RU2396075C2 - Применение n-(2-арилпропионил)сульфонамидов для лечения повреждения спинного мозга - Google Patents
Применение n-(2-арилпропионил)сульфонамидов для лечения повреждения спинного мозга Download PDFInfo
- Publication number
- RU2396075C2 RU2396075C2 RU2006137575/15A RU2006137575A RU2396075C2 RU 2396075 C2 RU2396075 C2 RU 2396075C2 RU 2006137575/15 A RU2006137575/15 A RU 2006137575/15A RU 2006137575 A RU2006137575 A RU 2006137575A RU 2396075 C2 RU2396075 C2 RU 2396075C2
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- Prior art keywords
- sci
- formula
- spinal cord
- compound
- arylpropionyl
- Prior art date
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04007177.1 | 2004-03-25 | ||
| EP04007177A EP1579859B1 (en) | 2004-03-25 | 2004-03-25 | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006137575A RU2006137575A (ru) | 2008-04-27 |
| RU2396075C2 true RU2396075C2 (ru) | 2010-08-10 |
Family
ID=34854609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006137575/15A RU2396075C2 (ru) | 2004-03-25 | 2005-03-17 | Применение n-(2-арилпропионил)сульфонамидов для лечения повреждения спинного мозга |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090030083A1 (enExample) |
| EP (1) | EP1579859B1 (enExample) |
| JP (1) | JP4988550B2 (enExample) |
| KR (2) | KR101327150B1 (enExample) |
| CN (2) | CN1933825A (enExample) |
| AT (1) | ATE347883T1 (enExample) |
| AU (1) | AU2005226901B2 (enExample) |
| BR (1) | BRPI0509167A (enExample) |
| CA (1) | CA2555162C (enExample) |
| CY (1) | CY1107562T1 (enExample) |
| DE (1) | DE602004003673T2 (enExample) |
| DK (1) | DK1579859T3 (enExample) |
| ES (1) | ES2279248T3 (enExample) |
| IL (1) | IL177169A (enExample) |
| MX (1) | MXPA06009085A (enExample) |
| NO (1) | NO20064793L (enExample) |
| NZ (1) | NZ548917A (enExample) |
| PL (1) | PL1579859T3 (enExample) |
| PT (1) | PT1579859E (enExample) |
| RU (1) | RU2396075C2 (enExample) |
| SI (1) | SI1579859T1 (enExample) |
| WO (1) | WO2005092315A1 (enExample) |
| ZA (1) | ZA200608517B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010504996A (ja) * | 2006-09-26 | 2010-02-18 | ケース ウエスタン リザーブ ユニバーシティ | サイトカインシグナリング |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| CN103172547B (zh) * | 2011-12-20 | 2016-10-12 | 天津市国际生物医药联合研究院 | 磺酰胺衍生物的制备及其应用 |
| CN103159674A (zh) * | 2013-04-03 | 2013-06-19 | 苏州安诺生物医药技术有限公司 | 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途 |
| KR20220064039A (ko) | 2020-11-11 | 2022-05-18 | 정성삼 | 척수 손상 예방 또는 치료용 조성물 |
| KR102320780B1 (ko) | 2021-01-29 | 2021-11-02 | 정성삼 | 척추 통증 완화 및 척추 유연성 개선을 위한 조성물 및 이의 제조방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000024710A1 (en) * | 1998-10-23 | 2000-05-04 | Dompe' S.P.A. | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them |
| WO2002062330A2 (en) * | 2001-02-02 | 2002-08-15 | Dompé S.p.A. | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| IT1318466B1 (it) * | 2000-04-14 | 2003-08-25 | Dompe Spa | Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria. |
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2004
- 2004-03-25 DE DE602004003673T patent/DE602004003673T2/de not_active Expired - Lifetime
- 2004-03-25 ES ES04007177T patent/ES2279248T3/es not_active Expired - Lifetime
- 2004-03-25 PL PL04007177T patent/PL1579859T3/pl unknown
- 2004-03-25 AT AT04007177T patent/ATE347883T1/de active
- 2004-03-25 PT PT04007177T patent/PT1579859E/pt unknown
- 2004-03-25 EP EP04007177A patent/EP1579859B1/en not_active Expired - Lifetime
- 2004-03-25 SI SI200430194T patent/SI1579859T1/sl unknown
- 2004-03-25 DK DK04007177T patent/DK1579859T3/da active
-
2005
- 2005-03-17 CN CNA2005800095602A patent/CN1933825A/zh active Pending
