PT1171132E - Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcool - Google Patents
Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcoolInfo
- Publication number
- PT1171132E PT1171132E PT00921946T PT00921946T PT1171132E PT 1171132 E PT1171132 E PT 1171132E PT 00921946 T PT00921946 T PT 00921946T PT 00921946 T PT00921946 T PT 00921946T PT 1171132 E PT1171132 E PT 1171132E
- Authority
- PT
- Portugal
- Prior art keywords
- naltrexone
- heroin
- reduction
- injectable formulations
- alcohol consumption
- Prior art date
Links
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title abstract 4
- 229960003086 naltrexone Drugs 0.000 title abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 239000007972 injectable composition Substances 0.000 title 1
- 239000004005 microsphere Substances 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 abstract 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 abstract 1
- 229960002069 diamorphine Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12847799P | 1999-04-09 | 1999-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1171132E true PT1171132E (pt) | 2004-07-30 |
Family
ID=22435553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00921946T PT1171132E (pt) | 1999-04-09 | 2000-04-08 | Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcool |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6306425B1 (https=) |
| EP (1) | EP1171132B1 (https=) |
| JP (2) | JP4995371B2 (https=) |
| KR (1) | KR100621261B1 (https=) |
| CN (1) | CN1210031C (https=) |
| AT (1) | ATE262906T1 (https=) |
| AU (1) | AU780852B2 (https=) |
| BR (1) | BR0009639A (https=) |
| CA (1) | CA2369302C (https=) |
| CZ (1) | CZ20013636A3 (https=) |
| DE (1) | DE60009477T2 (https=) |
| DK (1) | DK1171132T3 (https=) |
| EA (1) | EA004734B1 (https=) |
| ES (1) | ES2218147T3 (https=) |
| HK (1) | HK1047245B (https=) |
| HU (1) | HUP0200838A3 (https=) |
| IL (2) | IL145802A0 (https=) |
| MX (1) | MXPA01010185A (https=) |
| NO (1) | NO328647B1 (https=) |
| NZ (1) | NZ515359A (https=) |
| PL (1) | PL196930B1 (https=) |
| PT (1) | PT1171132E (https=) |
| TR (1) | TR200102880T2 (https=) |
| UA (1) | UA79921C2 (https=) |
| WO (1) | WO2000061147A1 (https=) |
Families Citing this family (59)
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|---|---|---|---|---|
| US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
| US7919119B2 (en) | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| AU2001223396A1 (en) * | 2000-02-01 | 2001-08-14 | Disetronic Licensing Ag | Container and device for administering a substance |
| US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| CN1610551A (zh) * | 2001-07-06 | 2005-04-27 | 恩德制药公司 | 用作止痛剂的6－羟基羟吗啡酮的肠胃外给药 |
| KR20030048026A (ko) | 2001-07-06 | 2003-06-18 | 펜웨스트 파머슈티칼즈 컴파니 | 옥시모르폰의 서방형 제제 |
| US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7053134B2 (en) | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
| US7041320B1 (en) | 2002-05-31 | 2006-05-09 | Biotek, Inc. | High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence |
| US7157102B1 (en) | 2002-05-31 | 2007-01-02 | Biotek, Inc. | Multi-layered microcapsules and method of preparing same |
| US6972291B2 (en) * | 2002-07-02 | 2005-12-06 | Bernstein Richard K | Method for reducing food intake |
| US7449236B2 (en) | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US20040109886A1 (en) * | 2002-08-27 | 2004-06-10 | Larry Rigby | Methods and apparatus for transdermal delivery of abusable drugs with a deterrent agent |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7588825B2 (en) | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
| US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| EP1610674A4 (en) * | 2003-03-13 | 2008-05-21 | Cheryl M Burgess | METHODS OF ADMINISTERING MATERIAL TO PATIENT TO OBTAIN DERMAL IMPROVEMENT |
| US7279579B2 (en) * | 2003-06-04 | 2007-10-09 | Alkermes, Inc. | Polymorphic forms of naltrexone |
| US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| US20050031713A1 (en) * | 2003-08-06 | 2005-02-10 | Elliot Ehrich | Methods for administering active agents to CYP3A4 sensitive patients |
| US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| BRPI0414907A (pt) * | 2003-09-30 | 2006-11-07 | Acusphere Inc | formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas |
| US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
| HRP20090363T1 (hr) * | 2004-02-23 | 2009-08-31 | Euro-Celtique S.A. | Transdermalni injektor opioida rezistentan na zlouporabu |
| US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| US20050245461A1 (en) * | 2004-03-19 | 2005-11-03 | Elliot Ehrich | Methods for treating alcoholism |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| US7919499B2 (en) | 2004-04-22 | 2011-04-05 | Alkermes, Inc. | Naltrexone long acting formulations and methods of use |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
| US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
| US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| CN1872063B (zh) * | 2005-06-03 | 2011-01-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 纳美芬或其盐的长效注射用微球或组合物及其制备方法 |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| US7501179B2 (en) | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| EP1810714A1 (de) * | 2006-01-19 | 2007-07-25 | Holger Lars Hermann | Verwendung einer Kombination von Heroin und Naloxon zur Drogensubstitution |
