PT1257577E - Processo para solubilizar compostos peptido 1 do tipo glucagon - Google Patents

Processo para solubilizar compostos peptido 1 do tipo glucagon

Info

Publication number
PT1257577E
PT1257577E PT01904785T PT01904785T PT1257577E PT 1257577 E PT1257577 E PT 1257577E PT 01904785 T PT01904785 T PT 01904785T PT 01904785 T PT01904785 T PT 01904785T PT 1257577 E PT1257577 E PT 1257577E
Authority
PT
Portugal
Prior art keywords
glp
solution
compound
peptide compounds
aqueous
Prior art date
Application number
PT01904785T
Other languages
English (en)
Inventor
Walter Francis Junior Prouty
Joseph Vincent Junior Rinella
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT1257577E publication Critical patent/PT1257577E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
PT01904785T 2000-01-27 2001-01-16 Processo para solubilizar compostos peptido 1 do tipo glucagon PT1257577E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17843800P 2000-01-27 2000-01-27
US22405800P 2000-08-09 2000-08-09

Publications (1)

Publication Number Publication Date
PT1257577E true PT1257577E (pt) 2004-08-31

Family

ID=26874307

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01904785T PT1257577E (pt) 2000-01-27 2001-01-16 Processo para solubilizar compostos peptido 1 do tipo glucagon

Country Status (17)

Country Link
US (4) US7598222B2 (pt)
EP (1) EP1257577B1 (pt)
JP (1) JP2003523366A (pt)
KR (1) KR20020073184A (pt)
AT (1) ATE264870T1 (pt)
AU (1) AU2001232735A1 (pt)
BR (1) BR0107837A (pt)
CA (1) CA2396920A1 (pt)
DE (1) DE60102899T2 (pt)
DK (1) DK1257577T3 (pt)
ES (1) ES2218381T3 (pt)
HU (1) HUP0204281A3 (pt)
IL (2) IL150913A0 (pt)
MX (1) MXPA02007231A (pt)
PT (1) PT1257577E (pt)
TR (1) TR200401142T4 (pt)
WO (1) WO2001055213A2 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1412384B1 (en) 2001-06-28 2007-12-26 Novo Nordisk A/S Stable formulation of modified glp-1
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
AU2003220125B2 (en) 2002-03-20 2006-06-15 Mannkind Corporation Inhalation apparatus
KR20050122220A (ko) * 2003-03-25 2005-12-28 다케다 샌디에고, 인코포레이티드 디펩티딜 펩티다제 억제제
CA2520537C (en) 2003-03-28 2012-01-31 National Institute Of Agrobiological Sciences Process for producing plant storage organ with high production of recombinant protein and novel recombinant protein
JP2007524592A (ja) * 2003-06-03 2007-08-30 ノボ・ノルデイスク・エー/エス 安定化された薬学的ペプチド組成物
KR101308912B1 (ko) 2003-06-03 2013-09-23 노보 노르디스크 에이/에스 안정화된 약학적 펩티드 조성물
ATE529126T1 (de) * 2003-06-03 2011-11-15 Novo Nordisk As Stabilisierte pharmazeutische peptid zusammensetzungen
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
CN1867560A (zh) * 2003-08-13 2006-11-22 武田药品工株式会社 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途
JP2007505121A (ja) * 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
WO2005030751A2 (en) * 2003-09-08 2005-04-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1687019B1 (en) 2003-11-20 2017-11-22 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
CN102134231B (zh) * 2004-03-15 2020-08-04 武田药品工业株式会社 二肽基肽酶抑制剂
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
EP2322180B1 (en) 2004-08-23 2015-05-27 MannKind Corporation Diketopiperazine salts for drug delivery
US8710181B2 (en) * 2004-08-31 2014-04-29 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
ES2735533T3 (es) 2004-11-12 2019-12-19 Novo Nordisk As Formulaciones estables de GLP-1
US7601423B2 (en) 2004-11-19 2009-10-13 Mitsui Chemicals, Inc. Ethylene-based polymer microparticles, functional group-containing ethylene-based polymer microparticles, and catalyst carriers for manufacture thereof
JP2008524331A (ja) 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
WO2006069779A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
TW200643033A (en) * 2005-03-08 2006-12-16 Chugai Pharmaceutical Co Ltd Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
JP5252915B2 (ja) 2005-04-07 2013-07-31 三井化学株式会社 オレフィン系重合体からなるカプセル状の微粒子
CN102908351B (zh) * 2005-09-14 2014-07-23 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
EA015169B1 (ru) 2005-09-14 2011-06-30 Такеда Фармасьютикал Компани Лимитед Применение ингибиторов дипептидилпептидазы
PE20070622A1 (es) * 2005-09-14 2007-08-22 Takeda Pharmaceutical Administracion de inhibidores de dipeptidil peptidasa
RU2390325C2 (ru) 2005-09-14 2010-05-27 Маннкайнд Корпорейшн Способ приготовления лекарственного препарата, основанный на увеличении сродства активных агентов к поверхностям кристаллических микрочастиц
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
CA2622642C (en) * 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
US8445433B2 (en) * 2006-02-08 2013-05-21 Lonza Ag Synthesis of glucagon-like peptide
RU2403059C2 (ru) 2006-02-22 2010-11-10 Маннкайнд Корпорейшн Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20100029941A1 (en) * 2006-03-28 2010-02-04 Takeda Pharmaceutical Company Limited Preparation of (r)-3-aminopiperidine dihydrochloride
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
ATE522216T1 (de) * 2006-09-13 2011-09-15 Takeda Pharmaceutical Verwendung von 2-6-(3-amin-piperidin-1-yl)-3- methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1- ylmethyl-4-fluor-benzonitril zur behandlung von diabetes, krebs, autoimmunerkrankungen und hiv- infektionen
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US8636001B2 (en) 2008-06-13 2014-01-28 Mannkind Corporation Dry powder inhaler and system for drug delivery
DK2609954T3 (da) 2008-06-20 2022-02-14 Mannkind Corp Interaktivt apparat til realtidsafbildning af inhalationspræstationer
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2749099A1 (en) 2009-01-08 2010-07-15 Mannkind Corporation Method for treating hyperglycemia with glp-1
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
EP2482840A4 (en) * 2009-08-07 2013-06-26 Mannkind Corp VAL (8) GLP-1 COMPOSITION AND METHOD FOR THE TREATMENT OF REAGENTS AND / OR IRRITATION SYNDROME
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
CN102718858B (zh) * 2011-03-29 2014-07-02 天津药物研究院 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
WO2012135765A2 (en) 2011-04-01 2012-10-04 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
ES2624961T3 (es) 2013-03-21 2017-07-18 Sanofi-Aventis Deutschland Gmbh Síntesis de productos de péptido que contienen imida cíclica
MX363522B (es) 2013-03-21 2019-03-26 Sanofi Aventis Deutschland Síntesis de productos peptídicos que contienen hidantoína.
MX2020009878A (es) 2013-07-18 2022-07-27 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos.
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
SG11201805255TA (en) 2015-12-23 2018-07-30 Amgen Inc Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
JOP20190177A1 (ar) 2017-01-17 2019-07-16 Amgen Inc طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
JP6633777B2 (ja) 2017-08-24 2020-01-22 ノヴォ ノルディスク アー/エス Glp−1組成物及びその使用
CN111491948A (zh) * 2017-12-19 2020-08-04 诺沃挪第克公司 Glp-1肽的溶解
US11318191B2 (en) 2020-02-18 2022-05-03 Novo Nordisk A/S GLP-1 compositions and uses thereof
WO2022157747A2 (en) 2021-01-25 2022-07-28 Mylan Ireland Limited Pharmaceutical peptide compositions and methods of preparation thereof
WO2022266927A1 (zh) * 2021-06-24 2022-12-29 深圳翰宇药业股份有限公司 一种利拉鲁肽变构体及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3419824A1 (de) * 1984-05-26 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren und formwerkzeug zum herstellen von formteilen mit grill-, gitter- oder rostartigen bereichen, wie kfz-soft-faces, spoiler, bumper, aus einer fliessfaehigen masse
NZ250844A (en) 1993-04-07 1996-03-26 Pfizer Treatment of non-insulin dependant diabetes with peptides; composition
US6380357B2 (en) * 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
ATE269103T1 (de) * 1998-03-13 2004-07-15 Novo Nordisk As Stabilisierte wässerige glukagonlösungen enthaltend detergenzien
US6844321B2 (en) * 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue

