CN100445284C - 制备晶体n-亚胺甲基沙钠霉素一水合物(亚胺培南一水合物)的方法 - Google Patents

制备晶体n-亚胺甲基沙钠霉素一水合物(亚胺培南一水合物)的方法 Download PDF

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Publication number
CN100445284C
CN100445284C CNB018207154A CN01820715A CN100445284C CN 100445284 C CN100445284 C CN 100445284C CN B018207154 A CNB018207154 A CN B018207154A CN 01820715 A CN01820715 A CN 01820715A CN 100445284 C CN100445284 C CN 100445284C
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China
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formula
structural formula
monohydrate
lactan
acid amides
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Expired - Fee Related
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CNB018207154A
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English (en)
Chinese (zh)
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CN1481384A (zh
Inventor
Y·库马尔
N·特瓦里
R·C·阿里亚恩
B·P·拉伊
S·阿户加
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Ranbaxy Laboratories Ltd
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Ranbaxy Laboratories Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB018207154A 2000-11-03 2001-11-05 制备晶体n-亚胺甲基沙钠霉素一水合物(亚胺培南一水合物)的方法 Expired - Fee Related CN100445284C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN983DE2000 IN191798B (enExample) 2000-11-03 2000-11-03
IN983/DEL/2000 2000-11-03

Publications (2)

Publication Number Publication Date
CN1481384A CN1481384A (zh) 2004-03-10
CN100445284C true CN100445284C (zh) 2008-12-24

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CNB018207154A Expired - Fee Related CN100445284C (zh) 2000-11-03 2001-11-05 制备晶体n-亚胺甲基沙钠霉素一水合物(亚胺培南一水合物)的方法

Country Status (19)

Country Link
US (1) US7078534B2 (enExample)
EP (1) EP1334105B1 (enExample)
JP (1) JP2004525084A (enExample)
KR (1) KR20030059812A (enExample)
CN (1) CN100445284C (enExample)
AT (1) ATE322495T1 (enExample)
AU (1) AU2002212591A1 (enExample)
BG (1) BG107852A (enExample)
CA (1) CA2427762C (enExample)
DE (1) DE60118593D1 (enExample)
DK (1) DK1334105T3 (enExample)
EA (1) EA006442B1 (enExample)
EE (1) EE200300206A (enExample)
ES (1) ES2261494T3 (enExample)
IN (1) IN191798B (enExample)
MX (1) MXPA03003916A (enExample)
PT (1) PT1334105E (enExample)
WO (1) WO2002036594A1 (enExample)
ZA (1) ZA200303338B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1522255A (zh) * 2001-05-18 2004-08-18 ʵ 结晶亚胺培南的分离方法
WO2002094742A1 (en) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Process for the preparation of amorphous cilastatin sodium
CA2447227A1 (en) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Process for the preparation of imipenem
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
MXPA04004604A (es) * 2001-11-16 2004-09-10 Ranbaxy Lab Ltd Proceso para la preparacion de imipenem cristalino.
US6537985B1 (en) 2001-11-30 2003-03-25 Phoenix Scientific, Inc. Antibiotic formulation and a method of making this formulation
CA2531578C (en) * 2003-12-09 2008-10-07 Choongwae Pharm. Co. A new process for preparation of imipenem
KR100848751B1 (ko) * 2006-11-10 2008-07-25 제일약품주식회사 이미페넴의 제조방법
KR100848752B1 (ko) * 2006-11-10 2008-07-25 제일약품주식회사 티에나마이신 용매화합물 및 그의 제조방법
US8293924B2 (en) * 2007-10-08 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN108623598A (zh) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 一种亚胺培南中间体及亚胺培南的制备方法
CN111413427A (zh) * 2020-04-08 2020-07-14 苏州和合医学检验有限公司 超滤前处理高效液相色谱测定血浆中亚胺培南含量的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
JP3048196B2 (ja) 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
DE69218445T2 (de) 1991-10-01 1997-08-07 Procter & Gamble Pharma Verfahren zur herstellung von antimikrobiellen quinolonyl-lactamen
HUT65301A (en) 1992-09-09 1994-05-02 Sankyo Co New method for preparing of carbapenem- and penem-carbonacid-derivatives with antibacterial activity
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates

Also Published As

Publication number Publication date
AU2002212591A1 (en) 2002-05-15
MXPA03003916A (es) 2004-01-29
EE200300206A (et) 2003-10-15
PT1334105E (pt) 2006-08-31
US20040054167A1 (en) 2004-03-18
ZA200303338B (en) 2004-03-09
CN1481384A (zh) 2004-03-10
DE60118593D1 (de) 2006-05-18
EA200300520A1 (ru) 2003-10-30
ES2261494T3 (es) 2006-11-16
US7078534B2 (en) 2006-07-18
ATE322495T1 (de) 2006-04-15
CA2427762A1 (en) 2002-05-10
WO2002036594A1 (en) 2002-05-10
JP2004525084A (ja) 2004-08-19
EP1334105B1 (en) 2006-04-05
EP1334105A1 (en) 2003-08-13
EA006442B1 (ru) 2005-12-29
DK1334105T3 (da) 2006-08-14
CA2427762C (en) 2009-10-20
IN191798B (enExample) 2004-01-03
BG107852A (bg) 2004-01-30
KR20030059812A (ko) 2003-07-10

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Granted publication date: 20081224

Termination date: 20131105