PT1095055E - Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretos - Google Patents
Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretosInfo
- Publication number
- PT1095055E PT1095055E PT99933442T PT99933442T PT1095055E PT 1095055 E PT1095055 E PT 1095055E PT 99933442 T PT99933442 T PT 99933442T PT 99933442 T PT99933442 T PT 99933442T PT 1095055 E PT1095055 E PT 1095055E
- Authority
- PT
- Portugal
- Prior art keywords
- recombinant
- production
- trysulfureth
- peptidees
- low
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802454A SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Production of peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1095055E true PT1095055E (pt) | 2003-12-31 |
Family
ID=20412012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99933442T PT1095055E (pt) | 1998-07-08 | 1999-07-05 | Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7232894B1 (sv) |
| EP (1) | EP1095055B1 (sv) |
| JP (1) | JP2002520332A (sv) |
| AT (1) | ATE248855T1 (sv) |
| AU (1) | AU755083B2 (sv) |
| CA (1) | CA2344506C (sv) |
| DE (1) | DE69911024T2 (sv) |
| DK (1) | DK1095055T3 (sv) |
| ES (1) | ES2207255T3 (sv) |
| IL (1) | IL140668A0 (sv) |
| NZ (1) | NZ509179A (sv) |
| PT (1) | PT1095055E (sv) |
| SE (1) | SE9802454D0 (sv) |
| WO (1) | WO2000002900A1 (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60042969D1 (de) | 1999-03-02 | 2009-10-29 | Life Technologies Corp | Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren |
| KR100674528B1 (ko) | 1999-06-28 | 2007-01-29 | 제넨테크, 인크. | 2가 금속 이온을 사용한 Ａｐｏ-2 리간드 제조 방법 |
| US20040048315A1 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| ZA200501841B (en) * | 2002-08-28 | 2007-06-27 | Pharmacia Corp | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| DE60330787D1 (de) * | 2002-09-20 | 2010-02-11 | Pharmacia Corp | Verfahren zur verringerung der aggregatmengen des pegylierten proteins |
| EP1697534B1 (en) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| US20090131311A1 (en) * | 2004-12-29 | 2009-05-21 | Novo Nordisk Healthcare Ag | Method for Preventing Formation of Trisulfide Derivatives of Polypeptides |
| EP2483289B1 (en) | 2009-10-02 | 2019-03-20 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| WO2012158551A1 (en) | 2011-05-13 | 2012-11-22 | Biogen Idec Ma Inc. | Methods of preventing and removing trisulfide bonds |
| SG10202102467RA (en) | 2014-07-24 | 2021-04-29 | Genentech Inc | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256546A (en) * | 1983-07-15 | 1993-10-26 | Bio-Technology General Corp. | Bacterial expression of porcine growth hormone |
| US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
| DK44593D0 (da) | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
-
1998
- 1998-07-08 SE SE9802454A patent/SE9802454D0/sv unknown
-
1999
- 1999-07-05 JP JP2000559129A patent/JP2002520332A/ja active Pending
- 1999-07-05 PT PT99933442T patent/PT1095055E/pt unknown
- 1999-07-05 IL IL14066899A patent/IL140668A0/xx unknown
- 1999-07-05 NZ NZ509179A patent/NZ509179A/xx unknown
- 1999-07-05 AT AT99933442T patent/ATE248855T1/de not_active IP Right Cessation
- 1999-07-05 US US09/743,023 patent/US7232894B1/en not_active Expired - Fee Related
- 1999-07-05 DK DK99933442T patent/DK1095055T3/da active
- 1999-07-05 DE DE69911024T patent/DE69911024T2/de not_active Expired - Lifetime
- 1999-07-05 AU AU49496/99A patent/AU755083B2/en not_active Ceased
- 1999-07-05 CA CA2344506A patent/CA2344506C/en not_active Expired - Fee Related
- 1999-07-05 ES ES99933442T patent/ES2207255T3/es not_active Expired - Lifetime
- 1999-07-05 EP EP99933442A patent/EP1095055B1/en not_active Revoked
- 1999-07-05 WO PCT/SE1999/001222 patent/WO2000002900A1/en active IP Right Grant
-
2007
- 2007-05-18 US US11/750,692 patent/US20070232792A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE248855T1 (de) | 2003-09-15 |
| DE69911024D1 (de) | 2003-10-09 |
| EP1095055A1 (en) | 2001-05-02 |
| CA2344506C (en) | 2010-05-11 |
| EP1095055B1 (en) | 2003-09-03 |
| DE69911024T2 (de) | 2004-04-01 |
| NZ509179A (en) | 2003-01-31 |
| AU755083B2 (en) | 2002-12-05 |
| ES2207255T3 (es) | 2004-05-16 |
| SE9802454D0 (sv) | 1998-07-08 |
| CA2344506A1 (en) | 2000-01-20 |
| IL140668A0 (en) | 2002-02-10 |
| US20070232792A1 (en) | 2007-10-04 |
| DK1095055T3 (da) | 2003-12-22 |
| WO2000002900A1 (en) | 2000-01-20 |
| US7232894B1 (en) | 2007-06-19 |
| AU4949699A (en) | 2000-02-01 |
| JP2002520332A (ja) | 2002-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1095055E (pt) | Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretos | |
| ATE298372T1 (de) | Verfahren zur ethanolherstellung mit kontinuierliche beimischung von hefe | |
| WO2001041740A3 (en) | Reconstitution of purified membrane proteins into preformed liposomes | |
| DE60138127D1 (de) | Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine | |
| WO1998014602A3 (en) | Preparation of d-amino acids by direct fermentative means | |
| DK1210411T3 (da) | Sammensætninger og fremgangsmåder til forbedret celledyrkning | |
| WO2002029083A3 (en) | Industrial-scale serum-free production of recombinant proteins in mammalian cells | |
| BR0012712B1 (pt) | métodos de produção de l-aminoácidos aumentando-se o nadph celular. | |
| AR020735A1 (es) | Un procedimiento para la obtencion de un polipeptido glucosilado a partir de celulas eucarioticas | |
| AP1726A (en) | Tobacco biomass utilization. | |
| ATE512230T1 (de) | Proteinherstellungsverfahren unter nutzung von yebf | |
| WO2002030958A3 (de) | Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen | |
| DE69939548D1 (de) | Verfahren zur herstellung von faktor vii | |
| WO2004033627A3 (en) | Methods for efficient production of mammalian recombinant proteins | |
| WO2005066208A3 (en) | Method for production of recombinant growth hormone in form of hybrid protein | |
| Foidart et al. | Biosynthesis of type IV and V (αA-αB) collagens by human placenta | |
| DK1472286T3 (da) | Produktionsmetode til rekombinant placental vækstfaktor | |
| WO2002040686A3 (en) | Expression system for recombinant proteins | |
| ATE354654T1 (de) | Identifizierung humaner zellinien zur produktion humaner proteine durch endogene genaktivierung | |
| JPS6420086A (en) | Polypeptide and production thereof | |
| DK0876610T3 (da) | Fremgangsmåde og anvendelse af polypeptid i sædcelle-æg-binding til at foröge eller mindske fertilitet | |
| WO2005046581A3 (en) | P18 in stem cell manipulations | |
| BR0009636A (pt) | Preparação de procarboxipeptidase b pancreática, formas iso e muteìnas das mesmas e seu emprego | |
| NZ516617A (en) | Soluble, active recombinant human MAO-B | |
| JO2429B1 (en) | Ways to produce recombinant peptides of antigen - merger |