Also Published As

Publication number Publication date
IL189371A0 (en) 2008-06-05
JP2003523366A (ja) 2003-08-05
IL150913A0 (en) 2003-02-12
AU2001232735A1 (en) 2001-08-07
US20110053838A1 (en) 2011-03-03
TR200401142T4 (tr) 2004-07-21
BR0107837A (pt) 2003-01-14
DE60102899D1 (de) 2004-05-27
US20120101034A9 (en) 2012-04-26
US8455433B2 (en) 2013-06-04
KR20020073184A (ko) 2002-09-19
DE60102899T2 (de) 2005-03-31
MXPA02007231A (es) 2002-12-09
US7598222B2 (en) 2009-10-06
EP1257577A2 (en) 2002-11-20
US8222205B2 (en) 2012-07-17
WO2001055213A3 (en) 2002-02-28
DK1257577T3 (da) 2004-08-02
US20030060412A1 (en) 2003-03-27
WO2001055213A2 (en) 2001-08-02
EP1257577B1 (en) 2004-04-21
ES2218381T3 (es) 2004-11-16
HUP0204281A3 (en) 2007-03-28
US20130072658A1 (en) 2013-03-21
CA2396920A1 (en) 2001-08-02
HUP0204281A2 (hu) 2003-04-28
ATE264870T1 (de) 2004-05-15
US8268780B2 (en) 2012-09-18
US20120208980A1 (en) 2012-08-16

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