PT1244625E - 4-piridinil-n-acil-l-fenilalaninas - Google Patents
4-piridinil-n-acil-l-fenilalaninasInfo
- Publication number
- PT1244625E PT1244625E PT00985117T PT00985117T PT1244625E PT 1244625 E PT1244625 E PT 1244625E PT 00985117 T PT00985117 T PT 00985117T PT 00985117 T PT00985117 T PT 00985117T PT 1244625 E PT1244625 E PT 1244625E
- Authority
- PT
- Portugal
- Prior art keywords
- phenylalanins
- pyridinyl
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16909099P | 1999-12-06 | 1999-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1244625E true PT1244625E (pt) | 2005-09-30 |
Family
ID=22614226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00985117T PT1244625E (pt) | 1999-12-06 | 2000-11-29 | 4-piridinil-n-acil-l-fenilalaninas |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1244625B1 (pt) |
| JP (2) | JP2003516392A (pt) |
| KR (1) | KR100492111B1 (pt) |
| CN (1) | CN1196682C (pt) |
| AR (1) | AR031083A1 (pt) |
| AT (1) | ATE297895T1 (pt) |
| AU (1) | AU779063B2 (pt) |
| BR (1) | BR0016172A (pt) |
| CA (1) | CA2392566A1 (pt) |
| CO (1) | CO5080771A1 (pt) |
| CZ (1) | CZ20022352A3 (pt) |
| DE (1) | DE60020883T2 (pt) |
| DK (1) | DK1244625T3 (pt) |
| ES (1) | ES2243335T3 (pt) |
| GC (1) | GC0000214A (pt) |
| HK (1) | HK1053470A1 (pt) |
| HR (1) | HRP20020467A2 (pt) |
| HU (1) | HUP0203735A3 (pt) |
| IL (2) | IL149622A0 (pt) |
| JO (1) | JO2281B1 (pt) |
| MA (1) | MA26849A1 (pt) |
| MX (1) | MXPA02005240A (pt) |
| MY (1) | MY128003A (pt) |
| NO (1) | NO322910B1 (pt) |
| NZ (1) | NZ518888A (pt) |
| PE (1) | PE20010960A1 (pt) |
| PL (1) | PL364814A1 (pt) |
| PT (1) | PT1244625E (pt) |
| RU (1) | RU2270193C2 (pt) |
| TW (1) | TWI276629B (pt) |
| UY (1) | UY26470A1 (pt) |
| WO (1) | WO2001042215A1 (pt) |
| YU (1) | YU40502A (pt) |
| ZA (1) | ZA200203762B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| CZ302653B6 (cs) | 2000-08-18 | 2011-08-17 | Ajinomoto Co., Inc. | Fenylalaninové deriváty, alfa-4-integrinový antagonist, terapeutické cinidlo nebo preventivní cinidlo a farmaceutický prostredek obsahující tyto deriváty |
| EP1323711B1 (en) * | 2000-09-29 | 2006-11-15 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| EP1454898A4 (en) | 2001-12-13 | 2006-12-13 | Ajinomoto Kk | NEW PHENYL ALANIDE DERIVATIVES |
| EP1465869B1 (en) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulators of lxr |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| ES2548853T3 (es) | 2003-12-22 | 2015-10-21 | Ajinomoto Co., Inc. | Derivado de fenilalanina |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| JP4649476B2 (ja) * | 2004-08-16 | 2011-03-09 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｖｌａ−４拮抗薬 |
| JP4784224B2 (ja) | 2004-09-24 | 2011-10-05 | 味の素株式会社 | 糖鎖転移方法および糖鎖転移酵素 |
| WO2007100763A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| AR060901A1 (es) * | 2006-05-12 | 2008-07-23 | Jerini Ag | Compuestos heterociclicos para la inhibicion de integrinas y uso de estos |
| US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| ES2525065T3 (es) | 2008-04-11 | 2014-12-17 | Merrimack Pharmaceuticals, Inc. | Ligadores de seroalbúmina humana y sus conjugados |
| BR112012001558A2 (pt) * | 2009-07-23 | 2016-03-08 | Bayer Cropscience Ag | alcoxienonas e enaminocetonas e um processo para a sua preparação |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| CN104023751B (zh) * | 2012-01-27 | 2016-11-09 | 弗·哈夫曼-拉罗切有限公司 | 靶向递送至表达vla-4的细胞的整联蛋白拮抗剂结合物 |
| CA2913791A1 (en) * | 2013-06-11 | 2014-12-18 | Receptos, Inc. | Novel glp-1 receptor modulators |
