PT1312608E - Análogos de discodermolide e a sua utilização farmacêutica - Google Patents

Análogos de discodermolide e a sua utilização farmacêutica Download PDF

Info

Publication number
PT1312608E
PT1312608E PT02025728T PT02025728T PT1312608E PT 1312608 E PT1312608 E PT 1312608E PT 02025728 T PT02025728 T PT 02025728T PT 02025728 T PT02025728 T PT 02025728T PT 1312608 E PT1312608 E PT 1312608E
Authority
PT
Portugal
Prior art keywords
alkyl
formula
hours
acid
compound
Prior art date
Application number
PT02025728T
Other languages
English (en)
Portuguese (pt)
Inventor
Timothy Michael Ramsey
Kenneth Walter Bair
Frederick Ray Kinder Jr
Michael Lloyd Sabio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1312608E publication Critical patent/PT1312608E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
PT02025728T 2001-11-16 2002-11-15 Análogos de discodermolide e a sua utilização farmacêutica PT1312608E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33239901P 2001-11-16 2001-11-16
US34339401P 2001-12-21 2001-12-21

Publications (1)

Publication Number Publication Date
PT1312608E true PT1312608E (pt) 2006-12-29

Family

ID=26988201

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02025728T PT1312608E (pt) 2001-11-16 2002-11-15 Análogos de discodermolide e a sua utilização farmacêutica

Country Status (9)

Country Link
US (2) US6833367B2 (cg-RX-API-DMAC7.html)
EP (1) EP1312608B1 (cg-RX-API-DMAC7.html)
JP (1) JP4410986B2 (cg-RX-API-DMAC7.html)
AT (1) ATE334977T1 (cg-RX-API-DMAC7.html)
CY (1) CY1106201T1 (cg-RX-API-DMAC7.html)
DE (1) DE60213541T2 (cg-RX-API-DMAC7.html)
DK (1) DK1312608T3 (cg-RX-API-DMAC7.html)
ES (1) ES2267928T3 (cg-RX-API-DMAC7.html)
PT (1) PT1312608E (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7348436B2 (en) * 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
FR2951720B1 (fr) * 2009-10-28 2011-12-16 Pf Medicament Molecules polyketides comme agents anticancereux
EP2588474A4 (en) * 2010-07-01 2014-07-23 Yuhan Corp PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATE PRODUCTS THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010099A (en) * 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
US5681847A (en) * 1995-12-05 1997-10-28 Harbor Branch Oceanographic Institution, Inc. Methods of using discodermolide compounds
US6242616B1 (en) * 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6096904A (en) * 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6870058B2 (en) 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6127406A (en) * 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use
AU2001247241A1 (en) * 2000-03-01 2001-09-12 Harbor Branch Oceanographic Institution, Inc. Biologically active analogs of discodermolide

Also Published As

Publication number Publication date
DK1312608T3 (da) 2006-11-27
JP2003160575A (ja) 2003-06-03
EP1312608A2 (en) 2003-05-21
DE60213541T2 (de) 2007-10-04
US7148218B2 (en) 2006-12-12
JP4410986B2 (ja) 2010-02-10
EP1312608A3 (en) 2003-06-18
CY1106201T1 (el) 2011-06-08
ATE334977T1 (de) 2006-08-15
US6833367B2 (en) 2004-12-21
ES2267928T3 (es) 2007-03-16
US20050080080A1 (en) 2005-04-14
DE60213541D1 (de) 2006-09-14
EP1312608B1 (en) 2006-08-02
US20030153601A1 (en) 2003-08-14

Similar Documents

Publication Publication Date Title
JP3984283B2 (ja) プロスタグランヂンニトロオキシ誘導体
RU2125996C1 (ru) 7-ГАЛО- И 7β, 8β-МЕТАНОТАКСОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ И СПОСОБЫ ПОЛУЧЕНИЯ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ
US6107338A (en) Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
JPH1192468A (ja) 新規なタキサン誘導体
NZ228175A (en) Amino acid derivatives and pharmaceutical compositions
JPWO1993003054A1 (ja) 新規なテトラペプチド誘導体
US5109021A (en) Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them
KR20080069228A (ko) 새로운 티오펜 유도체
EP3039009B1 (en) Mao-b selective inhibitor compounds, pharmaceutical compositions thereof and uses thereof
WO2023160039A1 (zh) 具有HDACi药效团的β-榄香烯衍生物及其制备方法和应用
PT1312608E (pt) Análogos de discodermolide e a sua utilização farmacêutica
US4087435A (en) 8-Aza-9-dioxothiaprostanoic acids
EP2233467A1 (en) Alpha-amino-n-substituted amides, pharmaceutical composition containing them and uses thereof
AU606213B2 (en) Novel aminoalkyl-substituted heterocyclic sulfur compounds
CA2431107A1 (en) Antitumoral carbazoles
CN100522956C (zh) 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途
JP2004527583A (ja) ディスコデルモライド酸のある種の塩、それらを含有する医薬組成物および腫瘍の処置におけるそれらの使用
JP2024178481A (ja) Ｇｃｌ阻害剤
US5595998A (en) Pyrazoloquinolines
US20160185743A1 (en) 15-Oxospiramilactone Derivatives, Preparation Method and Uses Thereof
PT88074B (pt) Processo para a preparacao de antagonistas de leucotrieno e de composicoes farmaceuticas que os contem
WO1991013869A1 (fr) Derive de 15-desoxyprostaglandine
JP2003160575A5 (cg-RX-API-DMAC7.html)
FI61691B (fi) Foerfarande foer framstaellning av farmaceutiskt anvaendbara 8,12-di-isoprostansyraderivat
JPWO2003055854A1 (ja) ２位に置換基を有するビタミンｄ誘導体