| RU2310449C1 (ru) * | 2006-05-17 | 2007-11-20 | Руслан Геннадьевич Нервалев | Способ лечения опиоидной и/или алкогольной зависимости |
| EP2214672B1 (en) * | 2007-10-18 | 2012-10-17 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| US8486448B2 (en) | 2007-12-17 | 2013-07-16 | Paladin Labs Inc. | Misuse preventative, controlled release formulation |
| AU2009327312A1 (en) | 2008-12-16 | 2011-08-04 | Labopharm Europe Limited | Misuse preventative, controlled release formulation |
| US20100196436A1 (en) * | 2009-01-30 | 2010-08-05 | Gooberman Lance L | Implants containing disulfiram and an anti-inflammatory agent |
| US8791093B2 (en) * | 2009-05-29 | 2014-07-29 | Lance L. Gooberman | Pharmaceutical delivery systems for treatment of substance abuse and other addictions |
| US20110223244A1 (en) * | 2010-03-09 | 2011-09-15 | Elan Pharma International Limited | Alcohol resistant enteric pharmaceutical compositions |
| RU2476209C1 (ru) * | 2012-02-29 | 2013-02-27 | Станислав Анатольевич Кедик | Имплантируемое лекарственное средство на основе налтрексона для лечения пациентов, зависимых от алкоголя или опиатов |
| BR112016002342A8 (pt) | 2013-08-06 | 2018-01-23 | Dong Kook Pharm Co Ltd | microesfera entecavir, método para preparação de uma microesfera entecavir, e, composição farmacêutica |
| WO2016013993A1 (en) * | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| AU2019362730B2 (en) | 2018-10-15 | 2022-10-20 | Chong Kun Dang Pharmaceutical Corp. | Injectable long-acting naltrexone microparticle compositions |
| GR1009871B (el) * | 2019-07-30 | 2020-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει μικροσφαιριδια ναλτρεξονης και μεθοδος παρασκευης αυτου |
| US20210059943A1 (en) * | 2019-09-04 | 2021-03-04 | Buffalo Pacific LLC | Systems and methods addressing multiple aspects to provide a comprehensive recovery program for addictions, chronic conditions and diseases |
| WO2022191615A1 (ko) * | 2021-03-09 | 2022-09-15 | (주)인벤티지랩 | 저용량 날트렉손을 함유하는 자가면역질환 예방 또는 치료용 서방성 제제 및 이를 이용한 방법 |
| CA3236690A1 (en) * | 2021-11-18 | 2023-05-25 | Ju Hee Kim | Sustained-release injectable composition containing naltrexone and method for preparing same |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
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| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
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| DE3710175A1 (de) | 1987-02-12 | 1988-08-25 | Hoechst Ag | Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung |
| FR2618674B1 (fr) | 1987-07-30 | 1990-06-15 | Ire Celltarg Sa | Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation |
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| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| US4902515A (en) | 1988-04-28 | 1990-02-20 | E. I. Dupont De Nemours And Company | Polylactide compositions |
| WO1990013361A1 (en) | 1989-05-04 | 1990-11-15 | Southern Research Institute | Improved encapsulation process and products therefrom |
| US5486362A (en) * | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
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| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| CA2290788A1 (en) * | 1997-05-20 | 1998-11-26 | Suchitra Krishnan-Sarin | Substance dependence treatment using opiate antagonists and serotonin compounds |
| JPH11269094A (ja) * | 1998-01-16 | 1999-10-05 | Takeda Chem Ind Ltd | 徐放性組成物、その製造法および用途 |
-
2000
- 2000-04-07 US US09/545,064 patent/US6306425B1/en not_active Expired - Fee Related
- 2000-04-08 JP JP2000610480A patent/JP4995371B2/ja not_active Expired - Fee Related
- 2000-04-08 AT AT00921946T patent/ATE262906T1/de not_active IP Right Cessation
- 2000-04-08 NZ NZ515359A patent/NZ515359A/xx unknown
- 2000-04-08 EA EA200101062A patent/EA004734B1/ru active IP Right Revival
- 2000-04-08 CN CNB008085684A patent/CN1210031C/zh not_active Expired - Fee Related
- 2000-04-08 ES ES00921946T patent/ES2218147T3/es not_active Expired - Lifetime
- 2000-04-08 AU AU42203/00A patent/AU780852B2/en not_active Ceased
- 2000-04-08 MX MXPA01010185A patent/MXPA01010185A/es active IP Right Grant
- 2000-04-08 EP EP00921946A patent/EP1171132B1/en not_active Expired - Lifetime
- 2000-04-08 PL PL350548A patent/PL196930B1/pl unknown
- 2000-04-08 TR TR2001/02880T patent/TR200102880T2/xx unknown
- 2000-04-08 DK DK00921946T patent/DK1171132T3/da active
- 2000-04-08 CZ CZ20013636A patent/CZ20013636A3/cs unknown
- 2000-04-08 IL IL14580200A patent/IL145802A0/xx active IP Right Grant
- 2000-04-08 BR BR0009639-3A patent/BR0009639A/pt not_active Application Discontinuation
- 2000-04-08 CA CA002369302A patent/CA2369302C/en not_active Expired - Fee Related
- 2000-04-08 WO PCT/US2000/009438 patent/WO2000061147A1/en not_active Ceased
- 2000-04-08 PT PT00921946T patent/PT1171132E/pt unknown
- 2000-04-08 HU HU0200838A patent/HUP0200838A3/hu unknown
- 2000-04-08 KR KR1020017012866A patent/KR100621261B1/ko not_active Expired - Fee Related
- 2000-04-08 HK HK02108954.5A patent/HK1047245B/zh not_active IP Right Cessation
- 2000-04-08 DE DE60009477T patent/DE60009477T2/de not_active Expired - Lifetime
- 2000-08-04 UA UA2001117615A patent/UA79921C2/uk unknown
-
2001
- 2001-10-05 IL IL145802A patent/IL145802A/en unknown
- 2001-10-08 NO NO20014896A patent/NO328647B1/no not_active IP Right Cessation
-
2009
- 2009-11-02 JP JP2009252183A patent/JP2010031036A/ja active Pending
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