PT1257577E - Processo para solubilizar compostos peptido 1 do tipo glucagon - Google Patents
Processo para solubilizar compostos peptido 1 do tipo glucagonInfo
- Publication number
- PT1257577E PT1257577E PT01904785T PT01904785T PT1257577E PT 1257577 E PT1257577 E PT 1257577E PT 01904785 T PT01904785 T PT 01904785T PT 01904785 T PT01904785 T PT 01904785T PT 1257577 E PT1257577 E PT 1257577E
- Authority
- PT
- Portugal
- Prior art keywords
- glp
- solution
- compound
- peptide compounds
- aqueous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17843800P | 2000-01-27 | 2000-01-27 | |
US22405800P | 2000-08-09 | 2000-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1257577E true PT1257577E (pt) | 2004-08-31 |
Family
ID=26874307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01904785T PT1257577E (pt) | 2000-01-27 | 2001-01-16 | Processo para solubilizar compostos peptido 1 do tipo glucagon |
Country Status (17)
Country | Link |
---|---|
US (4) | US7598222B2 (pt) |
EP (1) | EP1257577B1 (pt) |
JP (1) | JP2003523366A (pt) |
KR (1) | KR20020073184A (pt) |
AT (1) | ATE264870T1 (pt) |
AU (1) | AU2001232735A1 (pt) |
BR (1) | BR0107837A (pt) |
CA (1) | CA2396920A1 (pt) |
DE (1) | DE60102899T2 (pt) |
DK (1) | DK1257577T3 (pt) |
ES (1) | ES2218381T3 (pt) |
HU (1) | HUP0204281A3 (pt) |
IL (2) | IL150913A0 (pt) |
MX (1) | MXPA02007231A (pt) |
PT (1) | PT1257577E (pt) |
TR (1) | TR200401142T4 (pt) |
WO (1) | WO2001055213A2 (pt) |
Families Citing this family (72)
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US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
EP1412384B1 (en) | 2001-06-28 | 2007-12-26 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
CA2841097A1 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin and g-csf fusion proteins |
AU2003220125B2 (en) | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
KR20050122220A (ko) * | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
CA2520537C (en) | 2003-03-28 | 2012-01-31 | National Institute Of Agrobiological Sciences | Process for producing plant storage organ with high production of recombinant protein and novel recombinant protein |
JP2007524592A (ja) * | 2003-06-03 | 2007-08-30 | ノボ・ノルデイスク・エー/エス | 安定化された薬学的ペプチド組成物 |
KR101308912B1 (ko) | 2003-06-03 | 2013-09-23 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
ATE529126T1 (de) * | 2003-06-03 | 2011-11-15 | Novo Nordisk As | Stabilisierte pharmazeutische peptid zusammensetzungen |
US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
CN1867560A (zh) * | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
JP2007505121A (ja) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
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JP2008524331A (ja) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
WO2006069779A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
TW200643033A (en) * | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
JP5252915B2 (ja) | 2005-04-07 | 2013-07-31 | 三井化学株式会社 | オレフィン系重合体からなるカプセル状の微粒子 |
CN102908351B (zh) * | 2005-09-14 | 2014-07-23 | 武田药品工业株式会社 | 用于治疗糖尿病的二肽基肽酶抑制剂 |
EA015169B1 (ru) | 2005-09-14 | 2011-06-30 | Такеда Фармасьютикал Компани Лимитед | Применение ингибиторов дипептидилпептидазы |
PE20070622A1 (es) * | 2005-09-14 | 2007-08-22 | Takeda Pharmaceutical | Administracion de inhibidores de dipeptidil peptidasa |
RU2390325C2 (ru) | 2005-09-14 | 2010-05-27 | Маннкайнд Корпорейшн | Способ приготовления лекарственного препарата, основанный на увеличении сродства активных агентов к поверхностям кристаллических микрочастиц |
TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
CA2622642C (en) * | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
US8445433B2 (en) * | 2006-02-08 | 2013-05-21 | Lonza Ag | Synthesis of glucagon-like peptide |
RU2403059C2 (ru) | 2006-02-22 | 2010-11-10 | Маннкайнд Корпорейшн | Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US20100029941A1 (en) * | 2006-03-28 | 2010-02-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
ATE522216T1 (de) * | 2006-09-13 | 2011-09-15 | Takeda Pharmaceutical | Verwendung von 2-6-(3-amin-piperidin-1-yl)-3- methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1- ylmethyl-4-fluor-benzonitril zur behandlung von diabetes, krebs, autoimmunerkrankungen und hiv- infektionen |
TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
US8636001B2 (en) | 2008-06-13 | 2014-01-28 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
DK2609954T3 (da) | 2008-06-20 | 2022-02-14 | Mannkind Corp | Interaktivt apparat til realtidsafbildning af inhalationspræstationer |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
CA2749099A1 (en) | 2009-01-08 | 2010-07-15 | Mannkind Corporation | Method for treating hyperglycemia with glp-1 |
EP2405963B1 (en) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
CN102647979B (zh) | 2009-06-12 | 2015-03-04 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
EP2482840A4 (en) * | 2009-08-07 | 2013-06-26 | Mannkind Corp | VAL (8) GLP-1 COMPOSITION AND METHOD FOR THE TREATMENT OF REAGENTS AND / OR IRRITATION SYNDROME |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
