PT1334105E - Preparacao de n-formimidoil-tienamicina mono-hidrata cristalina ( (imipenem mono-hidratado) - Google Patents
Preparacao de n-formimidoil-tienamicina mono-hidrata cristalina ( (imipenem mono-hidratado)Info
- Publication number
- PT1334105E PT1334105E PT01980805T PT01980805T PT1334105E PT 1334105 E PT1334105 E PT 1334105E PT 01980805 T PT01980805 T PT 01980805T PT 01980805 T PT01980805 T PT 01980805T PT 1334105 E PT1334105 E PT 1334105E
- Authority
- PT
- Portugal
- Prior art keywords
- crystalline
- preparation
- imipenem
- formimidoyl
- tienamicine
- Prior art date
Links
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 title 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 title 1
- 229960002182 imipenem Drugs 0.000 title 1
- -1 N-formimidoyl thienamycin monohydrate Chemical class 0.000 abstract 1
- GSOSVVULSKVSLQ-JJVRHELESA-N imipenem hydrate Chemical compound O.C1C(SCCNC=N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 GSOSVVULSKVSLQ-JJVRHELESA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN983DE2000 IN191798B (enExample) | 2000-11-03 | 2000-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1334105E true PT1334105E (pt) | 2006-08-31 |
Family
ID=11097114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01980805T PT1334105E (pt) | 2000-11-03 | 2001-11-05 | Preparacao de n-formimidoil-tienamicina mono-hidrata cristalina ( (imipenem mono-hidratado) |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7078534B2 (enExample) |
| EP (1) | EP1334105B1 (enExample) |
| JP (1) | JP2004525084A (enExample) |
| KR (1) | KR20030059812A (enExample) |
| CN (1) | CN100445284C (enExample) |
| AT (1) | ATE322495T1 (enExample) |
| AU (1) | AU2002212591A1 (enExample) |
| BG (1) | BG107852A (enExample) |
| CA (1) | CA2427762C (enExample) |
| DE (1) | DE60118593D1 (enExample) |
| DK (1) | DK1334105T3 (enExample) |
| EA (1) | EA006442B1 (enExample) |
| EE (1) | EE200300206A (enExample) |
| ES (1) | ES2261494T3 (enExample) |
| IN (1) | IN191798B (enExample) |
| MX (1) | MXPA03003916A (enExample) |
| PT (1) | PT1334105E (enExample) |
| WO (1) | WO2002036594A1 (enExample) |
| ZA (1) | ZA200303338B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2328117T3 (es) * | 2001-05-18 | 2009-11-10 | Ranbaxy Laboratories Limited | Proceso para la preparacion de imipenem. |
| IL158945A0 (en) * | 2001-05-18 | 2004-05-12 | Ranbaxy Lab Ltd | Process for the preparation of amorphous cilastatin sodium |
| JP2005514323A (ja) | 2001-05-18 | 2005-05-19 | ランバクシー ラボラトリーズ リミテッド | 結晶イミペネムの単離方法 |
| WO2003016312A1 (en) * | 2001-08-13 | 2003-02-27 | Eisai Co., Ltd. | Process for preparation of carbapenem antibiotics |
| HUP0402112A2 (hu) | 2001-11-16 | 2005-02-28 | Ranbaxy Laboratories Limited | Eljárás kristályos imipenem előállítására |
| US6537985B1 (en) * | 2001-11-30 | 2003-03-25 | Phoenix Scientific, Inc. | Antibiotic formulation and a method of making this formulation |
| AU2004296261B2 (en) * | 2003-12-09 | 2007-08-23 | Choongwae Pharm. Co. | A new process for preparation of imipenem |
| KR100848751B1 (ko) * | 2006-11-10 | 2008-07-25 | 제일약품주식회사 | 이미페넴의 제조방법 |
| KR100848752B1 (ko) * | 2006-11-10 | 2008-07-25 | 제일약품주식회사 | 티에나마이신 용매화합물 및 그의 제조방법 |