| AU2017214589B2 (en) | 2016-02-05 | 2020-09-03 | Ea Pharma Co., Ltd. | Sulfonamide derivative and pharmaceutical composition containing same |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| SG11202103484RA (en) | 2018-10-30 | 2021-05-28 | Gilead Sciences Inc | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| CN112969504B (zh) | 2018-10-30 | 2024-04-09 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| CA3148613A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
| JP2001517245A (ja) * | 1997-05-29 | 2001-10-02 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としてのビアリールアルカン酸類 |
| US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6329372B1 (en) * | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| ES2226413T3 (es) * | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | Derivados de fenilalanina como inhibidores de alfa-4 integrinas. |
| GB9811159D0 (en) * | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE261932T1 (de) * | 1998-12-22 | 2004-04-15 | Tanabe Seiyaku Co | Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion |
| CN1231212C (zh) * | 1999-01-22 | 2005-12-14 | 依兰制药公司 | 抑制vla－4介导的白细胞粘着的多环化合物 |
-
2000
- 2000-11-29 AT AT00985117T patent/ATE297895T1/de not_active IP Right Cessation
- 2000-11-29 PT PT00985117T patent/PT1244625E/pt unknown
- 2000-11-29 CN CNB008164800A patent/CN1196682C/zh not_active Expired - Fee Related
- 2000-11-29 IL IL14962200A patent/IL149622A0/xx active IP Right Grant
- 2000-11-29 CA CA002392566A patent/CA2392566A1/en not_active Abandoned
- 2000-11-29 PL PL00364814A patent/PL364814A1/xx not_active Application Discontinuation
- 2000-11-29 BR BR0016172-1A patent/BR0016172A/pt not_active Application Discontinuation
- 2000-11-29 MX MXPA02005240A patent/MXPA02005240A/es active IP Right Grant
- 2000-11-29 JP JP2001543516A patent/JP2003516392A/ja active Pending
- 2000-11-29 RU RU2002117419/04A patent/RU2270193C2/ru not_active IP Right Cessation
- 2000-11-29 WO PCT/EP2000/011979 patent/WO2001042215A1/en active IP Right Grant
- 2000-11-29 DK DK00985117T patent/DK1244625T3/da active
- 2000-11-29 DE DE60020883T patent/DE60020883T2/de not_active Expired - Lifetime
- 2000-11-29 NZ NZ518888A patent/NZ518888A/en unknown
- 2000-11-29 AU AU21639/01A patent/AU779063B2/en not_active Ceased
- 2000-11-29 ES ES00985117T patent/ES2243335T3/es not_active Expired - Lifetime
- 2000-11-29 KR KR10-2002-7007201A patent/KR100492111B1/ko not_active IP Right Cessation
- 2000-11-29 JO JO2000189A patent/JO2281B1/en active
- 2000-11-29 EP EP00985117A patent/EP1244625B1/en not_active Expired - Lifetime
- 2000-11-29 HU HU0203735A patent/HUP0203735A3/hu unknown
- 2000-11-29 CZ CZ20022352A patent/CZ20022352A3/cs unknown
- 2000-11-29 YU YU40502A patent/YU40502A/sh unknown
- 2000-12-02 GC GCP20001072 patent/GC0000214A/en active
- 2000-12-04 MY MYPI20005689A patent/MY128003A/en unknown
- 2000-12-04 AR ARP000106416A patent/AR031083A1/es not_active Application Discontinuation
- 2000-12-05 CO CO00092690A patent/CO5080771A1/es unknown
- 2000-12-05 TW TW089125889A patent/TWI276629B/zh not_active IP Right Cessation
- 2000-12-05 UY UY26470A patent/UY26470A1/es not_active Application Discontinuation
- 2000-12-06 PE PE2000001306A patent/PE20010960A1/es not_active Application Discontinuation
-
2002
- 2002-05-10 ZA ZA200203762A patent/ZA200203762B/xx unknown
- 2002-05-13 IL IL149622A patent/IL149622A/en not_active IP Right Cessation
- 2002-05-28 HR HR20020467A patent/HRP20020467A2/xx not_active Application Discontinuation
- 2002-06-05 NO NO20022650A patent/NO322910B1/no unknown
- 2002-06-05 MA MA26672A patent/MA26849A1/fr unknown
-
2003
- 2003-08-13 HK HK03105803A patent/HK1053470A1/xx not_active IP Right Cessation
-
2007
- 2007-10-05 JP JP2007262543A patent/JP2008094842A/ja active Pending
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