PT1070051E - Processo para a produção de r-(+)-6-carboxamido-3-n- metilamino-1,2,3,4-tetra-hidrocarbazole - Google Patents

Processo para a produção de r-(+)-6-carboxamido-3-n- metilamino-1,2,3,4-tetra-hidrocarbazole Download PDF

Info

Publication number
PT1070051E
PT1070051E PT99915957T PT99915957T PT1070051E PT 1070051 E PT1070051 E PT 1070051E PT 99915957 T PT99915957 T PT 99915957T PT 99915957 T PT99915957 T PT 99915957T PT 1070051 E PT1070051 E PT 1070051E
Authority
PT
Portugal
Prior art keywords
tetrahydrocarbazole
carboxamido
methylamino
production
Prior art date
Application number
PT99915957T
Other languages
English (en)
Inventor
Ian Brackenridge
Caroline Mcgee
Steven Mcintyre
John Knight
David Hartley
Original Assignee
Vernalis Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Dev Ltd filed Critical Vernalis Dev Ltd
Publication of PT1070051E publication Critical patent/PT1070051E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT99915957T 1998-04-16 1999-04-16 Processo para a produção de r-(+)-6-carboxamido-3-n- metilamino-1,2,3,4-tetra-hidrocarbazole PT1070051E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9808069.0A GB9808069D0 (en) 1998-04-16 1998-04-16 Novel processes

Publications (1)

Publication Number Publication Date
PT1070051E true PT1070051E (pt) 2015-08-24

Family

ID=10830430

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99915957T PT1070051E (pt) 1998-04-16 1999-04-16 Processo para a produção de r-(+)-6-carboxamido-3-n- metilamino-1,2,3,4-tetra-hidrocarbazole

Country Status (34)

Country Link
US (1) US6359146B1 (pt)
EP (1) EP1070051B1 (pt)
JP (1) JP4756740B2 (pt)
KR (1) KR100612183B1 (pt)
CN (1) CN1200931C (pt)
AR (1) AR015771A1 (pt)
AU (1) AU3437099A (pt)
BR (1) BR9909627A (pt)
CA (1) CA2328345C (pt)
CY (1) CY1116418T1 (pt)
CZ (1) CZ297303B6 (pt)
DK (1) DK1070051T3 (pt)
EA (1) EA004586B1 (pt)
EE (1) EE05156B1 (pt)
ES (1) ES2541432T3 (pt)
GB (1) GB9808069D0 (pt)
HK (1) HK1037615A1 (pt)
HR (1) HRP20000683B1 (pt)
HU (1) HU230559B1 (pt)
ID (1) ID26783A (pt)
IL (1) IL139017A (pt)
MX (1) MXPA00010127A (pt)
MY (1) MY126530A (pt)
NO (1) NO317883B1 (pt)
PL (1) PL210864B1 (pt)
PT (1) PT1070051E (pt)
SI (1) SI1070051T1 (pt)
SK (1) SK286425B6 (pt)
TR (1) TR200100142T2 (pt)
TW (1) TWI255812B (pt)
UA (1) UA70943C2 (pt)
WO (1) WO1999054302A1 (pt)
YU (1) YU62800A (pt)
ZA (1) ZA200006303B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
WO2011095803A1 (en) * 2010-02-02 2011-08-11 Generics [Uk] Limited Hplc method for analyzing frovatriptan
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
CN103421855B (zh) * 2013-08-13 2016-04-13 凯莱英医药集团（天津）股份有限公司 一种制备琥珀酸夫罗曲坦关键中间体的方法
CN104529871A (zh) * 2014-12-22 2015-04-22 青岛正大海尔制药有限公司 一种琥珀酸呋罗曲坦的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
NL7514300A (nl) * 1975-12-09 1977-06-13 Stamicarbon Werkwijze voor de bereiding van optisch actief fenylglycineamide.
JPS6259274A (ja) * 1985-05-29 1987-03-14 Sumitomo Pharmaceut Co Ltd 光学活性なフエニルセリン誘導体の製造方法
US5827871A (en) 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
GB9113802D0 (en) 1991-06-26 1991-08-14 Smithkline Beecham Plc Medicaments
US5616603A (en) 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
JPH07229341A (ja) * 1994-02-15 1995-08-29 Takero Mori 観音開き扉用ロック
US5618948A (en) 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
US5917054A (en) 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists

