DE69911024D1 - Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden - Google Patents
Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfidenInfo
- Publication number
- DE69911024D1 DE69911024D1 DE69911024T DE69911024T DE69911024D1 DE 69911024 D1 DE69911024 D1 DE 69911024D1 DE 69911024 T DE69911024 T DE 69911024T DE 69911024 T DE69911024 T DE 69911024T DE 69911024 D1 DE69911024 D1 DE 69911024D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- trisulfides
- recombinant peptides
- recombinant
- low amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802454A SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Production of peptides |
| SE9802454 | 1998-07-08 | ||
| PCT/SE1999/001222 WO2000002900A1 (en) | 1998-07-08 | 1999-07-05 | Method for the production of recombinant peptides with a low amount of trisulfides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69911024D1 true DE69911024D1 (de) | 2003-10-09 |
| DE69911024T2 DE69911024T2 (de) | 2004-04-01 |
Family
ID=20412012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69911024T Expired - Lifetime DE69911024T2 (de) | 1998-07-08 | 1999-07-05 | Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7232894B1 (de) |
| EP (1) | EP1095055B1 (de) |
| JP (1) | JP2002520332A (de) |
| AT (1) | ATE248855T1 (de) |
| AU (1) | AU755083B2 (de) |
| CA (1) | CA2344506C (de) |
| DE (1) | DE69911024T2 (de) |
| DK (1) | DK1095055T3 (de) |
| ES (1) | ES2207255T3 (de) |
| IL (1) | IL140668A0 (de) |
| NZ (1) | NZ509179A (de) |
| PT (1) | PT1095055E (de) |
| SE (1) | SE9802454D0 (de) |
| WO (1) | WO2000002900A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ525134A (en) | 1999-03-02 | 2004-09-24 | Invitrogen Corp | Compositions and methods for use in recombinational cloning of nucleic acids |
| EP2339003A3 (de) | 1999-06-28 | 2011-10-19 | Genentech, Inc. | APO-2 LIGAND substitutionnelle Varianten |
| ZA200501841B (en) * | 2002-08-28 | 2007-06-27 | Pharmacia Corp | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| WO2004026251A2 (en) * | 2002-09-20 | 2004-04-01 | Pharmacia Corporation | Process for decreasing aggregate levels of pegylated protein |
| EP1697534B1 (de) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
| US20090131311A1 (en) * | 2004-12-29 | 2009-05-21 | Novo Nordisk Healthcare Ag | Method for Preventing Formation of Trisulfide Derivatives of Polypeptides |
| US9005926B2 (en) | 2009-10-02 | 2015-04-14 | Biogen Idec Ma Inc. | Methods of preventing and removing trisulfide bonds |
| DK2707383T3 (en) | 2011-05-13 | 2018-07-23 | Biogen Ma Inc | PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS |
| CN106536540A (zh) | 2014-07-24 | 2017-03-22 | 基因泰克公司 | 将试剂缀合至含有至少一个三硫键的蛋白质中的巯基部分的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256546A (en) * | 1983-07-15 | 1993-10-26 | Bio-Technology General Corp. | Bacterial expression of porcine growth hormone |
| US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
| DK44593D0 (da) | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| US5663304A (en) | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
-
1998
- 1998-07-08 SE SE9802454A patent/SE9802454D0/xx unknown
-
1999
- 1999-07-05 DE DE69911024T patent/DE69911024T2/de not_active Expired - Lifetime
- 1999-07-05 JP JP2000559129A patent/JP2002520332A/ja active Pending
- 1999-07-05 EP EP99933442A patent/EP1095055B1/de not_active Revoked
- 1999-07-05 ES ES99933442T patent/ES2207255T3/es not_active Expired - Lifetime
- 1999-07-05 AT AT99933442T patent/ATE248855T1/de not_active IP Right Cessation
- 1999-07-05 CA CA2344506A patent/CA2344506C/en not_active Expired - Fee Related
- 1999-07-05 PT PT99933442T patent/PT1095055E/pt unknown
- 1999-07-05 AU AU49496/99A patent/AU755083B2/en not_active Ceased
- 1999-07-05 WO PCT/SE1999/001222 patent/WO2000002900A1/en active IP Right Grant
- 1999-07-05 DK DK99933442T patent/DK1095055T3/da active
- 1999-07-05 US US09/743,023 patent/US7232894B1/en not_active Expired - Fee Related
- 1999-07-05 NZ NZ509179A patent/NZ509179A/xx unknown
- 1999-07-05 IL IL14066899A patent/IL140668A0/xx unknown
-
2007
- 2007-05-18 US US11/750,692 patent/US20070232792A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1095055E (pt) | 2003-12-31 |
| CA2344506A1 (en) | 2000-01-20 |
| ES2207255T3 (es) | 2004-05-16 |
| JP2002520332A (ja) | 2002-07-09 |
| SE9802454D0 (sv) | 1998-07-08 |
| WO2000002900A1 (en) | 2000-01-20 |
| AU4949699A (en) | 2000-02-01 |
| US20070232792A1 (en) | 2007-10-04 |
| ATE248855T1 (de) | 2003-09-15 |
| NZ509179A (en) | 2003-01-31 |
| DK1095055T3 (da) | 2003-12-22 |
| CA2344506C (en) | 2010-05-11 |
| DE69911024T2 (de) | 2004-04-01 |
| US7232894B1 (en) | 2007-06-19 |
| EP1095055B1 (de) | 2003-09-03 |
| IL140668A0 (en) | 2002-02-10 |
| EP1095055A1 (de) | 2001-05-02 |
| AU755083B2 (en) | 2002-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent |