PT1095055E - Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretos - Google Patents
Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretosInfo
- Publication number
- PT1095055E PT1095055E PT99933442T PT99933442T PT1095055E PT 1095055 E PT1095055 E PT 1095055E PT 99933442 T PT99933442 T PT 99933442T PT 99933442 T PT99933442 T PT 99933442T PT 1095055 E PT1095055 E PT 1095055E
- Authority
- PT
- Portugal
- Prior art keywords
- recombinant
- production
- trysulfureth
- peptidees
- low
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802454A SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Production of peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1095055E true PT1095055E (pt) | 2003-12-31 |
Family
ID=20412012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99933442T PT1095055E (pt) | 1998-07-08 | 1999-07-05 | Metodo para a producao de peptideos recombinantes com baixo teor de trissulfuretos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7232894B1 (pt) |
| EP (1) | EP1095055B1 (pt) |
| JP (1) | JP2002520332A (pt) |
| AT (1) | ATE248855T1 (pt) |
| AU (1) | AU755083B2 (pt) |
| CA (1) | CA2344506C (pt) |
| DE (1) | DE69911024T2 (pt) |
| DK (1) | DK1095055T3 (pt) |
| ES (1) | ES2207255T3 (pt) |
| IL (1) | IL140668A0 (pt) |
| NZ (1) | NZ509179A (pt) |
| PT (1) | PT1095055E (pt) |
| SE (1) | SE9802454D0 (pt) |
| WO (1) | WO2000002900A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4580106B2 (ja) | 1999-03-02 | 2010-11-10 | ライフ テクノロジーズ コーポレーション | 核酸の組換えクローニングにおける使用のための組成物および方法 |
| CN100526463C (zh) | 1999-06-28 | 2009-08-12 | 杰南技术公司 | 利用二价金属离子制备Apo-2配体的方法 |
| US20040048315A1 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| CN1697839B (zh) * | 2002-08-28 | 2010-10-27 | 法玛西亚公司 | 同工型杂质水平较低的生长激素及其拮抗剂的制备方法 |
| ES2337041T3 (es) * | 2002-09-20 | 2010-04-20 | Pharmacia Corporation | Procedimiento para disminuir los niveles de agregacion de proteina pegilada. |
| EP1697534B1 (en) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| WO2006069940A1 (en) * | 2004-12-29 | 2006-07-06 | Novo Nordisk Health Care Ag | Method for preventing formation of trisulfide derivatives of polypeptides |
| EP2483289B1 (en) | 2009-10-02 | 2019-03-20 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| EP3388443A1 (en) | 2011-05-13 | 2018-10-17 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| MX2017001022A (es) | 2014-07-24 | 2017-12-20 | Genentech Inc | Metodos para conjugar un agente a un resto tiol en una proteina que contiene al menos un enlace trisulfuro. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256546A (en) * | 1983-07-15 | 1993-10-26 | Bio-Technology General Corp. | Bacterial expression of porcine growth hormone |
| US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
| DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
-
1998
- 1998-07-08 SE SE9802454A patent/SE9802454D0/xx unknown
-
1999
- 1999-07-05 DE DE69911024T patent/DE69911024T2/de not_active Expired - Lifetime
- 1999-07-05 PT PT99933442T patent/PT1095055E/pt unknown
- 1999-07-05 NZ NZ509179A patent/NZ509179A/xx unknown
- 1999-07-05 DK DK99933442T patent/DK1095055T3/da active
- 1999-07-05 EP EP99933442A patent/EP1095055B1/en not_active Revoked
- 1999-07-05 JP JP2000559129A patent/JP2002520332A/ja active Pending
- 1999-07-05 ES ES99933442T patent/ES2207255T3/es not_active Expired - Lifetime
- 1999-07-05 AT AT99933442T patent/ATE248855T1/de not_active IP Right Cessation
- 1999-07-05 WO PCT/SE1999/001222 patent/WO2000002900A1/en active IP Right Grant
- 1999-07-05 AU AU49496/99A patent/AU755083B2/en not_active Ceased
- 1999-07-05 US US09/743,023 patent/US7232894B1/en not_active Expired - Fee Related
- 1999-07-05 IL IL14066899A patent/IL140668A0/xx unknown
- 1999-07-05 CA CA2344506A patent/CA2344506C/en not_active Expired - Fee Related
-
2007
- 2007-05-18 US US11/750,692 patent/US20070232792A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU4949699A (en) | 2000-02-01 |
| JP2002520332A (ja) | 2002-07-09 |
| EP1095055B1 (en) | 2003-09-03 |
| CA2344506A1 (en) | 2000-01-20 |
| CA2344506C (en) | 2010-05-11 |
| WO2000002900A1 (en) | 2000-01-20 |
| DK1095055T3 (da) | 2003-12-22 |
| SE9802454D0 (sv) | 1998-07-08 |
| US20070232792A1 (en) | 2007-10-04 |
| EP1095055A1 (en) | 2001-05-02 |
| NZ509179A (en) | 2003-01-31 |
| ATE248855T1 (de) | 2003-09-15 |
| AU755083B2 (en) | 2002-12-05 |
| DE69911024T2 (de) | 2004-04-01 |
| DE69911024D1 (de) | 2003-10-09 |
| ES2207255T3 (es) | 2004-05-16 |
| US7232894B1 (en) | 2007-06-19 |
| IL140668A0 (en) | 2002-02-10 |
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