| EP2209787A4 (en) * | 2007-10-08 | 2011-08-03 | Orchid Chemicals & Pharm Ltd | METHOD FOR PRODUCING A CARBAPENEM ANTIBIOTICS |
| CN108623598A (zh) * | 2018-05-21 | 2018-10-09 | 重庆天地药业有限责任公司 | 一种亚胺培南中间体及亚胺培南的制备方法 |
| CN111413427A (zh) * | 2020-04-08 | 2020-07-14 | 苏州和合医学检验有限公司 | 超滤前处理高效液相色谱测定血浆中亚胺培南含量的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4194047A (en) * | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
| US4260543A (en) * | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
| JP3048196B2 (ja) | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
| KR100253825B1 (ko) | 1991-10-01 | 2000-05-01 | 제이코버스 코넬리스 레이서 | 항미 생물성 퀴놀로 닐락탐의 제조방법 |
| CA2105746A1 (en) | 1992-09-09 | 1994-03-10 | Akira Yoshida | Process for preparing carbapenem and penem compounds and new compounds involved in that process |
| US5245069A (en) * | 1992-10-27 | 1993-09-14 | Merck & Co., Inc. | Process for the preparation of bis(aryl)-phosphorohalidates |
| US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
-
2000
- 2000-11-03 IN IN983DE2000 patent/IN191798B/en unknown
-
2001
- 2001-11-05 DE DE60118593T patent/DE60118593D1/de not_active Expired - Lifetime
- 2001-11-05 CA CA002427762A patent/CA2427762C/en not_active Expired - Fee Related
- 2001-11-05 MX MXPA03003916A patent/MXPA03003916A/es active IP Right Grant
- 2001-11-05 EP EP01980805A patent/EP1334105B1/en not_active Expired - Lifetime
- 2001-11-05 JP JP2002539352A patent/JP2004525084A/ja not_active Withdrawn
- 2001-11-05 KR KR10-2003-7006118A patent/KR20030059812A/ko not_active Withdrawn
- 2001-11-05 CN CNB018207154A patent/CN100445284C/zh not_active Expired - Fee Related
- 2001-11-05 DK DK01980805T patent/DK1334105T3/da active
- 2001-11-05 WO PCT/IB2001/002069 patent/WO2002036594A1/en not_active Ceased
- 2001-11-05 AU AU2002212591A patent/AU2002212591A1/en not_active Abandoned
- 2001-11-05 PT PT01980805T patent/PT1334105E/pt unknown
- 2001-11-05 ES ES01980805T patent/ES2261494T3/es not_active Expired - Lifetime
- 2001-11-05 EE EEP200300206A patent/EE200300206A/xx unknown
- 2001-11-05 US US10/415,633 patent/US7078534B2/en not_active Expired - Fee Related
- 2001-11-05 AT AT01980805T patent/ATE322495T1/de active
- 2001-11-05 EA EA200300520A patent/EA006442B1/ru not_active IP Right Cessation
-
2003
- 2003-04-30 ZA ZA200303338A patent/ZA200303338B/en unknown
- 2003-05-27 BG BG107852A patent/BG107852A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60118593D1 (de) | 2006-05-18 |
| JP2004525084A (ja) | 2004-08-19 |
| CA2427762C (en) | 2009-10-20 |
| CN100445284C (zh) | 2008-12-24 |
| DK1334105T3 (da) | 2006-08-14 |
| WO2002036594A1 (en) | 2002-05-10 |
| IN191798B (enExample) | 2004-01-03 |
| US7078534B2 (en) | 2006-07-18 |
| CN1481384A (zh) | 2004-03-10 |
| EA006442B1 (ru) | 2005-12-29 |
| KR20030059812A (ko) | 2003-07-10 |
| EP1334105A1 (en) | 2003-08-13 |
| BG107852A (bg) | 2004-01-30 |
| EP1334105B1 (en) | 2006-04-05 |
| EA200300520A1 (ru) | 2003-10-30 |
| EE200300206A (et) | 2003-10-15 |
| CA2427762A1 (en) | 2002-05-10 |
| ZA200303338B (en) | 2004-03-09 |
| US20040054167A1 (en) | 2004-03-18 |
| ES2261494T3 (es) | 2006-11-16 |
| MXPA03003916A (es) | 2004-01-29 |
| ATE322495T1 (de) | 2006-04-15 |
| AU2002212591A1 (en) | 2002-05-15 |
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