- 2005-03-17 BR BRPI0509167-5A patent/BRPI0509167A/pt active Search and Examination
- 2005-03-17 RU RU2006137575/15A patent/RU2396075C2/ru not_active IP Right Cessation
- 2005-03-17 US US10/588,454 patent/US20090030083A1/en not_active Abandoned
- 2005-03-17 JP JP2007504310A patent/JP4988550B2/ja not_active Expired - Fee Related
- 2005-03-17 CA CA2555162A patent/CA2555162C/en not_active Expired - Fee Related
- 2005-03-17 AU AU2005226901A patent/AU2005226901B2/en not_active Ceased
- 2005-03-17 CN CN2012104176511A patent/CN103054842A/zh active Pending
- 2005-03-17 WO PCT/EP2005/002822 patent/WO2005092315A1/en not_active Ceased
- 2005-03-17 MX MXPA06009085A patent/MXPA06009085A/es active IP Right Grant
- 2005-03-17 NZ NZ548917A patent/NZ548917A/en not_active IP Right Cessation
- 2005-03-17 KR KR1020127023407A patent/KR101327150B1/ko not_active Expired - Fee Related
- 2005-03-17 KR KR1020067018031A patent/KR101312235B1/ko not_active Expired - Fee Related
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2006
- 2006-07-31 IL IL177169A patent/IL177169A/en not_active IP Right Cessation
- 2006-10-12 ZA ZA2006/08517A patent/ZA200608517B/en unknown
- 2006-10-23 NO NO20064793A patent/NO20064793L/no not_active Application Discontinuation
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2007
- 2007-02-22 CY CY20071100248T patent/CY1107562T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000024710A1 (en) * | 1998-10-23 | 2000-05-04 | Dompe' S.P.A. | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them |
| WO2002062330A2 (en) * | 2001-02-02 | 2002-08-15 | Dompé S.p.A. | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
Non-Patent Citations (3)
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| BRACKEN M.B. "A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study." The New England journal of medicine, 1990 May 17; 322(20): 1405-1411, реферат [Найдено 03.03.2009] Medline [он-лайн] РМID: 2278545. * |
| KUNIHARAT. "Proinflammatory cytokines in cerebrospinal fluid in repair of thoracoabdominal aorta" The Annals of thoracic surgery 2001 Mar; 71(3):801-806. * |
| LI J.J. "Small molecule interieukin-8 modulators" Expert Opin. Ther. Patents, 2001 11(12):1905-1910. ISAKSSON J. "Expression of ICAM-1 and CD11b after experimental spinal cord injury in rats" Journal of neurotrauma 1999 Feb; 16(2):165-73. XU J. "Polymorphonuclear (PMN) cell infiltration in experimental spinal cord injury" Society for neuroscience abstracts, 1987, 13(3):1500. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090030083A1 (en) | 2009-01-29 |
| SI1579859T1 (sl) | 2007-04-30 |
| WO2005092315A1 (en) | 2005-10-06 |
| KR20070018015A (ko) | 2007-02-13 |
| BRPI0509167A (pt) | 2007-09-11 |
| CA2555162C (en) | 2012-11-27 |
| CY1107562T1 (el) | 2013-03-13 |
| DE602004003673D1 (de) | 2007-01-25 |
| MXPA06009085A (es) | 2007-04-02 |
| PT1579859E (pt) | 2007-03-30 |
| IL177169A (en) | 2010-12-30 |
| KR101312235B1 (ko) | 2013-09-26 |
| AU2005226901A1 (en) | 2005-10-06 |
| ES2279248T3 (es) | 2007-08-16 |
| ZA200608517B (en) | 2008-04-30 |
| ATE347883T1 (de) | 2007-01-15 |
| CN103054842A (zh) | 2013-04-24 |
| KR101327150B1 (ko) | 2013-11-06 |
| EP1579859A1 (en) | 2005-09-28 |
| DK1579859T3 (da) | 2007-04-10 |
| RU2006137575A (ru) | 2008-04-27 |
| JP4988550B2 (ja) | 2012-08-01 |
| NZ548917A (en) | 2010-06-25 |
| NO20064793L (no) | 2006-10-23 |
| PL1579859T3 (pl) | 2007-06-29 |
| DE602004003673T2 (de) | 2007-10-04 |
| JP2007530478A (ja) | 2007-11-01 |
| EP1579859B1 (en) | 2006-12-13 |
| CN1933825A (zh) | 2007-03-21 |
| IL177169A0 (en) | 2006-12-10 |
| CA2555162A1 (en) | 2005-10-06 |
| KR20120104445A (ko) | 2012-09-20 |
| AU2005226901B2 (en) | 2011-06-02 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160318 |