Also Published As

Publication number Publication date
HRP20000683B1 (hr) 2016-01-01
AU3437099A (en) 1999-11-08
CZ20003823A3 (cs) 2001-08-15
ZA200006303B (en) 2001-05-30
CN1200931C (zh) 2005-05-11
HU230559B1 (hu) 2016-12-28
HUP0101445A2 (hu) 2001-09-28
TWI255812B (en) 2006-06-01
HRP20000683A2 (en) 2001-04-30
SI1070051T1 (sl) 2015-07-31
NO20005158D0 (no) 2000-10-13
SK286425B6 (sk) 2008-09-05
GB9808069D0 (en) 1998-06-17
MY126530A (en) 2006-10-31
IL139017A (en) 2005-08-31
US6359146B1 (en) 2002-03-19
WO1999054302A1 (en) 1999-10-28
KR100612183B1 (ko) 2006-08-16
BR9909627A (pt) 2001-11-06
EP1070051A1 (en) 2001-01-24
NO20005158L (no) 2000-10-31
MXPA00010127A (es) 2002-08-06
NO317883B1 (no) 2004-12-27
CY1116418T1 (el) 2017-02-08
JP2002512227A (ja) 2002-04-23
HUP0101445A3 (en) 2002-12-28
TR200100142T2 (tr) 2001-07-23
KR20010042661A (ko) 2001-05-25
PL343528A1 (en) 2001-08-27
EP1070051B1 (en) 2015-06-03
HK1037615A1 (en) 2002-02-15
CN1305460A (zh) 2001-07-25
UA70943C2 (uk) 2004-11-15
CZ297303B6 (cs) 2006-11-15
AR015771A1 (es) 2001-05-16
CA2328345A1 (en) 1999-10-28
ES2541432T3 (es) 2015-07-20
EE05156B1 (et) 2009-04-15
JP4756740B2 (ja) 2011-08-24
DK1070051T3 (en) 2015-07-06
ID26783A (id) 2001-02-08
EE200000597A (et) 2002-04-15
EA004586B1 (ru) 2004-06-24
PL210864B1 (pl) 2012-03-30
SK15182000A3 (sk) 2001-06-11
CA2328345C (en) 2010-12-07
IL139017A0 (en) 2001-11-25
YU62800A (sh) 2002-11-15
EA200001080A1 (ru) 2001-06-25

Similar Documents

Publication Publication Date Title
PL348827A1 (en) Process for making 2,3-dihalopropanols
HUP0103946A3 (en) Process for the production of olefins
HK1030930A1 (en) Process for the production of aromatic amines.
IL133363A (en) Process for the production of herapin
IL139023A0 (en) Process for the preparation of 2,3,5-trimethyl-p- benzoquinone
ZA200001434B (en) Process for the production of polymer.
GB2343892B (en) Process for the preparation of d,l-menthol
ZA985918B (en) Process for the production of indole derivatives.
HUP0101445A3 (en) Process for the production of r-(+)-6-carboxamido-3-n-methylamino-1,2,3,4-tetrahydrocarbazole
IL149713A0 (en) Process for the production of trifluormethylacetophenones
GB9826175D0 (en) Novel process
MXPA01001471A (es) Nuevo proceso para la sintesis de exoquelinas.
HK1062678A1 (en) Process for preparing 8-cyclopentyl-6-ethyl-3-ÄsubstitutedÜ-5,8-dihydro-4H 7,8-pentaaza-as-indacenesand intermediates useful therein
HU0000208D0 (en) Process producing the secondary-alkoxy-1-alkenes
GB9817195D0 (en) Novel process
HK1034064A1 (en) Process for the production of formylimidazoles
GB9806786D0 (en) Novel process
AP2000001896A0 (en) Improved process for maintaining the stabillity of the fortification
ZA977562B (en) Process for the production of 2H-1-benzopyrans
ZA200204924B (en) Process for the production of olefins.
GB9813269D0 (en) Novel process
GB9816027D0 (en) Novel process
GB9817159D0 (en) Novel process
GB9812016D0 (en) Novel process
GB9805579D0 (en) Novel process