IL140668A0 - Method for the production of recombinant peptides with a low amount of trisulfides - Google Patents
Method for the production of recombinant peptides with a low amount of trisulfidesInfo
- Publication number
- IL140668A0 IL140668A0 IL14066899A IL14066899A IL140668A0 IL 140668 A0 IL140668 A0 IL 140668A0 IL 14066899 A IL14066899 A IL 14066899A IL 14066899 A IL14066899 A IL 14066899A IL 140668 A0 IL140668 A0 IL 140668A0
- Authority
- IL
- Israel
- Prior art keywords
- production
- recombinant
- recombinant peptides
- trisulfides
- low amount
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9802454A SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Production of peptides |
PCT/SE1999/001222 WO2000002900A1 (en) | 1998-07-08 | 1999-07-05 | Method for the production of recombinant peptides with a low amount of trisulfides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL140668A0 true IL140668A0 (en) | 2002-02-10 |
Family
ID=20412012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14066899A IL140668A0 (en) | 1998-07-08 | 1999-07-05 | Method for the production of recombinant peptides with a low amount of trisulfides |
Country Status (14)
Country | Link |
---|---|
US (2) | US7232894B1 (sv) |
EP (1) | EP1095055B1 (sv) |
JP (1) | JP2002520332A (sv) |
AT (1) | ATE248855T1 (sv) |
AU (1) | AU755083B2 (sv) |
CA (1) | CA2344506C (sv) |
DE (1) | DE69911024T2 (sv) |
DK (1) | DK1095055T3 (sv) |
ES (1) | ES2207255T3 (sv) |
IL (1) | IL140668A0 (sv) |
NZ (1) | NZ509179A (sv) |
PT (1) | PT1095055E (sv) |
SE (1) | SE9802454D0 (sv) |
WO (1) | WO2000002900A1 (sv) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE443074T1 (de) | 1999-03-02 | 2009-10-15 | Life Technologies Corp | Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren |
MXPA01013236A (es) | 1999-06-28 | 2002-06-21 | Genentech Inc | Metodos para hacer ligando apo-2 mediante el uso de iones metalicos divalentes. |
US20040048315A1 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
ZA200501841B (en) * | 2002-08-28 | 2007-06-27 | Pharmacia Corp | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
WO2004026251A2 (en) * | 2002-09-20 | 2004-04-01 | Pharmacia Corporation | Process for decreasing aggregate levels of pegylated protein |
WO2005054438A2 (en) | 2003-12-01 | 2005-06-16 | Invitrogen Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
WO2006069940A1 (en) * | 2004-12-29 | 2006-07-06 | Novo Nordisk Health Care Ag | Method for preventing formation of trisulfide derivatives of polypeptides |
DK2483289T3 (da) * | 2009-10-02 | 2019-06-11 | Biogen Ma Inc | Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger |
JP6236383B2 (ja) | 2011-05-13 | 2017-11-22 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | トリスルフィド結合を防止および除去する方法 |
SG11201700365TA (en) | 2014-07-24 | 2017-02-27 | Genentech Inc | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256546A (en) * | 1983-07-15 | 1993-10-26 | Bio-Technology General Corp. | Bacterial expression of porcine growth hormone |
US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
-
1998
- 1998-07-08 SE SE9802454A patent/SE9802454D0/sv unknown
-
1999
- 1999-07-05 DK DK99933442T patent/DK1095055T3/da active
- 1999-07-05 IL IL14066899A patent/IL140668A0/xx unknown
- 1999-07-05 NZ NZ509179A patent/NZ509179A/xx unknown
- 1999-07-05 US US09/743,023 patent/US7232894B1/en not_active Expired - Fee Related
- 1999-07-05 WO PCT/SE1999/001222 patent/WO2000002900A1/en active IP Right Grant
- 1999-07-05 EP EP99933442A patent/EP1095055B1/en not_active Revoked
- 1999-07-05 DE DE69911024T patent/DE69911024T2/de not_active Expired - Lifetime
- 1999-07-05 ES ES99933442T patent/ES2207255T3/es not_active Expired - Lifetime
- 1999-07-05 CA CA2344506A patent/CA2344506C/en not_active Expired - Fee Related
- 1999-07-05 JP JP2000559129A patent/JP2002520332A/ja active Pending
- 1999-07-05 PT PT99933442T patent/PT1095055E/pt unknown
- 1999-07-05 AU AU49496/99A patent/AU755083B2/en not_active Ceased
- 1999-07-05 AT AT99933442T patent/ATE248855T1/de not_active IP Right Cessation
-
2007
- 2007-05-18 US US11/750,692 patent/US20070232792A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT1095055E (pt) | 2003-12-31 |
AU4949699A (en) | 2000-02-01 |
ATE248855T1 (de) | 2003-09-15 |
US7232894B1 (en) | 2007-06-19 |
EP1095055A1 (en) | 2001-05-02 |
NZ509179A (en) | 2003-01-31 |
CA2344506C (en) | 2010-05-11 |
DE69911024T2 (de) | 2004-04-01 |
DE69911024D1 (de) | 2003-10-09 |
ES2207255T3 (es) | 2004-05-16 |
AU755083B2 (en) | 2002-12-05 |
DK1095055T3 (da) | 2003-12-22 |
US20070232792A1 (en) | 2007-10-04 |
CA2344506A1 (en) | 2000-01-20 |
WO2000002900A1 (en) | 2000-01-20 |
EP1095055B1 (en) | 2003-09-03 |
SE9802454D0 (sv) | 1998-07-08 |
JP2002520332A (ja) | 2002-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998014602A3 (en) | Preparation of d-amino acids by direct fermentative means | |
IL140668A0 (en) | Method for the production of recombinant peptides with a low amount of trisulfides | |
ES8604305A1 (es) | Un metodo de hidrolizar celulosa | |
AP1726A (en) | Tobacco biomass utilization. | |
AU3993495A (en) | Process for producing transformed cell | |
WO2001006988A3 (en) | Super-active porcine growth hormone releasing hormone analog | |
IL155482A0 (en) | Metabolic rate shifts in fermentations expressing recombinant proteins | |
AU1262900A (en) | Method for the production of fvii | |
EP0111389A3 (en) | Substantially pure porcine growth hormone, dna sequences therefor, and expression vehicles and transfected microorganisms for the production of porcine growth hormone | |
WO2002030958A3 (de) | Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen | |
EP0256421A3 (en) | Secretion of heterologous proteins from yeast | |
NZ504486A (en) | Attaching substances to micro-organisms | |
WO2005066208A3 (en) | Method for production of recombinant growth hormone in form of hybrid protein | |
WO2004033627A3 (en) | Methods for efficient production of mammalian recombinant proteins | |
WO2002040686A3 (en) | Expression system for recombinant proteins | |
HRP20040795A2 (en) | Production process of recombinant placental growth factor | |
WO2003099233A3 (en) | Microbial conversion of glucose to para-hydroxystyrene | |
FI964208A (sv) | Förfarande för kontrollering av utfällningen av metallofosfat i fermenteringar med hög celltäthet | |
IL148575A0 (en) | Method for increasing the yield of recombinant proteins in microbial fermentation processes | |
AU2001271344A1 (en) | Methods for improving cell growth and alcohol production during fermentation | |
WO2002016584A3 (en) | Process for the preparation of neutrophil inhibitory factor | |
AU1703201A (en) | Method for enhancing secretion of beta-lactam transport | |
WO2007149000A3 (en) | New structural protein preparations | |
WO2000008142A3 (de) | Faserproteine und ihre herstellung | |
TNSN01128A1 (en) | Process for the preparation of a neutrophil inhibitory factor |