EP2582421A1 (en) | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
CN102718858B (zh) * | 2011-03-29 | 2014-07-02 | 天津药物研究院 | 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用 |
WO2012135765A2 (en) | 2011-04-01 | 2012-10-04 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CN103945859A (zh) | 2011-10-24 | 2014-07-23 | 曼金德公司 | 用于治疗疼痛的方法和组合物 |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
SG11201507564PA (en) | 2013-03-15 | 2015-10-29 | Mannkind Corp | Microcrystalline diketopiperazine compositions and methods |
ES2624961T3 (es) | 2013-03-21 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos de péptido que contienen imida cíclica |
MX363522B (es) | 2013-03-21 | 2019-03-26 | Sanofi Aventis Deutschland | Síntesis de productos peptídicos que contienen hidantoína. |
MX2020009878A (es) | 2013-07-18 | 2022-07-27 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos. |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US10308677B2 (en) | 2014-12-19 | 2019-06-04 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
US9969769B2 (en) | 2014-12-19 | 2018-05-15 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
SG11201805255TA (en) | 2015-12-23 | 2018-07-30 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
JP6633777B2 (ja) | 2017-08-24 | 2020-01-22 | ノヴォ ノルディスク アー/エス | Glp−1組成物及びその使用 |
CN111491948A (zh) * | 2017-12-19 | 2020-08-04 | 诺沃挪第克公司 | Glp-1肽的溶解 |
US11318191B2 (en) | 2020-02-18 | 2022-05-03 | Novo Nordisk A/S | GLP-1 compositions and uses thereof |
WO2022157747A2 (en) | 2021-01-25 | 2022-07-28 | Mylan Ireland Limited | Pharmaceutical peptide compositions and methods of preparation thereof |
WO2022266927A1 (zh) * | 2021-06-24 | 2022-12-29 | 深圳翰宇药业股份有限公司 | 一种利拉鲁肽变构体及其制备方法、应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3419824A1 (de) * | 1984-05-26 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren und formwerkzeug zum herstellen von formteilen mit grill-, gitter- oder rostartigen bereichen, wie kfz-soft-faces, spoiler, bumper, aus einer fliessfaehigen masse |
NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
US6380357B2 (en) * | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
ATE269103T1 (de) * | 1998-03-13 | 2004-07-15 | Novo Nordisk As | Stabilisierte wässerige glukagonlösungen enthaltend detergenzien |
US6844321B2 (en) * | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
-
2001
- 2001-01-16 DE DE60102899T patent/DE60102899T2/de not_active Expired - Lifetime
- 2001-01-16 CA CA002396920A patent/CA2396920A1/en not_active Abandoned
- 2001-01-16 JP JP2001561060A patent/JP2003523366A/ja not_active Withdrawn
- 2001-01-16 US US10/169,657 patent/US7598222B2/en not_active Expired - Fee Related
- 2001-01-16 KR KR1020027009546A patent/KR20020073184A/ko not_active Application Discontinuation
- 2001-01-16 TR TR2004/01142T patent/TR200401142T4/xx unknown
- 2001-01-16 ES ES01904785T patent/ES2218381T3/es not_active Expired - Lifetime
- 2001-01-16 DK DK01904785T patent/DK1257577T3/da active
- 2001-01-16 BR BR0107837-2A patent/BR0107837A/pt not_active IP Right Cessation
- 2001-01-16 IL IL15091301A patent/IL150913A0/xx unknown
- 2001-01-16 EP EP01904785A patent/EP1257577B1/en not_active Expired - Lifetime
- 2001-01-16 HU HU0204281A patent/HUP0204281A3/hu not_active Application Discontinuation
- 2001-01-16 PT PT01904785T patent/PT1257577E/pt unknown
- 2001-01-16 WO PCT/US2001/000010 patent/WO2001055213A2/en active Application Filing
- 2001-01-16 AU AU2001232735A patent/AU2001232735A1/en not_active Abandoned
- 2001-01-16 AT AT01904785T patent/ATE264870T1/de not_active IP Right Cessation
- 2001-01-16 MX MXPA02007231A patent/MXPA02007231A/es active IP Right Grant
-
2008
- 2008-02-07 IL IL189371A patent/IL189371A0/en unknown
-
2009
- 2009-09-01 US US12/551,841 patent/US8222205B2/en not_active Expired - Fee Related
-
2012
- 2012-04-27 US US13/458,057 patent/US8268780B2/en not_active Expired - Fee Related
- 2012-08-10 US US13/571,443 patent/US8455433B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL189371A0 (en) | 2008-06-05 |
JP2003523366A (ja) | 2003-08-05 |
IL150913A0 (en) | 2003-02-12 |
AU2001232735A1 (en) | 2001-08-07 |
US20110053838A1 (en) | 2011-03-03 |
TR200401142T4 (tr) | 2004-07-21 |
BR0107837A (pt) | 2003-01-14 |
DE60102899D1 (de) | 2004-05-27 |
US20120101034A9 (en) | 2012-04-26 |
US8455433B2 (en) | 2013-06-04 |
KR20020073184A (ko) | 2002-09-19 |
DE60102899T2 (de) | 2005-03-31 |
MXPA02007231A (es) | 2002-12-09 |
US7598222B2 (en) | 2009-10-06 |
EP1257577A2 (en) | 2002-11-20 |
US8222205B2 (en) | 2012-07-17 |
WO2001055213A3 (en) | 2002-02-28 |
DK1257577T3 (da) | 2004-08-02 |
US20030060412A1 (en) | 2003-03-27 |
WO2001055213A2 (en) | 2001-08-02 |
EP1257577B1 (en) | 2004-04-21 |
ES2218381T3 (es) | 2004-11-16 |
HUP0204281A3 (en) | 2007-03-28 |
US20130072658A1 (en) | 2013-03-21 |
CA2396920A1 (en) | 2001-08-02 |
HUP0204281A2 (hu) | 2003-04-28 |
ATE264870T1 (de) | 2004-05-15 |
US8268780B2 (en) | 2012-09-18 |
US20120208980A1 (en) | 2012-08-16 |
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