DE69939548D1 - Verfahren zur herstellung von faktor vii - Google Patents

Verfahren zur herstellung von faktor vii

Info

Publication number
DE69939548D1
DE69939548D1 DE69939548T DE69939548T DE69939548D1 DE 69939548 D1 DE69939548 D1 DE 69939548D1 DE 69939548 T DE69939548 T DE 69939548T DE 69939548 T DE69939548 T DE 69939548T DE 69939548 D1 DE69939548 D1 DE 69939548D1
Authority
DE
Germany
Prior art keywords
factor vii
manufacture
cells
fvii
secretion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939548T
Other languages
English (en)
Inventor
Helle Woeldike
Finn C Wiberg
Lars Soegaard Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Novo Nordisk Health Care AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Application granted granted Critical
Publication of DE69939548D1 publication Critical patent/DE69939548D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
DE69939548T 1998-11-06 1999-11-05 Verfahren zur herstellung von faktor vii Expired - Lifetime DE69939548D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA199801436 1998-11-06
DKPA199801439 1998-11-09
US10806598P 1998-11-12 1998-11-12
PCT/DK1999/000607 WO2000028065A1 (en) 1998-11-06 1999-11-05 Method for the production of fvii

Publications (1)

Publication Number Publication Date
DE69939548D1 true DE69939548D1 (de) 2008-10-23

Family

ID=27221287

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939548T Expired - Lifetime DE69939548D1 (de) 1998-11-06 1999-11-05 Verfahren zur herstellung von faktor vii

Country Status (8)

Country Link
US (2) US6329176B1 (de)
EP (1) EP1127154B1 (de)
JP (1) JP4463988B2 (de)
AT (1) ATE408020T1 (de)
AU (1) AU1262900A (de)
DE (1) DE69939548D1 (de)
ES (1) ES2315022T3 (de)
WO (1) WO2000028065A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
JP2003521930A (ja) 2000-02-11 2003-07-22 マキシゲン・エイピーエス 第ＶＩＩ因子または第ＶＩＩａ因子様分子
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
EP1325113B1 (de) 2000-10-02 2010-04-21 Novo Nordisk Health Care AG Glykoformen von faktor vii
BR0212780A (pt) 2001-10-02 2004-10-13 Novo Nordisk Healthcare Ag Métodos para produzir polipeptìdeos em células eucarióticas, para cultivar células eucarióticas e para colher polipeptìdeos produzidos por células eucarióticas
AU2003221469A1 (en) 2002-04-30 2003-11-17 Bayer Healthcare Llc FACTOR VII OR VIIa POLYPEPTIDE VARIANTS
JP4847856B2 (ja) 2003-03-20 2011-12-28 バイエル ヘルスケア エルエルシー ＦＶＩＩおよびＦＶＩＩａの変種
EP1624846A2 (de) * 2003-05-06 2006-02-15 Syntonix Pharmaceuticals, Inc. Hemmung der arzneimittelbindung an serumalbumin
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2361036T3 (es) 2003-05-06 2011-06-13 Syntonix Pharmaceuticals, Inc. Proteínas quiméricas vii-fc del factor de coagulación para el tratamiento de un trastorno hemostático.
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
PT1644504E (pt) 2003-06-19 2010-03-22 Bayer Healthcare Llc Variantes do domínio gla dos factores vii ou viia
EP2392655A3 (de) 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Gerinnungsfaktor VII Polypeptide
DK2004214T3 (da) 2006-03-16 2013-02-18 Stellaris Pharmaceuticals Aps Lokalbehandling med faktor VII
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
MY184447A (en) 2009-06-09 2021-04-01 Prolong Pharmaceuticals Llc Hemoglobin compositions
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
RU2448160C1 (ru) * 2010-11-11 2012-04-20 Закрытое акционерное общество "ГЕНЕРИУМ" РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pAP271, КОДИРУЮЩАЯ ПОЛИПЕПТИД ФАКТОРА VII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, И ЛИНИЯ КЛЕТОК Mesocricetus auratus ВНК 21 k.13 (2H7) - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА VII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА
TWI745671B (zh) 2013-03-15 2021-11-11 美商百歐維拉提夫治療公司 因子ｉｘ多肽調配物
BR102015012334A2 (pt) 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
IE914102A1 (en) * 1990-11-26 1992-06-03 Genetics Inst Expression of pace in host cells and methods of use thereof
ES2107520T3 (es) * 1991-12-16 1997-12-01 Ciba Geigy Ag Endoproteasa dibasica recombinante situada en el reticulo endoplasmico y usos de la misma.

Also Published As

Publication number Publication date
EP1127154A1 (de) 2001-08-29
JP4463988B2 (ja) 2010-05-19
AU1262900A (en) 2000-05-29
ATE408020T1 (de) 2008-09-15
US6329176B1 (en) 2001-12-11
ES2315022T3 (es) 2009-03-16
EP1127154B1 (de) 2008-09-10
WO2000028065A1 (en) 2000-05-18
US20020160458A1 (en) 2002-10-31
JP2003523168A (ja) 2003-08-05

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