Heparin-based compositions and methods for the inhibition of metastasis | |
| US10738042B2 (en) | Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer | |
| JPS6248622A (ja) | 癌転移抑制剤 | |
| JPS61129124A (ja) | 抗腫瘍剤 | |
| BR112019018172A2 (pt) | composição para tratar uma doença de articulação humana, e, kit. | |
| CN119896660A (zh) | 酰胺衍生物在制备治疗或预防皮肤辐射损伤药物上的应用 | |
| HK1101358A (en) | Use of n-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | |
| JP2021514988A (ja) | ポリ硫酸化多糖類を用いた術後関節痛の処置 | |
| Brunstein et al. | hapter 4 | |
| EP1510209A1 (en) | Therapeutic agent for inflammatory intestinal diseases containing hydroxamic acid compound as active ingredient | |
| JPH09118620A (ja) | 放射線肺障害予防・治療剤 | |
| JP2005053890A (ja) | アディポネクチン濃度低下及び／又はｃ反応性蛋白濃度上昇及び／又はｉｌ−１８濃度上昇に起因する疾患の予防及び／又は治療剤。 | |
| JPS6393724A (ja) | ムラミルジペプチド誘導体含有鎮痛消炎剤 | |
| JPH05194424A (ja) | 新規なピリミジン誘導体及び該誘導体を有効成分とする医薬 |